ATE358419T1 - Neue substituierte bernsteinsäure metall-beta- lactamase-inhibitoren und ihre verwendung zur behandlung von bakteriellen infektionen - Google Patents
Neue substituierte bernsteinsäure metall-beta- lactamase-inhibitoren und ihre verwendung zur behandlung von bakteriellen infektionenInfo
- Publication number
- ATE358419T1 ATE358419T1 AT00975454T AT00975454T ATE358419T1 AT E358419 T1 ATE358419 T1 AT E358419T1 AT 00975454 T AT00975454 T AT 00975454T AT 00975454 T AT00975454 T AT 00975454T AT E358419 T1 ATE358419 T1 AT E358419T1
- Authority
- AT
- Austria
- Prior art keywords
- succinic acid
- bacterial infections
- substituted succinic
- lactamase inhibitors
- treatment
- Prior art date
Links
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical class OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 title abstract 4
- 208000035143 Bacterial infection Diseases 0.000 title abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 2
- 239000003781 beta lactamase inhibitor Substances 0.000 title abstract 2
- 229940126813 beta-lactamase inhibitor Drugs 0.000 title abstract 2
- 239000001384 succinic acid Substances 0.000 title abstract 2
- 239000002184 metal Substances 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 102000020235 metallo-beta-lactamase Human genes 0.000 abstract 1
- 108060004734 metallo-beta-lactamase Proteins 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 239000002132 β-lactam antibiotic Substances 0.000 abstract 1
- 229940124586 β-lactam antibiotics Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16237099P | 1999-10-28 | 1999-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE358419T1 true ATE358419T1 (de) | 2007-04-15 |
Family
ID=22585340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00975454T ATE358419T1 (de) | 1999-10-28 | 2000-10-27 | Neue substituierte bernsteinsäure metall-beta- lactamase-inhibitoren und ihre verwendung zur behandlung von bakteriellen infektionen |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6630510B1 (de) |
| EP (1) | EP1227721B1 (de) |
| JP (1) | JP2003527332A (de) |
| AT (1) | ATE358419T1 (de) |
| AU (1) | AU771274B2 (de) |
| CA (1) | CA2388076C (de) |
| DE (1) | DE60034244T2 (de) |
| ES (1) | ES2283327T3 (de) |
| WO (1) | WO2001030148A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2408937A (en) * | 2003-12-09 | 2005-06-15 | Johnson & Johnson Medical Ltd | pH dependent medicinal compositions |
| JP5128277B2 (ja) | 2004-05-28 | 2013-01-23 | ユニジェン・インコーポレーテッド | 二核酵素の強力な阻害剤としてのジアリールアルカン類 |
| WO2006059344A1 (en) * | 2004-12-02 | 2006-06-08 | Venus Remedies Limited | Compositions for combating beta-lactamase-mediated antibiotic resistance using beta-lactamase inhibitors useful for injection |
| JP4122049B2 (ja) | 2005-09-22 | 2008-07-23 | 明治製菓株式会社 | メタロ−β−ラクタマーゼ阻害剤 |
| JP5301272B2 (ja) * | 2006-07-31 | 2013-09-25 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | メタロ−β−ラクタマーゼ阻害剤 |
| WO2009114921A1 (en) * | 2008-03-17 | 2009-09-24 | Dmitrienko Gary I | INHIBITORS OF CLASS B AND CLASS D β-LACTAMASES |
| US8362305B2 (en) | 2008-07-21 | 2013-01-29 | Unigen, Inc. | Series of skin whitening (lightening) compounds |
| WO2010092446A1 (en) * | 2009-01-19 | 2010-08-19 | Orchid Chemicals & Pharmaceuticals Ltd | Pharmaceutical composition comprising cilastatin, a chelating agent and opt. a penem antibiotic |
| EP3822246A1 (de) | 2011-03-24 | 2021-05-19 | Unigen, Inc. | Verbindungen und verfahren zur herstellung von diarylpropanen |
