CN104736519B - 吲哚啉类 - Google Patents

吲哚啉类 Download PDF

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Publication number
CN104736519B
CN104736519B CN201380052826.6A CN201380052826A CN104736519B CN 104736519 B CN104736519 B CN 104736519B CN 201380052826 A CN201380052826 A CN 201380052826A CN 104736519 B CN104736519 B CN 104736519B
Authority
CN
China
Prior art keywords
compound
methyl
dihydro
propionamido
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380052826.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN104736519A (zh
Inventor
J·H·霍格
S·雷米斯泽维斯基
W·云
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN104736519A publication Critical patent/CN104736519A/zh
Application granted granted Critical
Publication of CN104736519B publication Critical patent/CN104736519B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
CN201380052826.6A 2012-10-11 2013-10-01 吲哚啉类 Expired - Fee Related CN104736519B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261712317P 2012-10-11 2012-10-11
US61/712,317 2012-10-11
PCT/EP2013/070407 WO2014056755A1 (en) 2012-10-11 2013-10-01 Indolines

Publications (2)

Publication Number Publication Date
CN104736519A CN104736519A (zh) 2015-06-24
CN104736519B true CN104736519B (zh) 2018-12-04

Family

ID=49293651

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380052826.6A Expired - Fee Related CN104736519B (zh) 2012-10-11 2013-10-01 吲哚啉类

Country Status (10)

Country Link
US (1) US9403768B2 (enExample)
EP (1) EP2906535B1 (enExample)
JP (1) JP6333825B2 (enExample)
KR (1) KR20150065718A (enExample)
CN (1) CN104736519B (enExample)
CA (1) CA2884708A1 (enExample)
HK (1) HK1211025A1 (enExample)
MX (1) MX2015004465A (enExample)
RU (1) RU2015113959A (enExample)
WO (1) WO2014056755A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015324411A1 (en) 2014-09-29 2017-04-20 New York Institute Of Technology Catheter for use in recording His electrogram alternans and application to various conditions
WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
CN109152843A (zh) 2016-05-20 2019-01-04 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
CA3148504A1 (en) 2019-08-08 2021-02-11 Institute For Cancer Research D/B/A/ The Research Institute Of Fox Chase Cancer Center Combination therapy for treatment of cancer
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101094833A (zh) * 2004-07-12 2007-12-26 伊邓药品公司 四肽类似物
CN102171209A (zh) * 2008-08-02 2011-08-31 健泰科生物技术公司 Iap抑制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2733995B1 (fr) 1995-05-09 1997-07-25 Inst Nat Sante Rech Med Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments
CN1933847A (zh) * 2004-01-16 2007-03-21 密歇根大学董事会 Smac肽模拟物及其应用
EP2457895A1 (en) * 2004-07-12 2012-05-30 Idun Pharmaceuticals, Inc. Tetrapeptide analogs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101094833A (zh) * 2004-07-12 2007-12-26 伊邓药品公司 四肽类似物
CN102171209A (zh) * 2008-08-02 2011-08-31 健泰科生物技术公司 Iap抑制剂

Also Published As

Publication number Publication date
HK1211025A1 (zh) 2016-05-13
RU2015113959A (ru) 2016-12-10
MX2015004465A (es) 2015-07-14
EP2906535A1 (en) 2015-08-19
JP2015534567A (ja) 2015-12-03
CA2884708A1 (en) 2014-04-17
US20150246882A1 (en) 2015-09-03
WO2014056755A1 (en) 2014-04-17
JP6333825B2 (ja) 2018-05-30
KR20150065718A (ko) 2015-06-15
EP2906535B1 (en) 2018-08-08
CN104736519A (zh) 2015-06-24
US9403768B2 (en) 2016-08-02

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