JP2018529770A5 - - Google Patents
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- Publication number
- JP2018529770A5 JP2018529770A5 JP2018535238A JP2018535238A JP2018529770A5 JP 2018529770 A5 JP2018529770 A5 JP 2018529770A5 JP 2018535238 A JP2018535238 A JP 2018535238A JP 2018535238 A JP2018535238 A JP 2018535238A JP 2018529770 A5 JP2018529770 A5 JP 2018529770A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- amino
- indol
- pyrazol
- propanamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 3-methoxy-1-methyl-1H-pyrazol-4-yl Chemical group 0.000 claims 68
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 31
- 150000001875 compounds Chemical class 0.000 claims 20
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- SXIBYTSRBYUVFK-UHFFFAOYSA-N n-(4-methylpiperazin-1-yl)propanamide Chemical compound CCC(=O)NN1CCN(C)CC1 SXIBYTSRBYUVFK-UHFFFAOYSA-N 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- PCJQEPKPLJLWMX-OAHLLOKOSA-N BrC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O Chemical compound BrC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O PCJQEPKPLJLWMX-OAHLLOKOSA-N 0.000 claims 1
- BEZNFCWNGQEVFF-GOSISDBHSA-N C(C)C1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)C Chemical compound C(C)C1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)C BEZNFCWNGQEVFF-GOSISDBHSA-N 0.000 claims 1
- AJZTUQXAOKWBRI-GOSISDBHSA-N C(C)N1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)OC Chemical compound C(C)N1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)OC AJZTUQXAOKWBRI-GOSISDBHSA-N 0.000 claims 1
- LVXVPEYLGZSSHF-GOSISDBHSA-N C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)C Chemical compound C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)C LVXVPEYLGZSSHF-GOSISDBHSA-N 0.000 claims 1
- YIPTWCREDSOPJH-LJQANCHMSA-N C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)CC Chemical compound C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)CC YIPTWCREDSOPJH-LJQANCHMSA-N 0.000 claims 1
- HYIDYFLOPVNQFJ-MRXNPFEDSA-N C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)F)C Chemical compound C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)F)C HYIDYFLOPVNQFJ-MRXNPFEDSA-N 0.000 claims 1
- WXQSNMJYETXXOU-LJQANCHMSA-N C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)CC)=O)C)C Chemical compound C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)CC)=O)C)C WXQSNMJYETXXOU-LJQANCHMSA-N 0.000 claims 1
- ILENBJYJIMEMLK-QGZVFWFLSA-N C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)CC)=O)F)C Chemical compound C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)CC)=O)F)C ILENBJYJIMEMLK-QGZVFWFLSA-N 0.000 claims 1
- MFLOYXVMLPUWDM-HSZRJFAPSA-N C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](CC)N1CCN(CC1)C)=O)C)C Chemical compound C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](CC)N1CCN(CC1)C)=O)C)C MFLOYXVMLPUWDM-HSZRJFAPSA-N 0.000 claims 1
- JOFKNRHXPSEBJP-HSZRJFAPSA-N C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](COC)N1CCN(CC1)C)=O)C)C Chemical compound C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](COC)N1CCN(CC1)C)=O)C)C JOFKNRHXPSEBJP-HSZRJFAPSA-N 0.000 claims 1
