CA2884708A1 - Indolines - Google Patents

Indolines Download PDF

Info

Publication number
CA2884708A1
CA2884708A1 CA2884708A CA2884708A CA2884708A1 CA 2884708 A1 CA2884708 A1 CA 2884708A1 CA 2884708 A CA2884708 A CA 2884708A CA 2884708 A CA2884708 A CA 2884708A CA 2884708 A1 CA2884708 A1 CA 2884708A1
Authority
CA
Canada
Prior art keywords
pharmaceutically acceptable
acceptable salt
alkyl
phenyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2884708A
Other languages
English (en)
French (fr)
Inventor
Joan Heather Hogg
Stacy Remiszewski
Weiya Yun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2884708A1 publication Critical patent/CA2884708A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Epidemiology (AREA)
CA2884708A 2012-10-11 2013-10-01 Indolines Abandoned CA2884708A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261712317P 2012-10-11 2012-10-11
US61/712,317 2012-10-11
PCT/EP2013/070407 WO2014056755A1 (en) 2012-10-11 2013-10-01 Indolines

Publications (1)

Publication Number Publication Date
CA2884708A1 true CA2884708A1 (en) 2014-04-17

Family

ID=49293651

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2884708A Abandoned CA2884708A1 (en) 2012-10-11 2013-10-01 Indolines

Country Status (10)

Country Link
US (1) US9403768B2 (enExample)
EP (1) EP2906535B1 (enExample)
JP (1) JP6333825B2 (enExample)
KR (1) KR20150065718A (enExample)
CN (1) CN104736519B (enExample)
CA (1) CA2884708A1 (enExample)
HK (1) HK1211025A1 (enExample)
MX (1) MX2015004465A (enExample)
RU (1) RU2015113959A (enExample)
WO (1) WO2014056755A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170062481A (ko) 2014-09-29 2017-06-07 뉴욕 인스티튜트 오브 테크놀로지 히스 전기도 교대맥을 기록하고 다양한 조건에 적용하는데 사용하기 위한 카테터
WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
CN118436801A (zh) 2016-05-20 2024-08-06 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
WO2021026349A1 (en) 2019-08-08 2021-02-11 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Combination therapy for treatment of cancer
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2733995B1 (fr) * 1995-05-09 1997-07-25 Inst Nat Sante Rech Med Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments
CA2553871A1 (en) * 2004-01-16 2005-08-04 The Regents Of The University Of Michigan Smac peptidomimetics and the uses thereof
BRPI0513310A (pt) * 2004-07-12 2008-05-06 Idun Pharmaceuticals Inc análogos de tetrapeptìdeo
CN101094833A (zh) * 2004-07-12 2007-12-26 伊邓药品公司 四肽类似物
CA2730448A1 (en) * 2008-08-02 2010-02-11 Genentech, Inc. Inhibitors of iap

Also Published As

Publication number Publication date
CN104736519B (zh) 2018-12-04
HK1211025A1 (zh) 2016-05-13
EP2906535B1 (en) 2018-08-08
KR20150065718A (ko) 2015-06-15
WO2014056755A1 (en) 2014-04-17
EP2906535A1 (en) 2015-08-19
JP6333825B2 (ja) 2018-05-30
MX2015004465A (es) 2015-07-14
JP2015534567A (ja) 2015-12-03
CN104736519A (zh) 2015-06-24
US9403768B2 (en) 2016-08-02
US20150246882A1 (en) 2015-09-03
RU2015113959A (ru) 2016-12-10

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Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20181002