| GB201317619D0 (en) | 2013-10-04 | 2013-11-20 | Uni I Oslo | Compounds |
| CA2977385C (en) * | 2015-02-23 | 2024-04-09 | Synthetic Biologics, Inc. | Carbapenemases for use with antibiotics for the protection of the intestinal microbiome |
| GB201613946D0 (en) | 2016-08-15 | 2016-09-28 | Univ Oslo | Compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63208596A (ja) * | 1986-11-05 | 1988-08-30 | メルク エンド カムパニー インコーポレーテツド | 新規な抗菌剤およびカルバペネム抗生物質の効力増強剤 |
| US4770799A (en) | 1987-01-02 | 1988-09-13 | Mobil Oil Corporation | Copper salts of hindered phenol substituted succinic anhydride derivatives as antioxidant additives |
| ZA897515B (en) * | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
| US5414108A (en) * | 1992-08-11 | 1995-05-09 | Biogal Gyogyszergrar | Process for the preparation of carboxylic acids and derivatives of them |
| US5559088A (en) * | 1995-07-07 | 1996-09-24 | The Proctor & Gamble Company | Dryer-activated fabric conditioning and antistatic compositions with improved perfume longevity |
| EP0850230A1 (de) | 1995-09-15 | 1998-07-01 | Smithkline Beecham Plc | Pyrrolidin- und thiazolderivate mit metallo-beta-lactamase hemmende und antibakterielle wirkungen |
| GB9524267D0 (en) | 1995-11-28 | 1996-01-31 | Isis Innovation | Enzyme inhibitor and method |
| US6048852A (en) | 1996-02-13 | 2000-04-11 | Smithkline Beecham P.L.C. | β-thiopropionyl-aminoacid derivatives and their use as β-lactamase inhibitors |
| EP0934262A1 (de) | 1996-10-17 | 1999-08-11 | Smithkline Beecham Plc | Beta-thiopropionylaminosäure-derivate und deren verwendung in der hemmung von beta-lactamase |
| GB9704522D0 (en) | 1997-03-05 | 1997-04-23 | Smithkline Beecham Plc | Compounds |
| EP0970062A2 (de) | 1997-03-13 | 2000-01-12 | Smithkline Beecham Plc | Pyrrolidin- und thiazolderivate mit metallo-beta-lactamasehemmenden eigenschaften |
| GB9705682D0 (en) * | 1997-03-19 | 1997-05-07 | Unilever Plc | Cleaning composition comprising fluoro-surfactants |
-
2000
- 2000-10-26 US US09/697,415 patent/US6630510B1/en not_active Expired - Fee Related
- 2000-10-27 ES ES00975454T patent/ES2283327T3/es not_active Expired - Lifetime
- 2000-10-27 EP EP00975454A patent/EP1227721B1/de not_active Expired - Lifetime
- 2000-10-27 WO PCT/US2000/029707 patent/WO2001030148A1/en not_active Ceased
- 2000-10-27 DE DE60034244T patent/DE60034244T2/de not_active Expired - Lifetime
- 2000-10-27 AT AT00975454T patent/ATE358419T1/de not_active IP Right Cessation
- 2000-10-27 CA CA002388076A patent/CA2388076C/en not_active Expired - Fee Related
- 2000-10-27 AU AU13504/01A patent/AU771274B2/en not_active Ceased
- 2000-10-27 JP JP2001532588A patent/JP2003527332A/ja active Pending
-
2002
- 2002-03-15 US US10/099,790 patent/US20030078418A1/en not_active Abandoned
-
2003
- 2003-01-09 US US10/339,043 patent/US20030207859A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2388076C (en) | 2008-07-22 |
| CA2388076A1 (en) | 2001-05-03 |
| AU771274B2 (en) | 2004-03-18 |
| ES2283327T3 (es) | 2007-11-01 |
| AU1350401A (en) | 2001-05-08 |
| US20030207859A1 (en) | 2003-11-06 |
| EP1227721B1 (de) | 2007-04-04 |
| WO2001030148A1 (en) | 2001-05-03 |
| US6630510B1 (en) | 2003-10-07 |
| JP2003527332A (ja) | 2003-09-16 |
| DE60034244T2 (de) | 2007-12-20 |
| US20030078418A1 (en) | 2003-04-24 |
| DE60034244D1 (de) | 2007-05-16 |
| EP1227721A1 (de) | 2002-08-07 |
| EP1227721A4 (de) | 2004-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |