DE69530104T2 - Neue benzylpyrimidine - Google Patents
Neue benzylpyrimidineInfo
- Publication number
- DE69530104T2 DE69530104T2 DE69530104T DE69530104T DE69530104T2 DE 69530104 T2 DE69530104 T2 DE 69530104T2 DE 69530104 T DE69530104 T DE 69530104T DE 69530104 T DE69530104 T DE 69530104T DE 69530104 T2 DE69530104 T2 DE 69530104T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- date
- heteroaryl
- sec
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OOLOAWZLPBDRJQ-UHFFFAOYSA-N 2-benzylpyrimidine Chemical compound N=1C=CC=NC=1CC1=CC=CC=C1 OOLOAWZLPBDRJQ-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
- -1 ethylene, vinylene Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH353694 | 1994-11-24 | ||
| CH270495 | 1995-09-25 | ||
| PCT/EP1995/004451 WO1996016046A2 (en) | 1994-11-24 | 1995-11-13 | Novel benzyl pyrimidines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69530104D1 DE69530104D1 (de) | 2003-04-30 |
| DE69530104T2 true DE69530104T2 (de) | 2003-12-24 |
Family
ID=25691190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69530104T Expired - Lifetime DE69530104T2 (de) | 1994-11-24 | 1995-11-13 | Neue benzylpyrimidine |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5763450A (de) |
| EP (1) | EP0793656B1 (de) |
| JP (1) | JP3117721B2 (de) |
| KR (1) | KR100417508B1 (de) |
| CN (1) | CN1136198C (de) |
| AT (1) | ATE235471T1 (de) |
| AU (1) | AU704911B2 (de) |
| BR (1) | BR9509768A (de) |
| CA (1) | CA2205406C (de) |
| CZ (1) | CZ157597A3 (de) |
| DE (1) | DE69530104T2 (de) |
| DK (1) | DK0793656T3 (de) |
| ES (1) | ES2193205T3 (de) |
| FI (1) | FI972194A0 (de) |
| HU (1) | HUT77372A (de) |
| MX (1) | MX9703687A (de) |
| NO (1) | NO308845B1 (de) |
| NZ (1) | NZ296532A (de) |
| PL (1) | PL320458A1 (de) |
| PT (1) | PT793656E (de) |
| WO (1) | WO1996016046A2 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW438796B (en) * | 1996-05-15 | 2001-06-07 | Hoffmann La Roche | 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same |
| CA2281642C (en) * | 1997-03-03 | 2008-02-05 | F. Hoffmann-La Roche Ag | Substituted 2,4-diaminopyrimidines |
| EP0966464B1 (de) * | 1997-03-03 | 2003-05-28 | Basilea Pharmaceutica AG | Substituierte 2,4-diaminopyrimidine |
| WO1999000359A1 (fr) | 1997-06-27 | 1999-01-07 | Fujisawa Pharmaceutical Co., Ltd. | Derives de noyau aromatique |
| US6893815B1 (en) * | 1997-06-30 | 2005-05-17 | Isis Pharmaceuticals, Inc. | Nucleobase heterocyclic combinatorialization |
| JP4370002B2 (ja) * | 1997-08-08 | 2009-11-25 | 富山化学工業株式会社 | キノロンカルボン酸誘導体またはその塩 |
| ES2248923T3 (es) * | 1997-12-22 | 2006-03-16 | PHARMACIA & UPJOHN COMPANY LLC | 4-hydroxiquinolin-3-carboxamidas y hidrazidas como agentes antivirales. |
| ATE342897T1 (de) * | 1998-04-06 | 2006-11-15 | Toyama Chemical Co Ltd | Chinoloncarbonsäurederivate oder deren salze |
| DE60041763D1 (de) * | 1999-04-23 | 2009-04-23 | Vertex Pharma | Inhibitoren von c-jun n-terminal kinasen (jnk) |
| DE50009143D1 (de) | 1999-11-04 | 2005-02-03 | Basilea Pharmaceutica Ag Basel | Substituierte 5-benzyl-2,4-diaminopyrimidine |
| US7612065B2 (en) | 2000-04-21 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-JUN N-terminal kinases (JNK) |
