PE20200616A1 - ANTICUERPOS CONTRA MAdCAM - Google Patents

ANTICUERPOS CONTRA MAdCAM

Info

Publication number
PE20200616A1
PE20200616A1 PE2020000060A PE2020000060A PE20200616A1 PE 20200616 A1 PE20200616 A1 PE 20200616A1 PE 2020000060 A PE2020000060 A PE 2020000060A PE 2020000060 A PE2020000060 A PE 2020000060A PE 20200616 A1 PE20200616 A1 PE 20200616A1
Authority
PE
Peru
Prior art keywords
antibodies
madcam
description further
human anti
nucleic acid
Prior art date
Application number
PE2020000060A
Other languages
English (en)
Inventor
Karin Anderson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20200616A1 publication Critical patent/PE20200616A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente descripcion se refiere a anticuerpos que incluyen anticuerpos humanos y porciones de union al antigeno de estos que se unen especificamente a MAdCAM, preferentemente MAdCAM humana y que funcionan para inhibir MAdCAM. La descripcion se refiere ademas a anticuerpos anti-MAdCAM humanos y porciones de union al antigeno de estos. La descripcion se refiere ademas a anticuerpos que son anticuerpos quimericos, biespecificos, derivatizados, de cadena sencilla o porciones de proteinas de fusion. La descripcion se refiere ademas a inmunoglobulinas de cadenas pesadas y ligeras aisladas derivadas de anticuerpos anti-MAdCAM humanos y moleculas de acido nucleico que codifican tales inmunoglobulinas. La presente descripcion se refiere ademas a metodos para producir anticuerpos anti-MAdCAM humanos, composiciones que comprenden estos anticuerpos y metodos de uso de los anticuerpos y composiciones para el diagnostico y tratamiento. La descripcion proporciona ademas metodos de terapia genica que usan moleculas de acido nucleico que codifican las moleculas de inmunoglobulina pesadas y/o ligeras que comprenden los anticuerpos anti-MAdCAM humanos. La descripcion se refiere ademas a plantas o animales transgenicos que comprenden moleculas de acido nucleico de la descripcion
PE2020000060A 2017-07-14 2018-07-13 ANTICUERPOS CONTRA MAdCAM PE20200616A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762532809P 2017-07-14 2017-07-14
PCT/US2018/042052 WO2019014572A1 (en) 2017-07-14 2018-07-13 ANTIBODIES DIRECTED AGAINST MADCAM

Publications (1)

Publication Number Publication Date
PE20200616A1 true PE20200616A1 (es) 2020-03-11

Family

ID=63209653

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020000060A PE20200616A1 (es) 2017-07-14 2018-07-13 ANTICUERPOS CONTRA MAdCAM

Country Status (25)

Country Link
US (2) US20190169291A1 (es)
EP (1) EP3652211A1 (es)
JP (1) JP7160491B2 (es)
KR (1) KR20200028006A (es)
CN (1) CN111032694B (es)
AR (1) AR112336A1 (es)
AU (1) AU2018300189A1 (es)
BR (1) BR112020000698A2 (es)
CA (1) CA3069914A1 (es)
CL (1) CL2020000102A1 (es)
CO (1) CO2020000352A2 (es)
CR (1) CR20200076A (es)
CU (1) CU20200002A7 (es)
DO (1) DOP2020000005A (es)
EA (1) EA202090286A1 (es)
EC (1) ECSP20011317A (es)
IL (1) IL272015A (es)
MA (1) MA48241A1 (es)
MX (1) MX2023014363A (es)
NI (1) NI202000004A (es)
PE (1) PE20200616A1 (es)
PH (1) PH12020500100A1 (es)
SG (1) SG11202000298VA (es)
TW (1) TW201920266A (es)
WO (1) WO2019014572A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024110868A1 (en) 2022-11-22 2024-05-30 Takeda Pharmaceutical Company Limited DOSAGE REGIMEN OF MAdCAM-1 ANTIBODY FOR TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS

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Also Published As

Publication number Publication date
CU20200002A7 (es) 2020-11-30
AU2018300189A1 (en) 2020-01-30
IL272015A (en) 2020-02-27
MA48241A1 (fr) 2021-03-31
CN111032694B (zh) 2024-03-08
JP2020533953A (ja) 2020-11-26
WO2019014572A1 (en) 2019-01-17
PH12020500100A1 (en) 2020-09-14
SG11202000298VA (en) 2020-02-27
CA3069914A1 (en) 2019-01-17
US11802156B2 (en) 2023-10-31
KR20200028006A (ko) 2020-03-13
NI202000004A (es) 2020-03-30
CL2020000102A1 (es) 2020-10-09
MX2023014363A (es) 2023-12-15
CR20200076A (es) 2020-06-10
CN111032694A (zh) 2020-04-17
EA202090286A1 (ru) 2020-05-12
US20220119521A1 (en) 2022-04-21
ECSP20011317A (es) 2020-12-31
BR112020000698A2 (pt) 2020-07-14
AR112336A1 (es) 2019-10-16
US20190169291A1 (en) 2019-06-06
JP7160491B2 (ja) 2022-10-25
TW201920266A (zh) 2019-06-01
DOP2020000005A (es) 2021-02-15
CO2020000352A2 (es) 2020-04-13
EP3652211A1 (en) 2020-05-20

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