JP2013517283A5 - - Google Patents
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- Publication number
- JP2013517283A5 JP2013517283A5 JP2012549074A JP2012549074A JP2013517283A5 JP 2013517283 A5 JP2013517283 A5 JP 2013517283A5 JP 2012549074 A JP2012549074 A JP 2012549074A JP 2012549074 A JP2012549074 A JP 2012549074A JP 2013517283 A5 JP2013517283 A5 JP 2013517283A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- phenyl
- methylethyl
- piperazinyl
- pyridinecarboxylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29513810P | 2010-01-14 | 2010-01-14 | |
| US61/295,138 | 2010-01-14 | ||
| US31700510P | 2010-03-24 | 2010-03-24 | |
| US61/317,005 | 2010-03-24 | ||
| PCT/US2011/021114 WO2011088201A1 (en) | 2010-01-14 | 2011-01-13 | Voltage-gated sodium channel blockers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013517283A JP2013517283A (ja) | 2013-05-16 |
| JP2013517283A5 true JP2013517283A5 (enExample) | 2014-03-13 |
Family
ID=44304640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012549074A Pending JP2013517283A (ja) | 2010-01-14 | 2011-01-13 | 電位依存性ナトリウムチャネル遮断薬 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20130023541A1 (enExample) |
| EP (1) | EP2523665A4 (enExample) |
| JP (1) | JP2013517283A (enExample) |
| KR (1) | KR20120124064A (enExample) |
| CN (1) | CN102802627A (enExample) |
| AR (1) | AR079906A1 (enExample) |
| AU (1) | AU2011205302B2 (enExample) |
| BR (1) | BR112012017266A2 (enExample) |
| CA (1) | CA2787025A1 (enExample) |
| CL (1) | CL2012001971A1 (enExample) |
| CO (1) | CO6592051A2 (enExample) |
| CR (1) | CR20120402A (enExample) |
| EA (1) | EA201290644A1 (enExample) |
| IL (1) | IL220836A0 (enExample) |
| MA (1) | MA33987B1 (enExample) |
| MX (1) | MX2012008285A (enExample) |
| NZ (1) | NZ601126A (enExample) |
| PE (1) | PE20121518A1 (enExample) |
| PH (1) | PH12012501421A1 (enExample) |
| SG (1) | SG182400A1 (enExample) |
| TW (1) | TW201139406A (enExample) |
| UY (1) | UY33186A (enExample) |
| WO (1) | WO2011088201A1 (enExample) |
| ZA (1) | ZA201205126B (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010137018A1 (en) | 2009-05-27 | 2010-12-02 | Atir Holding S.A. | Piperazine, piperidine and tetrahydropyridine derivatives and their pharmaceutical use |
| KR101178181B1 (ko) * | 2010-09-17 | 2012-09-19 | 대한민국(농촌진흥청장) | 신규한 항생활성 화합물 및 그 화합물을 포함하는 항생 조성물 |
| WO2012049555A1 (en) | 2010-10-13 | 2012-04-19 | Lupin Limited | Spirocyclic compounds as voltage-gated sodium channel modulators |
| EA201490210A1 (ru) * | 2011-07-06 | 2014-05-30 | Глэксо Груп Лимитед | Блокаторы потенциалзависимых натриевых каналов |
| JP6014155B2 (ja) | 2011-10-31 | 2016-10-25 | ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用 |
| ES2586213T3 (es) | 2011-10-31 | 2016-10-13 | Xenon Pharmaceuticals Inc. | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos |
| WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| DK3738434T3 (da) | 2011-12-28 | 2023-12-04 | Global Blood Therapeutics Inc | Mellemprodukter til opnåelse af substituerede benzaldehydforbindelser og fremgangsmåder til anvendelse deraf ved øgning af vævsoxygenering |
| BR112014029161A2 (pt) | 2012-05-22 | 2017-06-27 | Genentech Inc | benzamidas n-substituídas e seu uso no tratamento de dor |
| BR112015000187A2 (pt) | 2012-07-06 | 2017-06-27 | Genentech Inc | benzamidas substituídas com n e métodos de uso das mesmas |
| WO2014028829A1 (en) * | 2012-08-16 | 2014-02-20 | The Scripps Research Institute | Novel kappa opioid ligands |
| BR112015022488A2 (pt) | 2013-03-14 | 2017-07-18 | Genentech Inc | triazolopiridinas substituídas e métodos de uso das mesmas |
| EP2974730B1 (en) | 2013-03-14 | 2018-01-31 | Daiichi Sankyo Company, Limited | Drug for respiratory diseases |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| KR102280614B1 (ko) | 2013-03-15 | 2021-07-21 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| AU2014237330A1 (en) | 2013-03-15 | 2015-09-17 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| AU2014237361A1 (en) * | 2013-03-15 | 2015-09-17 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| BR112015021982B1 (pt) | 2013-03-15 | 2022-12-13 | Global Blood Therapeutics, Inc | Compostos e seus usos para a modulação de hemoglobina |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| BR112015023397A2 (pt) | 2013-03-15 | 2017-07-18 | Genentech Inc | benzoxazois substituídos e métodos de uso dos mesmos |
| US10005720B2 (en) | 2013-04-05 | 2018-06-26 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| CR20160296A (es) | 2013-11-27 | 2016-09-20 | Genentech Inc | Benzamidas sustituidas y métodos para usarlas |
| US9975876B2 (en) | 2013-12-09 | 2018-05-22 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-3-ester-4-ether orexin receptor antagonists |
| JP6045487B2 (ja) * | 2013-12-25 | 2016-12-14 | シャープ株式会社 | 操作入力システム、電子機器、携帯端末、及び操作入力方法 |
| SI3102208T2 (sl) | 2014-02-07 | 2024-10-30 | Global Blood Therapeutics, Inc. | Kristalinični polimorf proste baze 2-hidroksi-6-((2-(1-izopropil-1H-pirazol-5-IL)piridin-3-IL)metoksi)- benzaldehida |
| EP3110794A1 (en) * | 2014-02-27 | 2017-01-04 | Merck Patent GmbH | Heterocyclic compounds as nav channel inhibitors and uses thereof |
| TW201623264A (zh) | 2014-03-29 | 2016-07-01 | 魯賓有限公司 | 作為電位閘控鈉通道調節劑之磺胺化合物 |
| EP3166939B1 (en) | 2014-07-07 | 2019-06-05 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| WO2016021742A1 (en) | 2014-08-07 | 2016-02-11 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds as ep4 receptor antagonists |
| WO2016191312A1 (en) | 2015-05-22 | 2016-12-01 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| MA42683A (fr) | 2015-08-27 | 2018-07-04 | Genentech Inc | Composés thérapeutiques et leurs méthodes utilisation |
| TW201722938A (zh) | 2015-09-04 | 2017-07-01 | 魯賓有限公司 | 作為電位閘控鈉通道調節子之磺醯胺化合物 |
| PE20181003A1 (es) | 2015-09-28 | 2018-06-26 | Genentech Inc | Compuestos terapeuticos y sus metodos de uso |
| CN108495851A (zh) | 2015-11-25 | 2018-09-04 | 基因泰克公司 | 取代的苯甲酰胺及其使用方法 |
| US11020382B2 (en) | 2015-12-04 | 2021-06-01 | Global Blood Therapeutics, Inc. | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| AU2017215697A1 (en) | 2016-02-03 | 2018-07-05 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | N-sulfonyl benzamide derivative with heterocyclic substituent, preparation method therefor and pharmaceutical application thereof |
| EP3854782A1 (en) | 2016-03-30 | 2021-07-28 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| AR108435A1 (es) | 2016-05-12 | 2018-08-22 | Global Blood Therapeutics Inc | Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído |
| TWI778983B (zh) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| SG11201903348UA (en) | 2016-10-17 | 2019-05-30 | Genentech Inc | Therapeutic compounds and methods of use thereof |
| WO2018163077A1 (en) | 2017-03-08 | 2018-09-13 | Lupin Limited | Indanyl compounds as voltage gated sodium channel modulators |
| WO2018175707A1 (en) | 2017-03-24 | 2018-09-27 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