- MFLOYXVMLPUWDM-QHCPKHFHSA-N C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](CC)N1CCN(CC1)C)=O)C)C Chemical compound C(C)OC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](CC)N1CCN(CC1)C)=O)C)C MFLOYXVMLPUWDM-QHCPKHFHSA-N 0.000 claims 1
- KROOCQTURJKSTB-GOSISDBHSA-N CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)C Chemical compound CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)C KROOCQTURJKSTB-GOSISDBHSA-N 0.000 claims 1
- CFVIJZVXRQLUEX-MRXNPFEDSA-N CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)F)C Chemical compound CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)F)C CFVIJZVXRQLUEX-MRXNPFEDSA-N 0.000 claims 1
- RWZJXPSNVCNPSC-JOCHJYFZSA-N CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](CC)N1CCN(CC1)C)=O)F)C Chemical compound CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](CC)N1CCN(CC1)C)=O)F)C RWZJXPSNVCNPSC-JOCHJYFZSA-N 0.000 claims 1
- KROOCQTURJKSTB-SFHVURJKSA-N CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](C)N1CCN(CC1)C)=O)C)C Chemical compound CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](C)N1CCN(CC1)C)=O)C)C KROOCQTURJKSTB-SFHVURJKSA-N 0.000 claims 1
- RWZJXPSNVCNPSC-QFIPXVFZSA-N CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](CC)N1CCN(CC1)C)=O)F)C Chemical compound CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](CC)N1CCN(CC1)C)=O)F)C RWZJXPSNVCNPSC-QFIPXVFZSA-N 0.000 claims 1
- KRLOGMJQWZWUCD-QFIPXVFZSA-N CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](COC)N1CCN(CC1)C)=O)F)C Chemical compound CN1N=C(C(=C1)NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](COC)N1CCN(CC1)C)=O)F)C KRLOGMJQWZWUCD-QFIPXVFZSA-N 0.000 claims 1
- TUXNITAMWKSYNE-QGZVFWFLSA-N CN1N=C(C(=C1)NC1=NC=CC(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C Chemical compound CN1N=C(C(=C1)NC1=NC=CC(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C TUXNITAMWKSYNE-QGZVFWFLSA-N 0.000 claims 1
- DZGZZYZUXFBJLY-QGZVFWFLSA-N COC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)C Chemical compound COC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C)C DZGZZYZUXFBJLY-QGZVFWFLSA-N 0.000 claims 1
- BQZWKEHNKAZASP-JOCHJYFZSA-N COC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](CC)N1CCN(CC1)C)=O)C)C Chemical compound COC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](CC)N1CCN(CC1)C)=O)C)C BQZWKEHNKAZASP-JOCHJYFZSA-N 0.000 claims 1
- DZGZZYZUXFBJLY-KRWDZBQOSA-N COC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](C)N1CCN(CC1)C)=O)C)C Chemical compound COC1=NN(C=C1NC1=NC=C(C(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](C)N1CCN(CC1)C)=O)C)C DZGZZYZUXFBJLY-KRWDZBQOSA-N 0.000 claims 1
- CVCVOSPZEVINRM-MRXNPFEDSA-N COC1=NN(C=C1NC1=NC=CC(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C Chemical compound COC1=NN(C=C1NC1=NC=CC(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O)C CVCVOSPZEVINRM-MRXNPFEDSA-N 0.000 claims 1
- FXINXBSKXAZUGH-JOCHJYFZSA-N COC1=NN(C=C1NC1=NC=CC(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](CC)N1CCN(CC1)C)=O)C Chemical compound COC1=NN(C=C1NC1=NC=CC(=N1)C1=CNC2=C(C=CC=C12)NC([C@@H](CC)N1CCN(CC1)C)=O)C FXINXBSKXAZUGH-JOCHJYFZSA-N 0.000 claims 1
- FXINXBSKXAZUGH-QFIPXVFZSA-N COC1=NN(C=C1NC1=NC=CC(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](CC)N1CCN(CC1)C)=O)C Chemical compound COC1=NN(C=C1NC1=NC=CC(=N1)C1=CNC2=C(C=CC=C12)NC([C@H](CC)N1CCN(CC1)C)=O)C FXINXBSKXAZUGH-QFIPXVFZSA-N 0.000 claims 1