| PE20011349A1 (es) | 2000-06-16 | 2002-01-19 | Upjohn Co | 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales |
| AU2001278480A1 (en) * | 2000-07-24 | 2002-02-05 | Bayer Crop Science Ag | Biphenyl carboxamides |
| AU2001270630A1 (en) | 2000-07-24 | 2002-02-05 | Bayer Crop Science Ag | Pyrazolyl biphenyl carboxamides |
| US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
| BR0213233A (pt) | 2001-10-12 | 2005-01-04 | Warner Lambert Co | Alcinos inibidores de metaloproteinase de matriz |
| US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| ES2252600T3 (es) * | 2002-09-25 | 2006-05-16 | Degussa Ag | Metodo para producir acido 5-formil-2-furilboronico. |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| JP4850911B2 (ja) * | 2005-09-01 | 2012-01-11 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐ２ｘ３およびｐ２ｘ２／３モジュレーターとしてのジアミノピリミジン |
| US8268825B2 (en) | 2005-09-26 | 2012-09-18 | The Board Of Regents For Oklahoma State University | Method for the treatment of anthrax infections |
| JP5128603B2 (ja) * | 2006-10-04 | 2013-01-23 | エフ．ホフマン−ラ ロシュ アーゲー | フェノキシジアミノピリミジン誘導体の合成方法 |
| US8143293B2 (en) | 2007-04-20 | 2012-03-27 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoprolific diseases and other proliferative diseases |
| US8853228B2 (en) * | 2007-06-04 | 2014-10-07 | University Of Connecticut | Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase |
| EP2222639A1 (de) * | 2007-11-21 | 2010-09-01 | Decode Genetics EHF | Biaryle als pde4-inhibitoren zur behandlung von lungen- und herz-kreislauf-erkrankungen |
| JP5305704B2 (ja) * | 2008-03-24 | 2013-10-02 | 富士フイルム株式会社 | 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版 |
| GB0815962D0 (en) * | 2008-09-02 | 2008-10-08 | Merlion Pharmaceuticals Pte Ltd | Hybrid antibacterial compounds and their use |
| CN102256493A (zh) | 2008-10-29 | 2011-11-23 | 迪赛孚尔制药有限公司 | 表现出抗癌活性和抗增殖活性的环丙烷酰胺及其类似物 |
| BR112012004806B8 (pt) | 2009-09-02 | 2022-10-04 | Novartis Ag | composições imunogênicas que incluem moduladores da atividade de tlr, método para aumento da eficácia da referida composição e uso |
| CN102040591B (zh) * | 2009-10-15 | 2013-12-11 | 山东轩竹医药科技有限公司 | 7-苯基喹诺酮类化合物 |
| AU2011295853A1 (en) * | 2010-09-01 | 2013-04-04 | Irm Llc | Adsorption of immunopotentiators to insoluble metal salts |
| JP6191082B2 (ja) | 2011-03-02 | 2017-09-06 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | より低用量の抗原および／またはアジュバントを有する混合ワクチン |
| CA2866406A1 (en) | 2012-03-08 | 2013-09-12 | Novartis Ag | Adjuvanted formulations of booster vaccines |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| CN111818915B (zh) | 2018-01-31 | 2024-05-24 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
| EP4013412A1 (de) | 2019-08-12 | 2022-06-22 | Deciphera Pharmaceuticals, LLC | Ripretinib zur behandlung gastrointestinaler stromakarzinome |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| KR20220123057A (ko) | 2019-12-30 | 2022-09-05 | 데시페라 파마슈티칼스, 엘엘씨. | 비정질 키나아제 억제제 제형 및 이의 사용 방법 |
| EP4084779A1 (de) | 2019-12-30 | 2022-11-09 | Deciphera Pharmaceuticals, LLC | Zusammensetzungen von 1-(4-brom-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorphenyl)-3-phenylharnstoff |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515948A (en) * | 1973-09-12 | 1985-05-07 | Hoffmann-La Roche Inc. | 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines |
| US4039543A (en) * | 1974-12-24 | 1977-08-02 | Hoffmann-La Roche Inc. | Benzylpyrimidines |
| JPH07509215A (ja) * | 1990-11-14 | 1995-10-12 | カイロン コーポレイション | ジヒドロ葉酸還元酵素の特異的阻害およびそのための化合物 |
| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
-
1995
- 1995-11-13 DK DK95939267T patent/DK0793656T3/da active
- 1995-11-13 WO PCT/EP1995/004451 patent/WO1996016046A2/en active IP Right Grant
- 1995-11-13 MX MX9703687A patent/MX9703687A/es not_active IP Right Cessation
- 1995-11-13 AT AT95939267T patent/ATE235471T1/de not_active IP Right Cessation
- 1995-11-13 KR KR1019970703472A patent/KR100417508B1/ko not_active IP Right Cessation
- 1995-11-13 DE DE69530104T patent/DE69530104T2/de not_active Expired - Lifetime
- 1995-11-13 CN CNB951963988A patent/CN1136198C/zh not_active Expired - Fee Related
- 1995-11-13 US US08/836,857 patent/US5763450A/en not_active Expired - Lifetime
- 1995-11-13 BR BR9509768A patent/BR9509768A/pt not_active Application Discontinuation
- 1995-11-13 PT PT95939267T patent/PT793656E/pt unknown
- 1995-11-13 NZ NZ296532A patent/NZ296532A/en unknown
- 1995-11-13 HU HU9701973A patent/HUT77372A/hu unknown
- 1995-11-13 CA CA002205406A patent/CA2205406C/en not_active Expired - Fee Related
- 1995-11-13 EP EP95939267A patent/EP0793656B1/de not_active Expired - Lifetime
- 1995-11-13 ES ES95939267T patent/ES2193205T3/es not_active Expired - Lifetime
- 1995-11-13 JP JP08516521A patent/JP3117721B2/ja not_active Expired - Lifetime
- 1995-11-13 CZ CZ971575A patent/CZ157597A3/cs unknown
- 1995-11-13 AU AU41161/96A patent/AU704911B2/en not_active Ceased
- 1995-11-13 PL PL95320458A patent/PL320458A1/xx unknown
-
1997
- 1997-05-22 FI FI972194A patent/FI972194A0/fi not_active IP Right Cessation
- 1997-05-26 NO NO972393A patent/NO308845B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MX9703687A (es) | 1997-08-30 |
| ATE235471T1 (de) | 2003-04-15 |
| JP3117721B2 (ja) | 2000-12-18 |
| DK0793656T3 (da) | 2003-07-21 |
| CA2205406C (en) | 2008-02-05 |
| CZ157597A3 (en) | 1997-09-17 |
| EP0793656A1 (de) | 1997-09-10 |
| PL320458A1 (en) | 1997-09-29 |
| AU4116196A (en) | 1996-06-17 |
| CA2205406A1 (en) | 1996-05-30 |
| CN1166831A (zh) | 1997-12-03 |
| FI972194A (fi) | 1997-05-22 |
| DE69530104D1 (de) | 2003-04-30 |
| WO1996016046A3 (en) | 1996-07-25 |
| FI972194A0 (fi) | 1997-05-22 |
| NO308845B1 (no) | 2000-11-06 |
| CN1136198C (zh) | 2004-01-28 |
| KR100417508B1 (ko) | 2004-03-18 |
| WO1996016046A2 (en) | 1996-05-30 |
| JPH11507009A (ja) | 1999-06-22 |
| BR9509768A (pt) | 1998-07-07 |
| PT793656E (pt) | 2003-07-31 |
| HUT77372A (hu) | 1998-03-30 |
| US5763450A (en) | 1998-06-09 |
| AU704911B2 (en) | 1999-05-06 |
| ES2193205T3 (es) | 2003-11-01 |
| NO972393D0 (no) | 1997-05-26 |
| EP0793656B1 (de) | 2003-03-26 |
| NO972393L (no) | 1997-05-29 |
| NZ296532A (en) | 2000-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BASILEA PHARMACEUTICA AG, BASEL, CH |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: LEDERER & KELLER, 80538 MUENCHEN |
|
| 8364 | No opposition during term of opposition |