JP2015534567A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015534567A5 JP2015534567A5 JP2015536065A JP2015536065A JP2015534567A5 JP 2015534567 A5 JP2015534567 A5 JP 2015534567A5 JP 2015536065 A JP2015536065 A JP 2015536065A JP 2015536065 A JP2015536065 A JP 2015536065A JP 2015534567 A5 JP2015534567 A5 JP 2015534567A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound according
- acceptable salt
- alkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 3
- ZESHOXYMIFEAJJ-CUEVJCNZSA-N Cl.CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(=O)NCc1cc(F)ccc1C)c1ccccc1 Chemical compound Cl.CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(=O)NCc1cc(F)ccc1C)c1ccccc1 ZESHOXYMIFEAJJ-CUEVJCNZSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- LNJVZIQSYQJJDL-XZTZNFCFSA-N (2S)-N-(2-methoxyphenyl)-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]-2-phenylacetyl]-2,3-dihydroindole-2-carboxamide hydrochloride Chemical compound Cl.CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(=O)Nc1ccccc1OC)c1ccccc1 LNJVZIQSYQJJDL-XZTZNFCFSA-N 0.000 claims 1
- -1 (S) -1-[(S) -2-((S) -2-Methylamino-propionylamino) -2-phenyl-acetyl] -2,3-dihydro-1H-indole-2-carboxylic acid biphenyl- 2-ylamine hydrochloride Chemical compound 0.000 claims 1
- HZGCTAZDCKDJIJ-HJFUZJNISA-N Cl.CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(=O)Nc1ccccc1)c1ccccc1 Chemical compound Cl.CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(=O)Nc1ccccc1)c1ccccc1 HZGCTAZDCKDJIJ-HJFUZJNISA-N 0.000 claims 1
- WHZUDFCJBPJMBV-QVVOIHHZSA-N Cl.CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(N)=O)c1ccccc1 Chemical compound Cl.CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(N)=O)c1ccccc1 WHZUDFCJBPJMBV-QVVOIHHZSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000004431 deuterium atom Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261712317P | 2012-10-11 | 2012-10-11 | |
| US61/712,317 | 2012-10-11 | ||
| PCT/EP2013/070407 WO2014056755A1 (en) | 2012-10-11 | 2013-10-01 | Indolines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015534567A JP2015534567A (ja) | 2015-12-03 |
| JP2015534567A5 true JP2015534567A5 (enExample) | 2017-11-30 |
| JP6333825B2 JP6333825B2 (ja) | 2018-05-30 |
Family
ID=49293651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536065A Expired - Fee Related JP6333825B2 (ja) | 2012-10-11 | 2013-10-01 | インドリン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9403768B2 (enExample) |
| EP (1) | EP2906535B1 (enExample) |
| JP (1) | JP6333825B2 (enExample) |
| KR (1) | KR20150065718A (enExample) |
| CN (1) | CN104736519B (enExample) |
| CA (1) | CA2884708A1 (enExample) |
| HK (1) | HK1211025A1 (enExample) |
| MX (1) | MX2015004465A (enExample) |
| RU (1) | RU2015113959A (enExample) |
| WO (1) | WO2014056755A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017531536A (ja) | 2014-09-29 | 2017-10-26 | ニューヨーク インスティチュート オブ テクノロジーＮｅｗ Ｙｏｒｋ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｔｅｃｈｎｏｌｏｇｙ | ヒス心電図交互現象を記録するために使用するカテーテル及び種々の状態への適用 |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| EP4010081A4 (en) | 2019-08-08 | 2023-07-26 | Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center | POLYTHERAPY FOR THE TREATMENT OF CANCER |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2733995B1 (fr) * | 1995-05-09 | 1997-07-25 | Inst Nat Sante Rech Med | Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments |
| EP1715882A4 (en) * | 2004-01-16 | 2009-04-08 | Univ Michigan | SMAC-PEPTIDOMIMETIKA AND ITS USES |
| EP2457895A1 (en) * | 2004-07-12 | 2012-05-30 | Idun Pharmaceuticals, Inc. | Tetrapeptide analogs |
| AP2007003894A0 (en) * | 2004-07-12 | 2007-02-28 | Bin Chao | Tetrapeptide analogs |
| JP2011529962A (ja) * | 2008-08-02 | 2011-12-15 | ジェネンテック， インコーポレイテッド | Ｉａｐのインヒビター |
-
2013
- 2013-10-01 KR KR1020157009107A patent/KR20150065718A/ko not_active Withdrawn
- 2013-10-01 US US14/432,990 patent/US9403768B2/en not_active Expired - Fee Related
- 2013-10-01 RU RU2015113959A patent/RU2015113959A/ru not_active Application Discontinuation
- 2013-10-01 JP JP2015536065A patent/JP6333825B2/ja not_active Expired - Fee Related
- 2013-10-01 MX MX2015004465A patent/MX2015004465A/es unknown
- 2013-10-01 HK HK15111756.4A patent/HK1211025A1/xx unknown
- 2013-10-01 EP EP13771145.3A patent/EP2906535B1/en not_active Not-in-force
- 2013-10-01 CN CN201380052826.6A patent/CN104736519B/zh not_active Expired - Fee Related
- 2013-10-01 WO PCT/EP2013/070407 patent/WO2014056755A1/en not_active Ceased
- 2013-10-01 CA CA2884708A patent/CA2884708A1/en not_active Abandoned