AR112336A1 - ANTICUERPOS CONTRA MAdCAM - Google Patents

ANTICUERPOS CONTRA MAdCAM

Info

Publication number
AR112336A1
AR112336A1 ARP180101961A AR112336A1 AR 112336 A1 AR112336 A1 AR 112336A1 AR P180101961 A ARP180101961 A AR P180101961A AR 112336 A1 AR112336 A1 AR 112336A1
Authority
AR
Argentina
Prior art keywords
antibodies
madcam
description
human anti
nucleic acid
Prior art date
Application number
Other languages
English (en)
Inventor
Karin Anderson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR112336A1 publication Critical patent/AR112336A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente descripción se refiere a anticuerpos que incluyen anticuerpos humanos y porciones que ligan antígeno de los mismos que se ligan específicamente a MAdCAM, preferentemente a MAdCAM humano y que funcionan para inhibir MAdCAM. La descripción también se refiere a anticuerpos anti-MAdCAM humanos y porciones que ligan antígeno de los mismos. La descripción también se refiere a anticuerpos que son quiméricos, biespecíficos, derivatizados, anticuerpos de cadena simple o porciones de proteínas de fusión. La descripción también se refiere a inmunoglobulinas aisladas de cadena pesada y liviana derivadas de anticuerpos anti-MAdCAM humanos y a moléculas de ácido nucleico que codifican tales inmunoglobulinas. La presente descripción también se refiere a métodos para fabricar anticuerpos anti-MAdCAM humanos, a composiciones que comprenden estos anticuerpos y a métodos para usar los anticuerpos y composiciones para diagnóstico y tratamiento. La descripción también provee métodos de terapia con genes que usan moléculas de ácido nucleico que codifican la cadena pesada y/o liviana de moléculas de inmunoglobulina que comprenden los anticuerpos anti-MAdCAM humanos. La descripción también se refiere a animales o plantas transgénicos que comprenden moléculas de ácido nucleico de la descripción.
ARP180101961 2017-07-14 2018-07-13 ANTICUERPOS CONTRA MAdCAM AR112336A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762532809P 2017-07-14 2017-07-14

Publications (1)

Publication Number Publication Date
AR112336A1 true AR112336A1 (es) 2019-10-16

Family

ID=63209653

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180101961 AR112336A1 (es) 2017-07-14 2018-07-13 ANTICUERPOS CONTRA MAdCAM

Country Status (25)

Country Link
US (2) US20190169291A1 (es)
EP (1) EP3652211A1 (es)
JP (1) JP7160491B2 (es)
KR (1) KR20200028006A (es)
CN (2) CN118406148A (es)
AR (1) AR112336A1 (es)
AU (1) AU2018300189A1 (es)
BR (1) BR112020000698A2 (es)
CA (1) CA3069914A1 (es)
CL (1) CL2020000102A1 (es)
CO (1) CO2020000352A2 (es)
CR (1) CR20200076A (es)
CU (1) CU20200002A7 (es)
DO (1) DOP2020000005A (es)
EA (1) EA202090286A1 (es)
EC (1) ECSP20011317A (es)
IL (1) IL272015A (es)
MA (1) MA48241A1 (es)
MX (1) MX2023014363A (es)
NI (1) NI202000004A (es)
PE (1) PE20200616A1 (es)
PH (1) PH12020500100A1 (es)
SG (1) SG11202000298VA (es)
TW (1) TW201920266A (es)
WO (1) WO2019014572A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240166746A1 (en) 2022-11-22 2024-05-23 Takeda Pharmaceutical Company Limited DOSAGE REGIMEN OF MAdCAM-1 ANTIBODY FOR TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS

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Also Published As

Publication number Publication date
CU20200002A7 (es) 2020-11-30
US20220119521A1 (en) 2022-04-21
DOP2020000005A (es) 2021-02-15
MX2023014363A (es) 2023-12-15
EA202090286A1 (ru) 2020-05-12
BR112020000698A2 (pt) 2020-07-14
CR20200076A (es) 2020-06-10
US11802156B2 (en) 2023-10-31
MA48241A1 (fr) 2021-03-31
CL2020000102A1 (es) 2020-10-09
JP2020533953A (ja) 2020-11-26
IL272015A (en) 2020-02-27
KR20200028006A (ko) 2020-03-13
PH12020500100A1 (en) 2020-09-14
CA3069914A1 (en) 2019-01-17
ECSP20011317A (es) 2020-12-31
JP7160491B2 (ja) 2022-10-25
NI202000004A (es) 2020-03-30
SG11202000298VA (en) 2020-02-27
US20190169291A1 (en) 2019-06-06
TW201920266A (zh) 2019-06-01
CN111032694B (zh) 2024-03-08
EP3652211A1 (en) 2020-05-20
PE20200616A1 (es) 2020-03-11
CO2020000352A2 (es) 2020-04-13
AU2018300189A1 (en) 2020-01-30
CN111032694A (zh) 2020-04-17
WO2019014572A1 (en) 2019-01-17
CN118406148A (zh) 2024-07-30

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