JP2018508516A5 - - Google Patents
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- Publication number
- JP2018508516A5 JP2018508516A5 JP2017546075A JP2017546075A JP2018508516A5 JP 2018508516 A5 JP2018508516 A5 JP 2018508516A5 JP 2017546075 A JP2017546075 A JP 2017546075A JP 2017546075 A JP2017546075 A JP 2017546075A JP 2018508516 A5 JP2018508516 A5 JP 2018508516A5
- Authority
- JP
- Japan
- Prior art keywords
- eribulin
- breast cancer
- medicament
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 27
- UFNVPOGXISZXJD-JBQZKEIOSA-N eribulin Chemical compound C([C@H]1CC[C@@H]2O[C@@H]3[C@H]4O[C@@H]5C[C@](O[C@H]4[C@H]2O1)(O[C@@H]53)CC[C@@H]1O[C@H](C(C1)=C)CC1)C(=O)C[C@@H]2[C@@H](OC)[C@@H](C[C@H](O)CN)O[C@H]2C[C@@H]2C(=C)[C@H](C)C[C@H]1O2 UFNVPOGXISZXJD-JBQZKEIOSA-N 0.000 claims 19
- 206010006187 Breast cancer Diseases 0.000 claims 15
- 208000026310 Breast neoplasm Diseases 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 229960003649 eribulin Drugs 0.000 claims 14
- 229960002621 pembrolizumab Drugs 0.000 claims 10
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 229940124060 PD-1 antagonist Drugs 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 4
- 229960000439 eribulin mesylate Drugs 0.000 claims 4
- 230000002055 immunohistochemical effect Effects 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 3
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 3
- 230000001394 metastastic effect Effects 0.000 claims 3
- 206010061289 metastatic neoplasm Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 3
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 239000003183 carcinogenic agent Substances 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562128373P | 2015-03-04 | 2015-03-04 | |
| US62/128,373 | 2015-03-04 | ||
| US201562264068P | 2015-12-07 | 2015-12-07 | |
| US62/264,068 | 2015-12-07 | ||
| PCT/US2016/020734 WO2016141209A1 (en) | 2015-03-04 | 2016-03-03 | Combination of a pd-1 antagonist and eribulin for treating cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508516A JP2018508516A (ja) | 2018-03-29 |
| JP2018508516A5 true JP2018508516A5 (enExample) | 2019-04-18 |
| JP6951248B2 JP6951248B2 (ja) | 2021-10-20 |
Family
ID=55586425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546075A Active JP6951248B2 (ja) | 2015-03-04 | 2016-03-03 | がんを治療するための、ｐｄ−１アンタゴニスト及びエリブリンの組合せ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10945990B2 (enExample) |
| EP (1) | EP3265122B1 (enExample) |
| JP (1) | JP6951248B2 (enExample) |
| KR (1) | KR20170122810A (enExample) |
| CN (1) | CN107810013B (enExample) |
| AU (1) | AU2016226157B2 (enExample) |
| BR (1) | BR112017018872A2 (enExample) |
| CA (1) | CA2978311A1 (enExample) |
| IL (1) | IL254133B (enExample) |
| MX (1) | MX386547B (enExample) |
| RU (1) | RU2737216C2 (enExample) |
| SG (1) | SG11201706872SA (enExample) |
| WO (1) | WO2016141209A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1771431A1 (en) | 2004-06-03 | 2007-04-11 | Eisai Co., Ltd. | Intermediates for the preparation of halichondrin b |
| CA2691357C (en) | 2007-06-18 | 2014-09-23 | N.V. Organon | Antibodies to human programmed death receptor pd-1 |
| PL2415470T3 (pl) | 2009-03-30 | 2016-12-30 | Kompozycja liposomowa | |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| MX386547B (es) | 2015-03-04 | 2025-03-19 | Merck Sharp & Dohme | Combinación de un antagonista con muerte programada 1 (pd-1) y eribulina para el tratamiento de cáncer. |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| EP3307265B1 (en) * | 2015-06-11 | 2023-12-13 | Bionomics Limited | Pharmaceutical combination and uses thereof |
| JP7014706B2 (ja) | 2015-07-13 | 2022-02-01 | サイトメックス セラピューティクス インコーポレイテッド | 抗ｐｄ－１抗体、活性化可能抗ｐｄ－１抗体、およびその使用方法 |
| ES2952680T3 (es) | 2016-04-28 | 2023-11-03 | Eisai R&D Man Co Ltd | Eribulina para inhibir el crecimiento tumoral |
| SG11201902974PA (en) * | 2016-10-14 | 2019-05-30 | Merck Sharp & Dohme | Combination of a pd-1 antagonist and eribulin for treating urothelial cancer |
| EP3528834A4 (en) * | 2016-10-21 | 2020-07-01 | Merck Sharp&Dohme Corp. | TREATMENT OF CANCER USING A COMBINATION OF A PD-1 ANTAGONIST AND AN IL-27 ANTAGONIST |
| EP3654967A4 (en) * | 2017-07-21 | 2021-04-21 | Eisai R&D Management Co., Ltd. | USE OF EIBULIN AND CYCLINE-DEPENDENT KINASE INHIBITORS IN THE TREATMENT OF CANCER |
| US11419856B2 (en) | 2017-11-20 | 2022-08-23 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| US11090286B2 (en) * | 2018-06-15 | 2021-08-17 | The Board Of Regents Of The University Of Texas System | Methods of treating and preventing breast cancer with S-equol |
| WO2019240872A1 (en) | 2018-06-15 | 2019-12-19 | The Board Of Regents Of The University Of Texas System | Methods of treating and preventing melanoma with s-equol |
| US12036204B2 (en) | 2019-07-26 | 2024-07-16 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| US11083705B2 (en) * | 2019-07-26 | 2021-08-10 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
| US20220370397A1 (en) * | 2019-10-28 | 2022-11-24 | Enzychem Lifesciences Corporation | Methods and compositions for treatment of cancer |
| WO2025049528A1 (en) * | 2023-08-29 | 2025-03-06 | Cullinan Amber Corp. | Combination therapies for cancer |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| EP2277873B1 (en) | 1998-06-17 | 2012-05-30 | Eisai R&D Management Co., Ltd. | Intermediate compound for the preparation of halichondrin analogs |
| US8097648B2 (en) * | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| CN1214043C (zh) | 1998-12-01 | 2005-08-10 | 蛋白质设计实验室股份有限公司 | 抗γ－干扰素的人化抗体 |
| ES2350687T3 (es) | 2002-07-03 | 2011-01-26 | Ono Pharmaceutical Co., Ltd. | Composiciones de inmunopotenciación. |
| ES2367430T3 (es) | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
| ES2729974T3 (es) | 2003-01-23 | 2019-11-07 | Ono Pharmaceutical Co | Anticuerpo específico de PD-1 y CD3 humanas |
| EP1771431A1 (en) | 2004-06-03 | 2007-04-11 | Eisai Co., Ltd. | Intermediates for the preparation of halichondrin b |
| AU2006244885B2 (en) | 2005-05-09 | 2011-03-31 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
| AU2006265108C1 (en) | 2005-07-01 | 2013-01-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death ligand 1 (PD-L1) |
| CA2691357C (en) | 2007-06-18 | 2014-09-23 | N.V. Organon | Antibodies to human programmed death receptor pd-1 |
| JP5735277B2 (ja) | 2007-10-03 | 2015-06-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂ類似体の合成のための中間体および方法 |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| MX2011002250A (es) | 2008-08-25 | 2011-08-17 | Amplimmune Inc | Antagonistas de muerte celular programada-1 y métodos de uso de los mismos. |
