RU2737216C2 - Комбинация антагониста pd-1 и эрибулина для лечения рака - Google Patents
Комбинация антагониста pd-1 и эрибулина для лечения рака Download PDFInfo
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- RU2737216C2 RU2737216C2 RU2017132877A RU2017132877A RU2737216C2 RU 2737216 C2 RU2737216 C2 RU 2737216C2 RU 2017132877 A RU2017132877 A RU 2017132877A RU 2017132877 A RU2017132877 A RU 2017132877A RU 2737216 C2 RU2737216 C2 RU 2737216C2
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- eribulin
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| EP1771431A1 (en) | 2004-06-03 | 2007-04-11 | Eisai Co., Ltd. | Intermediates for the preparation of halichondrin b |
| CA2691357C (en) | 2007-06-18 | 2014-09-23 | N.V. Organon | Antibodies to human programmed death receptor pd-1 |
| PL2415470T3 (pl) | 2009-03-30 | 2016-12-30 | Kompozycja liposomowa | |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| MX386547B (es) | 2015-03-04 | 2025-03-19 | Merck Sharp & Dohme | Combinación de un antagonista con muerte programada 1 (pd-1) y eribulina para el tratamiento de cáncer. |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| EP3307265B1 (en) * | 2015-06-11 | 2023-12-13 | Bionomics Limited | Pharmaceutical combination and uses thereof |
| JP7014706B2 (ja) | 2015-07-13 | 2022-02-01 | サイトメックス セラピューティクス インコーポレイテッド | 抗ｐｄ－１抗体、活性化可能抗ｐｄ－１抗体、およびその使用方法 |
| ES2952680T3 (es) | 2016-04-28 | 2023-11-03 | Eisai R&D Man Co Ltd | Eribulina para inhibir el crecimiento tumoral |
| SG11201902974PA (en) * | 2016-10-14 | 2019-05-30 | Merck Sharp & Dohme | Combination of a pd-1 antagonist and eribulin for treating urothelial cancer |
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| US11419856B2 (en) | 2017-11-20 | 2022-08-23 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| US11090286B2 (en) * | 2018-06-15 | 2021-08-17 | The Board Of Regents Of The University Of Texas System | Methods of treating and preventing breast cancer with S-equol |
| WO2019240872A1 (en) | 2018-06-15 | 2019-12-19 | The Board Of Regents Of The University Of Texas System | Methods of treating and preventing melanoma with s-equol |
| US12036204B2 (en) | 2019-07-26 | 2024-07-16 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating tumor |
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| WO2025049528A1 (en) * | 2023-08-29 | 2025-03-06 | Cullinan Amber Corp. | Combination therapies for cancer |
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| WO2014087230A1 (en) * | 2012-12-04 | 2014-06-12 | Eisai R&D Management Co., Ltd. | Use of eribulin in the treatment of breast cancer |
| WO2014159562A1 (en) * | 2013-03-14 | 2014-10-02 | Bristol-Myers Squibb Company | Combination of dr5 agonist and anti-pd-1 antagonist and methods of use |
| WO2014208774A1 (en) * | 2013-06-26 | 2014-12-31 | Eisai R&D Management Co., Ltd. | Use of eribulin and lenvatinib as combination therapy for treatment of cancer |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| EP2277873B1 (en) | 1998-06-17 | 2012-05-30 | Eisai R&D Management Co., Ltd. | Intermediate compound for the preparation of halichondrin analogs |
| US8097648B2 (en) * | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| CN1214043C (zh) | 1998-12-01 | 2005-08-10 | 蛋白质设计实验室股份有限公司 | 抗γ－干扰素的人化抗体 |
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| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| MX2011002250A (es) | 2008-08-25 | 2011-08-17 | Amplimmune Inc | Antagonistas de muerte celular programada-1 y métodos de uso de los mismos. |
| PL2342226T3 (pl) | 2008-09-26 | 2017-01-31 | Dana-Farber Cancer Institute, Inc. | Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania |
| PT2376535T (pt) | 2008-12-09 | 2017-06-23 | Hoffmann La Roche | Anticorpos anti-pd-l1 e a sua utilização para a melhoria do funcionamento das células t |
| EP2504028A4 (en) | 2009-11-24 | 2014-04-09 | Amplimmune Inc | SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2 |
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| JP2014508165A (ja) | 2011-03-02 | 2014-04-03 | モルフォテック、インク． | 乳癌の治療のためのエリブリンおよびファーレツズマブの共投与 |
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| WO2014199294A1 (en) | 2013-06-11 | 2014-12-18 | Novartis Ag | Pharmaceutical combinations of a pi3k inhibitor and a microtubule destabilizing agent |
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| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| KR20220127940A (ko) | 2014-03-05 | 2022-09-20 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항암제의 조합물을 이용한 신장암의 치료 |
| JP2017516802A (ja) | 2014-05-28 | 2017-06-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | がんの治療におけるエリブリンの使用 |
| MX386547B (es) | 2015-03-04 | 2025-03-19 | Merck Sharp & Dohme | Combinación de un antagonista con muerte programada 1 (pd-1) y eribulina para el tratamiento de cáncer. |
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| AU2016226157B2 (en) | 2022-01-27 |
| CN107810013A (zh) | 2018-03-16 |
| US20180071247A1 (en) | 2018-03-15 |
| EP3265122A1 (en) | 2018-01-10 |
| CN107810013B (zh) | 2021-04-02 |
| AU2016226157A1 (en) | 2017-09-14 |
| RU2017132877A3 (enExample) | 2019-08-29 |
| US10945990B2 (en) | 2021-03-16 |
| IL254133A0 (en) | 2017-10-31 |
| KR20170122810A (ko) | 2017-11-06 |
| JP6951248B2 (ja) | 2021-10-20 |
| MX2017011206A (es) | 2018-05-17 |
| SG11201706872SA (en) | 2017-09-28 |
| JP2018508516A (ja) | 2018-03-29 |
| BR112017018872A2 (pt) | 2018-05-29 |
| RU2017132877A (ru) | 2019-04-05 |
| WO2016141209A1 (en) | 2016-09-09 |
| EP3265122B1 (en) | 2022-05-04 |
| CA2978311A1 (en) | 2016-09-09 |
| IL254133B (en) | 2021-09-30 |
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