MX9708147A - Compuestos de bencimidazol y su uso como moduladores del complejo receptor de gabaa. - Google Patents
Compuestos de bencimidazol y su uso como moduladores del complejo receptor de gabaa.Info
- Publication number
- MX9708147A MX9708147A MX9708147A MX9708147A MX9708147A MX 9708147 A MX9708147 A MX 9708147A MX 9708147 A MX9708147 A MX 9708147A MX 9708147 A MX9708147 A MX 9708147A MX 9708147 A MX9708147 A MX 9708147A
- Authority
- MX
- Mexico
- Prior art keywords
- phenyl
- disorders
- modulators
- receptor complex
- gabaa receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente solicitud de patente describe compuestos que tienen la formula (I): o una sal farmacéuticamente aceptable de los mismos o un oxido de los mismos en donde R3 es (II): en donde A, B y D cada uno es CH, o uno o dos de A, B y D es N y los demás son CH; R11 es fenilo, bencimidazolilo o heteroarilo monocíclico, todos los cuales pueden ser substituidos una o más veces con sustituyentes seleccionados a partir de alquilo, alcoxi, halogeno, CF3, amino, nitro, ciano, acilamino, acilo, fenilo y heteroarilo monocíclico; uno de R6 y R7 es hidrogeno y el otro es -CR'=NO", en donde R' y R" son cada uno independientemente hidrogeno, alquilo, alquenilo, alquinilo o fenilo; los compuestos son utiles para el tratamiento de varios trastornos del sistema nervioso central, tales como epilepsia y otros trastornos convulsivos, ansiedad, trastornos del sueño y trastornos de la memoria.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK46095 | 1995-04-21 | ||
| DK74195 | 1995-06-27 | ||
| PCT/EP1996/001649 WO1996033191A1 (en) | 1995-04-21 | 1996-04-19 | Benzimidazole compounds and their use as modulators of the gabaa receptor complex |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9708147A true MX9708147A (es) | 1997-12-31 |
Family
ID=26064049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9708147A MX9708147A (es) | 1995-04-21 | 1996-04-19 | Compuestos de bencimidazol y su uso como moduladores del complejo receptor de gabaa. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5922725A (es) |
| EP (1) | EP0821682B1 (es) |
| JP (1) | JP3171852B2 (es) |
| KR (1) | KR100283363B1 (es) |
| CN (1) | CN1089762C (es) |
| AT (1) | ATE194836T1 (es) |
| AU (1) | AU699623B2 (es) |
| BR (1) | BR9608056A (es) |
| CA (1) | CA2218552C (es) |
| CZ (1) | CZ287538B6 (es) |
| DE (1) | DE69609413T2 (es) |
| DK (1) | DK0821682T3 (es) |
| EE (1) | EE04308B1 (es) |
| ES (1) | ES2150671T3 (es) |
| GR (1) | GR3034558T3 (es) |
| HK (1) | HK1018048A1 (es) |
| HU (1) | HU224031B1 (es) |
| IS (1) | IS2020B (es) |
| MX (1) | MX9708147A (es) |
| NO (1) | NO314502B1 (es) |
| NZ (1) | NZ307532A (es) |
| PL (1) | PL184020B1 (es) |
| PT (1) | PT821682E (es) |
| RU (1) | RU2136676C1 (es) |
| SK (1) | SK282105B6 (es) |
| TR (1) | TR199701219T1 (es) |
| UA (1) | UA54394C2 (es) |
| WO (1) | WO1996033191A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6218547B1 (en) | 1996-10-21 | 2001-04-17 | Neurosearch A/S | 1-phenyl-benzimidazole compounds and their use as GABA-a receptor modulators |
| JP3868502B2 (ja) * | 1996-10-25 | 2007-01-17 | ニューロサーチ・アクティーゼルスカブ | 抗不安作用を有する化合物の同定方法 |
| GB9702524D0 (en) * | 1997-02-07 | 1997-03-26 | Merck Sharp & Dohme | Therapeutic agents |
| JP2001519429A (ja) * | 1997-10-10 | 2001-10-23 | ニューロサーチ、アクティーゼルスカブ | ベンズイミダゾール化合物、この化合物を含む医薬組成物、およびそれらの使用 |
| AU1224499A (en) * | 1997-12-09 | 1999-06-28 | Neurosearch A/S | Chemical compounds for use as anxiolytic agents and a method for the identification of anxiolytic compounds |
| EP1097918A4 (en) * | 1998-07-15 | 2003-04-02 | Meiji Seika Kaisha | PROCESS FOR THE PRODUCTION OF 2-NITRO-FLUOROBENZENES SUBSTITUTED IN POSITION 4 |
| JP2002528499A (ja) * | 1998-10-29 | 2002-09-03 | ブリストル−マイヤーズ スクイブ カンパニー | Ｉｍｐｄｈ酵素のインヒビターであるアミノ核誘導化合物 |
| US6627624B1 (en) | 1999-04-02 | 2003-09-30 | Neurogen Corporation | Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
| US6380210B1 (en) | 1999-04-02 | 2002-04-30 | Neurogen Corporation | Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
| US6281237B1 (en) | 1999-04-02 | 2001-08-28 | Neurogen Corporation | N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives |
| US6271241B1 (en) | 1999-04-02 | 2001-08-07 | Neurogen Corporation | Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors |
| DE60025604T2 (de) * | 1999-06-22 | 2006-07-27 | Neurosearch A/S | Benzimidazol-derivate und diese enthaltende pharmazeutische zusammensetzungen |
| WO2001090108A1 (en) * | 2000-05-24 | 2001-11-29 | Merck Sharp & Dohme Limited | 3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors |
| TWI248936B (en) * | 2001-03-21 | 2006-02-11 | Merck Sharp & Dohme | Imidazo-pyrimidine derivatives as ligands for GABA receptors |
| ATE338758T1 (de) * | 2001-03-23 | 2006-09-15 | Merck Sharp & Dohme | Imidazopyrimidin-derivate als liganden für gaba- rezeptoren |
| WO2004069160A2 (en) * | 2003-01-28 | 2004-08-19 | Smithkline Beecham Corporation | Chemical compounds |
| NZ541544A (en) | 2003-04-03 | 2008-06-30 | Neurosearch As | Benzimidazole derivatives and their use for modulating the GABAA receptor complex |
| ATE386519T1 (de) | 2003-04-03 | 2008-03-15 | Neurosearch As | Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren |
| TWI391381B (zh) * | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
| WO2010055126A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
| US8278460B2 (en) * | 2009-10-15 | 2012-10-02 | Concert Pharmaceuticals, Inc. | Substituted benzimidazoles |
| WO2019062803A1 (zh) * | 2017-09-28 | 2019-04-04 | 基石药业 | 作为a2a受体抑制剂的并环类衍生物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0520200T3 (da) * | 1991-06-24 | 1998-09-23 | Neurosearch As | Imadazol-forbindelser, deres fremstilling og anvendelse |
| US5158969A (en) * | 1991-08-21 | 1992-10-27 | Neurosearch A/S | Indole derivatives as potassium channel blockers |
| DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| AU675484B2 (en) * | 1993-03-24 | 1997-02-06 | Neurosearch A/S | Benzimidazole compounds, their use and preparation |
-
1996
- 1996-04-19 BR BR9608056-6A patent/BR9608056A/pt not_active IP Right Cessation
- 1996-04-19 CA CA002218552A patent/CA2218552C/en not_active Expired - Fee Related
- 1996-04-19 SK SK1406-97A patent/SK282105B6/sk unknown
- 1996-04-19 DK DK96914957T patent/DK0821682T3/da active
- 1996-04-19 ES ES96914957T patent/ES2150671T3/es not_active Expired - Lifetime
- 1996-04-19 RU RU97119174A patent/RU2136676C1/ru not_active IP Right Cessation
- 1996-04-19 EP EP96914957A patent/EP0821682B1/en not_active Expired - Lifetime
- 1996-04-19 MX MX9708147A patent/MX9708147A/es not_active IP Right Cessation
- 1996-04-19 EE EE9700282A patent/EE04308B1/xx not_active IP Right Cessation
- 1996-04-19 KR KR1019970707463A patent/KR100283363B1/ko not_active IP Right Cessation
- 1996-04-19 UA UA97115592A patent/UA54394C2/uk unknown
- 1996-04-19 US US08/945,123 patent/US5922725A/en not_active Expired - Lifetime
- 1996-04-19 AT AT96914957T patent/ATE194836T1/de not_active IP Right Cessation
- 1996-04-19 CN CN96193421A patent/CN1089762C/zh not_active Expired - Fee Related
- 1996-04-19 WO PCT/EP1996/001649 patent/WO1996033191A1/en active IP Right Grant
- 1996-04-19 NZ NZ307532A patent/NZ307532A/xx unknown
- 1996-04-19 CZ CZ19973291A patent/CZ287538B6/cs not_active IP Right Cessation
- 1996-04-19 PT PT96914957T patent/PT821682E/pt unknown
- 1996-04-19 JP JP53148496A patent/JP3171852B2/ja not_active Expired - Fee Related
- 1996-04-19 TR TR97/01219T patent/TR199701219T1/xx unknown
- 1996-04-19 DE DE69609413T patent/DE69609413T2/de not_active Expired - Lifetime
- 1996-04-19 AU AU56906/96A patent/AU699623B2/en not_active Ceased
- 1996-04-19 PL PL96322944A patent/PL184020B1/pl not_active IP Right Cessation
- 1996-04-19 HU HU9802272A patent/HU224031B1/hu not_active IP Right Cessation
-
1997
- 1997-10-17 IS IS4593A patent/IS2020B/is unknown
- 1997-10-20 NO NO19974843A patent/NO314502B1/no unknown
-
1998
- 1998-10-09 HK HK98111154A patent/HK1018048A1/xx not_active IP Right Cessation
-
2000
- 2000-10-04 GR GR20000402248T patent/GR3034558T3/el not_active IP Right Cessation
Also Published As
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| CA2218493A1 (en) | Benzimidazole compounds and their use as modulators of the gabaa receptor complex | |
| MX9708147A (es) | Compuestos de bencimidazol y su uso como moduladores del complejo receptor de gabaa. | |
| ATE454375T1 (de) | 1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| PD | Change of proprietorship |
Owner name: NEUROSEARCH A/S |
|
| MM | Annulment or lapse due to non-payment of fees |