ATE323084T1 - Für die behandlung von alzheimer krankheit geeignete makrocyclen - Google Patents

Für die behandlung von alzheimer krankheit geeignete makrocyclen

Info

Publication number
ATE323084T1
ATE323084T1 AT02752056T AT02752056T ATE323084T1 AT E323084 T1 ATE323084 T1 AT E323084T1 AT 02752056 T AT02752056 T AT 02752056T AT 02752056 T AT02752056 T AT 02752056T AT E323084 T1 ATE323084 T1 AT E323084T1
Authority
AT
Austria
Prior art keywords
disease
treatment
alzheimer
macrocycles
useful
Prior art date
Application number
AT02752056T
Other languages
English (en)
Inventor
Shon R Pulley
James P Beck
Ruth E Tenbrink
Original Assignee
Elan Pharm Inc
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, Pharmacia & Upjohn Co Llc filed Critical Elan Pharm Inc
Application granted granted Critical
Publication of ATE323084T1 publication Critical patent/ATE323084T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
AT02752056T 2001-06-12 2002-06-12 Für die behandlung von alzheimer krankheit geeignete makrocyclen ATE323084T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29754601P 2001-06-12 2001-06-12
US33308301P 2001-11-19 2001-11-19

Publications (1)

Publication Number Publication Date
ATE323084T1 true ATE323084T1 (de) 2006-04-15

Family

ID=26970209

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02752056T ATE323084T1 (de) 2001-06-12 2002-06-12 Für die behandlung von alzheimer krankheit geeignete makrocyclen

Country Status (10)

Country Link
US (2) US6969709B2 (de)
EP (1) EP1404671B1 (de)
JP (1) JP2004534064A (de)
AT (1) ATE323084T1 (de)
BR (1) BR0210392A (de)
CA (1) CA2450202A1 (de)
DE (1) DE60210614T2 (de)
ES (1) ES2261699T3 (de)
MX (1) MXPA03011466A (de)
WO (1) WO2002100856A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2469622A1 (en) * 2001-12-06 2003-06-19 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamines
US7371853B2 (en) 2003-01-07 2008-05-13 Merck & Co., Inc. Macrocyclic β-secretase inhibitors for the treatment of Alzheimer's disease
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
DK1633774T3 (da) 2003-06-18 2010-05-25 Tranzyme Pharma Inc Makrocykliske motilinreceptorantagonister
GB0325830D0 (en) * 2003-11-05 2003-12-10 Novartis Ag Organic compounds
DE602005007245D1 (de) 2004-07-28 2008-07-10 Schering Corp
MX2007008507A (es) * 2005-01-13 2009-02-16 Novartis Ag Compuestos macrociclicos utiles como inhibidores de bace.
GB0500683D0 (en) * 2005-01-13 2005-02-23 Novartis Ag Organic compounds
AU2006235344B2 (en) 2005-04-08 2012-07-26 Comentis, Inc. Compounds which inhibit beta-secretase activity and methods of use thereof
US7338974B2 (en) 2005-08-12 2008-03-04 Bristol-Myers Squibb Company Macrocyclic diaminopropanes as beta-secretase inhibitors
GB0526614D0 (en) * 2005-12-30 2006-02-08 Novartis Ag Organic compounds
WO2008009734A1 (en) * 2006-07-20 2008-01-24 Novartis Ag Macrocyclic lactams
JP2009544599A (ja) * 2006-07-20 2009-12-17 ノバルティス アクチエンゲゼルシャフト Ｂａｃｅ阻害剤として有用な大環状化合物
US7678784B2 (en) 2006-11-20 2010-03-16 Bristol-Myers Squibb Company Oxime-containing macrocyclic acyl guanidines as β-secretase inhibitors
US7772221B2 (en) 2007-02-09 2010-08-10 Bristol-Meyers Squibb Company Diaminopropane derived macrocycles as inhibitors of β amyloid production
US20100063013A1 (en) * 2007-03-26 2010-03-11 Renata Oballa Cathepsin cysteine protease inhibitors
US7732434B2 (en) 2007-04-20 2010-06-08 Bristol-Myers Squibb Company Macrocyclic acyl guanidines as beta-secretase inhibitors
US20160022649A1 (en) * 2013-03-15 2016-01-28 The Board Of Regents Of The University Of Texas System Use of inhibitors of mtor to improve vascular functions in apoe4 carriers
DK3089737T3 (da) 2013-12-31 2021-12-13 Rapamycin Holdings Llc Orale rapamycin-nanopartikelpræparater og anvendelse.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM982594A0 (en) 1994-12-02 1995-01-05 University Of Queensland, The HIV protease inhibitors
EP1192177A1 (de) * 1999-06-15 2002-04-03 Elan Pharmaceuticals, Inc. Statin-abstammende tetrapeptide als inhibitoren der beta-secretase

Also Published As

Publication number Publication date
DE60210614D1 (de) 2006-05-24
US20060040910A1 (en) 2006-02-23
US6969709B2 (en) 2005-11-29
BR0210392A (pt) 2004-10-13
JP2004534064A (ja) 2004-11-11
MXPA03011466A (es) 2004-07-01
EP1404671A1 (de) 2004-04-07
EP1404671B1 (de) 2006-04-12
US7442691B2 (en) 2008-10-28
US20030236199A1 (en) 2003-12-25
CA2450202A1 (en) 2002-12-19
WO2002100856A1 (en) 2002-12-19
DE60210614T2 (de) 2007-03-01
ES2261699T3 (es) 2006-11-16

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties