ATE208374T1 - Beta-laktam und cepham verbindungen und ihre herstellung - Google Patents
Beta-laktam und cepham verbindungen und ihre herstellungInfo
- Publication number
- ATE208374T1 ATE208374T1 AT93903302T AT93903302T ATE208374T1 AT E208374 T1 ATE208374 T1 AT E208374T1 AT 93903302 T AT93903302 T AT 93903302T AT 93903302 T AT93903302 T AT 93903302T AT E208374 T1 ATE208374 T1 AT E208374T1
- Authority
- AT
- Austria
- Prior art keywords
- lactam
- beta
- optionally substituted
- production
- compound
- Prior art date
Links
- 150000001781 cephams Chemical class 0.000 title 1
- 150000003952 β-lactams Chemical class 0.000 title 1
- -1 beta -lactam compound Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001782 cephems Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03031092A JP3227497B2 (ja) | 1992-02-18 | 1992-02-18 | β−ラクタム化合物及びその製造法 |
| JP03031192A JP3265381B2 (ja) | 1992-02-18 | 1992-02-18 | 2−置換メチル−3−セフェム化合物及びその製造法並びに2−エキソメチレンセフェム誘導体の製造法 |
| PCT/JP1993/000131 WO1993016043A1 (en) | 1992-02-18 | 1993-02-03 | β-LACTAM COMPOUND AND CEPHEM COMPOUND, AND PRODUCTION THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE208374T1 true ATE208374T1 (de) | 2001-11-15 |
Family
ID=26368636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93903302T ATE208374T1 (de) | 1992-02-18 | 1993-02-03 | Beta-laktam und cepham verbindungen und ihre herstellung |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US5470972A (de) |
| EP (1) | EP0592677B1 (de) |
| AT (1) | ATE208374T1 (de) |
| DE (1) | DE69331089T2 (de) |
| WO (1) | WO1993016043A1 (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE05627B1 (et) * | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| US7109003B2 (en) * | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| DK2112166T3 (en) | 1998-12-23 | 2019-02-04 | Pfizer | Human monoclonal antibodies to CTLA-4 |
| US7605238B2 (en) * | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| NZ517202A (en) | 1999-08-24 | 2004-05-28 | Medarex Inc | Human CTLA-4 antibodies and their uses |
| EP2796468A2 (de) | 2001-01-05 | 2014-10-29 | Pfizer Inc | Antikörper für Insulinähnlichen Wachstumsfaktor-1-Rezeptor |
| US6578724B1 (en) * | 2001-12-29 | 2003-06-17 | United States Can Company | Connector for use in packaging aerosol containers |
| IL164287A0 (en) * | 2002-04-12 | 2005-12-18 | Medarex Inc | Methods of treatment using ctla-4 antibodies |
| ES2557769T3 (es) | 2003-03-19 | 2016-01-28 | Amgen Fremont Inc. | Anticuerpos contra el antígeno del dominio de inmunoglobulina de células T y el dominio 1 de mucina (TIM-1) y usos de los mismos |
| SI2177537T1 (sl) * | 2004-01-09 | 2012-01-31 | Pfizer | Protitielesa proti MAdCAM |
| CA2569509C (en) | 2004-06-03 | 2014-08-12 | Novimmune S.A. | Anti-cd3 antibodies and methods of use thereof |
| WO2006008639A1 (en) * | 2004-07-16 | 2006-01-26 | Pfizer Products Inc. | Combination treatment for non-hematologic malignancies using an anti-igf-1r antibody |
| EP3312196B1 (de) | 2005-03-23 | 2019-07-17 | Genmab A/S | Antikörper gegen cd38 zur behandlung von multiplem myelom |
| EP2384767B1 (de) | 2005-03-24 | 2016-03-09 | Millennium Pharmaceuticals, Inc. | OV064-bindende Antikörper und Verfahren zu deren Verwendung |
| KR101203328B1 (ko) | 2005-04-26 | 2012-11-20 | 화이자 인코포레이티드 | P-카드헤린 항체 |
| US8642330B2 (en) * | 2005-08-08 | 2014-02-04 | Onconon, Llc | Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility |
| EA014025B1 (ru) * | 2005-09-12 | 2010-08-30 | Новиммун С.А. | Композиции антитела против cd3 |
| EP1957115B8 (de) | 2005-11-10 | 2014-03-05 | Celldex Therapeutics, Inc. | Verfahren zur behandlung von ovarial- und nierenkarzinom mit antikörpern gegen t-zell-immunglobulin-domänen- und mucin-domänen-1-(tim-1)-antigen |
| AU2006321593B2 (en) | 2005-12-07 | 2012-10-04 | E. R. Squibb & Sons, L.L.C. | CTLA-4 antibody dosage escalation regimens |
| CN101578297A (zh) * | 2006-04-07 | 2009-11-11 | 美国政府健康及人类服务部 | 治疗肿瘤疾病的抗体组合物和方法 |
| JP2010534719A (ja) * | 2007-07-27 | 2010-11-11 | ファイザー・リミテッド | 沈殿化による抗体精製方法 |
| CA2935651A1 (en) | 2007-10-09 | 2009-04-16 | Gladius Pharmaceuticals Corporation | Broad spectrum beta-lactamase inhibitors |
| WO2015164330A1 (en) | 2014-04-21 | 2015-10-29 | Millennium Pharmaceuticals, Inc. | Anti-psyk antibody molecules and use of same for syk-targeted therapy |
| US8137671B2 (en) | 2009-05-05 | 2012-03-20 | Genentech, Inc. | Anti-IL-17F antibodies |
| CA2774032C (en) | 2009-10-23 | 2019-03-26 | Millennium Pharmaceuticals, Inc. | Anti-gcc antibody molecules and related compositions and methods |
| US9211302B2 (en) | 2011-01-17 | 2015-12-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulation of LRCH4 activity and therapeutic application thereof |
| US9150644B2 (en) | 2011-04-12 | 2015-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II |
| CA2835603A1 (en) | 2011-05-09 | 2012-11-15 | Perseus Proteomics Inc. | Antibody capable of specifically recognizing transferrin receptor |
| WO2012158818A2 (en) | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| KR102338833B1 (ko) | 2012-02-06 | 2021-12-13 | 인히브릭스, 인크. | Cd47 항체 및 그 사용 방법 |
| US9156915B2 (en) | 2012-04-26 | 2015-10-13 | Thomas Jefferson University | Anti-GCC antibody molecules |
| US9593165B2 (en) | 2012-11-08 | 2017-03-14 | University Of Miyazaki | Antibody capable of specifically recognizing transferrin receptor |
| WO2014123580A1 (en) | 2013-02-06 | 2014-08-14 | Inhibrx Llc | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
| EP3441071A1 (de) | 2013-03-12 | 2019-02-13 | Gladius Pharmaceuticals Corporation | Derivatisierte cephalosporine |
| US10077304B2 (en) | 2013-08-14 | 2018-09-18 | The Governing Council Of The University Of Toronto | Antibodies against frizzled receptor |
| JP6552412B2 (ja) | 2013-09-05 | 2019-07-31 | 国立大学法人 宮崎大学 | ヒトインテグリンa6b4と特異的に反応する抗体 |
| TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
| CA2967379A1 (en) | 2014-11-18 | 2016-05-26 | Janssen Pharmaceutica Nv | Cd47 antibodies, methods, and uses |
| CN109476756B (zh) | 2016-03-15 | 2022-05-31 | 埃泰美德(香港)有限公司 | 一种多特异性Fab融合蛋白及其用途 |
| AU2017234163B2 (en) | 2016-03-15 | 2023-01-19 | Mersana Therapeutics, Inc. | NaPi2b-targeted antibody-drug conjugates and methods of use thereof |
| WO2017221883A1 (ja) | 2016-06-20 | 2017-12-28 | 武田薬品工業株式会社 | 抗体-薬物コンジュゲート |
| WO2018049261A1 (en) | 2016-09-09 | 2018-03-15 | Icellhealth Consulting Llc | Oncolytic virus expressing immune checkpoint modulators |
| CR20200076A (es) | 2017-07-14 | 2020-06-10 | Pfizer | ANTICUERPOS CONTRA MAdCAM |
| US12460000B2 (en) | 2018-09-07 | 2025-11-04 | Itabmed (Hk) Limited | Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof |
| JP7410051B2 (ja) | 2018-11-20 | 2024-01-09 | 株式会社ペルセウスプロテオミクス | 細胞内への鉄の取り込み阻害剤 |
| WO2020132810A1 (en) | 2018-12-24 | 2020-07-02 | Generon (Shanghai) Corporation Ltd. | Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof |
