PE20121496A1 - Agentes inductores de apoptosis para el tratamiento de cancer y enfermedades inmunes y autoinmunes - Google Patents

Agentes inductores de apoptosis para el tratamiento de cancer y enfermedades inmunes y autoinmunes

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Publication number
PE20121496A1
PE20121496A1 PE2012000765A PE2012000765A PE20121496A1 PE 20121496 A1 PE20121496 A1 PE 20121496A1 PE 2012000765 A PE2012000765 A PE 2012000765A PE 2012000765 A PE2012000765 A PE 2012000765A PE 20121496 A1 PE20121496 A1 PE 20121496A1
Authority
PE
Peru
Prior art keywords
cancer
treatment
immune
autoimmune diseases
phenyl
Prior art date
Application number
PE2012000765A
Other languages
English (en)
Inventor
Milan Bruncko
Yujia Dai
Hong Ding
George A Doherty
Steven W Elmore
Lisa Hasvold
Laura Hexamer
Aaron Kunzer
Robert Mantei
William J Mcclellan
Chang H Park
Cheol-Min Park
Andrew M Petros
Xiaohong Song
Andrew J Souers
Gerard M Sullivan
Zhi-Fu Tao
Gary T Wang
Le Wang
Xilu Wang
Michael D Wendt
Todd M Hansen
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42463423&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20121496(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20121496A1 publication Critical patent/PE20121496A1/es

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    • C07D209/04—Indoles; Hydrogenated indoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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  • Chemical & Material Sciences (AREA)
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  • Hydrogenated Pyridines (AREA)
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  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE REFIERE A UN COMPUESTOS DE FORMULA (I) Y (II) DONDE: A1 ES N O C(A2); B1 ES H, R1, OR1; ENTRE OTROS; D1 ES H, R1, OR1, ENTRE OTROS; E1 ES H, R1, SR1, ENTRE OTROS; Y1 ES H, CN, NO2, ENTRE OTROS; L1 ES C(O)NH, SO2NH, C(N)NH, ENTRE OTROS; Z1 ES R26 O R27; Z2 ES R28, R29 O R30; Z3 ES R38, R39 O R40; Z1A Y Z2A ESTAN AMBOS AUSENTES O JUNTOS FORMAN CH2, CH2CH2, ENTRE OTROS; A2 ES H, R1, S(O)R1, ENTRE OTROS; R1 ES R2, R3, R4 O R5; R2 ES FENILO ENTRE OTROS; R3 ES HETROARILOENTRE OTROS; R4 ES CICLOALQUILO, CICLOALQUENILO, ENTRE OTROS; R5 ES ALQUILO, ALQUENILO, ENTRE OTROS; R100 ES FENILENO ENTRE OTROS; R101 ES FENILO ENTRE OTROS; n ES 0,1,2, O 3; m ES 1, 2, 3, 4, O 5. ES COMPUESTO PREFERIDO: 4-(4-((4'-CLORO-1,1'-BIFENIL-2-IL)METIL)PIPERAZIN-1-IL)-2-(3-((DIMETILAMINO)METIL)FENOXI)-N-((3-NITRO-4-((TETRAHIDRO-2H-PIRAN-4-ILMETIL)AMINO)FENIL)SULFONIL)BENZAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA ACTIVIDAD DE PROTEINAS ANTI-APOPTOTICAS Bcl-2 SIENDO UTIL EN EL TRATAMIENTO DE CANCER
PE2012000765A 2009-12-04 2010-06-01 Agentes inductores de apoptosis para el tratamiento de cancer y enfermedades inmunes y autoinmunes PE20121496A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/631,367 US20100160322A1 (en) 2008-12-04 2009-12-04 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

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