- FDFGTWUYSOUXBN-QFIPXVFZSA-N COC[C@@H](C(=O)NC=1C=CC=C2C(=CNC=12)C1=NC(=NC=C1)NC=1C(=NN(C=1)C)OC)N1CCN(CC1)C Chemical compound COC[C@@H](C(=O)NC=1C=CC=C2C(=CNC=12)C1=NC(=NC=C1)NC=1C(=NN(C=1)C)OC)N1CCN(CC1)C FDFGTWUYSOUXBN-QFIPXVFZSA-N 0.000 claims 1
- FDFGTWUYSOUXBN-JOCHJYFZSA-N COC[C@H](C(=O)NC=1C=CC=C2C(=CNC=12)C1=NC(=NC=C1)NC=1C(=NN(C=1)C)OC)N1CCN(CC1)C Chemical compound COC[C@H](C(=O)NC=1C=CC=C2C(=CNC=12)C1=NC(=NC=C1)NC=1C(=NN(C=1)C)OC)N1CCN(CC1)C FDFGTWUYSOUXBN-JOCHJYFZSA-N 0.000 claims 1
- KVEJGMPRJMCUMB-OAHLLOKOSA-N ClC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O Chemical compound ClC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O KVEJGMPRJMCUMB-OAHLLOKOSA-N 0.000 claims 1
- VFSQXXYAIWPJKL-MRXNPFEDSA-N ClC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OCC)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O Chemical compound ClC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OCC)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O VFSQXXYAIWPJKL-MRXNPFEDSA-N 0.000 claims 1
- OEONIHQPMGEGIL-OAHLLOKOSA-N FC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O Chemical compound FC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)C)=O OEONIHQPMGEGIL-OAHLLOKOSA-N 0.000 claims 1
- ZPMFUXKSMSXPGS-QGZVFWFLSA-N FC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)CCOC)=O Chemical compound FC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@@H](C)N1CCN(CC1)CCOC)=O ZPMFUXKSMSXPGS-QGZVFWFLSA-N 0.000 claims 1
- RPODFSQJXHMERD-OAQYLSRUSA-N FC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@@H](CC)N1CCN(CC1)C)=O Chemical compound FC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@@H](CC)N1CCN(CC1)C)=O RPODFSQJXHMERD-OAQYLSRUSA-N 0.000 claims 1
- RPODFSQJXHMERD-NRFANRHFSA-N FC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@H](CC)N1CCN(CC1)C)=O Chemical compound FC=1C(=NC(=NC=1)NC=1C(=NN(C=1)C)OC)C1=CNC2=C(C=CC=C12)NC([C@H](CC)N1CCN(CC1)C)=O RPODFSQJXHMERD-NRFANRHFSA-N 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N ethyl acetate Substances CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 1
- 229940125216 golidocitinib Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Substances CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562232629P | 2015-09-25 | 2015-09-25 | |
| US62/232,629 | 2015-09-25 | ||
| PCT/EP2016/072616 WO2017050938A1 (en) | 2015-09-25 | 2016-09-22 | Compounds and methods for inhibiting jak |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529770A JP2018529770A (ja) | 2018-10-11 |
| JP2018529770A5 true JP2018529770A5 (enExample) | 2020-01-23 |
| JP6767491B2 JP6767491B2 (ja) | 2020-10-14 |
Family
ID=56979589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018535238A Active JP6767491B2 (ja) | 2015-09-25 | 2016-09-22 | Ｊａｋを阻害するための化合物及び方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US9714236B2 (enExample) |
| EP (2) | EP4219482A1 (enExample) |
| JP (1) | JP6767491B2 (enExample) |
| KR (2) | KR20250035597A (enExample) |
| CN (4) | CN111606893B (enExample) |
| AR (1) | AR106138A1 (enExample) |
| AU (1) | AU2016328764B2 (enExample) |
| BR (1) | BR112018005833B1 (enExample) |
| CA (1) | CA2995430C (enExample) |
