JP2016530280A5 - - Google Patents

Download PDF

Info

Publication number
JP2016530280A5
JP2016530280A5 JP2016537902A JP2016537902A JP2016530280A5 JP 2016530280 A5 JP2016530280 A5 JP 2016530280A5 JP 2016537902 A JP2016537902 A JP 2016537902A JP 2016537902 A JP2016537902 A JP 2016537902A JP 2016530280 A5 JP2016530280 A5 JP 2016530280A5
Authority
JP
Japan
Prior art keywords
vegf antibody
glioblastoma
chemotherapeutic agent
patient
effective amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016537902A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016530280A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/053463 external-priority patent/WO2015031782A1/en
Publication of JP2016530280A publication Critical patent/JP2016530280A/ja
Publication of JP2016530280A5 publication Critical patent/JP2016530280A5/ja
Pending legal-status Critical Current

Links

JP2016537902A 2013-08-30 2014-08-29 膠芽腫治療のための併用療法 Pending JP2016530280A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361872165P 2013-08-30 2013-08-30
US61/872,165 2013-08-30
US201462004687P 2014-05-29 2014-05-29
US62/004,687 2014-05-29
PCT/US2014/053463 WO2015031782A1 (en) 2013-08-30 2014-08-29 Combination therapy for the treatment of glioblastoma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019204258A Division JP2020059713A (ja) 2013-08-30 2019-11-11 膠芽腫治療のための併用療法

Publications (2)

Publication Number Publication Date
JP2016530280A JP2016530280A (ja) 2016-09-29
JP2016530280A5 true JP2016530280A5 (enExample) 2017-10-12

Family

ID=52584140

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016537902A Pending JP2016530280A (ja) 2013-08-30 2014-08-29 膠芽腫治療のための併用療法
JP2019204258A Pending JP2020059713A (ja) 2013-08-30 2019-11-11 膠芽腫治療のための併用療法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019204258A Pending JP2020059713A (ja) 2013-08-30 2019-11-11 膠芽腫治療のための併用療法

Country Status (14)

Country Link
US (1) US10617755B2 (enExample)
EP (1) EP3038647B1 (enExample)
JP (2) JP2016530280A (enExample)
KR (1) KR20160048095A (enExample)
CN (1) CN105611939A (enExample)
AU (1) AU2014312130B2 (enExample)
BR (1) BR112016004415A2 (enExample)
CA (1) CA2921213A1 (enExample)
HK (1) HK1221408A1 (enExample)
IL (1) IL244014A0 (enExample)
MX (1) MX2016002645A (enExample)
RU (1) RU2692075C2 (enExample)
SG (2) SG10201704334QA (enExample)
WO (1) WO2015031782A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2371865B1 (en) 2006-04-07 2017-07-12 Aerpio Therapeutics, Inc. Antibodies that bind human protein tyrosine phosphatase beta (HPTP-ß) and uses thereof
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
EP3556367A1 (en) 2009-07-06 2019-10-23 Aerpio Therapeutics, Inc. Benzosulfonamide derivatives, compositions thereof, and their use in the treatment of cancer or metastasis
CA2850830A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for treating vascular leak syndrome and cancer
US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases
US10617755B2 (en) 2013-08-30 2020-04-14 Genentech, Inc. Combination therapy for the treatment of glioblastoma
US10456470B2 (en) 2013-08-30 2019-10-29 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
CN106456614A (zh) 2014-03-14 2017-02-22 爱尔皮奥治疗有限公司 HPTP‑β抑制剂
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
JP2017523776A (ja) 2014-07-14 2017-08-24 ジェネンテック， インコーポレイテッド 膠芽腫の診断方法及びその治療用組成物
ES2981607T3 (es) 2015-09-23 2024-10-09 Eyepoint Pharmaceuticals Inc Activadores de Tie-2 para uso en el tratamiento de la presión intraocular
EP3397276A4 (en) 2015-12-30 2019-12-18 Kodiak Sciences Inc. ANTIBODIES AND CONJUGATES THEREOF
WO2017210463A1 (en) 2016-06-01 2017-12-07 Celgene Tri A Holdings Ltd. Use of marizomib for the treatment of central nervous system (cns) cancers
JP7107914B2 (ja) 2016-07-20 2022-07-27 アイポイント ファーマシューティカルズ， インコーポレイテッド ＶＥ－ＰＴＰ（ＨＰＴＰ－β）を標的化するヒト化モノクローナル抗体
WO2019136185A1 (en) * 2018-01-08 2019-07-11 Susavion Biosciences, Inc. Compositions and methods of treating cancer with glycomimetic peptides
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof
KR102837015B1 (ko) * 2018-03-20 2025-07-23 아브락시스 바이오사이언스, 엘엘씨 mTOR 억제제 및 알부민의 나노입자의 투여를 통한 중추 신경계 장애의 치료 방법
CN113189345B (zh) * 2018-07-09 2022-08-19 广东格锐科技有限公司 Pdlim4用作胃癌标志物的应用
CN113164597B (zh) 2018-09-24 2025-02-28 视点制药公司 靶向HPTP-β（VE-PTP）和VEGF的多特异性抗体
AU2020264969B2 (en) 2019-04-29 2025-06-05 EyePoint, Inc. Tie-2 activators targeting the schlemm's canal
AU2019461286B2 (en) * 2019-08-09 2024-01-04 Akeso Biopharma, Inc Anti-VEGF-anti-PD1 bispecific antibody with new-type structure
AU2020364071A1 (en) 2019-10-10 2022-05-26 Kodiak Sciences Inc. Methods of treating an eye disorder
RU2765112C1 (ru) * 2021-04-15 2022-01-25 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ выбора тактики проведения лучевой терапии у больных злокачественными глиомами