| IT201900008376A1 (it) | 2019-06-07 | 2020-12-07 | Univ Degli Studi Di Modena E Reggio Emilia | Anticorpi ad attività antitumorale |
| EP4026560A4 (de) | 2019-09-04 | 2023-10-25 | Perseus Proteomics Inc. | Therapeutisches mittel für polyzythämie |
| JP7622926B2 (ja) | 2019-11-27 | 2025-01-28 | 株式会社ペルセウスプロテオミクス | 癌性腹膜炎の治療薬 |
| EP3909601A1 (de) | 2020-05-11 | 2021-11-17 | LeukoCom GmbH | Neuer antikörper, der spezifisch an menschliches ceacam1/3/5 bindet, und dessen verwendung |
| WO2021247908A1 (en) | 2020-06-03 | 2021-12-09 | Bionecure Therapeutics, Inc. | Trophoblast cell-surface antigen-2 (trop-2) antibodies |
| JP7789304B2 (ja) | 2020-07-31 | 2025-12-22 | バイオ-テラ ソリュ-ションズ,エルティーディー. | Cd47抗体及びその応用 |
| WO2022075439A1 (ja) | 2020-10-08 | 2022-04-14 | 国立大学法人東海国立大学機構 | 抗トランスフェリンレセプター抗体の薬効又は感受性の判定方法 |
| CN117836003A (zh) | 2021-08-26 | 2024-04-05 | 株式会社英仙蛋白质科学 | Ros(活性氧类)产生增强剂 |
| WO2023116911A1 (zh) | 2021-12-24 | 2023-06-29 | 百奥泰生物制药股份有限公司 | 抗FRα抗体及其抗体药物偶联物和用途 |
| US12122850B2 (en) | 2022-03-14 | 2024-10-22 | LamKap Bio gamma AG | Bispecific GPC3xCD28 and GPC3xCD3 antibodies and their combination for targeted killing of GPC3 positive malignant cells |
| KR20250007549A (ko) | 2022-04-19 | 2025-01-14 | 토카이 유니버시티 에듀케이셔널시스템 | Nk 세포종양 치료제 |
| EP4635983A1 (de) | 2024-04-15 | 2025-10-22 | Ymmunobio AG | Neuartiger antikörper mit spezifischer bindung an nptxr und verwendung davon |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT342197B (de) * | 1975-02-20 | 1978-03-28 | Ciba Geigy Ag | Neues verfahren zur herstellung von 3-cephemverbindungen |
| JPS5214789A (en) * | 1975-07-22 | 1977-02-03 | Shionogi & Co Ltd | Process for preparing 3-substiuted cephem compounds by ring closure |
| JPS56118085A (en) * | 1980-02-25 | 1981-09-16 | Takeda Chem Ind Ltd | 2-methylcephalosporin derivative and its preparation |
| EP0124081A3 (de) * | 1983-05-02 | 1986-11-26 | Merck & Co. Inc. | Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung |
| US5132301A (en) * | 1983-05-02 | 1992-07-21 | Merck & Co., Inc. | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents |
| JPS60237061A (ja) * | 1984-05-08 | 1985-11-25 | Otsuka Chem Co Ltd | アゼチジノン誘導体の製造法 |
| NZ222399A (en) * | 1986-11-12 | 1991-07-26 | Merck & Co Inc | Cephalosporin derivatives; pharmaceutical compositions and processes for preparation |
| GB8808701D0 (en) * | 1988-04-13 | 1988-05-18 | Erba Carlo Spa | Beta-lactam derivatives |
| US5162521A (en) * | 1991-06-06 | 1992-11-10 | Bristol-Myers Squibb Company | Processes for making cephems from allenylazetidinone derivatives |
-
1993
- 1993-02-03 WO PCT/JP1993/000131 patent/WO1993016043A1/ja not_active Ceased
- 1993-02-03 DE DE69331089T patent/DE69331089T2/de not_active Expired - Fee Related
- 1993-02-03 EP EP93903302A patent/EP0592677B1/de not_active Expired - Lifetime
- 1993-02-03 AT AT93903302T patent/ATE208374T1/de not_active IP Right Cessation
- 1993-10-14 US US08/129,130 patent/US5470972A/en not_active Expired - Fee Related
-
1995
- 1995-08-15 US US08/515,166 patent/US5693792A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0592677A4 (en) | 1994-07-06 |
| DE69331089T2 (de) | 2002-07-18 |
| EP0592677B1 (de) | 2001-11-07 |
| DE69331089D1 (de) | 2001-12-13 |
| WO1993016043A1 (en) | 1993-08-19 |
| US5470972A (en) | 1995-11-28 |
| EP0592677A1 (de) | 1994-04-20 |
| US5693792A (en) | 1997-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |