DE69805975D1 - 2-beta-substituierte-6-alkylidenpenizillansäure-derivate als beta-laktamase inhibitoren - Google Patents

2-beta-substituierte-6-alkylidenpenizillansäure-derivate als beta-laktamase inhibitoren

Info

Publication number
DE69805975D1
DE69805975D1 DE69805975T DE69805975T DE69805975D1 DE 69805975 D1 DE69805975 D1 DE 69805975D1 DE 69805975 T DE69805975 T DE 69805975T DE 69805975 T DE69805975 T DE 69805975T DE 69805975 D1 DE69805975 D1 DE 69805975D1
Authority
DE
Germany
Prior art keywords
beta
sup
alkylidenpenicilic
substituted
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69805975T
Other languages
English (en)
Other versions
DE69805975T2 (de
Inventor
D Buynak
Srinivasa Rao
Venkata Ramana Doppalapudi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Publication of DE69805975D1 publication Critical patent/DE69805975D1/de
Application granted granted Critical
Publication of DE69805975T2 publication Critical patent/DE69805975T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
DE69805975T 1997-12-29 1998-12-29 2-beta-substituierte-6-alkylidenpenizillansäure-derivate als beta-laktamase inhibitoren Expired - Fee Related DE69805975T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7024097P 1997-12-29 1997-12-29
PCT/US1998/027639 WO1999033838A1 (en) 1997-12-29 1998-12-29 2-β-SUBSTITUTED-6-ALKYLIDENE PENICILLANIC ACID DERIVATIVES AS β-LACTAMASE INHIBITORS

Publications (2)

Publication Number Publication Date
DE69805975D1 true DE69805975D1 (de) 2002-07-18
DE69805975T2 DE69805975T2 (de) 2002-12-19

Family

ID=22094065

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69805975T Expired - Fee Related DE69805975T2 (de) 1997-12-29 1998-12-29 2-beta-substituierte-6-alkylidenpenizillansäure-derivate als beta-laktamase inhibitoren

Country Status (8)

Country Link
US (4) US6156745A (de)
EP (1) EP0966471B1 (de)
JP (1) JP3866298B2 (de)
AT (1) ATE219085T1 (de)
CA (1) CA2282461C (de)
DE (1) DE69805975T2 (de)
ES (1) ES2178301T3 (de)
WO (1) WO1999033838A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3866298B2 (ja) * 1997-12-29 2007-01-10 リサーチ コーポレイション テクノロジーズ，インコーポレイティド β−ラクタマーゼインヒビターとしての２β−置換化−６−アルキリデンペニシラン酸誘導体
US6407091B1 (en) * 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
JP2005502687A (ja) * 2001-07-24 2005-01-27 アラムクス エルエルシー β−ラクタマーゼ阻害剤としての７−アルキリデン−３−置換型−３−セフェム−４−カルボキシラート
US20040072815A1 (en) * 2002-02-12 2004-04-15 Koppel Gary A. Antibiotic composition and method
AU2003224874A1 (en) * 2002-04-04 2003-10-27 Alamx, L.L.C. INHIBITORS OF SERINE AND METALLO-ss-LACTAMASES
US20050245498A1 (en) * 2002-05-14 2005-11-03 Shoichet Brian K Sterically-awkward beta-lactamase inhibitors
BRPI0410936A (pt) * 2003-06-05 2006-06-27 Pfizer Prod Inc pró-fármaco inibidor da beta-lactamase
SI2046802T1 (sl) * 2006-07-12 2014-03-31 Allecra Therapeutics Gmbh C/O Loeba Treuhand Gmbh 2-substituirani metil penamski derivati
US8299051B2 (en) 2008-05-13 2012-10-30 Southern Methodist University Beta-lactamase inhibitory compounds
WO2014070774A1 (en) 2012-10-29 2014-05-08 Southern Methodist University Methods of generating beta-lactamase resistant carbapenem compounds
GB201319776D0 (en) 2013-11-08 2013-12-25 Allecra Therapeutics Sas Compound
CN112174983B (zh) * 2020-10-21 2021-12-31 山东安信制药有限公司 一种他唑巴坦二苯甲酯的制备方法

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* Cited by examiner, † Cited by third party
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US4053468A (en) * 1976-02-25 1977-10-11 Smithkline Corporation Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
ZA80993B (en) 1979-02-24 1981-02-25 Erba Farmitalia -lactam-containing antibacterial agents and -lactamase inhibitors and preparation thereof
GR73623B (de) 1979-02-24 1984-03-26 Erba Farmitalia
GB2076812A (en) 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
EP0043546B1 (de) * 1980-07-04 1986-01-29 Fujisawa Pharmaceutical Co., Ltd. 7-Oxo-cephalosporine und 6-Oxo-penicilline, ihre Analoge und Verfahren zu ihrer Herstellung
CA1180005A (en) 1980-10-24 1984-12-27 Solange Adam-Molina .beta.-LACTAMS
ZA826687B (en) 1981-09-14 1983-07-27 Pfizer Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
EP0150984B1 (de) * 1984-01-30 1991-09-11 Pfizer Inc. 6-(substituierte) Methylen-Penicillansäure und 6-(substituierte) Hydroxymethyl-Penicillansäure und deren Derivate
US4826833A (en) 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
DD234015A5 (de) 1984-01-30 1986-03-19 Pfizer Verfahren zur herstellung von 6-(subst.)-methylen-penicillan-und 6-(subst.)-hydroxymethyl-penicillansaeure und deren derivaten
EP0170192B1 (de) 1984-07-30 1992-05-13 Merck & Co. Inc. Penicillin-Derivate als entzündungshemmende und degenerierungskämpfende Arzneimittel
JPS62198687A (ja) 1986-02-27 1987-09-02 Taiho Yakuhin Kogyo Kk ２β−置換チオメチルペニシリン誘導体
US4861768A (en) 1986-02-27 1989-08-29 Taiho Pharmaceutical Company, Limited 2 β-substituted thiomethylpenicillin derivatives and their preparation and use
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
JP2603082B2 (ja) 1987-09-07 1997-04-23 大塚化学株式会社 ペニシラン酸誘導体の製造法
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
IT1227462B (it) * 1988-11-04 1991-04-11 Glaxo Spa Procedimento di preparazione di 6-ossopenicillanati
TW383308B (en) 1993-08-24 2000-03-01 Hoffmann La Roche 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors
US5629306A (en) * 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US5597817A (en) * 1994-12-09 1997-01-28 Southern Methodist University 7-vinylidene cephalosporins and methods of using the same
US5760027A (en) * 1996-12-06 1998-06-02 Research Corporation Technologies, Inc. Use of 7-alkylidene cephalosporins to inhibit elastase activity
JP3866298B2 (ja) 1997-12-29 2007-01-10 リサーチ コーポレイション テクノロジーズ，インコーポレイティド β−ラクタマーゼインヒビターとしての２β−置換化−６−アルキリデンペニシラン酸誘導体
US6395726B1 (en) * 1999-01-26 2002-05-28 American Cyanamid Company 3,6-disubstituted penam sulfone derivatives
CA2371389A1 (en) 1999-04-15 2000-10-26 Research Corporation Technologies, Inc. Beta-lactamase inhibiting 7-alkyldiene cephalosporanic acid derivatives
US6391855B1 (en) 1999-06-02 2002-05-21 Adherex Technologies, Inc. Compounds and methods for modulating junctional adhesion molecule-mediated functions
JP2005502687A (ja) 2001-07-24 2005-01-27 アラムクス エルエルシー β−ラクタマーゼ阻害剤としての７−アルキリデン−３−置換型−３−セフェム−４−カルボキシラート

Also Published As

Publication number Publication date
JP2001501978A (ja) 2001-02-13
US7125986B2 (en) 2006-10-24
CA2282461A1 (en) 1999-07-08
US6770759B2 (en) 2004-08-03
ATE219085T1 (de) 2002-06-15
JP3866298B2 (ja) 2007-01-10
US20020198180A1 (en) 2002-12-26
WO1999033838A1 (en) 1999-07-08
US6436398B2 (en) 2002-08-20
EP0966471B1 (de) 2002-06-12
US20010021706A1 (en) 2001-09-13
DE69805975T2 (de) 2002-12-19
ES2178301T3 (es) 2002-12-16
EP0966471A1 (de) 1999-12-29
US20040220399A1 (en) 2004-11-04
CA2282461C (en) 2004-04-20
US6156745A (en) 2000-12-05

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee