PE20030607A1 - Alquinos como inhibidores de metaloproteinasa de matriz - Google Patents

Alquinos como inhibidores de metaloproteinasa de matriz

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Publication number
PE20030607A1
PE20030607A1 PE2002001006A PE2002001006A PE20030607A1 PE 20030607 A1 PE20030607 A1 PE 20030607A1 PE 2002001006 A PE2002001006 A PE 2002001006A PE 2002001006 A PE2002001006 A PE 2002001006A PE 20030607 A1 PE20030607 A1 PE 20030607A1
Authority
PE
Peru
Prior art keywords
alkinees
alkyl
inhibitors
benzamide
prop
Prior art date
Application number
PE2002001006A
Other languages
English (en)
Inventor
William Howard Roark
Joseph Armand Picard
James Lester Hicks
Patrick Michael O'brien
Ly Thi Pham
Amy Mae Bunker
William Glen Harter
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PE20030607A1 publication Critical patent/PE20030607A1/es

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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40Acylated substituent nitrogen atom
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
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    • A61P19/00Drugs for skeletal disorders
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    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • C07C233/87Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C255/60Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07C311/30Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

SE REFIERE A ALQUINOS DE FORMULA I DONDE G1 Y G2 SON SON INDEPENDIENTEMENTE -(E)=C-A DONDE E ES O, S; A ES OR1, NR1R2; R1 Y R2 SON H, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, (CH2)nARILO, ENTRE OTROS; G1 Y G2 SON H, HALO, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, (CH2)mC(S)NR3R4, ENTRE OTROS; m ES 0-6; q ES 0-1; R3 Y R4 SON H, ALQUILO C1-C6, (CH2)mARILO, (CH2)mHETEROARILO; R3 Y R4 JUNTO A N FORMAN UN ANILLO DE 3-7 MIEMBROS. SON COMPUESTOS PREFERIDOS 3-(4-METOXI-FENIL)-PROP-1-INIL)-N-(4-CARBOXIBENCIL)-BENZAMIDA, N-(4-METANOSULFONIL-BENCIL)-3-(4-METOXI-FENIL)PROP-1-INIL)-BENZAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES SELECTIVOS DE LA MMP-13 UTILES PARA EL TRATAMIENTO DE CANCER, ARTRITIS
PE2002001006A 2001-10-12 2002-10-11 Alquinos como inhibidores de metaloproteinasa de matriz PE20030607A1 (es)

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DOP2002000473A (es) 2003-04-15
BR0213233A (pt) 2005-01-04
EP1434585A1 (en) 2004-07-07
GT200200210A (es) 2003-06-25
US6849648B2 (en) 2005-02-01
UY27481A1 (es) 2003-05-30
WO2003032999A1 (en) 2003-04-24
MXPA04002537A (es) 2004-05-31
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JP2005514334A (ja) 2005-05-19
US20030144274A1 (en) 2003-07-31
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