MX2017005281A - Etil n-boc piperidinil pirazolo piridonas como inhibidores de janus quinasa. - Google Patents

Etil n-boc piperidinil pirazolo piridonas como inhibidores de janus quinasa.

Info

Publication number
MX2017005281A
MX2017005281A MX2017005281A MX2017005281A MX2017005281A MX 2017005281 A MX2017005281 A MX 2017005281A MX 2017005281 A MX2017005281 A MX 2017005281A MX 2017005281 A MX2017005281 A MX 2017005281A MX 2017005281 A MX2017005281 A MX 2017005281A
Authority
MX
Mexico
Prior art keywords
boc
piperidinyl
ethyl
kinase inhibitors
janus kinase
Prior art date
Application number
MX2017005281A
Other languages
English (en)
Inventor
Mark E Scott
Kong Norman
David Guerin
Yunfeng Bai
Yumei Liu
Zhixiang Zheng
Christopher Dinsmore
Fuller Peter
MOLINARI Danielle
Kattar Sam
Fu Jiamin
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2017005281A publication Critical patent/MX2017005281A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente invención proporciona compuestos de fórmula I, que son inhibidores de JAK y como tal son útiles para el tratamiento de enfermedades mediadas con JAK tales como artritis reumatoide, asma, COPD y cáncer; la presente invención proporciona novedosos compuestos que son inhibidores de JAK; la invención también proporciona un método para el tratamiento y prevención de enfermedades y trastornos mediados por JAK usando los novedosos compuestos, así como composiciones farmacéuticas que contienen los compuestos.(ver Fórmula).
MX2017005281A 2014-10-22 2015-10-21 Etil n-boc piperidinil pirazolo piridonas como inhibidores de janus quinasa. MX2017005281A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2014/089139 WO2016061751A1 (en) 2014-10-22 2014-10-22 Ethyl n-boc piperidinyl pyrazolo pyridones as janus kinase inhibitors
PCT/US2015/056541 WO2016064935A1 (en) 2014-10-22 2015-10-21 Ethyl n-boc piperidinyl pyrazolo pyridones as janus kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2017005281A true MX2017005281A (es) 2017-08-15

Family

ID=55760043

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017005281A MX2017005281A (es) 2014-10-22 2015-10-21 Etil n-boc piperidinil pirazolo piridonas como inhibidores de janus quinasa.

Country Status (11)

Country Link
US (1) US10072025B2 (es)
EP (1) EP3209296B1 (es)
JP (1) JP2017531672A (es)
KR (1) KR20170068585A (es)
CN (1) CN107106547A (es)
AU (1) AU2015336035A1 (es)
BR (1) BR112017008103A2 (es)
CA (1) CA2964375A1 (es)
MX (1) MX2017005281A (es)
RU (1) RU2017117248A (es)
WO (2) WO2016061751A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017191098A1 (en) 2016-05-05 2017-11-09 F. Hoffmann-La Roche Ag Pyrazole derivatives, compositions and therapeutic use thereof
CN106749081B (zh) * 2016-11-21 2019-06-25 浙江嘉圣生物医药有限公司 一种(s)-(4-溴-2-甲苯)(3-甲基吗啉)甲酮的制备方法
EP3559005A1 (en) 2016-12-21 2019-10-30 Biotheryx Inc. Thienopyrrole derivatives for use in targeting proteins, compositions, methods, and uses thereof
WO2018169777A1 (en) 2017-03-14 2018-09-20 Biotheryx, Inc. Compounds targeting proteins, compositions, methods, and uses thereof
PE20211237A1 (es) 2017-12-22 2021-07-09 Siegfried Ag Preparacion de nicotina racemica mediante reaccion de etil nicotinato con n-vinilpirrolidona en presencia de una base de alcoholato y etapas de proceso posteriores
WO2019214399A1 (zh) * 2018-05-10 2019-11-14 罗欣药业(上海)有限公司 苯并七元杂环类化合物、其制备方法、药物组合物及应用
US20210395239A1 (en) * 2018-09-27 2021-12-23 Hoffmann-La Roche Inc. Heterocyclyl compounds for the treatment of autoimmune disease
CN114901659A (zh) 2019-11-26 2022-08-12 施万生物制药研发Ip有限责任公司 作为jak抑制剂的稠合嘧啶吡啶酮化合物
CN114939349B (zh) * 2022-05-03 2023-08-01 北京工业大学 一种用于气体分离的金属-有机空穴配合物混合基质膜的制备

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA111854C2 (uk) * 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
JP6305510B2 (ja) 2013-03-19 2018-04-04 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ヤヌスキナーゼ阻害剤としての非環式シアノエチルピラゾロピリドン
BR112015023878A2 (pt) 2013-03-19 2017-07-18 Merck Sharp & Dohme composto, composição farmacêutica, e, uso de um composto
WO2014146249A1 (en) * 2013-03-19 2014-09-25 Merck Sharp & Dohme Corp. Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors

Also Published As

Publication number Publication date
US20170240567A1 (en) 2017-08-24
WO2016061751A1 (en) 2016-04-28
CN107106547A (zh) 2017-08-29
BR112017008103A2 (pt) 2018-02-20
US10072025B2 (en) 2018-09-11
EP3209296A4 (en) 2018-04-11
KR20170068585A (ko) 2017-06-19
JP2017531672A (ja) 2017-10-26
EP3209296A1 (en) 2017-08-30
RU2017117248A (ru) 2018-11-22
EP3209296B1 (en) 2019-07-10
WO2016064935A1 (en) 2016-04-28
AU2015336035A1 (en) 2017-04-20
CA2964375A1 (en) 2016-04-28

Similar Documents

Publication Publication Date Title
MX2017005281A (es) Etil n-boc piperidinil pirazolo piridonas como inhibidores de janus quinasa.
PH12017502203A1 (en) Tyrosine kinase inhibitors
PH12019501985A1 (en) Fused imidazo-piperidine jak inhibitors
WO2012054364A3 (en) Bicyclic diamines as janus kinase inhibitors
PH12017502050B1 (en) Naphthyridine compounds as jak kinase inhibitors
PH12017500276A1 (en) Aminopyrimidinyl compounds as jak inhibitors
MY194262A (en) Inhibitors of ret
NZ729603A (en) Heteroaryl compounds as btk inhibitors and uses thereof
MX2013012776A (es) Inhibidores de la tirosina cinasa de bazo que contienen aminopiridina.
WO2015200680A3 (en) Prmt5 inhibitors and uses thereof
EA033163B1 (ru) Ингибиторы глутаминазы
MX2015013419A (es) Cianoetilpirazolo piridonas aciclicas como inhibidores de janus quinasa.
MX2018013191A (es) Compuestos de pirimidina como inhibidores de la quinasa jak.
MX2013013090A (es) Aminopirimidinas como inhibidores de tirosina cinaza del bazo.
MX2015013418A (es) Cicloalquil nitrilo pirazolo piridonas como inhibidores de janus quinasa.
PH12019500196A1 (en) Compounds and compositions and uses thereof
PH12017501699A1 (en) Fused bicyclic heteroaryl derivatives having activity as phd inhibitors
WO2016102672A3 (en) Inhibitors of akt kinase
PH12019500198A1 (en) Compounds and compositions and uses thereof
PH12016501613B1 (en) Pyrazines modulators of gpr6
MX2017015300A (es) Derivados de aminoesteres.
MX2016015959A (es) Derivados de carbamato los cuales son tanto inhibidores de la enzima fosfodiesterasa 4 (pde4) como antagonistas del receptor muscarinico m3.