UY28716A1 - Anticuerpos contra madcam - Google Patents

Anticuerpos contra madcam

Info

Publication number
UY28716A1
UY28716A1 UY28716A UY28716A UY28716A1 UY 28716 A1 UY28716 A1 UY 28716A1 UY 28716 A UY28716 A UY 28716A UY 28716 A UY28716 A UY 28716A UY 28716 A1 UY28716 A1 UY 28716A1
Authority
UY
Uruguay
Prior art keywords
antibodies
madcam
relates
human
methods
Prior art date
Application number
UY28716A
Other languages
English (en)
Inventor
Larry L Green
Sirid-Aimee Kellermann
Mary Haak-Frendscho
Nicholas Pullen
Elizabeth Molloy
Original Assignee
Pfizer
Abgenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34794356&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY28716(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer, Abgenix Inc filed Critical Pfizer
Publication of UY28716A1 publication Critical patent/UY28716A1/es

Links

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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Abstract

La presente invención se refiere a anticuerpos que incluyen anticuerpos humanos y porciones que ligan antígeno de los mismos que se ligan especialmente a MAdCAM, preferentemente a MAdCAM humano y que funcionan para ihnibir MAdCAM. La invención también se refiere a anticuerpos anti- MAdCAM humano y porciones que ligan antígeno de los mismos. La invención se refiere a anticuerpos que son quiméricos, biespecíficos, derivatizados, anticuerpos de cadena simple o porciones de proteínas de fución. La invención también se refiere a inmunoglobulinas aisladas de cadena pesada y liviana derivadas de anticuerpos anti-MAdCAM humanos y a moléculas de ácido nucleido que codifican tales inmunoglobulinas. La presente invención también se refiere métodos para fabricar anticuerpos anti. MAdCAM humanos, a composiciones que comprenden estos anticuerpos y a métodos para usar los anticuerpos y comprenden estos anticuerpos y métodos para usar los anticuerpos y composiciones para diagnóstico y tratamiento. La invención también prevé métodos de terapia con genes que usan moléculas de inmunoglubulina que comprenden los anticuerpos anti- MAdCAM humanos. La invención también se refiere a animales o plantas transgénicos que comprenden moléculas de ácido nucleico de la invención.
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