HUT77372A - Új benzil-pirimidinek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents
Új benzil-pirimidinek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukraInfo
- Publication number
- HUT77372A HUT77372A HU9701973A HU9701973A HUT77372A HU T77372 A HUT77372 A HU T77372A HU 9701973 A HU9701973 A HU 9701973A HU 9701973 A HU9701973 A HU 9701973A HU T77372 A HUT77372 A HU T77372A
- Authority
- HU
- Hungary
- Prior art keywords
- pct
- producing
- pharmaceutical compositions
- compositions containing
- date
- Prior art date
Links
- OOLOAWZLPBDRJQ-UHFFFAOYSA-N 2-benzylpyrimidine Chemical class N=1C=CC=NC=1CC1=CC=CC=C1 OOLOAWZLPBDRJQ-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
- -1 ethylene, vinylene Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH353694 | 1994-11-24 | ||
| CH270495 | 1995-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUT77372A true HUT77372A (hu) | 1998-03-30 |
Family
ID=25691190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9701973A HUT77372A (hu) | 1994-11-24 | 1995-11-13 | Új benzil-pirimidinek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5763450A (hu) |
| EP (1) | EP0793656B1 (hu) |
| JP (1) | JP3117721B2 (hu) |
| KR (1) | KR100417508B1 (hu) |
| CN (1) | CN1136198C (hu) |
| AT (1) | ATE235471T1 (hu) |
| AU (1) | AU704911B2 (hu) |
| BR (1) | BR9509768A (hu) |
| CA (1) | CA2205406C (hu) |
| CZ (1) | CZ157597A3 (hu) |
| DE (1) | DE69530104T2 (hu) |
| DK (1) | DK0793656T3 (hu) |
| ES (1) | ES2193205T3 (hu) |
| FI (1) | FI972194A0 (hu) |
| HU (1) | HUT77372A (hu) |
| MX (1) | MX9703687A (hu) |
| NO (1) | NO308845B1 (hu) |
| NZ (1) | NZ296532A (hu) |
| PL (1) | PL320458A1 (hu) |
| PT (1) | PT793656E (hu) |
| WO (1) | WO1996016046A2 (hu) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW438796B (en) * | 1996-05-15 | 2001-06-07 | Hoffmann La Roche | 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same |
| ZA981529B (en) * | 1997-03-03 | 1998-09-03 | Hoffmann La Roche | Substituted 2,4-diaminopyrimidine |
| EP0966464B1 (en) * | 1997-03-03 | 2003-05-28 | Basilea Pharmaceutica AG | Substituted 2,4-diaminopyrimidines |
| EP1000932B9 (en) * | 1997-06-27 | 2005-12-28 | Fujisawa Pharmaceutical Co., Ltd. | Aromatic ring derivatives |
| US6893815B1 (en) * | 1997-06-30 | 2005-05-17 | Isis Pharmaceuticals, Inc. | Nucleobase heterocyclic combinatorialization |
| WO1999007682A1 (fr) * | 1997-08-08 | 1999-02-18 | Toyama Chemical Co., Ltd. | Derives d'acide quinolonecarboxylique ou sels de ces derives |
| US6093732A (en) * | 1997-12-22 | 2000-07-25 | Pharmacia & Upjohn Company | 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents |
| CA2327328C (en) * | 1998-04-06 | 2007-11-13 | Toyama Chemical Co., Ltd. | Quinolonecarboxylic acid derivatives or salts thereof |
| DE60041763D1 (de) * | 1999-04-23 | 2009-04-23 | Vertex Pharma | Inhibitoren von c-jun n-terminal kinasen (jnk) |
| CN1186328C (zh) | 1999-11-04 | 2005-01-26 | 巴斯利尔药物股份公司 | 取代的5－苄基－2,4－二氨基嘧啶 |
| US7612065B2 (en) | 2000-04-21 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-JUN N-terminal kinases (JNK) |
| PE20011349A1 (es) | 2000-06-16 | 2002-01-19 | Upjohn Co | 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales |
| CN1252055C (zh) * | 2000-07-24 | 2006-04-19 | 拜尔农作物科学股份公司 | 联苯甲酰胺类化合物 |
| PL359809A1 (en) | 2000-07-24 | 2004-09-06 | Bayer Cropscience Ag | Pyrazolyl biphenyl carboxamides and the use thereof for controlling undesired microorganisms |
| US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
| EP1434585A1 (en) | 2001-10-12 | 2004-07-07 | Warner-Lambert Company LLC | Alkyne matrix metalloproteinase inhibitors |
| US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| EP1403271B1 (en) * | 2002-09-25 | 2005-11-16 | Degussa AG | Method of producing 5-formyl-2-furylboronic acid |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| CA2619919C (en) * | 2005-09-01 | 2014-04-01 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| US8268825B2 (en) | 2005-09-26 | 2012-09-18 | The Board Of Regents For Oklahoma State University | Method for the treatment of anthrax infections |
| SI2343281T1 (sl) * | 2006-10-04 | 2014-06-30 | F. Hoffmann-La Roche Ag | Postopek za sintezo fenoksi diaminopirimidinskih derivatov |
| WO2008131253A1 (en) | 2007-04-20 | 2008-10-30 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| US8853228B2 (en) * | 2007-06-04 | 2014-10-07 | University Of Connecticut | Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase |
| EP2222639A1 (en) | 2007-11-21 | 2010-09-01 | Decode Genetics EHF | Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders |
| JP5305704B2 (ja) * | 2008-03-24 | 2013-10-02 | 富士フイルム株式会社 | 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版 |
