HK1259422A1 - 用於抑制jak的化合物和方法 - Google Patents

用於抑制jak的化合物和方法

Info

Publication number
HK1259422A1
HK1259422A1 HK19101824.9A HK19101824A HK1259422A1 HK 1259422 A1 HK1259422 A1 HK 1259422A1 HK 19101824 A HK19101824 A HK 19101824A HK 1259422 A1 HK1259422 A1 HK 1259422A1
Authority
HK
Hong Kong
Prior art keywords
compounds
methods
inhibiting jak
jak
inhibiting
Prior art date
Application number
HK19101824.9A
Other languages
English (en)
Inventor
A‧B‧M‧阿斯特蘭
N‧P‧格林斯特
S‧卡沃特卡爾
J‧G‧凱特勒
M‧K‧尼爾遜
L‧L‧拉斯頓
Q‧蘇
M‧M‧瓦斯賓德
J‧J‧溫特-霍爾特
D‧吳
W‧楊
T‧格雷庫
J‧麥卡貝
R‧D‧韋斯納
C‧E‧丘阿基
Original Assignee
迪哲(江蘇)醫藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 迪哲(江蘇)醫藥有限公司 filed Critical 迪哲(江蘇)醫藥有限公司
Publication of HK1259422A1 publication Critical patent/HK1259422A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK19101824.9A 2015-09-25 2019-01-31 用於抑制jak的化合物和方法 HK1259422A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562232629P 2015-09-25 2015-09-25
PCT/EP2016/072616 WO2017050938A1 (en) 2015-09-25 2016-09-22 Compounds and methods for inhibiting jak

Publications (1)

Publication Number Publication Date
HK1259422A1 true HK1259422A1 (zh) 2019-11-29

Family

ID=56979589

Family Applications (1)

Application Number Title Priority Date Filing Date
HK19101824.9A HK1259422A1 (zh) 2015-09-25 2019-01-31 用於抑制jak的化合物和方法

Country Status (18)

Country Link
US (5) US9714236B2 (zh)
EP (2) EP4219482A1 (zh)
JP (1) JP6767491B2 (zh)
KR (1) KR20180058719A (zh)
CN (4) CN111606893B (zh)
AR (1) AR106138A1 (zh)
AU (1) AU2016328764B2 (zh)
BR (1) BR112018005833B1 (zh)
CA (1) CA2995430C (zh)
DK (1) DK3353168T3 (zh)
ES (1) ES2956642T3 (zh)
HK (1) HK1259422A1 (zh)
MX (1) MX2018003590A (zh)
PT (1) PT3353168T (zh)
RU (1) RU2760359C2 (zh)
TW (1) TWI740843B (zh)
WO (1) WO2017050938A1 (zh)
ZA (1) ZA201800782B (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9714236B2 (en) * 2015-09-25 2017-07-25 Astrazeneca Ab Compounds and methods for inhibiting JAK
AR110038A1 (es) 2016-05-26 2019-02-20 Kalyra Pharmaceuticals Inc Compuestos inhibidores de egfr; composición farmacéutica que lo comprende; métodos para mejorar o tratar un cáncer; método para inhibir la replicación de un crecimiento maligno o un tumor; métodos para inhibir la actividad del egfr; y usos de los compuestos
AU2018209667B2 (en) * 2017-01-17 2020-05-07 Astrazeneca Ab JAK1 selective inhibitors
KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
WO2020016302A1 (en) * 2018-07-18 2020-01-23 Astrazeneca Ab A xinafoate salt of a jak inhibiting compound
CN112823159B (zh) * 2018-09-21 2024-03-01 上海轶诺药业有限公司 一类具有激酶抑制活性的芳香杂环类化合物
KR102195348B1 (ko) * 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
US20220220096A1 (en) * 2019-04-19 2022-07-14 Dizal (Jiangsu) Pharmaceutical Co., Ltd. Jak1 selective kinase inhibitor
CN110627775A (zh) * 2019-10-24 2019-12-31 嘉兴特科罗生物科技有限公司 一种小分子化合物
CN111961037B (zh) * 2020-09-17 2021-09-21 嘉兴特科罗生物科技有限公司 一种作为jak激酶抑制剂的药物化合物
CN114269736B (zh) * 2020-11-26 2024-02-02 科辉智药(深圳)新药研究中心有限公司 一种酰胺化合物、药物组合物及其应用
US20220288041A1 (en) * 2021-03-11 2022-09-15 Janssen Pharmaceutica Nv Small molecule inhibitor of the jak family of kinases
CN115260128B (zh) * 2022-09-21 2022-12-09 苏州凯瑞医药科技有限公司 一种新型jak抑制剂关键中间体的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1730146E (pt) * 2004-03-30 2011-07-11 Vertex Pharma Azaindoles úteis como inibidores de jak e outras proteínas quinases
GB0500492D0 (en) * 2005-01-11 2005-02-16 Cyclacel Ltd Compound
AU2006307657B2 (en) 2005-10-28 2010-10-28 Astrazeneca Ab 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer
BRPI0706747A2 (pt) * 2006-01-30 2011-04-05 Exelixis Inc 4-aril-2-amino-pirimidinas ou 4-aril-2-aminoalquil-pirimidinas como moduladores jak-2 e composições farmacêuticas que os contenham
AU2007333394C1 (en) * 2006-12-08 2011-08-18 Novartis Ag Compounds and compositions as protein kinase inhibitors
CA2760794C (en) * 2009-05-05 2017-07-25 Dana Farber Cancer Institute Egfr inhibitors and methods of treating disorders
TW201100429A (en) * 2009-05-22 2011-01-01 Incyte Corp N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
TWI466885B (zh) * 2009-07-31 2015-01-01 Japan Tobacco Inc 含氮螺環化合物及其醫藥用途
EP2611793A1 (en) * 2010-09-01 2013-07-10 Ambit Biosciences Corporation 2-cycloquinazoline derivatives and methods of use thereof
US9198911B2 (en) 2010-11-02 2015-12-01 The Trustees Of Columbia University In The City Of New York Methods for treating hair loss disorders
CN103298794A (zh) * 2010-11-09 2013-09-11 塞尔卓姆有限公司 作为tyk2抑制剂的吡啶化合物及其氮杂类似物
JP5917545B2 (ja) * 2010-11-19 2016-05-18 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｊａｋ阻害剤としてのシクロブチル置換ピロロピリジンおよびピロロピリミジン誘導体
WO2012116247A1 (en) * 2011-02-25 2012-08-30 Synta Pharmaceuticals Corp. Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers
AR086983A1 (es) * 2011-06-20 2014-02-05 Incyte Corp Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
CN104334191A (zh) 2012-03-29 2015-02-04 纽约市哥伦比亚大学托管会 治疗毛发脱落疾病的方法
US9714236B2 (en) * 2015-09-25 2017-07-25 Astrazeneca Ab Compounds and methods for inhibiting JAK