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DK0546073T3 (da) 1990-08-29 1998-02-02 Genpharm Int Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
US6582959B2 (en) 1991-03-29 2003-06-24 Genentech, Inc. Antibodies to vascular endothelial cell growth factor
US20030206899A1 (en) 1991-03-29 2003-11-06 Genentech, Inc. Vascular endothelial cell growth factor antagonists
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
AU675916B2 (en) 1991-06-14 1997-02-27 Genentech Inc. Method for making humanized antibodies
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
AU4528493A (en) 1992-06-04 1994-01-04 Regents Of The University Of California, The In vivo gene therapy with intron-free sequence of interest
HU221343B1 (en) 1992-10-28 2002-09-28 Genentech Inc Use of anti-vegf antibodies for the treatment of cancer
US5635388A (en) 1994-04-04 1997-06-03 Genentech, Inc. Agonist antibodies against the flk2/flt3 receptor and uses thereof
US5910486A (en) 1994-09-06 1999-06-08 Uab Research Foundation Methods for modulating protein function in cells using, intracellular antibody homologues
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
DE69637481T2 (de) 1995-04-27 2009-04-09 Amgen Fremont Inc. Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
CA2616914C (en) 1996-12-03 2012-05-29 Abgenix, Inc. Egfr-binding antibody
US6884879B1 (en) * 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
ES2236634T3 (es) 1997-04-07 2005-07-16 Genentech, Inc. Anticuerpos anti-vegf.
KR100794454B1 (ko) 1997-04-07 2008-01-16 제넨테크, 인크. 항-ｖｅｇｆ 항체
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
US6610833B1 (en) 1997-11-24 2003-08-26 The Institute For Human Genetics And Biochemistry Monoclonal human natural antibodies
ES2375931T3 (es) 1997-12-05 2012-03-07 The Scripps Research Institute Humanización de anticuerpo murino.
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
CA2393869A1 (en) 1999-12-15 2001-06-21 Genetech,Inc. Shotgun scanning, a combinatorial method for mapping functional protein epitopes
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
WO2002043478A2 (en) 2000-11-30 2002-06-06 Medarex, Inc. Transgenic transchromosomal rodents for making human antibodies
IL156618A0 (en) 2000-12-28 2004-01-04 Altus Biologics Inc Crystals of whole antibodies and fragments thereof, methods for the preparation thereof and diagnostic kits utilizing the same
NZ556507A (en) 2002-06-03 2010-03-26 Genentech Inc Synthetic antibody phage libraries
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
CA2510003A1 (en) 2003-01-16 2004-08-05 Genentech, Inc. Synthetic antibody phage libraries
KR20150008458A (ko) 2003-05-30 2015-01-22 제넨테크, 인크. 항-ｖｅｇｆ 항체를 사용한 치료
JP4599355B2 (ja) 2003-07-28 2010-12-15 ジェネンテック， インコーポレイテッド プロテインａアフィニティークロマトグラフィーの間のプロテインａの浸出の低減
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
WO2005044853A2 (en) 2003-11-01 2005-05-19 Genentech, Inc. Anti-vegf antibodies
RU2386638C2 (ru) 2004-03-31 2010-04-20 Дженентек, Инк. Гуманизированные анти-тфр-бета-антитела
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
US20060009360A1 (en) 2004-06-25 2006-01-12 Robert Pifer New adjuvant composition
EP1957531B1 (en) 2005-11-07 2016-04-13 Genentech, Inc. Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
US20070237764A1 (en) 2005-12-02 2007-10-11 Genentech, Inc. Binding polypeptides with restricted diversity sequences
CA2633593A1 (en) 2005-12-16 2007-10-04 Genentech, Inc. Method for diagnosing, prognosing and treating glioma
JP2009536527A (ja) 2006-05-09 2009-10-15 ジェネンテック・インコーポレーテッド 最適化されたスキャフォールドを備えた結合ポリペプチド
WO2008109423A1 (en) 2007-03-02 2008-09-12 Board Of Regents, The University Of Texas System Multigene assay to predict outcome in an individual with glioblastoma
CN100592373C (zh) 2007-05-25 2010-02-24 群康科技(深圳)有限公司 液晶显示面板驱动装置及其驱动方法
JP2012524083A (ja) 2009-04-20 2012-10-11 ジェネンテック， インコーポレイテッド アジュバント癌治療
CN102575298A (zh) 2009-08-14 2012-07-11 霍夫曼-拉罗奇有限公司 用于监测患者对vegf拮抗剂的响应的生物学标志物
CN103237810A (zh) 2010-02-23 2013-08-07 霍夫曼-拉罗奇有限公司 用于治疗卵巢癌的抗血管发生疗法
ES2930809T3 (es) 2010-08-24 2022-12-22 Univ Pittsburgh Commonwealth Sys Higher Education Vacunas contra el cáncer cerebral basadas en el péptido receptor de interleucina-13 alfa 2
MX2013014065A (es) 2011-06-02 2014-06-23 Almac Diagnostics Ltd Prueba diagnóstica molecular para el cancer.
CA2862835A1 (en) 2012-01-13 2013-07-18 Genentech, Inc. Biological markers for identifying patients for treatment with vegf antagonists
KR20140142719A (ko) 2012-03-30 2014-12-12 제넨테크, 인크. 암의 치료를 위한 진단 방법 및 조성물
EP3446709A1 (en) 2012-08-07 2019-02-27 F. Hoffmann-La Roche AG Combination therapy for the treatment of glioblastoma
HK1214633A1 (zh) 2012-12-03 2016-07-29 Almac Diagnostics Limited 癌症的分子诊断测试
US10617755B2 (en) 2013-08-30 2020-04-14 Genentech, Inc. Combination therapy for the treatment of glioblastoma
US10456470B2 (en) 2013-08-30 2019-10-29 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
JP2017523776A (ja) 2014-07-14 2017-08-24 ジェネンテック， インコーポレイテッド 膠芽腫の診断方法及びその治療用組成物

