ATE208374T1 - Beta-laktam und cepham verbindungen und ihre herstellung - Google Patents

Beta-laktam und cepham verbindungen und ihre herstellung

Info

Publication number
ATE208374T1
ATE208374T1 AT93903302T AT93903302T ATE208374T1 AT E208374 T1 ATE208374 T1 AT E208374T1 AT 93903302 T AT93903302 T AT 93903302T AT 93903302 T AT93903302 T AT 93903302T AT E208374 T1 ATE208374 T1 AT E208374T1
Authority
AT
Austria
Prior art keywords
lactam
beta
optionally substituted
production
compound
Prior art date
Application number
AT93903302T
Other languages
English (en)
Inventor
Shigeru Torii
Hideo Tanaka
Mitio Sasaoka
Takashi Shiroi
Yutaka Kameyama
Original Assignee
Otsuka Kagaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP03031092A external-priority patent/JP3227497B2/ja
Priority claimed from JP03031192A external-priority patent/JP3265381B2/ja
Application filed by Otsuka Kagaku Kk filed Critical Otsuka Kagaku Kk
Application granted granted Critical
Publication of ATE208374T1 publication Critical patent/ATE208374T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
AT93903302T 1992-02-18 1993-02-03 Beta-laktam und cepham verbindungen und ihre herstellung ATE208374T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP03031092A JP3227497B2 (ja) 1992-02-18 1992-02-18 β−ラクタム化合物及びその製造法
JP03031192A JP3265381B2 (ja) 1992-02-18 1992-02-18 2−置換メチル−3−セフェム化合物及びその製造法並びに2−エキソメチレンセフェム誘導体の製造法
PCT/JP1993/000131 WO1993016043A1 (en) 1992-02-18 1993-02-03 β-LACTAM COMPOUND AND CEPHEM COMPOUND, AND PRODUCTION THEREOF

Publications (1)

Publication Number Publication Date
ATE208374T1 true ATE208374T1 (de) 2001-11-15

Family

ID=26368636

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93903302T ATE208374T1 (de) 1992-02-18 1993-02-03 Beta-laktam und cepham verbindungen und ihre herstellung

Country Status (5)

