MX2015013419A - Cianoetilpirazolo piridonas aciclicas como inhibidores de janus quinasa. - Google Patents

Cianoetilpirazolo piridonas aciclicas como inhibidores de janus quinasa.

Info

Publication number
MX2015013419A
MX2015013419A MX2015013419A MX2015013419A MX2015013419A MX 2015013419 A MX2015013419 A MX 2015013419A MX 2015013419 A MX2015013419 A MX 2015013419A MX 2015013419 A MX2015013419 A MX 2015013419A MX 2015013419 A MX2015013419 A MX 2015013419A
Authority
MX
Mexico
Prior art keywords
cyanoethylpyrazolo
pyridones
acyclic
kinase inhibitors
janus kinase
Prior art date
Application number
MX2015013419A
Other languages
English (en)
Inventor
Christopher F Thompson
Jianmin Fu
Hongbo Zeng
Mark E Scott
Danielle Falcone
David Guerin
Jason David Katz
Luis Torres
Yunfeng Bai
Norman Kong
Yumei Liu
Zhixiang Zheng
Christopher Dinsmore
Peter Fuller
Wei Deng
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2015013419A publication Critical patent/MX2015013419A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La presente invención provee compuestos de fórmula 1, que son inhibidores de JAK y como tal son útiles para el tratamiento de enfermedades mediadas por JAK tales como artritis reumatoide, asma, CODE Y cáncer.
MX2015013419A 2013-03-19 2014-03-19 Cianoetilpirazolo piridonas aciclicas como inhibidores de janus quinasa. MX2015013419A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361803241P 2013-03-19 2013-03-19
PCT/CN2014/000299 WO2014146493A1 (en) 2013-03-19 2014-03-19 Acyclic cyanoethylpyrazolo pyridones as janus kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2015013419A true MX2015013419A (es) 2016-07-19

Family

ID=51579322

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015013419A MX2015013419A (es) 2013-03-19 2014-03-19 Cianoetilpirazolo piridonas aciclicas como inhibidores de janus quinasa.

Country Status (11)

Country Link
US (1) US10059705B2 (es)
EP (1) EP2976341B1 (es)
JP (1) JP6305510B2 (es)
KR (1) KR20150132170A (es)
CN (1) CN105121444B (es)
AU (1) AU2014234909B2 (es)
BR (1) BR112015024050A2 (es)
CA (1) CA2901770A1 (es)
MX (1) MX2015013419A (es)
RU (1) RU2015144385A (es)
WO (1) WO2014146493A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014146246A1 (en) 2013-03-19 2014-09-25 Merck Sharp & Dohme Corp. Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors
WO2016061751A1 (en) * 2014-10-22 2016-04-28 Merck Sharp & Dohme Corp. Ethyl n-boc piperidinyl pyrazolo pyridones as janus kinase inhibitors
CN105327207A (zh) * 2015-12-07 2016-02-17 雷文金 一种治疗风湿热痹的中药组合物
CN105435170A (zh) * 2015-12-11 2016-03-30 张量才 一种食药同源的中药保健食品
AU2018289759B2 (en) 2017-06-23 2022-03-10 Kyowa Kirin Co., Ltd. Alpha, beta-unsaturated amide compound
US11098216B2 (en) 2017-09-28 2021-08-24 Ricoh Company, Ltd. Image forming method, image forming apparatus, and method for manufacturing printed matter
EP3650447A1 (en) * 2018-11-08 2020-05-13 Universite de Nantes New selective modulators of insect nicotinic acetylcholine receptors
CN111499592B (zh) * 2020-03-14 2023-06-23 江苏省农用激素工程技术研究中心有限公司 5-氨甲基糖精的合成方法
EP4159718A4 (en) * 2020-05-29 2023-10-04 Daegu-Gyeongbuk Medical Innovation Foundation SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR THE PREVENTION OR TREATMENT OF MENTAL ILLNESS
CN112694497A (zh) * 2020-12-25 2021-04-23 蚌埠中实化学技术有限公司 一种4-异丙基磺酰基苯硼酸的制备方法
WO2023244710A1 (en) * 2022-06-16 2023-12-21 Ensem Therapeutics, Inc. Anilino-pyrazole derivatives, compositions and methods thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009007426A (es) 2007-01-12 2009-07-17 Astellas Pharma Inc Compuesto de piridina condensado.
CA2767079A1 (en) * 2009-07-08 2011-01-13 Leo Pharma A/S Heterocyclic compounds as jak receptor and protein tyrosine kinase inhibitors
JP5658756B2 (ja) * 2009-09-10 2015-01-28 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｊａｋの阻害剤
SI3354652T1 (sl) 2010-03-10 2020-08-31 Incyte Holdings Corporation Derivati piperidin-4-il azetidina kot inhibitorji JAK1
AU2012232658B2 (en) * 2011-03-22 2016-06-09 Advinus Therapeutics Limited Substituted fused tricyclic compounds, compositions and medicinal applications thereof
WO2013017480A1 (en) 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
WO2013017479A1 (en) * 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
CA2874987A1 (en) * 2012-06-01 2013-12-05 Takeda Pharmaceutical Company Limited Heterocyclic compound

Also Published As

Publication number Publication date
CN105121444B (zh) 2018-02-16
JP6305510B2 (ja) 2018-04-04
BR112015024050A2 (pt) 2017-07-18
CN105121444A (zh) 2015-12-02
RU2015144385A (ru) 2017-04-26
AU2014234909B2 (en) 2017-10-05
EP2976341A4 (en) 2016-10-12
AU2014234909A1 (en) 2015-08-13
WO2014146493A1 (en) 2014-09-25
JP2016514711A (ja) 2016-05-23
US20160272634A1 (en) 2016-09-22
US10059705B2 (en) 2018-08-28
EP2976341A1 (en) 2016-01-27
EP2976341B1 (en) 2018-02-28
CA2901770A1 (en) 2014-09-25
KR20150132170A (ko) 2015-11-25

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