JP2018522028A5 - - Google Patents

Info

Publication number

JP2018522028A5

JP2018522028A5 JP2018504750A JP2018504750A JP2018522028A5 JP 2018522028 A5 JP2018522028 A5 JP 2018522028A5 JP 2018504750 A JP2018504750 A JP 2018504750A JP 2018504750 A JP2018504750 A JP 2018504750A JP 2018522028 A5 JP2018522028 A5 JP 2018522028A5

Authority

JP

Japan

Prior art keywords

ibrutinib

btk inhibitor

subject

treatment

therapeutically effective

Prior art date

2016-07-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000002177 L01XE27 - Ibrutinib Substances 0.000 claims 10
• XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical group C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 claims 10
• 229960001507 ibrutinib Drugs 0.000 claims 10
• 229940124291 BTK inhibitor Drugs 0.000 claims 8
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 3
• 229930012538 Paclitaxel Natural products 0.000 claims 3
• 229960005395 cetuximab Drugs 0.000 claims 3
• 229960003668 docetaxel Drugs 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 229940121647 egfr inhibitor Drugs 0.000 claims 3
• 229960001592 paclitaxel Drugs 0.000 claims 3
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
• 206010009944 Colon cancer Diseases 0.000 claims 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 201000006585 gastric adenocarcinoma Diseases 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 206010044412 transitional cell carcinoma Diseases 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1