RU2015113959A - Индолины - Google Patents
Индолины Download PDFInfo
- Publication number
- RU2015113959A RU2015113959A RU2015113959A RU2015113959A RU2015113959A RU 2015113959 A RU2015113959 A RU 2015113959A RU 2015113959 A RU2015113959 A RU 2015113959A RU 2015113959 A RU2015113959 A RU 2015113959A RU 2015113959 A RU2015113959 A RU 2015113959A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- pharmaceutically acceptable
- alkyl
- acceptable salt
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 68
- 150000003839 salts Chemical class 0.000 claims abstract 36
- 125000003118 aryl group Chemical group 0.000 claims abstract 25
- -1 propanyl Chemical group 0.000 claims abstract 16
- 229910052736 halogen Inorganic materials 0.000 claims abstract 9
- 150000002367 halogens Chemical class 0.000 claims abstract 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 3
- 125000004431 deuterium atom Chemical group 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- ODUZJBKKYBQIBX-UHFFFAOYSA-N 2,6-difluoroaniline Chemical compound NC1=C(F)C=CC=C1F ODUZJBKKYBQIBX-UHFFFAOYSA-N 0.000 claims 2
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- SJCSWALYIRCORO-CQDKDKBSSA-N CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](Cc2ccccc12)C(O)=O Chemical compound CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](Cc2ccccc12)C(O)=O SJCSWALYIRCORO-CQDKDKBSSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261712317P | 2012-10-11 | 2012-10-11 | |
| US61/712,317 | 2012-10-11 | ||
| PCT/EP2013/070407 WO2014056755A1 (en) | 2012-10-11 | 2013-10-01 | Indolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015113959A true RU2015113959A (ru) | 2016-12-10 |
Family
ID=49293651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015113959A RU2015113959A (ru) | 2012-10-11 | 2013-10-01 | Индолины |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9403768B2 (enExample) |
| EP (1) | EP2906535B1 (enExample) |
| JP (1) | JP6333825B2 (enExample) |
| KR (1) | KR20150065718A (enExample) |
| CN (1) | CN104736519B (enExample) |
| CA (1) | CA2884708A1 (enExample) |
| HK (1) | HK1211025A1 (enExample) |
| MX (1) | MX2015004465A (enExample) |
| RU (1) | RU2015113959A (enExample) |
| WO (1) | WO2014056755A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170062481A (ko) | 2014-09-29 | 2017-06-07 | 뉴욕 인스티튜트 오브 테크놀로지 | 히스 전기도 교대맥을 기록하고 다양한 조건에 적용하는데 사용하기 위한 카테터 |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| WO2021026349A1 (en) | 2019-08-08 | 2021-02-11 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Combination therapy for treatment of cancer |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2733995B1 (fr) * | 1995-05-09 | 1997-07-25 | Inst Nat Sante Rech Med | Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments |
| CA2553871A1 (en) * | 2004-01-16 | 2005-08-04 | The Regents Of The University Of Michigan | Smac peptidomimetics and the uses thereof |
| BRPI0513310A (pt) * | 2004-07-12 | 2008-05-06 | Idun Pharmaceuticals Inc | análogos de tetrapeptìdeo |
| CN101094833A (zh) * | 2004-07-12 | 2007-12-26 | 伊邓药品公司 | 四肽类似物 |
| CA2730448A1 (en) * | 2008-08-02 | 2010-02-11 | Genentech, Inc. | Inhibitors of iap |
-
2013
- 2013-10-01 EP EP13771145.3A patent/EP2906535B1/en not_active Not-in-force
- 2013-10-01 RU RU2015113959A patent/RU2015113959A/ru not_active Application Discontinuation
- 2013-10-01 WO PCT/EP2013/070407 patent/WO2014056755A1/en not_active Ceased
- 2013-10-01 MX MX2015004465A patent/MX2015004465A/es unknown
- 2013-10-01 KR KR1020157009107A patent/KR20150065718A/ko not_active Withdrawn
- 2013-10-01 US US14/432,990 patent/US9403768B2/en not_active Expired - Fee Related
- 2013-10-01 JP JP2015536065A patent/JP6333825B2/ja not_active Expired - Fee Related
- 2013-10-01 HK HK15111756.4A patent/HK1211025A1/xx unknown
- 2013-10-01 CN CN201380052826.6A patent/CN104736519B/zh not_active Expired - Fee Related
- 2013-10-01 CA CA2884708A patent/CA2884708A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN104736519B (zh) | 2018-12-04 |
| HK1211025A1 (zh) | 2016-05-13 |
| EP2906535B1 (en) | 2018-08-08 |
| CA2884708A1 (en) | 2014-04-17 |
| KR20150065718A (ko) | 2015-06-15 |
| WO2014056755A1 (en) | 2014-04-17 |
| EP2906535A1 (en) | 2015-08-19 |
| JP6333825B2 (ja) | 2018-05-30 |
| MX2015004465A (es) | 2015-07-14 |
| JP2015534567A (ja) | 2015-12-03 |
| CN104736519A (zh) | 2015-06-24 |
| US9403768B2 (en) | 2016-08-02 |
| US20150246882A1 (en) | 2015-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20171017 |