| GB0815962D0 (en) * | 2008-09-02 | 2008-10-08 | Merlion Pharmaceuticals Pte Ltd | Hybrid antibacterial compounds and their use |
| MX2011004535A (es) | 2008-10-29 | 2011-11-18 | Deciphera Pharmaceuticals Llc | Ciclopropanamidas y analogos que exhiben actividades anti-cancer y anti-proliferativas. |
| ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
| CN102040591B (zh) * | 2009-10-15 | 2013-12-11 | 山东轩竹医药科技有限公司 | 7-苯基喹诺酮类化合物 |
| EP2719395A1 (en) | 2010-09-01 | 2014-04-16 | Novartis AG | Adsorption of immunopotentiators to insoluble metal salts |
| JP6191082B2 (ja) | 2011-03-02 | 2017-09-06 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | より低用量の抗原および／またはアジュバントを有する混合ワクチン |
| RU2014140521A (ru) | 2012-03-08 | 2016-04-27 | Новартис Аг | Адъювантные составы бустерных вакцин |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| SG11202007198WA (en) | 2018-01-31 | 2020-08-28 | Deciphera Pharmaceuticals Llc | Combination therapy for the treatment of gastrointestinal stromal tumors |
| BR112022002609A2 (pt) | 2019-08-12 | 2022-08-09 | Deciphera Pharmaceuticals Llc | Métodos de tratamento de tumores estromais gastrointestinais |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| DK4084778T3 (da) | 2019-12-30 | 2023-12-11 | Deciphera Pharmaceuticals Llc | Amorfe kinaseinhibitorformuleringer og fremgangsmåder til anvendelse deraf |
| KR20220123058A (ko) | 2019-12-30 | 2022-09-05 | 데시페라 파마슈티칼스, 엘엘씨. | 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515948A (en) * | 1973-09-12 | 1985-05-07 | Hoffmann-La Roche Inc. | 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines |
| US4039543A (en) * | 1974-12-24 | 1977-08-02 | Hoffmann-La Roche Inc. | Benzylpyrimidines |
| EP0639075A1 (en) * | 1990-11-14 | 1995-02-22 | Chiron Corporation | Specific inhibition of dihydrofolate reductase and compounds therefor |
| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
-
1995
- 1995-11-13 PT PT95939267T patent/PT793656E/pt unknown
- 1995-11-13 WO PCT/EP1995/004451 patent/WO1996016046A2/en active IP Right Grant
- 1995-11-13 BR BR9509768A patent/BR9509768A/pt not_active Application Discontinuation
- 1995-11-13 KR KR1019970703472A patent/KR100417508B1/ko not_active IP Right Cessation
- 1995-11-13 US US08/836,857 patent/US5763450A/en not_active Expired - Lifetime
- 1995-11-13 AT AT95939267T patent/ATE235471T1/de not_active IP Right Cessation
- 1995-11-13 JP JP08516521A patent/JP3117721B2/ja not_active Expired - Lifetime
- 1995-11-13 ES ES95939267T patent/ES2193205T3/es not_active Expired - Lifetime
- 1995-11-13 MX MX9703687A patent/MX9703687A/es not_active IP Right Cessation
- 1995-11-13 PL PL95320458A patent/PL320458A1/xx unknown
- 1995-11-13 CA CA002205406A patent/CA2205406C/en not_active Expired - Fee Related
- 1995-11-13 AU AU41161/96A patent/AU704911B2/en not_active Ceased
- 1995-11-13 EP EP95939267A patent/EP0793656B1/en not_active Expired - Lifetime
- 1995-11-13 DE DE69530104T patent/DE69530104T2/de not_active Expired - Lifetime
- 1995-11-13 DK DK95939267T patent/DK0793656T3/da active
- 1995-11-13 CN CNB951963988A patent/CN1136198C/zh not_active Expired - Fee Related
- 1995-11-13 CZ CZ971575A patent/CZ157597A3/cs unknown
- 1995-11-13 NZ NZ296532A patent/NZ296532A/en unknown
- 1995-11-13 HU HU9701973A patent/HUT77372A/hu unknown
-
1997
- 1997-05-22 FI FI972194A patent/FI972194A0/fi not_active IP Right Cessation
- 1997-05-26 NO NO972393A patent/NO308845B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69530104D1 (de) | 2003-04-30 |
| NZ296532A (en) | 2000-02-28 |
| CA2205406A1 (en) | 1996-05-30 |
| DE69530104T2 (de) | 2003-12-24 |
| PL320458A1 (en) | 1997-09-29 |
| PT793656E (pt) | 2003-07-31 |
| EP0793656B1 (en) | 2003-03-26 |
| WO1996016046A3 (en) | 1996-07-25 |
| ES2193205T3 (es) | 2003-11-01 |
| CN1136198C (zh) | 2004-01-28 |
| CA2205406C (en) | 2008-02-05 |
| AU704911B2 (en) | 1999-05-06 |
| EP0793656A1 (en) | 1997-09-10 |
| DK0793656T3 (da) | 2003-07-21 |
| NO972393D0 (no) | 1997-05-26 |
| NO308845B1 (no) | 2000-11-06 |
| JPH11507009A (ja) | 1999-06-22 |
| WO1996016046A2 (en) | 1996-05-30 |
| JP3117721B2 (ja) | 2000-12-18 |
| ATE235471T1 (de) | 2003-04-15 |
| CZ157597A3 (en) | 1997-09-17 |
| KR100417508B1 (ko) | 2004-03-18 |
| AU4116196A (en) | 1996-06-17 |
| NO972393L (no) | 1997-05-29 |
| US5763450A (en) | 1998-06-09 |
| BR9509768A (pt) | 1998-07-07 |
| MX9703687A (es) | 1997-08-30 |
| CN1166831A (zh) | 1997-12-03 |
| FI972194A (fi) | 1997-05-22 |
| FI972194A0 (fi) | 1997-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFD9 | Temporary protection cancelled due to non-payment of fee |