AR106138A1 - Compuestos y métodos para inhibir jak - Google Patents

Compuestos y métodos para inhibir jak

Info

Publication number
AR106138A1
AR106138A1 ARP160102919A ARP160102919A AR106138A1 AR 106138 A1 AR106138 A1 AR 106138A1 AR P160102919 A ARP160102919 A AR P160102919A AR P160102919 A ARP160102919 A AR P160102919A AR 106138 A1 AR106138 A1 AR 106138A1
Authority
AR
Argentina
Prior art keywords
methyl
compounds
methods
ethyl
inhibit jak
Prior art date
Application number
ARP160102919A
Other languages
English (en)
Inventor
Edmundo Chuaqui Claudio
Marie Vasbinder Melissa
Lys Ruston Linette
Mcabe James
Grecu Tudor
Grant Kettl Jason
James Winter-Holt Jon
Donald Woessner Richard
Yang Wenzhan
Wu Dedong
Su Qibin
Kawatkar Sameer
Patrick Grimster Neil
K Nilsson Magnus
Birgitta Margareta Strand Annika
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR106138A1 publication Critical patent/AR106138A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), en donde R¹ es metilo o etilo; R² se selecciona de metilo, etilo, metoxilo y etoxilo; R³ se selecciona de hidrógeno, cloro, flúor, bromo y metilo; R⁴ se selecciona de metilo, etilo y -CH₂OCH₃; R⁵ y R⁶ son cada uno individualmente metilo o hidrógeno; y R⁷ se selecciona de metilo, etilo, -(CH₂)₂OH y -(CH₂)₂OCH₃; o una sal farmacéuticamente aceptable del mismo.
ARP160102919A 2015-09-25 2016-09-23 Compuestos y métodos para inhibir jak AR106138A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562232629P 2015-09-25 2015-09-25

Publications (1)

Publication Number Publication Date
AR106138A1 true AR106138A1 (es) 2017-12-13

Family

ID=56979589

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102919A AR106138A1 (es) 2015-09-25 2016-09-23 Compuestos y métodos para inhibir jak

Country Status (18)