Country Link
US (2) US5470972A (de)
EP (1) EP0592677B1 (de)
AT (1) ATE208374T1 (de)
DE (1) DE69331089T2 (de)
WO (1) WO1993016043A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE05627B1 (et) * 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
US7109003B2 (en) * 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
MXPA01006422A (es) 1998-12-23 2002-06-04 Pfizer Inc Abgenix Inc Anticuerpos monoclonales humanos de ctla-4.
MXPA02001911A (es) 1999-08-24 2003-07-21 Medarex Inc Anticuerpos ctla-4 humanos y sus usos.
US7605238B2 (en) * 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
EE05724B1 (et) * 2001-01-05 2014-10-15 Pfizer Inc. Antikehad insuliinitaolise kasvufaktori I retseptorile
US6578724B1 (en) * 2001-12-29 2003-06-17 United States Can Company Connector for use in packaging aerosol containers
JP2005529873A (ja) * 2002-04-12 2005-10-06 メダレックス インコーポレイテッド Ctla−4抗体を使用した治療の方法
EP1613750B1 (de) 2003-03-19 2015-10-14 Amgen Fremont Inc. Antikörper gegen das t-zellen-immunglobulindomäne- und mucindomäne-1 (tim-1) antigen und verwendungen davon
EA012872B1 (ru) 2004-01-09 2009-12-30 Пфайзер Инк. АНТИТЕЛА ПРОТИВ MAdCAM
EA010350B1 (ru) 2004-06-03 2008-08-29 Новиммун С.А. Антитела против cd3 и способы их применения
EP2322215A3 (de) * 2004-07-16 2011-09-28 Pfizer Products Inc. Kombinationsbehandlung für nicht-hämatologische bösartige Erkrankungen mit einem anti-IGF-1R-Antikörper
IL296666A (en) 2005-03-23 2022-11-01 Genmab As Antibodies against 38cd for the treatment of multiple myeloma
US8323645B2 (en) 2005-03-24 2012-12-04 Millennium Pharmaceuticals, Inc. Antibodies that bind OV064 and methods of use therefor
KR101203328B1 (ko) 2005-04-26 2012-11-20 화이자 인코포레이티드 P-카드헤린 항체
AU2006278260B2 (en) * 2005-08-08 2012-03-08 Onconon, Llc. Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility
EP2354162A1 (de) * 2005-09-12 2011-08-10 Novimmune SA Anti-CD3-Antikorper-formulierungen
AU2006315580A1 (en) 2005-11-10 2007-05-24 Curagen Corporation Method of treating ovarian and renal cancer using antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen
EP1954311A4 (de) 2005-12-07 2009-12-23 Medarex Inc Ctla-4-antikörper-dosierungseskalationstherapien
CN101578297A (zh) * 2006-04-07 2009-11-11 美国政府健康及人类服务部 治疗肿瘤疾病的抗体组合物和方法
WO2009016449A1 (en) * 2007-07-27 2009-02-05 Pfizer Limited Antibody purification process by precipitation
WO2009049086A1 (en) * 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
WO2015164330A1 (en) 2014-04-21 2015-10-29 Millennium Pharmaceuticals, Inc. Anti-psyk antibody molecules and use of same for syk-targeted therapy
MX2011011729A (es) 2009-05-05 2012-04-10 Novimmune Sa Anticuerpo anti il-17f y metodos de uso de los mismos.
NZ623607A (en) 2009-10-23 2016-07-29 Millennium Pharm Inc Anti-gcc antibody molecules and related compositions and methods
US9211302B2 (en) 2011-01-17 2015-12-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulation of LRCH4 activity and therapeutic application thereof
US9150644B2 (en) 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
EP2708560A4 (de) 2011-05-09 2015-01-14 Perseus Proteomics Inc Antikörper zum spezifischen nachweis von transferrin-rezeptoren
WO2012158818A2 (en) 2011-05-16 2012-11-22 Fabion Pharmaceuticals, Inc. Multi-specific fab fusion proteins and methods of use
BR112014019331A2 (pt) 2012-02-06 2022-07-12 Inhibrx Inc anticorpos para cd47 e métodos de uso desses
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
EP2918603B1 (de) 2012-11-08 2018-08-29 University of Miyazaki Zur spezifischen erkennung eines transferrin-rezeptors fähiger antikörper
SG10201706383XA (en) 2013-02-06 2017-09-28 Inhibrx Lp Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof
EP3441071A1 (de) 2013-03-12 2019-02-13 Gladius Pharmaceuticals Corporation Derivatisierte cephalosporine
CA2921398C (en) 2013-08-14 2021-12-14 The Governing Council Of The University Of Toronto Antibodies for inhibiting frizzled receptors and pharmaceutical compositions containing antibodies for inhibiting frizzled receptors
EP3042956A4 (de) 2013-09-05 2017-03-15 University of Miyazaki Spezifisch mit menschlichem integrin a6b4 reagierender antikörper
TWI695011B (zh) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 抗her2表位之單株抗體及其使用之方法
EA201791093A1 (ru) 2014-11-18 2018-04-30 Янссен Фармацевтика Нв Антитела к cd47, способы и применение
JP7034489B2 (ja) 2016-03-15 2022-03-14 アイタブメッド (エイチケイ) リミテッド 多重特異性Fab融合タンパクおよびその使用
AU2017234163B2 (en) 2016-03-15 2023-01-19 Mersana Therapeutics, Inc. NaPi2b-targeted antibody-drug conjugates and methods of use thereof
CN109310765A (zh) 2016-06-20 2019-02-05 领先基因生物技术股份有限公司 抗体-药物偶联物
WO2018049261A1 (en) 2016-09-09 2018-03-15 Icellhealth Consulting Llc Oncolytic virus expressing immune checkpoint modulators
PE20200616A1 (es) 2017-07-14 2020-03-11 Pfizer ANTICUERPOS CONTRA MAdCAM
SG11202105163UA (en) 2018-11-20 2021-06-29 Perseus Proteomics Inc Agent for inhibiting iron uptake into cells
IT201900008376A1 (it) 2019-06-07 2020-12-07 Univ Degli Studi Di Modena E Reggio Emilia Anticorpi ad attività antitumorale
EP4026560A4 (de) 2019-09-04 2023-10-25 Perseus Proteomics Inc. Therapeutisches mittel für polyzythämie
WO2021107082A1 (ja) 2019-11-27 2021-06-03 株式会社ペルセウスプロテオミクス 癌性腹膜炎の治療薬
EP3909601A1 (de) 2020-05-11 2021-11-17 LeukoCom GmbH Neuer antikörper, der spezifisch an menschliches ceacam1/3/5 bindet, und dessen verwendung
CN115803062A (zh) 2020-06-03 2023-03-14 博泰康医药公司 滋养层细胞表面抗原2(trop-2)抗体
CN114057876A (zh) 2020-07-31 2022-02-18 百奥泰生物制药股份有限公司 Cd47抗体及其应用
EP4227686A1 (de) 2020-10-08 2023-08-16 National University Corporation Tokai National Higher Education and Research System Verfahren zur bestimmung der empfindlichkeit oder der medizinischen wirkung eines anti-transferrin-rezeptorantikörpers
WO2023027164A1 (ja) 2021-08-26 2023-03-02 株式会社ペルセウスプロテオミクス Ros(活性酸素種)産生増強剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
JPS5214789A (en) * 1975-07-22 1977-02-03 Shionogi & Co Ltd Process for preparing 3-substiuted cephem compounds by ring closure
JPS56118085A (en) * 1980-02-25 1981-09-16 Takeda Chem Ind Ltd 2-methylcephalosporin derivative and its preparation
US5132301A (en) * 1983-05-02 1992-07-21 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
EP0124081A3 (de) * 1983-05-02 1986-11-26 Merck & Co. Inc. Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung
JPS60237061A (ja) * 1984-05-08 1985-11-25 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
ATE133954T1 (de) * 1986-11-12 1996-02-15 Merck & Co Inc Substituierte cephalosporinsulfone als anti- entzündliche und anti-degenerative mittel
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
US5162521A (en) * 1991-06-06 1992-11-10 Bristol-Myers Squibb Company Processes for making cephems from allenylazetidinone derivatives

Also Published As

Publication number Publication date
DE69331089D1 (de) 2001-12-13
DE69331089T2 (de) 2002-07-18
US5470972A (en) 1995-11-28
US5693792A (en) 1997-12-02
EP0592677A1 (de) 1994-04-20
EP0592677B1 (de) 2001-11-07
EP0592677A4 (en) 1994-07-06
WO1993016043A1 (en) 1993-08-19

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