JP2003531129A5 - - Google Patents
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- Publication number
- JP2003531129A5 JP2003531129A5 JP2001576078A JP2001576078A JP2003531129A5 JP 2003531129 A5 JP2003531129 A5 JP 2003531129A5 JP 2001576078 A JP2001576078 A JP 2001576078A JP 2001576078 A JP2001576078 A JP 2001576078A JP 2003531129 A5 JP2003531129 A5 JP 2003531129A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- pharmaceutical composition
- immunoglobulin
- antigen
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108060003951 Immunoglobulin Proteins 0.000 description 29
- 102000018358 immunoglobulin Human genes 0.000 description 29
- 239000012634 fragment Substances 0.000 description 23
- 239000000427 antigen Substances 0.000 description 20
- 108091007433 antigens Proteins 0.000 description 19
- 102000036639 antigens Human genes 0.000 description 19
- 239000008194 pharmaceutical composition Substances 0.000 description 19
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 102000006495 integrins Human genes 0.000 description 7
- 108010044426 integrins Proteins 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 230000008595 infiltration Effects 0.000 description 6
- 238000001764 infiltration Methods 0.000 description 6
- 210000000265 leukocyte Anatomy 0.000 description 6
- 210000004400 mucous membrane Anatomy 0.000 description 6
- 206010009900 Colitis ulcerative Diseases 0.000 description 4
- 208000011231 Crohn disease Diseases 0.000 description 4
- 201000006704 Ulcerative Colitis Diseases 0.000 description 4
- 229940072221 immunoglobulins Drugs 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- 208000004396 mastitis Diseases 0.000 description 4
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 208000003167 cholangitis Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 206010006458 Bronchitis chronic Diseases 0.000 description 2
- 206010009137 Chronic sinusitis Diseases 0.000 description 2
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 2
- 206010033645 Pancreatitis Diseases 0.000 description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 2
- 229960002170 azathioprine Drugs 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000001352 cholecystitis Diseases 0.000 description 2
- 208000023819 chronic asthma Diseases 0.000 description 2
- 208000007451 chronic bronchitis Diseases 0.000 description 2
- 208000027157 chronic rhinosinusitis Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000002955 immunomodulating agent Substances 0.000 description 2
- 229940121354 immunomodulator Drugs 0.000 description 2
- 229960003444 immunosuppressant agent Drugs 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 229960001428 mercaptopurine Drugs 0.000 description 2
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 2
- 229960004963 mesalazine Drugs 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 2
- 229960005205 prednisolone Drugs 0.000 description 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 2
- 229960004618 prednisone Drugs 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 239000011232 storage material Substances 0.000 description 2
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 2
- 229960001940 sulfasalazine Drugs 0.000 description 2
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 208000017760 chronic graft versus host disease Diseases 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 201000010315 pericholangitis Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55008200A | 2000-04-14 | 2000-04-14 | |
| US09/550,082 | 2000-04-14 | ||
| US09/748,960 US20010046496A1 (en) | 2000-04-14 | 2000-12-27 | Method of administering an antibody |
| US09/748,960 | 2000-12-27 | ||
| PCT/US2001/012234 WO2001078779A2 (en) | 2000-04-14 | 2001-04-13 | Antibody alpha4beta7 integrin and its use to treat inflammatory bowel disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012105379A Division JP5764524B2 (ja) | 2000-04-14 | 2012-05-02 | 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003531129A JP2003531129A (ja) | 2003-10-21 |