Country Link
US (5) US9714236B2 (es)
EP (2) EP4219482A1 (es)
JP (1) JP6767491B2 (es)
KR (1) KR20180058719A (es)
CN (4) CN111606893B (es)
AR (1) AR106138A1 (es)
AU (1) AU2016328764B2 (es)
BR (1) BR112018005833B1 (es)
CA (1) CA2995430C (es)
DK (1) DK3353168T3 (es)
ES (1) ES2956642T3 (es)
HK (1) HK1259422A1 (es)
MX (1) MX2018003590A (es)
PT (1) PT3353168T (es)
RU (1) RU2760359C2 (es)
TW (1) TWI740843B (es)
WO (1) WO2017050938A1 (es)
ZA (1) ZA201800782B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3353168T3 (da) * 2015-09-25 2023-10-02 Dizal Jiangsu Pharmaceutical Co Ltd Forbindelser og fremgangsmåder til at inhibere jak
KR20220130249A (ko) 2016-05-26 2022-09-26 리커리엄 아이피 홀딩스, 엘엘씨 Egfr 억제제 화합물
SG11201906222WA (en) * 2017-01-17 2019-08-27 Astrazeneca Ab Jak1 selective inhibitors
JOP20180094A1 (ar) 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
CN112424187B (zh) 2018-07-18 2024-06-21 阿斯利康(瑞典)有限公司 抑制jak的化合物的昔萘酸盐
US20210371415A1 (en) * 2018-09-21 2021-12-02 Shanghai Ennovabio Pharmaceuticals Co., Ltd. Aromatic heterocyclic compound with kinase inhibitory activity
KR102195348B1 (ko) * 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
AU2020258619A1 (en) * 2019-04-19 2021-09-16 Dizal (Jiangsu) Pharmaceutical Co., Ltd. JAK1 selective kinase inhibitor
CN110627775A (zh) * 2019-10-24 2019-12-31 嘉兴特科罗生物科技有限公司 一种小分子化合物
CN111961037B (zh) * 2020-09-17 2021-09-21 嘉兴特科罗生物科技有限公司 一种作为jak激酶抑制剂的药物化合物
WO2022111499A1 (zh) * 2020-11-26 2022-06-02 深圳铂立健医药有限公司 一种酰胺化合物、药物组合物及其应用
EP4304590A1 (en) * 2021-03-11 2024-01-17 Janssen Pharmaceutica NV Lorpucitinib for use in the treatment of jak mediated disorders
CN115260128B (zh) * 2022-09-21 2022-12-09 苏州凯瑞医药科技有限公司 一种新型jak抑制剂关键中间体的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE508129T1 (de) * 2004-03-30 2011-05-15 Vertex Pharma Als inhibitoren von jak und anderen proteinkinasen geeignete azaindole
GB0500492D0 (en) * 2005-01-11 2005-02-16 Cyclacel Ltd Compound
DK1945631T3 (da) 2005-10-28 2012-10-22 Astrazeneca Ab 4- (3-aminopyrazole) pyrimidinderivater til anvendelse som tyrosinkinaseinhibitorer til behandling af cancer
JP2009525337A (ja) * 2006-01-30 2009-07-09 エクセリクシス， インク． Ｊａｋ−２調節因子としての４−アリール−２−アミノ−ピリミジン類又は４−アリール−２−アミノアルキル−ピリミジン類と使用方法
CA2671744C (en) * 2006-12-08 2012-08-28 Irm Llc Compounds and compositions as protein kinase inhibitors
CN102482277B (zh) * 2009-05-05 2017-09-19 达纳-法伯癌症研究所有限公司 表皮生长因子受体抑制剂及治疗障碍的方法
MX2011012353A (es) 2009-05-22 2011-12-14 Incyte Corp Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus.
TWI466885B (zh) * 2009-07-31 2015-01-01 Japan Tobacco Inc 含氮螺環化合物及其醫藥用途
EP2611793A1 (en) * 2010-09-01 2013-07-10 Ambit Biosciences Corporation 2-cycloquinazoline derivatives and methods of use thereof
US9198911B2 (en) 2010-11-02 2015-12-01 The Trustees Of Columbia University In The City Of New York Methods for treating hair loss disorders
CA2815330A1 (en) * 2010-11-09 2012-05-18 Cellzome Limited Pyridine compounds and aza analogues thereof as tyk2 inhibitors
BR112013012502A2 (pt) * 2010-11-19 2019-03-06 Incyte Corporation pirrolopiridina ciclobutil substituída e derivados de pirrolopirimidina derivativos como inibidores de jak
WO2012116247A1 (en) * 2011-02-25 2012-08-30 Synta Pharmaceuticals Corp. Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers
MX344479B (es) * 2011-06-20 2016-12-16 Incyte Holdings Corp Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de cinasa janus (jak).
CN104334191A (zh) 2012-03-29 2015-02-04 纽约市哥伦比亚大学托管会 治疗毛发脱落疾病的方法
DK3353168T3 (da) * 2015-09-25 2023-10-02 Dizal Jiangsu Pharmaceutical Co Ltd Forbindelser og fremgangsmåder til at inhibere jak

Also Published As

Publication number Publication date
WO2017050938A1 (en) 2017-03-30
US20170320857A1 (en) 2017-11-09
RU2018112993A3 (es) 2020-01-30
BR112018005833A2 (pt) 2018-10-16
EP3353168A1 (en) 2018-08-01
HK1259422A1 (zh) 2019-11-29
CA2995430A1 (en) 2017-03-30
CN111606893A (zh) 2020-09-01
RU2018112993A (ru) 2019-10-28
DK3353168T3 (da) 2023-10-02
CN111646980B (zh) 2021-08-27
EP3353168B1 (en) 2023-08-30
CN111606893B (zh) 2021-05-04
PT3353168T (pt) 2023-09-20
AU2016328764B2 (en) 2020-07-09
AU2016328764A1 (en) 2018-02-22
CN111848586A (zh) 2020-10-30
RU2760359C2 (ru) 2021-11-24
US11247983B2 (en) 2022-02-15
US20170088543A1 (en) 2017-03-30
US20220119372A1 (en) 2022-04-21
CN111848586B (zh) 2024-05-03
EP4219482A1 (en) 2023-08-02
CN108368091A (zh) 2018-08-03
CN111646980A (zh) 2020-09-11
TW201730186A (zh) 2017-09-01
US20190092760A1 (en) 2019-03-28
ES2956642T3 (es) 2023-12-26
JP2018529770A (ja) 2018-10-11
BR112018005833B1 (pt) 2023-10-10
KR20180058719A (ko) 2018-06-01
US20210078981A1 (en) 2021-03-18
US10654835B2 (en) 2020-05-19
CA2995430C (en) 2023-07-11
US10167276B2 (en) 2019-01-01
CN108368091B (zh) 2020-08-11
ZA201800782B (en) 2018-12-19
MX2018003590A (es) 2018-11-29
JP6767491B2 (ja) 2020-10-14
TWI740843B (zh) 2021-10-01
US9714236B2 (en) 2017-07-25

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