| EP3759098A1 (en) | 2018-02-26 | 2021-01-06 | Genentech, Inc. | Pyridine-sulfonamide compounds and their use against pain and related conditions |
| EP3774801A1 (en) | 2018-03-30 | 2021-02-17 | F. Hoffmann-La Roche AG | Fused ring hydro-pyrido compounds as sodium channel inhibitors |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| EP3860975B1 (en) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
| CN109796402A (zh) * | 2018-12-28 | 2019-05-24 | 京博农化科技有限公司 | 一种烟嘧磺隆中间体2-氯-n，n-二甲基烟酰胺的制备方法 |
| KR102845511B1 (ko) * | 2019-02-08 | 2025-08-12 | 삼성디스플레이 주식회사 | 축합환 화합물 및 이를 포함한 유기 발광 소자 |
| KR20210135521A (ko) | 2019-03-06 | 2021-11-15 | 다이이찌 산쿄 가부시키가이샤 | 피롤로피라졸 유도체 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9909773A (pt) * | 1998-04-20 | 2000-12-19 | Basf Ag | Amida heterociclicamente substituìda, uso da mesma, e, preparação farmacêutica para uso oral, parenteral e intraperitoneal |
| CL2004000409A1 (es) * | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| KR20060032190A (ko) * | 2003-07-02 | 2006-04-14 | 버텍스 파마슈티칼스 인코포레이티드 | 전압 개폐 이온 채널의 조절제로서 유용한 피리미딘 |
| GB0520581D0 (en) * | 2005-10-10 | 2005-11-16 | Glaxo Group Ltd | Novel compounds |
| GB0520578D0 (en) * | 2005-10-10 | 2005-11-16 | Glaxo Group Ltd | Novel compounds |
| AU2006329202A1 (en) * | 2005-12-21 | 2007-06-28 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| KR20100007956A (ko) * | 2007-05-03 | 2010-01-22 | 화이자 리미티드 | 나트륨 채널 조절제로서의 2-피리딘 카복스아마이드 유도체 |
| WO2008147864A2 (en) * | 2007-05-22 | 2008-12-04 | Xenon Pharmaceuticals Inc. | Methods of using piperazine compounds in treating sodium channel-mediated diseases or conditions |
| US8642660B2 (en) * | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| TW201024282A (en) * | 2008-11-20 | 2010-07-01 | Orion Corp | New pharmaceutical compounds |
-
2011
- 2011-01-12 TW TW100101047A patent/TW201139406A/zh unknown
- 2011-01-13 KR KR1020127021186A patent/KR20120124064A/ko not_active Withdrawn
- 2011-01-13 PH PH1/2012/501421A patent/PH12012501421A1/en unknown
- 2011-01-13 AU AU2011205302A patent/AU2011205302B2/en not_active Ceased
- 2011-01-13 JP JP2012549074A patent/JP2013517283A/ja active Pending
- 2011-01-13 PE PE2012000982A patent/PE20121518A1/es not_active Application Discontinuation
- 2011-01-13 EA EA201290644A patent/EA201290644A1/ru unknown
- 2011-01-13 MA MA35122A patent/MA33987B1/fr unknown
- 2011-01-13 CA CA2787025A patent/CA2787025A1/en not_active Abandoned
- 2011-01-13 SG SG2012050068A patent/SG182400A1/en unknown
- 2011-01-13 NZ NZ601126A patent/NZ601126A/en not_active IP Right Cessation
- 2011-01-13 EP EP11733370.8A patent/EP2523665A4/en not_active Withdrawn
- 2011-01-13 CN CN2011800141112A patent/CN102802627A/zh active Pending
- 2011-01-13 WO PCT/US2011/021114 patent/WO2011088201A1/en not_active Ceased
- 2011-01-13 BR BR112012017266A patent/BR112012017266A2/pt not_active IP Right Cessation
- 2011-01-13 MX MX2012008285A patent/MX2012008285A/es not_active Application Discontinuation
- 2011-01-13 US US13/522,183 patent/US20130023541A1/en not_active Abandoned
- 2011-01-14 UY UY33186A patent/UY33186A/es not_active Application Discontinuation
- 2011-01-14 AR ARP110100127A patent/AR079906A1/es unknown
-
2012
- 2012-07-09 IL IL220836A patent/IL220836A0/en unknown
- 2012-07-10 ZA ZA2012/05126A patent/ZA201205126B/en unknown
- 2012-07-13 CO CO12118387A patent/CO6592051A2/es active IP Right Grant
- 2012-07-13 CL CL2012001971A patent/CL2012001971A1/es unknown
- 2012-07-31 CR CR20120402A patent/CR20120402A/es unknown
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