EA201170627A1 - Циклопропанамиды и аналоги, проявляющие противораковые и антипролиферативные активности - Google Patents

Циклопропанамиды и аналоги, проявляющие противораковые и антипролиферативные активности

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Publication number
EA201170627A1
EA201170627A1 EA201170627A EA201170627A EA201170627A1 EA 201170627 A1 EA201170627 A1 EA 201170627A1 EA 201170627 A EA201170627 A EA 201170627A EA 201170627 A EA201170627 A EA 201170627A EA 201170627 A1 EA201170627 A1 EA 201170627A1
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EA
Eurasian Patent Office
Prior art keywords
cancer
kinase
obstructive pulmonary
leukemia
pdgfr
Prior art date
Application number
EA201170627A
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English (en)
Inventor
Дэниел Л. Флинн
Питер А. Петилло
Майкл Д. Кауфман
Original Assignee
ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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Application filed by ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи filed Critical ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
Publication of EA201170627A1 publication Critical patent/EA201170627A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Соединения настоящего изобретения находят применение в лечении рака у млекопитающих и, особенно, рака у человека, включая, но не ограничиваясь этим, злокачественные меланомы, солидные опухоли, глиобластому, рак яичника, рак поджелудочной железы, рак легких, рак молочной железы, рак предстательной железы, рак почек, рак печени, рак шейки матки, метастаз первичных опухолевых сайтов, миелопролиферативные заболевания, хронический миелоидный лейкоз, лейкозы, папиллярную карциному щитовидной железы, немелкоклеточный рак легких, мезотелиому, гиперэозинофилии синдром, желудочно-кишечные стромальные опухоли, рак ободочной кишки, глазные болезни, характеризующиеся гиперпролиферацией, ведущей к слепоте, включая ретинопатии, диабетическую ретинопатию, возрастную дегенерацию желтого пятна и гиперэозинофилии синдром, ревматоидный артрит, астму, хроническое обструктивное легочное расстройство, мастоцитоз, базофильный лейкоз, и заболевания, обусловленные PDGFR-α киназой, PDGFR-β киназой, c-KIT киназой, cFMS киназой, с-МЕТ киназой и онкогенными формами, аберрантными гибридными белками и полиморфами любых из вышеупомянутых киназ.
EA201170627A 2008-10-29 2009-10-29 Циклопропанамиды и аналоги, проявляющие противораковые и антипролиферативные активности EA201170627A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10930908P 2008-10-29 2008-10-29
PCT/US2009/062575 WO2010051373A1 (en) 2008-10-29 2009-10-29 Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities

Publications (1)

Publication Number Publication Date
EA201170627A1 true EA201170627A1 (ru) 2011-10-31

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Application Number Title Priority Date Filing Date
EA201170627A EA201170627A1 (ru) 2008-10-29 2009-10-29 Циклопропанамиды и аналоги, проявляющие противораковые и антипролиферативные активности

Country Status (13)

Country Link
US (2) US8278331B2 (ru)
EP (1) EP2365752B1 (ru)
JP (1) JP5444365B2 (ru)
KR (1) KR20110099687A (ru)
CN (1) CN102256493A (ru)
AU (1) AU2009308853A1 (ru)
BR (1) BRPI0920765A2 (ru)
CA (1) CA2742007C (ru)
EA (1) EA201170627A1 (ru)
IL (1) IL212574A0 (ru)
MX (1) MX2011004535A (ru)
NZ (1) NZ603654A (ru)
WO (1) WO2010051373A1 (ru)

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EP2365752A4 (en) 2012-06-20
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US20130079362A1 (en) 2013-03-28
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