EA200970280A1 - Ингибиторы киназ, полезные для лечения пролиферативных заболеваний - Google Patents

Ингибиторы киназ, полезные для лечения пролиферативных заболеваний

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Publication number
EA200970280A1
EA200970280A1 EA200970280A EA200970280A EA200970280A1 EA 200970280 A1 EA200970280 A1 EA 200970280A1 EA 200970280 A EA200970280 A EA 200970280A EA 200970280 A EA200970280 A EA 200970280A EA 200970280 A1 EA200970280 A1 EA 200970280A1
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Prior art keywords
compounds
treatment
cancer
present
diseases
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EA200970280A
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English (en)
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EA016055B1 (ru
Inventor
Дэниел Л. Флинн
Майкл Д. Кауфман
Уилльям К. Патт
Питер А. Петилло
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ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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Publication of EA200970280A1 publication Critical patent/EA200970280A1/ru
Publication of EA016055B1 publication Critical patent/EA016055B1/ru

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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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  • Health & Medical Sciences (AREA)
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  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к новым ингибиторам киназ и соединениям, модулирующим киназы, которые можно применять для лечения различных заболеваний. В частности, изобретение относится к таким соединениям, киназа/соединениям присоединения, способам лечения заболеваний и способам синтеза соединений. Соединения можно применять преимущественно для модуляции киназной активности киназ Raf и различных полиморфных форм Raf-киназ, встречающихся при заболеваниях. Соединения согласно настоящему изобретению находят применение в лечении различных видов рака млекопитающих и, в частности, человека, включая, но не ограничиваясь, злокачественную меланому, рак кишечника, рак яичника, сосочковую карциному щитовидной железы, немелкоклеточный рак легкого и мезотелиому. Соединения согласно настоящему изобретению также находят применение при лечении ревматоидного артрита и ретинопатий, включая диабетическую нейропатию сетчатки и дегенерацию желтого пятна.
EA200970280A 2006-09-14 2007-09-13 Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе EA016055B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84455206P 2006-09-14 2006-09-14
US11/854,354 US8188113B2 (en) 2006-09-14 2007-09-12 Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
PCT/US2007/078408 WO2008034008A2 (en) 2006-09-14 2007-09-13 Kinase inhibitors useful for the treatment of proliferative diseases

Publications (2)

Publication Number Publication Date
EA200970280A1 true EA200970280A1 (ru) 2009-10-30
EA016055B1 EA016055B1 (ru) 2012-01-30

Family

ID=39184593

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200970280A EA016055B1 (ru) 2006-09-14 2007-09-13 Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе
EA201101341A EA026730B1 (ru) 2006-09-14 2007-09-13 Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе

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EA201101341A EA026730B1 (ru) 2006-09-14 2007-09-13 Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе

Country Status (10)

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US (2) US8188113B2 (ru)
EP (1) EP2063897A4 (ru)
JP (1) JP5265550B2 (ru)
KR (1) KR101110530B1 (ru)
AU (1) AU2007296450C1 (ru)
BR (2) BR122012012032B8 (ru)
CA (1) CA2663577A1 (ru)
EA (2) EA016055B1 (ru)
MX (1) MX2009002814A (ru)
WO (1) WO2008034008A2 (ru)

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