MX2013013090A - Aminopirimidinas como inhibidores de tirosina cinaza del bazo. - Google Patents
Aminopirimidinas como inhibidores de tirosina cinaza del bazo.Info
- Publication number
- MX2013013090A MX2013013090A MX2013013090A MX2013013090A MX2013013090A MX 2013013090 A MX2013013090 A MX 2013013090A MX 2013013090 A MX2013013090 A MX 2013013090A MX 2013013090 A MX2013013090 A MX 2013013090A MX 2013013090 A MX2013013090 A MX 2013013090A
- Authority
- MX
- Mexico
- Prior art keywords
- aminopyrimidines
- syk inhibitors
- copd
- asthma
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
La presente invención proporciona nuevas pirimidina aminas de fórmula I que son potentes inhibidores de la tirosina cinasa del bazo, y son útiles en el tratamiento y prevención de enfermedades mediadas por dicha enzima, tales como asma, COPD, artritis reumatoide y cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161484418P | 2011-05-10 | 2011-05-10 | |
PCT/US2012/036423 WO2012154519A1 (en) | 2011-05-10 | 2012-05-04 | Aminopyrimidines as syk inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013013090A true MX2013013090A (es) | 2013-12-16 |
Family
ID=47139531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013013090A MX2013013090A (es) | 2011-05-10 | 2012-05-04 | Aminopirimidinas como inhibidores de tirosina cinaza del bazo. |
Country Status (11)
Country | Link |
---|---|
US (1) | US9290490B2 (es) |
EP (1) | EP2706853B1 (es) |
JP (1) | JP2014513686A (es) |
KR (1) | KR20140028062A (es) |
CN (1) | CN103619172A (es) |
AU (1) | AU2012253885A1 (es) |
BR (1) | BR112013028900A2 (es) |
CA (1) | CA2834604A1 (es) |
MX (1) | MX2013013090A (es) |
RU (1) | RU2013154412A (es) |
WO (1) | WO2012154519A1 (es) |
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KR20140025500A (ko) | 2011-05-04 | 2014-03-04 | 머크 샤프 앤드 돔 코포레이션 | 아미노-피리딘-함유 비장 티로신 키나제 (Syk) 억제제 |
JP2014513687A (ja) | 2011-05-10 | 2014-06-05 | メルク・シャープ・アンド・ドーム・コーポレーション | Syk阻害薬としてのピリジルアミノピリジン |
US9145391B2 (en) | 2011-05-10 | 2015-09-29 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as Syk inhibitors |
BR112013028900A2 (pt) | 2011-05-10 | 2017-01-03 | Merck Sharp & Dohe Corp | Composto, composição farmacêutica, e, método para o tratamento ou a prevenção de doenças |
EP2863913B1 (en) | 2012-06-20 | 2018-09-12 | Merck Sharp & Dohme Corp. | Imidazolyl analogs as syk inhibitors |
WO2013192125A1 (en) | 2012-06-20 | 2013-12-27 | Merck Sharp & Dohme Corp. | Pyrazolyl derivatives as syk inhibitors |
US9416111B2 (en) | 2012-06-22 | 2016-08-16 | Merck Sharp & Dohme Corp. | Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors |
US9376418B2 (en) | 2012-06-22 | 2016-06-28 | Merck Sharp & Dohme Corp. | Substituted pyridine spleen tyrosine kinase (SYK) inhibitors |
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US9598405B2 (en) | 2012-12-21 | 2017-03-21 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors |
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WO2015095445A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
US9783531B2 (en) | 2013-12-20 | 2017-10-10 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
WO2015095444A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
EP3116506B1 (en) | 2014-03-13 | 2019-04-17 | Merck Sharp & Dohme Corp. | 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors |
CN104262157B (zh) * | 2014-09-19 | 2016-01-13 | 江西仁明医药化工有限公司 | 3-乙酰基环戊烷羧酸甲酯顺、反异构体的控制方法 |
EP3512519A1 (en) | 2016-09-14 | 2019-07-24 | Gilead Sciences, Inc. | Syk inhibitors |
TW201822764A (zh) | 2016-09-14 | 2018-07-01 | 美商基利科學股份有限公司 | Syk抑制劑 |
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CN108794331A (zh) * | 2018-07-23 | 2018-11-13 | 蚌埠中实化学技术有限公司 | 一种3-乙酰基环戊基甲酸甲酯的制备方法 |
JP2022526713A (ja) | 2019-03-21 | 2022-05-26 | オンクセオ | がんの処置のための、キナーゼ阻害剤と組み合わせたDbait分子 |
CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
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2012
- 2012-05-04 BR BR112013028900A patent/BR112013028900A2/pt not_active IP Right Cessation
- 2012-05-04 MX MX2013013090A patent/MX2013013090A/es not_active Application Discontinuation
- 2012-05-04 US US14/116,207 patent/US9290490B2/en active Active
- 2012-05-04 EP EP12782298.9A patent/EP2706853B1/en active Active
- 2012-05-04 CA CA2834604A patent/CA2834604A1/en not_active Abandoned
- 2012-05-04 JP JP2014510371A patent/JP2014513686A/ja active Pending
- 2012-05-04 RU RU2013154412/04A patent/RU2013154412A/ru not_active Application Discontinuation
- 2012-05-04 CN CN201280032430.0A patent/CN103619172A/zh active Pending
- 2012-05-04 WO PCT/US2012/036423 patent/WO2012154519A1/en active Application Filing
- 2012-05-04 AU AU2012253885A patent/AU2012253885A1/en not_active Abandoned
- 2012-05-04 KR KR1020137032289A patent/KR20140028062A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN103619172A (zh) | 2014-03-05 |
EP2706853A1 (en) | 2014-03-19 |
AU2012253885A1 (en) | 2013-10-31 |
KR20140028062A (ko) | 2014-03-07 |
EP2706853A4 (en) | 2014-11-05 |
WO2012154519A1 (en) | 2012-11-15 |
EP2706853B1 (en) | 2017-06-14 |
JP2014513686A (ja) | 2014-06-05 |
RU2013154412A (ru) | 2015-06-20 |
BR112013028900A2 (pt) | 2017-01-03 |
US9290490B2 (en) | 2016-03-22 |
CA2834604A1 (en) | 2012-11-15 |
US20140148474A1 (en) | 2014-05-29 |
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