| JP2003531129A5 true JP2003531129A5 (enExample) | 2011-02-17 |
Family
ID=27069332
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001576078A Withdrawn JP2003531129A (ja) | 2000-04-14 | 2001-04-13 | 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 |
| JP2012105379A Expired - Lifetime JP5764524B2 (ja) | 2000-04-14 | 2012-05-02 | 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 |
| JP2015007655A Expired - Lifetime JP6021959B2 (ja) | 2000-04-14 | 2015-01-19 | 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012105379A Expired - Lifetime JP5764524B2 (ja) | 2000-04-14 | 2012-05-02 | 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 |
| JP2015007655A Expired - Lifetime JP6021959B2 (ja) | 2000-04-14 | 2015-01-19 | 炎症性腸疾患を治療するための抗体α４β７インテグリンおよびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US20010046496A1 (enExample) |
| EP (3) | EP1278543B1 (enExample) |
| JP (3) | JP2003531129A (enExample) |
| AU (1) | AU2001251629A1 (enExample) |
| BE (1) | BE2017C009I2 (enExample) |
| CA (1) | CA2406220C (enExample) |
| CY (3) | CY1113489T1 (enExample) |
| DK (2) | DK1278543T3 (enExample) |
| ES (2) | ES2609689T3 (enExample) |
| FR (1) | FR14C0080I2 (enExample) |
| LU (1) | LUC00014I2 (enExample) |
| MX (1) | MXPA02010059A (enExample) |
| NL (1) | NL300702I2 (enExample) |
| PT (1) | PT2298348T (enExample) |
| WO (1) | WO2001078779A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8030025B2 (en) | 2008-02-20 | 2011-10-04 | Amgen Inc. | Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| PL215263B1 (pl) * | 2002-02-25 | 2013-11-29 | Elan Pharm Inc | Kompozycja do przewleklego leczenia patologicznego zapalenia i zastosowanie natalizumabu lub jego immunologicznie aktywnego fragmentu do wytwarzania leku |
| GB0210121D0 (en) | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
| TWI438010B (zh) * | 2002-05-02 | 2014-05-21 | Wyeth Corp | 卡奇黴素（ｃａｌｉｃｈｅａｍｉｃｉｎ）衍生物-載體共軛物 |
| CN1956738B (zh) * | 2004-01-09 | 2013-05-29 | 辉瑞大药厂 | MAdCAM抗体 |
| SI1784426T1 (sl) | 2004-09-03 | 2012-03-30 | Genentech Inc | Humanizirani antagonisti proti beta in njihove uporabe |
| ATE483732T1 (de) * | 2005-07-08 | 2010-10-15 | Pfizer Ltd | Madcam-antikörper |
| WO2007007152A2 (en) * | 2005-07-11 | 2007-01-18 | Pfizer Limited | Anti-madcam antibodies to treat metastatic cancers and chloroma |
| BRPI0613459A2 (pt) * | 2005-07-11 | 2011-01-11 | Pfizer Ltd | combinação de anticorpo anti-madcam e inibidor de caspase antifibrótica para tratar fibrose hepática |
| CA2675291C (en) * | 2007-01-11 | 2017-05-23 | Novo Nordisk A/S | Killer ig-like receptor (kir) antibodies, formulations, and uses thereof |
| WO2008115504A2 (en) * | 2007-03-20 | 2008-09-25 | Millennium Pharmaceuticals, Inc. | Nucleic acids encoding humanized immunoglobulin that binds a4b7 integrin |
| WO2009026117A2 (en) * | 2007-08-16 | 2009-02-26 | Glaxo Group Limited | Novel compounds |
| US20100255508A1 (en) * | 2008-05-16 | 2010-10-07 | Thomas Richard Gelzleichter | Use of biomarkers for assessing treatment of gastrointestinal inflammatory disorders with beta7 integrin antagonists |
| KR101391472B1 (ko) * | 2009-03-20 | 2014-05-07 | 암젠 인크 | 알파-4-베타-7 이종이량체 특이적 길항제 항체 |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| KR101875155B1 (ko) | 2011-05-02 | 2018-07-09 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| CA2856866C (en) * | 2011-11-23 | 2022-07-12 | Amgen Inc. | Administration of alpha4beta7 hetero-dimer-specific antibody |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| EA034583B1 (ru) * | 2012-01-12 | 2020-02-21 | Милленниум Фармасьютикалз, Инк. | ПРИМЕНЕНИЯ АНТИ-α4β7 АНТИТЕЛА |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| WO2016086147A1 (en) | 2014-11-26 | 2016-06-02 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| US20170360926A1 (en) | 2014-12-24 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-alpha4beta7 INTEGRIN ANTIBODY |
