EA200600122A1 - Производные пиримидина для лечения патологического роста клеток - Google Patents

Производные пиримидина для лечения патологического роста клеток

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Publication number
EA200600122A1
EA200600122A1 EA200600122A EA200600122A EA200600122A1 EA 200600122 A1 EA200600122 A1 EA 200600122A1 EA 200600122 A EA200600122 A EA 200600122A EA 200600122 A EA200600122 A EA 200600122A EA 200600122 A1 EA200600122 A1 EA 200600122A1
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EA
Eurasian Patent Office
Prior art keywords
treatment
derivatives
pyrimidine
cells
pathological growth
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Application number
EA200600122A
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English (en)
Other versions
EA013248B1 (ru
Inventor
Джон Чарльз Кат
Майкл Джозеф Луццио
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Пфайзер Продактс Инк.
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Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200600122A1 publication Critical patent/EA200600122A1/ru
Publication of EA013248B1 publication Critical patent/EA013248B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к соединению формулы (1), в котором R-Rимеют значения, определенные в данном описании. Такие новые производные пиримидина применимы для лечения патологического роста клеток, такого как злокачественная опухоль, у млекопитающих. Данное изобретение также относится к способу применения таких соединений для лечения патологического роста клеток у млекопитающих, в частности у человека, и к фармацевтическим композициям, содержащим такие соединения.
EA200600122A 2002-12-20 2003-12-08 Производные пиримидина для лечения патологического роста клеток EA013248B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43567002P 2002-12-20 2002-12-20
US50074203P 2003-09-05 2003-09-05
PCT/IB2003/005883 WO2004056807A1 (en) 2002-12-20 2003-12-08 Pyrimidine derivatives for the treatment of abnormal cell growth

Publications (2)

Publication Number Publication Date
EA200600122A1 true EA200600122A1 (ru) 2006-06-30
EA013248B1 EA013248B1 (ru) 2010-04-30

Family

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EA200600122A EA013248B1 (ru) 2002-12-20 2003-12-08 Производные пиримидина для лечения патологического роста клеток

Country Status (31)

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US (4) US7109335B2 (ru)
EP (1) EP1625121B1 (ru)
AP (1) AP2385A (ru)
AR (1) AR043682A1 (ru)
AT (1) ATE458731T1 (ru)
AU (2) AU2003285614B2 (ru)
CA (1) CA2529611C (ru)
CR (2) CR8266A (ru)
CY (1) CY1110069T1 (ru)
DE (1) DE60331479D1 (ru)
DK (1) DK1625121T3 (ru)
DO (1) DOP2003000793A (ru)
EA (1) EA013248B1 (ru)
EC (1) ECSP066406A (ru)
ES (1) ES2338545T3 (ru)
GE (1) GEP20084357B (ru)
IL (1) IL172047A (ru)
MX (1) MXPA06002608A (ru)
MY (1) MY142109A (ru)
NL (1) NL1025067C2 (ru)
NZ (1) NZ543719A (ru)
OA (1) OA13309A (ru)
PA (1) PA8593001A1 (ru)
PE (1) PE20041016A1 (ru)
PL (1) PL379330A1 (ru)
PT (1) PT1625121E (ru)
RS (1) RS20060097A (ru)
SI (1) SI1625121T1 (ru)
TN (1) TNSN06074A1 (ru)
TW (1) TWI283673B (ru)
WO (1) WO2004056807A1 (ru)

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US7674796B2 (en) 2010-03-09
US20080300234A1 (en) 2008-12-04
AU2009208172B2 (en) 2011-06-16
NL1025067A1 (nl) 2004-06-22
NL1025067C2 (nl) 2005-02-15
OA13309A (en) 2007-04-13
PL379330A1 (pl) 2006-08-21
US7741336B2 (en) 2010-06-22
EA013248B1 (ru) 2010-04-30
AR043682A1 (es) 2005-08-10
PE20041016A1 (es) 2004-12-30
US7351712B2 (en) 2008-04-01
ES2338545T3 (es) 2010-05-10
ATE458731T1 (de) 2010-03-15
DE60331479D1 (de) 2010-04-08
AU2003285614B2 (en) 2009-05-14
AP2005003438A0 (en) 2005-12-31
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CA2529611C (en) 2009-12-15
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AU2009208172A1 (en) 2009-09-10
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DK1625121T3 (da) 2010-05-10
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AP2385A (en) 2012-03-23
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