Also Published As

Publication number Publication date
US20170088543A1 (en) 2017-03-30
EP3353168B1 (en) 2023-08-30
KR20180058719A (ko) 2018-06-01
BR112018005833B1 (pt) 2023-10-10
US20190092760A1 (en) 2019-03-28
CN108368091B (zh) 2020-08-11
EP3353168A1 (en) 2018-08-01
CA2995430A1 (en) 2017-03-30
AR106138A1 (es) 2017-12-13
CN111606893B (zh) 2021-05-04
AU2016328764A1 (en) 2018-02-22
RU2760359C2 (ru) 2021-11-24
US20220119372A1 (en) 2022-04-21
ZA201800782B (en) 2018-12-19
US20170320857A1 (en) 2017-11-09
PT3353168T (pt) 2023-09-20
TW201730186A (zh) 2017-09-01
CN111646980B (zh) 2021-08-27
CN111606893A (zh) 2020-09-01
WO2017050938A1 (en) 2017-03-30
CN111848586B (zh) 2024-05-03
RU2018112993A (ru) 2019-10-28
JP6767491B2 (ja) 2020-10-14
US20210078981A1 (en) 2021-03-18
AU2016328764B2 (en) 2020-07-09
EP4219482A1 (en) 2023-08-02
CN111848586A (zh) 2020-10-30
CA2995430C (en) 2023-07-11
TWI740843B (zh) 2021-10-01
US10167276B2 (en) 2019-01-01
RU2018112993A3 (zh) 2020-01-30
CN108368091A (zh) 2018-08-03
BR112018005833A2 (pt) 2018-10-16
US10654835B2 (en) 2020-05-19
DK3353168T3 (da) 2023-10-02
ES2956642T3 (es) 2023-12-26
US9714236B2 (en) 2017-07-25
US11247983B2 (en) 2022-02-15
MX2018003590A (es) 2018-11-29
CN111646980A (zh) 2020-09-11
JP2018529770A (ja) 2018-10-11

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