JP2014074046A5 - - Google Patents

Info

Publication number

JP2014074046A5

JP2014074046A5 JP2013255627A JP2013255627A JP2014074046A5 JP 2014074046 A5 JP2014074046 A5 JP 2014074046A5 JP 2013255627 A JP2013255627 A JP 2013255627A JP 2013255627 A JP2013255627 A JP 2013255627A JP 2014074046 A5 JP2014074046 A5 JP 2014074046A5

Authority

JP

Japan

Prior art keywords

bone resorption

resorption inhibitor

human

administered

patient

Prior art date

2013-12-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• 229940078581 Bone resorption inhibitor Drugs 0.000 claims 8
• 239000003814 drug Substances 0.000 claims 6
• 102000019307 Sclerostin Human genes 0.000 claims 5
• 108050006698 Sclerostin Proteins 0.000 claims 5
• 239000003795 chemical substances by application Substances 0.000 claims 5
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 4
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 4
• 239000005557 antagonist Substances 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 3
• 230000037182 bone density Effects 0.000 claims 2
• LDVRMNJZLWXJPL-JKQNMTHDSA-N calcitonin (human synthetic) Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 LDVRMNJZLWXJPL-JKQNMTHDSA-N 0.000 claims 2
• OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical group NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims 1
• 229940122361 Bisphosphonate Drugs 0.000 claims 1
• 108060001064 Calcitonin Proteins 0.000 claims 1
• 102000055006 Calcitonin Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 208000029725 Metabolic bone disease Diseases 0.000 claims 1
• IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims 1
• 229930003316 Vitamin D Natural products 0.000 claims 1
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
• 229940037127 actonel Drugs 0.000 claims 1
• 150000001413 amino acids Chemical group 0.000 claims 1
• 150000004663 bisphosphonates Chemical group 0.000 claims 1
• BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 1
• 229960004015 calcitonin Drugs 0.000 claims 1
• 229940085363 evista Drugs 0.000 claims 1
• 229940001490 fosamax Drugs 0.000 claims 1
• 230000002452 interceptive effect Effects 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 claims 1
• 108010068072 salmon calcitonin Proteins 0.000 claims 1
• 239000000333 selective estrogen receptor modulator Substances 0.000 claims 1
• 229940095743 selective estrogen receptor modulator Drugs 0.000 claims 1
• 230000009885 systemic effect Effects 0.000 claims 1
• 235000019166 vitamin D Nutrition 0.000 claims 1
• 239000011710 vitamin D Substances 0.000 claims 1
• 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
• 229940046008 vitamin d Drugs 0.000 claims 1