AR090836A1 - Derivados de benzamida - Google Patents

Derivados de benzamida

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Publication number
AR090836A1
AR090836A1 ARP130101382A ARP130101382A AR090836A1 AR 090836 A1 AR090836 A1 AR 090836A1 AR P130101382 A ARP130101382 A AR P130101382A AR P130101382 A ARP130101382 A AR P130101382A AR 090836 A1 AR090836 A1 AR 090836A1
Authority
AR
Argentina
Prior art keywords
group
alkyl group
alkyl
substituted
heterocycle
Prior art date
Application number
ARP130101382A
Other languages
English (en)
Inventor
Murata Takeshi
Niizuma Satoshi
Hara Sousuke
Kawada Hatsuo
Hada Kihito
Shimida Hideaki
Tanaka Hiroshi
Nakanishi Yoshito
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of AR090836A1 publication Critical patent/AR090836A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/42—Y being a carbon atom of a six-membered aromatic ring
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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/48—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W30/00—Technologies for solid waste management
    • Y02W30/50—Reuse, recycling or recovery technologies
    • Y02W30/62—Plastics recycling; Rubber recycling

Abstract

Reivindicación 1: Un compuesto representado por la fórmula general (1), en la cual Q representa CH₂ o NH; el Anillo A representa la fórmula (2) ó (3), en la cual A¹ representa N ó CR¹; R¹ representa un átomo de halógeno, grupo ciano, grupo alquilo C₁₋₃ ó grupo alcoxi C₁₋₃, en el cual el grupo alquilo C₁₋₃ y el grupo alcoxi C₁₋₃ puede ser sustituido con 1 a 5 átomos de halógeno; R¹ puede ser un átomo de hidrógeno cuando A² y/o A³ son N; A² representa N ó CR²; R² representa un átomo de hidrógeno, átomo de halógeno, grupo alquilo C₁₋₃ ó grupo alcoxi C₁₋₃, en el cual el grupo alquilo C₁₋₃ y el grupo alcoxi C₁₋₃ puede ser sustituido con 1 a 5 átomos de halógeno; A³ representa N ó CR³; R³ representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C₁₋₃ ó un grupo alcoxi C₁₋₃, en el cual el grupo alquilo C₁₋₃ y el grupo alcoxi C₁₋₃ puede ser sustituido con 1 a 5 átomos de halógeno; y R⁴ representa un grupo alquil C₁₋₆sulfonilo, grupo alquil C₁₋₆sulfanilo, grupo alquil C₁₋₆sulfinilo, grupo cicloalquil C₃₋₈sulfonilo, grupo cicloalquil C₃₋₈sulfanilo, grupo cicloalquil C₃₋₈sulfinilo, grupo aril C₆₋₁₀sulfonilo, grupo aril C₆₋₁₀sulfanilo o grupo aril C₆₋₁₀sulfinilo; y el Anillo B representa cualquiera de las fórmulas (4) a (10), en las cuales B¹ representa N ó CH; B² representa N ó CR⁵; R⁵ representa un átomo de halógeno, grupo alquilo C₁₋₆, grupo alcoxi C₁₋₆, grupo alquenilo C₂₋₆, grupo ciano, grupo nitro, grupo cicloalquilo C₃₋₈, anillo aromático de 4 a 10 miembros, heterociclo aromático de 4 a 10 miembros, heterociclo de 3 a 12 miembros ó grupo alquil C₁₋₆sulfanilo, en el cual el grupo alquilo C₁₋₆, grupo alcoxi C₁₋₆, grupo alquenilo C₂₋₆ ó grupo alquil C₁₋₆sulfanilo puede ser sustituido con 1 a 5 átomos de halógeno; B³ representa N ó CR⁶; B⁶ representa O, S ó NR⁶; R⁶ representa un átomo de hidrógeno, grupo alquilo C₁₋₃ sustituido opcionalmente con un grupo hidroxilo, átomo de halógeno, grupo amino, grupo OCOCH₃ ó grupo representado por la formula (i): ·--X--Y--Z, en el cual en la fórmula (i), X representa -(CH₂)ₙ-, -NH- ó -O-; Y representa un grupo cicloalquilo C₃₋₈, anillo aromático de 4 a 10 miembros, heterociclo de 3 a 12 miembros, heterociclo aromático de 4 a 10 miembros ó -(NH(CH₂)q)ʳ-, en el cual el grupo cicloalquilo C₃₋₈, anillo aromático de 4 a 10 miembros, heterociclo de 3 a 12 miembros ó heterociclo aromático de 4 a 10 miembros puede ser sustituido con 1 a 5 grupos alquilo C₁₋₆; Z representa un átomo de hidrógeno, un grupo alquilo C₁₋₆, óxido de dimetilamina, -(CH₂)ₘNRᵃRᵇ, -NRⁱCOCH₂Rᶜ, -(CH₂)ₘNRⁱCORᶜ, -(CH₂)ₘORᵈ, -(CH₂)ₘCORᵉ, -(CH₂)ₘNRʲSO₂Rᵏ, -(CH₂)ₘSO₂Rᵏ, -(CH₂)ₘCONRˡRᵐ, grupo cicloalquilo C₃₋₈, heterociclo aromático de 4 a 10 miembros ó heterociclo de 3 a 12 miembros, en el cual el heterociclo aromático de 4 a 10 miembros o heterociclo de 3 a 12 miembros puede ser sustituido con 1 a 5 grupos alquilo C₁₋₆; n representa 0, 1, 2 ó 3; m representa 0, 1, 2 ó 3; q representa 0, 1, 2 ó 3; r representa 0, 1, 2 ó 3; Rᵃ y Rᵇ son idénticos o diferentes, cada uno representa un átomo de hidrógeno, grupo alquilo C₁₋₆, grupo alquinilo C₂₋₆, grupo cicloalquilo C₃₋₈, heterociclo de 3 a 12 miembros ó -SO₂CH₃, en el cual el grupo alquilo C₁₋₆, grupo cicloalquilo C₃₋₈, heterociclo de 3 a 12 miembros ó grupo alquinilo C₂₋₆ puede ser sustituido con 1 a 5 átomos de halógeno, grupos hidroxilo, grupos C₁₋₆ alcoxi, grupos amino, -CONH₂, mono-alquil C₁₋₆amino, di-alquil C₁₋₆amino, grupos ciano, OCH₂Ph y/o heterociclo de 3 a 12 miembros; Rᶜ representa un grupo alquilo C₁₋₆, grupo alcoxi C₁₋₆, grupo cicloalquilo C₃₋₈, grupo hidroxilo, grupo ciano, heterociclo de 3 a 12 miembros, heterociclo aromático de 4 a 10 miembros ó grupo amino, en el cual el grupo alquilo C₁₋₆ puede ser sustituido por separado con 1 a 3 grupos hidroxilo, amino, mono-alquil C₁₋₆amino y/o di-alquil C₁₋₆amino; Rᵈ representa un átomo de hidrógeno o un grupo alquilo C₁₋₆, en el cual el grupo alquilo C₁₋₆ puede ser sustituido con 1 a 3 grupos hidroxilo y/o amino; Rᵉ representa un grupo alquilo C₁₋₆, grupo hidroxilo, heterociclo de 3 a 12 miembros ó heterociclo aromático de 4 a 10 miembros, en el cual el grupo alquilo C₁₋₆ puede ser sustituido con 1 a 3 grupos hidroxilo y/o amino; Rⁱ representa un átomo de hidrógeno o un grupo alquilo C₁₋₆, en el cual el grupo alquilo C₁₋₆ puede ser sustituido con 1 a 5 átomos de halógeno; Rʲ representa un átomo de hidrógeno ó grupo alquilo C₁₋₆, en el cual el grupo alquilo C₁₋₆ puede ser sustituido con 1 a 5 átomos de halógeno; Rᵏ representa un átomo de hidrógeno, grupo alquilo C₁₋₆, grupo amino, grupo mono-alquil C₁₋₆amino ó grupo di-alquil C₁₋₆amino, en el cual el grupo alquilo C₁₋₆ puede ser sustituido con 1 a 3 hidroxilo, amino, mono-alquil C₁₋₆amino y/o di-alquil C₁₋₆amino; y Rˡ y Rᵐ son idénticos o diferentes, cada uno representa un átomo de hidrógeno, grupo alquilo C₁₋₆ ó heterociclo de 3 a 12 miembros, en el cual el grupo alquilo C₁₋₆ puede ser sustituido por separado con 1 a 3 amino, mono-alquil C₁₋₆amino y/o di-alquil C₁₋₆amino; B⁴ representa N ó CR⁷; R⁷ representa un átomo de hidrógeno, átomo de halógeno, grupo ciano, grupo alquilo C₁₋₆, grupo alcoxi C₁₋₆, grupo alquenilo C₂₋₆ ó grupo cicloalquilo C₃₋₈ (en el cual el grupo alquilo C₁₋₆, grupo alcoxi C₁₋₆, grupo alquenilo C₂₋₆ ó grupo cicloalquilo C₃₋₈ puede ser sustituido con 1 a 5 átomos de halógeno) ó a grupo representado por la fórmula (ii): ·--X²--Y²--Z², en el cual X² representa -(CH₂)ₚ-; p representa 0, 1, 2 ó 3; Y² representa un anillo aromático de 4 a 10 miembros, heterociclo de 3 a 12 miembros ó heterociclo aromático de 4 a 10 miembros, en el cual el anillo aromático de 4 a 10 miembros, heterociclo de 3 a 12 miembros ó heterociclo aromático de 4 a 10 miembros puede ser sustituido con 1 a 5 grupos alquilo C₁₋₆; Z² representa un átomo de hidrógeno, un grupo alquilo C₁₋₆, grupo hidroxilo, -NRᶠRᵍ, heterociclo de 3 a 12 miembros ó heterociclo aromático de 4 a 10 miembros, en el cual el grupo alquilo C₁₋₆ puede ser sustituido con 1 a 5 átomos de halógeno y el heterociclo de 3 a 12 miembros o heterociclo aromático de 4 a 10 miembros puede ser sustituido con 1 a 5 grupos alquilo C₁₋₆; y Rᶠ y Rᵍ son idénticos o diferentes, cada uno representa un átomo de hidrógeno, grupo alquilo C₁₋₆, -COCH₃ ó - SO₂CH₃; B⁵ representa N ó CR⁸; y R⁸ representa un átomo de hidrógeno, un grupo alquilo C₁₋₆ ó átomo de halógeno, en el cual el grupo alquilo C₁₋₆ puede ser sustituido con 1 a 5 átomos de halógeno; o una sal del mismo aceptable farmacéuticamente.
ARP130101382A 2012-04-24 2013-04-24 Derivados de benzamida AR090836A1 (es)

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