| CN117298268A (zh) | 2016-03-14 | 2023-12-29 | 千禧制药公司 | 治疗或预防移植物抗宿主疾病的方法 |
| AU2017234009B2 (en) | 2016-03-14 | 2024-06-06 | Millennium Pharmaceuticals, Inc. | Method of preventing graft versus host disease |
| TW201735949A (zh) | 2016-03-24 | 2017-10-16 | 千禧製藥公司 | 治療抗ctla4及抗pd-1組合治療中的胃腸道免疫相關不良事件之方法 |
| JP7069032B2 (ja) | 2016-03-24 | 2022-05-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | がん免疫治療における胃腸の免疫関連有害事象の治療方法 |
| WO2017192867A1 (en) | 2016-05-04 | 2017-11-09 | Millennium Pharmaceuticals, Inc. | Triple combination therapy for treating inflammatory bowel disease |
| MA45245A (fr) | 2016-06-12 | 2019-04-17 | Millennium Pharm Inc | Méthode de traitement de maladie intestinale inflammatoire |
| SG11202000298VA (en) | 2017-07-14 | 2020-02-27 | Pfizer | Antibodies to madcam |
| US12492245B2 (en) * | 2021-09-21 | 2025-12-09 | University Of South Carolina | Anti-CCL8 antibodies and treatment of lung injury by CCL8 inhibition |
| AU2024282654A1 (en) | 2023-05-30 | 2025-12-04 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
| WO2024252368A2 (en) | 2023-06-09 | 2024-12-12 | Takeda Pharmaceutical Company Limited | Methods and compositions for treating ulcerative colitis |
| WO2025149974A1 (en) | 2024-01-11 | 2025-07-17 | Takeda Pharmaceutical Company Limited | Combination therapy with an anti-alpha4beta7 antibody |
| WO2025177214A1 (en) | 2024-02-20 | 2025-08-28 | Takeda Pharmaceutical Company Limited | Therapeutic methods |
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| US4172124A (en) | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
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| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
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-
2000
- 2000-12-27 US US09/748,960 patent/US20010046496A1/en not_active Abandoned
-
2001
- 2001-04-13 PT PT100109974T patent/PT2298348T/pt unknown
- 2001-04-13 MX MXPA02010059A patent/MXPA02010059A/es active IP Right Grant
- 2001-04-13 DK DK01925028.1T patent/DK1278543T3/da active
- 2001-04-13 ES ES10010997.4T patent/ES2609689T3/es not_active Expired - Lifetime
- 2001-04-13 CA CA2406220A patent/CA2406220C/en not_active Expired - Lifetime
- 2001-04-13 ES ES01925028T patent/ES2398096T3/es not_active Expired - Lifetime
- 2001-04-13 EP EP01925028A patent/EP1278543B1/en not_active Expired - Lifetime
- 2001-04-13 AU AU2001251629A patent/AU2001251629A1/en not_active Abandoned
- 2001-04-13 DK DK10010997.4T patent/DK2298348T3/en active
- 2001-04-13 WO PCT/US2001/012234 patent/WO2001078779A2/en not_active Ceased
- 2001-04-13 EP EP16191558.2A patent/EP3167902B1/en not_active Revoked
- 2001-04-13 JP JP2001576078A patent/JP2003531129A/ja not_active Withdrawn
- 2001-04-13 EP EP10010997.4A patent/EP2298348B9/en not_active Expired - Lifetime
-
2003
- 2003-12-15 US US10/735,863 patent/US20050095238A1/en not_active Abandoned
-
2011
- 2011-08-05 US US13/204,139 patent/US20120034243A1/en not_active Abandoned
-
2012
- 2012-05-02 JP JP2012105379A patent/JP5764524B2/ja not_active Expired - Lifetime
- 2012-12-18 CY CY20121101236T patent/CY1113489T1/el unknown
-
2014
- 2014-02-03 US US14/171,161 patent/US20140186345A1/en not_active Abandoned
- 2014-11-11 NL NL300702C patent/NL300702I2/nl unknown
- 2014-11-13 FR FR14C0080C patent/FR14C0080I2/fr active Active
- 2014-11-17 CY CY2014046C patent/CY2014046I1/el unknown
-
2015
- 2015-01-19 JP JP2015007655A patent/JP6021959B2/ja not_active Expired - Lifetime
-
2017
- 2017-01-05 CY CY20171100013T patent/CY1118429T1/el unknown
- 2017-04-11 BE BE2017C009C patent/BE2017C009I2/nl unknown
- 2017-04-11 LU LU00014C patent/LUC00014I2/fr unknown
-
2018
- 2018-11-02 US US16/179,157 patent/US20200002423A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8030025B2 (en) | 2008-02-20 | 2011-10-04 | Amgen Inc. | Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof |
| US8221749B2 (en) | 2008-02-20 | 2012-07-17 | Amgen Inc. | Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof |
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