DK0793656T3 - Hidtil ukendte benzyl-pyrimidiner - Google Patents
Hidtil ukendte benzyl-pyrimidinerInfo
- Publication number
- DK0793656T3 DK0793656T3 DK95939267T DK95939267T DK0793656T3 DK 0793656 T3 DK0793656 T3 DK 0793656T3 DK 95939267 T DK95939267 T DK 95939267T DK 95939267 T DK95939267 T DK 95939267T DK 0793656 T3 DK0793656 T3 DK 0793656T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- date
- heteroaryl
- sec
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH353694 | 1994-11-24 | ||
| CH270495 | 1995-09-25 | ||
| PCT/EP1995/004451 WO1996016046A2 (en) | 1994-11-24 | 1995-11-13 | Novel benzyl pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0793656T3 true DK0793656T3 (da) | 2003-07-21 |
Family
ID=25691190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95939267T DK0793656T3 (da) | 1994-11-24 | 1995-11-13 | Hidtil ukendte benzyl-pyrimidiner |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5763450A (da) |
| EP (1) | EP0793656B1 (da) |
| JP (1) | JP3117721B2 (da) |
| KR (1) | KR100417508B1 (da) |
| CN (1) | CN1136198C (da) |
| AT (1) | ATE235471T1 (da) |
| AU (1) | AU704911B2 (da) |
| BR (1) | BR9509768A (da) |
| CA (1) | CA2205406C (da) |
| CZ (1) | CZ157597A3 (da) |
| DE (1) | DE69530104T2 (da) |
| DK (1) | DK0793656T3 (da) |
| ES (1) | ES2193205T3 (da) |
| FI (1) | FI972194A (da) |
| HU (1) | HUT77372A (da) |
| MX (1) | MX9703687A (da) |
| NO (1) | NO308845B1 (da) |
| NZ (1) | NZ296532A (da) |
| PL (1) | PL320458A1 (da) |
| PT (1) | PT793656E (da) |
| WO (1) | WO1996016046A2 (da) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW438796B (en) * | 1996-05-15 | 2001-06-07 | Hoffmann La Roche | 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same |
| EP0966464B1 (en) * | 1997-03-03 | 2003-05-28 | Basilea Pharmaceutica AG | Substituted 2,4-diaminopyrimidines |
| CN1091109C (zh) * | 1997-03-03 | 2002-09-18 | 巴斯利尔药物股份公司 | 取代的2,4－二氨基嘧啶类 |
| US6242474B1 (en) | 1997-06-27 | 2001-06-05 | Fujisawa Pharmaceutical Co., Ltd. | Aromatic ring derivatives |
| US6893815B1 (en) * | 1997-06-30 | 2005-05-17 | Isis Pharmaceuticals, Inc. | Nucleobase heterocyclic combinatorialization |
| JP4370002B2 (ja) * | 1997-08-08 | 2009-11-25 | 富山化学工業株式会社 | キノロンカルボン酸誘導体またはその塩 |
| BR9814323A (pt) * | 1997-12-22 | 2004-06-29 | Upjohn Co | 4-hidroxiquinolina-3-carboxamidas e hidrazidas como agentes antiviróticos |
| DK1070713T3 (da) * | 1998-04-06 | 2006-12-27 | Toyama Chemical Co Ltd | Quinoloncarboxylsyrederivater eller salte deraf |
| ATE425142T1 (de) * | 1999-04-23 | 2009-03-15 | Vertex Pharma | Inhibitoren von c-jun n-terminal kinasen (jnk) |
| KR20020063888A (ko) * | 1999-11-04 | 2002-08-05 | 바실리어 파마슈티카 아게 | 치환된 5-벤질-2,4-디아미노피리미딘 |
| US7612065B2 (en) | 2000-04-21 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-JUN N-terminal kinases (JNK) |
| PE20011349A1 (es) | 2000-06-16 | 2002-01-19 | Upjohn Co | 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales |
| AU2001278480A1 (en) * | 2000-07-24 | 2002-02-05 | Bayer Crop Science Ag | Biphenyl carboxamides |
| WO2002008195A1 (de) * | 2000-07-24 | 2002-01-31 | Bayer Cropscience Ag | Pyrazolylbiphenylcarboxamide und deren verwendung zur bekämpfung unerwünschter mikroorganismen |
| EP1434585A1 (en) * | 2001-10-12 | 2004-07-07 | Warner-Lambert Company LLC | Alkyne matrix metalloproteinase inhibitors |
| US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
| US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| DE60302309T2 (de) * | 2002-09-25 | 2006-07-20 | Degussa Ag | Herstellung von 5-Formyl-2-furylborsäure |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| EP1924564B1 (en) * | 2005-09-01 | 2016-11-09 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| US8268825B2 (en) | 2005-09-26 | 2012-09-18 | The Board Of Regents For Oklahoma State University | Method for the treatment of anthrax infections |
| ES2466667T3 (es) * | 2006-10-04 | 2014-06-10 | F. Hoffmann-La Roche Ag | Proceso para síntesis de derivados de fenoxi diaminopirimidina |
| EA200970700A1 (ru) | 2007-04-20 | 2010-02-26 | ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Ингибиторы киназы, пригодные для лечения миелопролиферативных заболеваний и других пролиферативных заболеваний |
| US8853228B2 (en) * | 2007-06-04 | 2014-10-07 | University Of Connecticut | Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase |
| CN103351390A (zh) * | 2007-11-21 | 2013-10-16 | 解码遗传Ehf公司 | 用于治疗肺部和心血管病症的联芳基pde4 抑制剂 |
