MXPA03006749A - Proceso para la sintesis de compuestos de urea sustituidos con heteroarilo, utiles como agentes antiinflamatorios. - Google Patents

Proceso para la sintesis de compuestos de urea sustituidos con heteroarilo, utiles como agentes antiinflamatorios.

Info

Publication number
MXPA03006749A
MXPA03006749A MXPA03006749A MXPA03006749A MXPA03006749A MX PA03006749 A MXPA03006749 A MX PA03006749A MX PA03006749 A MXPA03006749 A MX PA03006749A MX PA03006749 A MXPA03006749 A MX PA03006749A MX PA03006749 A MXPA03006749 A MX PA03006749A
Authority
MX
Mexico
Prior art keywords
heteroaryl
urea compounds
synthesis
substituted urea
compounds useful
Prior art date
Application number
MXPA03006749A
Other languages
English (en)
Inventor
Tan Zhulin
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MXPA03006749A publication Critical patent/MXPA03006749A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion se refiere a nuevos procesos para preparar los compuestos de urea sustituidos con heteroarilo de la formula (I) que son utiles para tratar enfermedades y condiciones patologicas que involucran inflamacion, tales como la enfermedad inflamatoria cronica.
MXPA03006749A 2001-02-15 2002-01-01 Proceso para la sintesis de compuestos de urea sustituidos con heteroarilo, utiles como agentes antiinflamatorios. MXPA03006749A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26884101P 2001-02-15 2001-02-15
PCT/US2002/002982 WO2002066442A1 (en) 2001-02-15 2002-01-01 Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents

Publications (1)

Publication Number Publication Date
MXPA03006749A true MXPA03006749A (es) 2004-05-31

Family

ID=23024722

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03006749A MXPA03006749A (es) 2001-02-15 2002-01-01 Proceso para la sintesis de compuestos de urea sustituidos con heteroarilo, utiles como agentes antiinflamatorios.

Country Status (6)

Country Link
US (1) US6916924B2 (es)
EP (1) EP1362037A1 (es)
JP (1) JP2004518739A (es)
CA (1) CA2435446A1 (es)
MX (1) MXPA03006749A (es)
WO (1) WO2002066442A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2299689T3 (es) 2002-02-25 2008-06-01 Boehringer Ingelheim Pharmaceuticals Inc. Compuestos de cicloalquil-uera fusionada con benzo 1,4-disustituido, utiles para el tratamiento de enfermedades por citoquinas.
US20040138216A1 (en) * 2002-12-23 2004-07-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for the preparation of an essentially pure polymorph of an n-pyrazolyl-n'-naphthyl-urea
US7144911B2 (en) * 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
AU2004270733B2 (en) 2003-09-11 2011-05-19 Itherx Pharma, Inc. Cytokine inhibitors
JP2007514791A (ja) * 2003-12-18 2007-06-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Ｐ３８ｍａｐキナーゼインヒビターであるｂｉｒｂ７９６の多形
ATE517885T1 (de) * 2004-04-30 2011-08-15 Bayer Healthcare Llc Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs
US20090312349A1 (en) * 2004-12-23 2009-12-17 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
EP2942349A1 (en) 2004-12-23 2015-11-11 Deciphera Pharmaceuticals, LLC Enzyme modulators and treatments
US8188113B2 (en) 2006-09-14 2012-05-29 Deciphera Pharmaceuticals, Inc. Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
US7790756B2 (en) 2006-10-11 2010-09-07 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
US20110189167A1 (en) * 2007-04-20 2011-08-04 Flynn Daniel L Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases
AU2008242720A1 (en) * 2007-04-20 2008-10-30 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
GB0818033D0 (en) 2008-10-02 2008-11-05 Respivert Ltd Novel compound
NZ591427A (en) 2008-10-02 2012-12-21 Respivert Ltd P38 map kinase inhibitors
MX2011004535A (es) * 2008-10-29 2011-11-18 Deciphera Pharmaceuticals Llc Ciclopropanamidas y analogos que exhiben actividades anti-cancer y anti-proliferativas.
NZ593104A (en) 2008-12-11 2012-11-30 Respivert Ltd P38 map kinase inhibitors
GB0905955D0 (en) 2009-04-06 2009-05-20 Respivert Ltd Novel compounds
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CN111818915B (zh) 2018-01-31 2024-05-24 德西费拉制药有限责任公司 治疗胃肠道间质瘤的组合疗法
TW202122082A (zh) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
AU2020329956B2 (en) 2019-08-12 2023-11-16 Deciphera Pharmaceuticals, Llc. Ripretinib for treating gastrointestinal stromal tumors
JP2023509628A (ja) 2019-12-30 2023-03-09 デシフェラ・ファーマシューティカルズ，エルエルシー １－（４－ブロモ－５－（１－エチル－７－（メチルアミノ）－２－オキソ－１，２－ジヒドロ－１，６－ナフチリジン－３－イル）－２－フルオロフェニル）－３－フェニル尿素の組成物
BR112022013109A2 (pt) 2019-12-30 2022-09-06 Deciphera Pharmaceuticals Llc Formulações de inibidor de quinase amorfo e métodos de uso das mesmas
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1367599A (en) 1997-11-03 1999-05-24 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
DE60014603T2 (de) 1999-03-12 2006-02-16 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Heterocyklischer harnstoff und verwandte verbindungen als entzündungshemmende mittel
WO2001004115A2 (en) 1999-07-09 2001-01-18 Boehringer Ingelheim Pharmaceuticals, Inc. Novel process for synthesis of heteroaryl-substituted urea compounds
CA2387762C (en) 1999-10-29 2008-07-29 Boehringer Ingelheim Pharmaceuticals, Inc. Process of making substituted pyrazoles
US6635767B2 (en) 2000-05-23 2003-10-21 Boehringer Ingelheim Pharmaceuticals, Inc. Synthesis of heteroarylamine intermediate compounds

Also Published As

Publication number Publication date
WO2002066442A1 (en) 2002-08-29
CA2435446A1 (en) 2002-08-29
EP1362037A1 (en) 2003-11-19
US20020123631A1 (en) 2002-09-05
JP2004518739A (ja) 2004-06-24
US6916924B2 (en) 2005-07-12

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