JP2013512899A5 - - Google Patents

Info

Publication number

JP2013512899A5

JP2013512899A5 JP2012541997A JP2012541997A JP2013512899A5 JP 2013512899 A5 JP2013512899 A5 JP 2013512899A5 JP 2012541997 A JP2012541997 A JP 2012541997A JP 2012541997 A JP2012541997 A JP 2012541997A JP 2013512899 A5 JP2013512899 A5 JP 2013512899A5

Authority

JP

Japan

Prior art keywords

methyl

amino

piperazin

chlorophenyl

oxy

Prior art date

2010-06-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• -1 4-{[2- (4-chlorophenyl) -4,4 -Dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl Chemical group 0.000 claims 92
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 65
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 22
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 8
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 5
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 4
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 4
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 3
• 206010005003 Bladder cancer Diseases 0.000 claims 3
• 208000003174 Brain Neoplasms Diseases 0.000 claims 3
• 206010006187 Breast cancer Diseases 0.000 claims 3
• 208000026310 Breast neoplasm Diseases 0.000 claims 3
• 206010008342 Cervix carcinoma Diseases 0.000 claims 3
• 206010009944 Colon cancer Diseases 0.000 claims 3
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 3
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 3
• 208000003445 Mouth Neoplasms Diseases 0.000 claims 3
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 3
• 206010033128 Ovarian cancer Diseases 0.000 claims 3
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 3
• 206010060862 Prostate cancer Diseases 0.000 claims 3
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
• 206010041067 Small cell lung cancer Diseases 0.000 claims 3
• 208000000277 Splenic Neoplasms Diseases 0.000 claims 3
• 210000001744 T-lymphocyte Anatomy 0.000 claims 3
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
• 210000003719 b-lymphocyte Anatomy 0.000 claims 3
• 201000006491 bone marrow cancer Diseases 0.000 claims 3
• 201000010881 cervical cancer Diseases 0.000 claims 3
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 201000004101 esophageal cancer Diseases 0.000 claims 3
• 201000003444 follicular lymphoma Diseases 0.000 claims 3
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 3
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 3
• 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 3
• 208000003747 lymphoid leukemia Diseases 0.000 claims 3
• 201000001441 melanoma Diseases 0.000 claims 3
• 208000025113 myeloid leukemia Diseases 0.000 claims 3
• 201000000050 myeloid neoplasm Diseases 0.000 claims 3
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
• 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 208000000587 small cell lung carcinoma Diseases 0.000 claims 3
• 201000002471 spleen cancer Diseases 0.000 claims 3
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
• 201000005112 urinary bladder cancer Diseases 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 230000036210 malignancy Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 230000003211 malignant effect Effects 0.000 claims 1
• XDOCKJXYYKYDQV-UHFFFAOYSA-N n-[4-[[2-(6-amino-5-chloropyridin-3-yl)oxy-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]benzoyl]sulfamoyl]-2-nitrophenyl]morpholine-4-carboxamide Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C(Cl)C(N)=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NC(=O)N1CCOCC1 XDOCKJXYYKYDQV-UHFFFAOYSA-N 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1