| JP5305704B2 (ja) * | 2008-03-24 | 2013-10-02 | 富士フイルム株式会社 | 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版 |
| GB0815962D0 (en) * | 2008-09-02 | 2008-10-08 | Merlion Pharmaceuticals Pte Ltd | Hybrid antibacterial compounds and their use |
| EA201170627A1 (ru) | 2008-10-29 | 2011-10-31 | ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Циклопропанамиды и аналоги, проявляющие противораковые и антипролиферативные активности |
| ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
| CN102040591B (zh) * | 2009-10-15 | 2013-12-11 | 山东轩竹医药科技有限公司 | 7-苯基喹诺酮类化合物 |
| CA2810011A1 (en) * | 2010-09-01 | 2012-03-08 | Novartis Ag | Adsorption of immunopotentiators to insoluble metal salts |
| KR20140026392A (ko) | 2011-03-02 | 2014-03-05 | 노파르티스 아게 | 저용량의 항원 및/또는 보조제를 갖는 조합 백신 |
| RU2014140521A (ru) | 2012-03-08 | 2016-04-27 | Новартис Аг | Адъювантные составы бустерных вакцин |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| MX2022001863A (es) | 2019-08-12 | 2022-05-30 | Deciphera Pharmaceuticals Llc | Metodos para tratar los tumores del estroma gastrointestinal. |
| KR20220123058A (ko) | 2019-12-30 | 2022-09-05 | 데시페라 파마슈티칼스, 엘엘씨. | 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물 |
| MX2022008103A (es) | 2019-12-30 | 2022-09-19 | Deciphera Pharmaceuticals Llc | Formulaciones de inhibidores de la cinasa amorfa y metodos de estas. |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515948A (en) * | 1973-09-12 | 1985-05-07 | Hoffmann-La Roche Inc. | 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines |
| US4039543A (en) * | 1974-12-24 | 1977-08-02 | Hoffmann-La Roche Inc. | Benzylpyrimidines |
| JPH07509215A (ja) * | 1990-11-14 | 1995-10-12 | カイロン コーポレイション | ジヒドロ葉酸還元酵素の特異的阻害およびそのための化合物 |
| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
-
1995
- 1995-11-13 CN CNB951963988A patent/CN1136198C/zh not_active Expired - Fee Related
- 1995-11-13 NZ NZ296532A patent/NZ296532A/en unknown
- 1995-11-13 CA CA002205406A patent/CA2205406C/en not_active Expired - Fee Related
- 1995-11-13 DE DE69530104T patent/DE69530104T2/de not_active Expired - Lifetime
- 1995-11-13 MX MX9703687A patent/MX9703687A/es not_active IP Right Cessation
- 1995-11-13 BR BR9509768A patent/BR9509768A/pt not_active Application Discontinuation
- 1995-11-13 DK DK95939267T patent/DK0793656T3/da active
- 1995-11-13 WO PCT/EP1995/004451 patent/WO1996016046A2/en active IP Right Grant
- 1995-11-13 EP EP95939267A patent/EP0793656B1/en not_active Expired - Lifetime
- 1995-11-13 HU HU9701973A patent/HUT77372A/hu unknown
- 1995-11-13 CZ CZ971575A patent/CZ157597A3/cs unknown
- 1995-11-13 KR KR1019970703472A patent/KR100417508B1/ko not_active IP Right Cessation
- 1995-11-13 ES ES95939267T patent/ES2193205T3/es not_active Expired - Lifetime
- 1995-11-13 US US08/836,857 patent/US5763450A/en not_active Expired - Lifetime
- 1995-11-13 JP JP08516521A patent/JP3117721B2/ja not_active Expired - Lifetime
- 1995-11-13 PL PL95320458A patent/PL320458A1/xx unknown
- 1995-11-13 PT PT95939267T patent/PT793656E/pt unknown
- 1995-11-13 AT AT95939267T patent/ATE235471T1/de not_active IP Right Cessation
- 1995-11-13 AU AU41161/96A patent/AU704911B2/en not_active Ceased
-
1997
- 1997-05-22 FI FI972194A patent/FI972194A/fi not_active IP Right Cessation
- 1997-05-26 NO NO972393A patent/NO308845B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5763450A (en) | 1998-06-09 |
| NO972393L (no) | 1997-05-29 |
| CN1136198C (zh) | 2004-01-28 |
| NO308845B1 (no) | 2000-11-06 |
| JP3117721B2 (ja) | 2000-12-18 |
| CZ157597A3 (en) | 1997-09-17 |
| CN1166831A (zh) | 1997-12-03 |
| HUT77372A (hu) | 1998-03-30 |
| ES2193205T3 (es) | 2003-11-01 |
| FI972194A0 (fi) | 1997-05-22 |
| PT793656E (pt) | 2003-07-31 |
| DE69530104T2 (de) | 2003-12-24 |
| ATE235471T1 (de) | 2003-04-15 |
| BR9509768A (pt) | 1998-07-07 |
| AU704911B2 (en) | 1999-05-06 |
| EP0793656A1 (en) | 1997-09-10 |
| CA2205406A1 (en) | 1996-05-30 |
| KR100417508B1 (ko) | 2004-03-18 |
| EP0793656B1 (en) | 2003-03-26 |
| NO972393D0 (no) | 1997-05-26 |
| PL320458A1 (en) | 1997-09-29 |
| FI972194A (fi) | 1997-05-22 |
| AU4116196A (en) | 1996-06-17 |
| WO1996016046A3 (en) | 1996-07-25 |
| NZ296532A (en) | 2000-02-28 |
| JPH11507009A (ja) | 1999-06-22 |
| WO1996016046A2 (en) | 1996-05-30 |
| MX9703687A (es) | 1997-08-30 |
| DE69530104D1 (de) | 2003-04-30 |
| CA2205406C (en) | 2008-02-05 |
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