CO5680479A2 - Derivados de pirimidilsulfonamida como moduladores del receptor de quimiocina, sus composiciones y proceso de obtencion - Google Patents

Derivados de pirimidilsulfonamida como moduladores del receptor de quimiocina, sus composiciones y proceso de obtencion

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Publication number
CO5680479A2
CO5680479A2 CO05005309A CO05005309A CO5680479A2 CO 5680479 A2 CO5680479 A2 CO 5680479A2 CO 05005309 A CO05005309 A CO 05005309A CO 05005309 A CO05005309 A CO 05005309A CO 5680479 A2 CO5680479 A2 CO 5680479A2
Authority
CO
Colombia
Prior art keywords
6alkyl
phenyl
optionally substituted
substituents independently
independently selected
Prior art date
Application number
CO05005309A
Other languages
English (en)
Inventor
Mark Richard Ebden
Premji Meghani
Colin Bennion
Antony Ronald Cook
Roger Victor Bonnert
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5680479A2 publication Critical patent/CO5680479A2/es

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Abstract

1.- Un compuesto de fórmula (1), sal farmacéuticamente aceptable, solvato o éster hidrolizable in vivo del mismo. En donde R1 es un grupo seleccionado de C3-7carbociclil, C1-8alquil, C2-6alquenil y C2-6alquinil;en donde el grupo es sustituído opcionalmente por 1, 2 o 3 sustituyentes independientemente seleccionados de flúor, nitrilo, -OR4, -NR5R6, -CONR5R6, -COOR7, -NR8COR9, -SR10, -SO2R10, -SO2NR5R6, -NR8SO2R9, fenil o heteroaril; en donde fenil y heteroaril son sustituídos opcionalmente por 1, 2 o 3 sustituyentes independientemente seleccionados de halo, ciano, nitro -OR4, -NR5R6, -CONR5R6, -COOR7, -NR8COR9, -SR10, -SO2R10, -SO2NR5R6, -NR8SO2R9, C1-6alquil y trifluorometil;En donde R2 es C3-7carbociclil, sustituído opcionalmente por 1, 2 o 3 sustituyentes seleccionados independientemente de:(a) flúor, -OR4, -NR5R6, -CONR5R6, -COOR7, -NR8COR9, -SR10, -SO2R10, -SO2NR5R6, -NR8SO2R9;(b) un anillo de 3-8 miembros conteniendo opcionalmente 1, 2 o 3 átomos seleccionados de O, S, -NR8 y en donde el anillo es sustituído opcionalmente por C1-3alquil o flúor; o (c) fenil o heteroaril, cada uno de los cuales es sustituído opcionalmente por 1, 2 o 3 sustituyentes independientemente seleccionados de halo, ciano, nitro, -OR4, -NR5R6, CONR5R6, -NR8COR9, -SO2NR5R6, -NR8SO2R9, C1-6alquil y trifluorometil;o R2 es un grupo seleccionado de C1-8alquil, C2-6alquenil o C2-6alquinil en donde el grupo es sustituido por 1, 2 o 3 sustituyentes independientemente seleccionados de hidroxi, amino, C1-6alcoxi, C1-6alquilamino, di(C1-6alquil)amino, N-(C1-6alquil)-N-(fenil)amino, N-C1-6alquilcarbamoil, N,N-di(C1-6alquil)carbamoil, N-(C1-6alquil)-N-(fenil)carbamoil, carboxi, fenoxicarbonil, NR8COR9, -SO2R10, -SO2NR5R6 y -NR8SO2R9;en donde R3 es hidrógeno o independientemente R2;R4 es hidrógeno o un grupo seleccionado de C1-6alquil y fenil, en donde el grupo es sustituido opcionalmente por 1 o 2 sustituyentes seleccionados independientemente de halo, fenil, -OR11 y -NR12R13; ...
CO05005309A 2002-07-27 2005-01-24 Derivados de pirimidilsulfonamida como moduladores del receptor de quimiocina, sus composiciones y proceso de obtencion CO5680479A2 (es)

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IS7697A (is) 2005-02-17
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