ATE219085T1 - 2-beta-substituierte-6-alkylidenpenizillansäure derivate als beta-laktamase inhibitoren - Google Patents

2-beta-substituierte-6-alkylidenpenizillansäure derivate als beta-laktamase inhibitoren

Info

Publication number
ATE219085T1
ATE219085T1 AT98964952T AT98964952T ATE219085T1 AT E219085 T1 ATE219085 T1 AT E219085T1 AT 98964952 T AT98964952 T AT 98964952T AT 98964952 T AT98964952 T AT 98964952T AT E219085 T1 ATE219085 T1 AT E219085T1
Authority
AT
Austria
Prior art keywords
beta
sup
alkylidenepenicillanic
substituted
formula
Prior art date
Application number
AT98964952T
Other languages
English (en)
Inventor
John D Buynak
Akireddy Srinivasa Rao
Venkata Ramana Doppalapudi
Original Assignee
Res Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Corp Technologies Inc filed Critical Res Corp Technologies Inc
Application granted granted Critical
Publication of ATE219085T1 publication Critical patent/ATE219085T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
AT98964952T 1997-12-29 1998-12-29 2-beta-substituierte-6-alkylidenpenizillansäure derivate als beta-laktamase inhibitoren ATE219085T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7024097P 1997-12-29 1997-12-29
PCT/US1998/027639 WO1999033838A1 (en) 1997-12-29 1998-12-29 2-β-SUBSTITUTED-6-ALKYLIDENE PENICILLANIC ACID DERIVATIVES AS β-LACTAMASE INHIBITORS

Publications (1)

Publication Number Publication Date
ATE219085T1 true ATE219085T1 (de) 2002-06-15

Family

ID=22094065

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98964952T ATE219085T1 (de) 1997-12-29 1998-12-29 2-beta-substituierte-6-alkylidenpenizillansäure derivate als beta-laktamase inhibitoren

Country Status (8)

Country Link
US (4) US6156745A (de)
EP (1) EP0966471B1 (de)
JP (1) JP3866298B2 (de)
AT (1) ATE219085T1 (de)
CA (1) CA2282461C (de)
DE (1) DE69805975T2 (de)
ES (1) ES2178301T3 (de)
WO (1) WO1999033838A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2178301T3 (es) * 1997-12-29 2002-12-16 Res Corp Technologies Inc Derivados del acido penicilanico 2-beta-sustituido-6-alquilideno como inhibidores de la beta-lactama.
US6407091B1 (en) * 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
AU2002353768A1 (en) * 2001-07-24 2003-03-18 Alamx, L.L.C. 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors.
US20040072815A1 (en) * 2002-02-12 2004-04-15 Koppel Gary A. Antibiotic composition and method
US7022691B2 (en) * 2002-04-04 2006-04-04 John D. Buynak Inhibitors of serine and metallo-β-lactamases
US20050245498A1 (en) * 2002-05-14 2005-11-03 Shoichet Brian K Sterically-awkward beta-lactamase inhibitors
JP2006526612A (ja) * 2003-06-05 2006-11-24 ファイザー・プロダクツ・インク ベータ−ラクタマーゼ阻害剤・プロドラッグ
SI2046802T1 (sl) * 2006-07-12 2014-03-31 Allecra Therapeutics Gmbh C/O Loeba Treuhand Gmbh 2-substituirani metil penamski derivati
US8299051B2 (en) 2008-05-13 2012-10-30 Southern Methodist University Beta-lactamase inhibitory compounds
WO2014070774A1 (en) 2012-10-29 2014-05-08 Southern Methodist University Methods of generating beta-lactamase resistant carbapenem compounds
GB201319776D0 (en) * 2013-11-08 2013-12-25 Allecra Therapeutics Sas Compound
EP4028404A4 (de) * 2019-09-11 2023-07-26 Tennor Therapeutics (Suzhou) Limited Penam-derivate zur behandlung bakterieller infektionen
CN112174983B (zh) * 2020-10-21 2021-12-31 山东安信制药有限公司 一种他唑巴坦二苯甲酯的制备方法