| DK (1) | DK3353168T3 (enExample) |
| ES (1) | ES2956642T3 (enExample) |
| MX (1) | MX375724B (enExample) |
| PT (1) | PT3353168T (enExample) |
| RU (1) | RU2760359C2 (enExample) |
| TW (1) | TWI740843B (enExample) |
| WO (1) | WO2017050938A1 (enExample) |
| ZA (1) | ZA201800782B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250035597A (ko) * | 2015-09-25 | 2025-03-12 | 디잘 (지앙수) 파마슈티칼 씨오., 리미티드 | Jak를 억제하기 위한 화합물 및 방법 |
| US10513509B2 (en) | 2016-05-26 | 2019-12-24 | Recurium Ip Holdings, Llc | EGFR inhibitor compounds |
| MX390625B (es) * | 2017-01-17 | 2025-03-19 | Astrazeneca Ab | Inhibidores selectivos de jak1. |
| JOP20180094A1 (ar) | 2017-10-18 | 2019-04-18 | Hk Inno N Corp | مركب حلقي غير متجانس كمثبط بروتين كيناز |
| CN118580223A (zh) * | 2018-07-18 | 2024-09-03 | 阿斯利康(瑞典)有限公司 | 抑制jak的化合物的昔萘酸盐 |
| CN112823159B (zh) * | 2018-09-21 | 2024-03-01 | 上海轶诺药业有限公司 | 一类具有激酶抑制活性的芳香杂环类化合物 |
| KR102195348B1 (ko) * | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| MX2021012749A (es) * | 2019-04-19 | 2021-11-18 | Dizal Jiangsu Pharmaceutical Co Ltd | Inhibidor selectivo de la jak1 cinasa. |
| CN110627775A (zh) * | 2019-10-24 | 2019-12-31 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
| CN111961037B (zh) * | 2020-09-17 | 2021-09-21 | 嘉兴特科罗生物科技有限公司 | 一种作为jak激酶抑制剂的药物化合物 |
| CN114269736B (zh) * | 2020-11-26 | 2024-02-02 | 科辉智药(深圳)新药研究中心有限公司 | 一种酰胺化合物、药物组合物及其应用 |
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| WO2025230951A1 (en) * | 2024-04-29 | 2025-11-06 | Icahn School Of Medicine At Mount Sinai | Method of treating adenoid cystic carcinoma |
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| CA2560454C (en) * | 2004-03-30 | 2013-05-21 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of jak and other protein kinases |
| GB0500492D0 (en) * | 2005-01-11 | 2005-02-16 | Cyclacel Ltd | Compound |
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| WO2007089768A2 (en) * | 2006-01-30 | 2007-08-09 | Exelixis, Inc. | 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as jak-2 modulators and pharmaceutical compositions containing them |
| ME00811B (me) * | 2006-12-08 | 2012-03-20 | Novartis Ag | JEDINJENJA l KOMPOZICIJE KAO INHIBITORI PROTEIN KINAZE |
| US9908884B2 (en) * | 2009-05-05 | 2018-03-06 | Dana-Farber Cancer Institute, Inc. | EGFR inhibitors and methods of treating disorders |
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| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| US20130225615A1 (en) * | 2010-09-01 | 2013-08-29 | Ambit Biosciences Corporation | 2-cycloquinazoline derivatives and methods of use thereof |
| US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| JP2014500254A (ja) * | 2010-11-09 | 2014-01-09 | セルゾーム リミティッド | Ｔｙｋ２阻害剤としてのピリジン化合物およびそのアザ類似体 |
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| WO2012116247A1 (en) * | 2011-02-25 | 2012-08-30 | Synta Pharmaceuticals Corp. | Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers |
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| CN104334191A (zh) | 2012-03-29 | 2015-02-04 | 纽约市哥伦比亚大学托管会 | 治疗毛发脱落疾病的方法 |
| KR20250035597A (ko) * | 2015-09-25 | 2025-03-12 | 디잘 (지앙수) 파마슈티칼 씨오., 리미티드 | Jak를 억제하기 위한 화합물 및 방법 |
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