| PL2342226T3 (pl) | 2008-09-26 | 2017-01-31 | Dana-Farber Cancer Institute, Inc. | Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania |
| PT2376535T (pt) | 2008-12-09 | 2017-06-23 | Hoffmann La Roche | Anticorpos anti-pd-l1 e a sua utilização para a melhoria do funcionamento das células t |
| EP2504028A4 (en) | 2009-11-24 | 2014-04-09 | Amplimmune Inc | SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2 |
| EP2528914B1 (en) | 2010-01-26 | 2014-06-11 | Eisai R&D Management Co., Ltd. | Furo[3,2-b]pyrane derivatives useful in the synthesis of halichondrin b analogs |
| JP2014508165A (ja) | 2011-03-02 | 2014-04-03 | モルフォテック、インク． | 乳癌の治療のためのエリブリンおよびファーレツズマブの共投与 |
| EP2686441B1 (en) * | 2011-03-18 | 2019-05-08 | Eisai R&D Management Co., Ltd. | Methods and uses for predicting response to eribulin |
| KR102031020B1 (ko) | 2011-03-31 | 2019-10-14 | 머크 샤프 앤드 돔 코포레이션 | 인간 프로그램화된 사멸 수용체 pd-1에 대한 항체의 안정한 제제 및 관련된 치료 |
| JP6238459B2 (ja) | 2011-08-01 | 2017-11-29 | ジェネンテック， インコーポレイテッド | Ｐｄ−１軸結合アンタゴニストとｍｅｋ阻害剤を使用する癌の治療方法 |
| EP2928464A1 (en) * | 2012-12-04 | 2015-10-14 | Eisai R&D Management Co., Ltd. | Use of eribulin in the treatment of breast cancer |
| AR093984A1 (es) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
| EP3305812B1 (en) | 2013-03-14 | 2020-06-17 | Bristol-Myers Squibb Company | Combination of dr5 agonist and anti-pd-1 antagonist and methods of use |
| EP3003316B1 (en) * | 2013-05-31 | 2020-07-22 | Merck Sharp & Dohme Corp. | Combination therapies for cancer |
| WO2014199294A1 (en) | 2013-06-11 | 2014-12-18 | Novartis Ag | Pharmaceutical combinations of a pi3k inhibitor and a microtubule destabilizing agent |
| ES2705698T3 (es) | 2013-06-26 | 2019-03-26 | Eisai R&D Man Co Ltd | Terapia de combinación para el tratamiento del cáncer que comprende eribulina y lenvatinib |
| US9457019B2 (en) * | 2013-11-07 | 2016-10-04 | Deciphera Pharmaceuticals, Llc | Methods for inhibiting tie-2 kinase useful in the treatment of cancer |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| KR20220127940A (ko) | 2014-03-05 | 2022-09-20 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항암제의 조합물을 이용한 신장암의 치료 |
| JP2017516802A (ja) | 2014-05-28 | 2017-06-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | がんの治療におけるエリブリンの使用 |
| MX386547B (es) | 2015-03-04 | 2025-03-19 | Merck Sharp & Dohme | Combinación de un antagonista con muerte programada 1 (pd-1) y eribulina para el tratamiento de cáncer. |
-
2016
- 2016-03-03 MX MX2017011206A patent/MX386547B/es unknown
- 2016-03-03 AU AU2016226157A patent/AU2016226157B2/en not_active Ceased
- 2016-03-03 EP EP16710891.9A patent/EP3265122B1/en not_active Revoked
- 2016-03-03 JP JP2017546075A patent/JP6951248B2/ja active Active
- 2016-03-03 CA CA2978311A patent/CA2978311A1/en not_active Abandoned
- 2016-03-03 KR KR1020177027617A patent/KR20170122810A/ko not_active Ceased
- 2016-03-03 BR BR112017018872A patent/BR112017018872A2/pt not_active IP Right Cessation
- 2016-03-03 SG SG11201706872SA patent/SG11201706872SA/en unknown
- 2016-03-03 RU RU2017132877A patent/RU2737216C2/ru active
- 2016-03-03 US US15/554,540 patent/US10945990B2/en active Active
- 2016-03-03 CN CN201680025588.3A patent/CN107810013B/zh not_active Expired - Fee Related
- 2016-03-03 WO PCT/US2016/020734 patent/WO2016141209A1/en not_active Ceased
-
2017
- 2017-08-24 IL IL254133A patent/IL254133B/en unknown
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