MX363551B - Compuestos derivados de pirazina como inhibidores de cinasa. - Google Patents

Compuestos derivados de pirazina como inhibidores de cinasa.

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Publication number
MX363551B
MX363551B MX2014006242A MX2014006242A MX363551B MX 363551 B MX363551 B MX 363551B MX 2014006242 A MX2014006242 A MX 2014006242A MX 2014006242 A MX2014006242 A MX 2014006242A MX 363551 B MX363551 B MX 363551B
Authority
MX
Mexico
Prior art keywords
kinase inhibitors
methods
pyrazine
syk kinase
kinase activity
Prior art date
Application number
MX2014006242A
Other languages
English (en)
Other versions
MX2014006242A (es
Inventor
M Bauer Shawn
Song Yonghong
Xu Qing
Pandey Anjali
Kane Brian
J Jia Zhaozhong
Original Assignee
Portola Pharmaceuticals Inc Star
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Portola Pharmaceuticals Inc Star filed Critical Portola Pharmaceuticals Inc Star
Publication of MX2014006242A publication Critical patent/MX2014006242A/es
Publication of MX363551B publication Critical patent/MX363551B/es

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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

En la presente se proporcionan compuestos de pirazina para inhibir cinasa Syk, los intermedios utilizados para realizar dichos compuestos, métodos para su preparación, composiciones farmacéuticas de estos, métodos para inhibir la actividad de cinasa Syk, y métodos para tratar afecciones mediadas al menos en parte por la actividad cinasa Syk.
MX2014006242A 2011-11-23 2012-11-23 Compuestos derivados de pirazina como inhibidores de cinasa. MX363551B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161563466P 2011-11-23 2011-11-23
PCT/US2012/066468 WO2013078466A1 (en) 2011-11-23 2012-11-23 Pyrazine kinase inhibitors

Publications (2)

Publication Number Publication Date
MX2014006242A MX2014006242A (es) 2014-10-06
MX363551B true MX363551B (es) 2019-03-27

Family

ID=48427516

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014006242A MX363551B (es) 2011-11-23 2012-11-23 Compuestos derivados de pirazina como inhibidores de cinasa.

Country Status (18)

Country Link
US (2) US9359308B2 (es)
EP (1) EP2782579B1 (es)
JP (1) JP6039683B2 (es)
KR (1) KR102019530B1 (es)
CN (1) CN104066431B (es)
AU (1) AU2012340555B2 (es)
BR (1) BR112014012396B1 (es)
CA (2) CA2856301C (es)
CL (1) CL2014001346A1 (es)
CO (1) CO6990735A2 (es)
EA (1) EA026939B1 (es)
HK (1) HK1201460A1 (es)
IL (1) IL232701A (es)
IN (1) IN2014CN04065A (es)
MX (1) MX363551B (es)
SG (2) SG10201601352UA (es)
WO (1) WO2013078466A1 (es)
ZA (1) ZA201403651B (es)

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UY34807A (es) 2012-05-16 2013-12-31 Novartis Ag Derivados monocíclicos de heteroarilcicloalquil- diamina
RU2015116532A (ru) 2012-10-19 2016-12-10 Ф. Хоффманн-Ля Рош Аг Ингибиторы тирозинкиназы syk
WO2015084998A1 (en) * 2013-12-05 2015-06-11 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP3116506B1 (en) * 2014-03-13 2019-04-17 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
CZ306322B6 (cs) 2014-12-17 2016-11-30 Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Substituovaný 2-(2-fenylhydrazinyl)pyrazin, způsob jeho přípravy, jeho použití a farmaceutický přípravek ho obsahující
KR20180021740A (ko) * 2015-06-02 2018-03-05 파마싸이클릭스 엘엘씨 브루톤 티로신 키나제의 억제제
WO2019237125A1 (en) * 2018-06-08 2019-12-12 The General Hospital Corporation Inhibitors of prolyl-trna-synthetase
CN112047899A (zh) * 2020-10-19 2020-12-08 成都睿智化学研究有限公司 一种合成3-取代氨基苯并[c]异噻唑衍生物的方法
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