Similar Documents

Publication Publication Date Title
JP2016530280A5 (enExample)
RU2016109448A (ru) Комбинированная терапия для лечения глиобластомы
JP2015525798A5 (enExample)
CN106604750B (zh) 治疗骨髓瘤
RU2015104001A (ru) Комбинированная терапия для лечения глиобластомы
JP2017031213A5 (enExample)
JP2016528247A5 (enExample)
RU2017108173A (ru) Комбинированная терапия на основе антител, активирующих человеческий cd40, и антител к человеческому pd-l1
JP2016528202A5 (enExample)
JP2014533279A5 (enExample)
JP2017533912A5 (enExample)
WO2013152034A1 (en) Dosage and administration of monospecific and bispecific anti-igf-1r and anti-erbb3 antibodies
RU2017132877A (ru) Комбинация антагониста pd-1 и эрибулина для лечения рака
JP2017537105A5 (enExample)
JP2018508516A5 (enExample)
JP2016536352A5 (enExample)
JP2016512564A5 (enExample)
JP2019517549A5 (enExample)
RU2017134443A (ru) Способ лечения с применением традипитанта
FI3463345T3 (fi) Farmaseuttisia yhdistelmiä
JP2019530706A5 (enExample)
JP2016526531A5 (enExample)
JP2017503014A5 (enExample)
JP2018522028A5 (enExample)
JP2017512194A5 (enExample)