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US4053468A (en) 1976-02-25 1977-10-11 Smithkline Corporation Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
IT1193922B (it) 1979-02-24 1988-08-31 Erba Farmitalia Agenti antibatterici ed inibitori di beta -lattamasi e loro preparazione
ZA80993B (en) 1979-02-24 1981-02-25 Erba Farmitalia -lactam-containing antibacterial agents and -lactamase inhibitors and preparation thereof
GB2076812A (en) 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
DE3173613D1 (en) * 1980-07-04 1986-03-13 Fujisawa Pharmaceutical Co 7-oxo-cephalosporins and 6-oxo-penicillins, their analogues and process for their preparation
CA1180005A (en) 1980-10-24 1984-12-27 Solange Adam-Molina .beta.-LACTAMS
ZA826687B (en) 1981-09-14 1983-07-27 Pfizer Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
PT79893B (en) 1984-01-30 1987-02-03 Pfizer Process for preparing 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicilanic and derivatives thereof
US4826833A (en) 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
DE3584015D1 (de) * 1984-01-30 1991-10-17 Pfizer 6-(substituierte) methylen-penicillansaeure und 6-(substituierte) hydroxymethyl-penicillansaeure und deren derivate.
EP0170192B1 (de) 1984-07-30 1992-05-13 Merck & Co. Inc. Penicillin-Derivate als entzündungshemmende und degenerierungskämpfende Arzneimittel
JPS62198687A (ja) 1986-02-27 1987-09-02 Taiho Yakuhin Kogyo Kk ２β−置換チオメチルペニシリン誘導体
US4861768A (en) 1986-02-27 1989-08-29 Taiho Pharmaceutical Company, Limited 2 β-substituted thiomethylpenicillin derivatives and their preparation and use
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
JP2603082B2 (ja) 1987-09-07 1997-04-23 大塚化学株式会社 ペニシラン酸誘導体の製造法
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
IT1227462B (it) * 1988-11-04 1991-04-11 Glaxo Spa Procedimento di preparazione di 6-ossopenicillanati
TW383308B (en) 1993-08-24 2000-03-01 Hoffmann La Roche 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors
US5597817A (en) * 1994-12-09 1997-01-28 Southern Methodist University 7-vinylidene cephalosporins and methods of using the same
US5629306A (en) 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US5760027A (en) * 1996-12-06 1998-06-02 Research Corporation Technologies, Inc. Use of 7-alkylidene cephalosporins to inhibit elastase activity
ES2178301T3 (es) 1997-12-29 2002-12-16 Res Corp Technologies Inc Derivados del acido penicilanico 2-beta-sustituido-6-alquilideno como inhibidores de la beta-lactama.
US6395726B1 (en) * 1999-01-26 2002-05-28 American Cyanamid Company 3,6-disubstituted penam sulfone derivatives
AU773013B2 (en) 1999-04-15 2004-05-13 Research Corporation Technologies, Inc. Beta-lactamase inhibiting compounds
US6391855B1 (en) 1999-06-02 2002-05-21 Adherex Technologies, Inc. Compounds and methods for modulating junctional adhesion molecule-mediated functions
AU2002353768A1 (en) 2001-07-24 2003-03-18 Alamx, L.L.C. 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors.

Also Published As

Publication number Publication date
US6156745A (en) 2000-12-05
CA2282461A1 (en) 1999-07-08
ES2178301T3 (es) 2002-12-16
US6436398B2 (en) 2002-08-20
CA2282461C (en) 2004-04-20
US20020198180A1 (en) 2002-12-26
US20010021706A1 (en) 2001-09-13
JP2001501978A (ja) 2001-02-13
US7125986B2 (en) 2006-10-24
EP0966471B1 (de) 2002-06-12
WO1999033838A1 (en) 1999-07-08
DE69805975T2 (de) 2002-12-19
JP3866298B2 (ja) 2007-01-10
US20040220399A1 (en) 2004-11-04
EP0966471A1 (de) 1999-12-29
DE69805975D1 (de) 2002-07-18
US6770759B2 (en) 2004-08-03

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee