ATE172964T1 - Verfahren zur herstellung von (-)-n-methyl-n-(4- (4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4- dichlorophenyl)butyl>-benzamid und ihr pharmazeutisch annehmbares salz - Google Patents

Verfahren zur herstellung von (-)-n-methyl-n-(4- (4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4- dichlorophenyl)butyl>-benzamid und ihr pharmazeutisch annehmbares salz

Info

Publication number
ATE172964T1
ATE172964T1 AT95401935T AT95401935T ATE172964T1 AT E172964 T1 ATE172964 T1 AT E172964T1 AT 95401935 T AT95401935 T AT 95401935T AT 95401935 T AT95401935 T AT 95401935T AT E172964 T1 ATE172964 T1 AT E172964T1
Authority
AT
Austria
Prior art keywords
benzamide
dichlorophenyl
phenyl
methyl
pharmaceutically acceptable
Prior art date
Application number
AT95401935T
Other languages
English (en)
Inventor
Marcel Descamps
Gilles Anne-Archard
Joel Radisson
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE172964T1 publication Critical patent/ATE172964T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95401935T 1994-08-24 1995-08-23 Verfahren zur herstellung von (-)-n-methyl-n-(4- (4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4- dichlorophenyl)butyl>-benzamid und ihr pharmazeutisch annehmbares salz ATE172964T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/294,035 US5512680A (en) 1993-02-26 1994-08-24 Process for the preparation of an optically pure aminoalcohol

Publications (1)

Publication Number Publication Date
ATE172964T1 true ATE172964T1 (de) 1998-11-15

Family

ID=23131621

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95401935T ATE172964T1 (de) 1994-08-24 1995-08-23 Verfahren zur herstellung von (-)-n-methyl-n-(4- (4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4- dichlorophenyl)butyl>-benzamid und ihr pharmazeutisch annehmbares salz

Country Status (24)

Country Link
US (2) US5512680A (de)
EP (1) EP0698601B1 (de)
JP (1) JP3037592B2 (de)
KR (1) KR100275978B1 (de)
AT (1) ATE172964T1 (de)
AU (1) AU685971B2 (de)
BR (1) BR9503776A (de)
CA (1) CA2156764C (de)
CZ (1) CZ289654B6 (de)
DE (1) DE69505756T2 (de)
DK (1) DK0698601T3 (de)
ES (1) ES2125574T3 (de)
FI (1) FI116221B (de)
HU (1) HU218485B (de)
IL (1) IL114866A (de)
MY (1) MY116365A (de)
NO (1) NO305167B1 (de)
NZ (1) NZ272827A (de)
PL (1) PL182914B1 (de)
RU (1) RU2097376C1 (de)
SI (1) SI0698601T1 (de)
SK (1) SK281454B6 (de)
TW (1) TW410223B (de)
ZA (1) ZA957025B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2792835B3 (fr) * 1999-04-27 2001-05-25 Sanofi Sa Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression
WO2007020079A2 (en) * 2005-08-17 2007-02-22 Synthon B.V. Orally disintegratable simvastatin tablets
JP2009191006A (ja) * 2008-02-14 2009-08-27 Sumitomo Chemical Co Ltd 光学活性な４−アミノ−３−（３，４−ジクロロフェニル）ブタン−１−オールの製造方法およびその中間体
US20180208544A1 (en) 2015-07-13 2018-07-26 Piramal Enterprises Limited An improved process for the preparation of baclofen and its intermediate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
IL99320A (en) 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
FR2676054B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
US5391819A (en) * 1992-09-30 1995-02-21 Merck & Co., Inc. Process of making chiral 2-aryl-1,4-butanediamine derivatives as useful neurokinin-A antagonists
FR2701946B1 (fr) * 1993-02-26 1995-05-24 Sanofi Elf Procédé pour la préparation d'un aminoalcool optiquement pur.

Also Published As

Publication number Publication date
EP0698601B1 (de) 1998-11-04
JP3037592B2 (ja) 2000-04-24
AU3021695A (en) 1996-03-07
CZ289654B6 (cs) 2002-03-13
CZ216495A3 (en) 1996-03-13
IL114866A0 (en) 1995-12-08
ZA957025B (en) 1996-03-26
CA2156764A1 (en) 1996-02-25
NO953313D0 (no) 1995-08-23
FI116221B (fi) 2005-10-14
SK103095A3 (en) 1996-03-06
FI953994A0 (fi) 1995-08-24
AU685971B2 (en) 1998-01-29
DE69505756D1 (de) 1998-12-10
JPH08176108A (ja) 1996-07-09
PL182914B1 (pl) 2002-04-30
PL310155A1 (en) 1996-03-04
NO953313L (no) 1996-02-26
RU2097376C1 (ru) 1997-11-27
IL114866A (en) 1999-12-22
KR100275978B1 (ko) 2000-12-15
US5512680A (en) 1996-04-30
DK0698601T3 (da) 1999-07-19
DE69505756T2 (de) 1999-05-27
HU9502481D0 (en) 1995-10-30
FI953994A (fi) 1996-02-25
SK281454B6 (sk) 2001-03-12
US5780666A (en) 1998-07-14
HUT74184A (en) 1996-11-28
HU218485B (hu) 2000-09-28
ES2125574T3 (es) 1999-03-01
EP0698601A1 (de) 1996-02-28
CA2156764C (en) 2006-06-13
NZ272827A (en) 1997-11-24
KR960007562A (ko) 1996-03-22
MY116365A (en) 2004-01-31
SI0698601T1 (en) 1999-04-30
NO305167B1 (no) 1999-04-12
BR9503776A (pt) 1996-04-16
TW410223B (en) 2000-11-01

Similar Documents

Publication Publication Date Title
MX9203346A (es) (+)-1-(3-dimetilaminopropil)-1-(4'-fluorfenil)-1,3-dihidro-sobenofuran -5-carbonitrilo y sus sales de adicion de acido no toxicas farmaceuticamente utiles.
ATE190614T1 (de) Dihydrat des n-(4-amino-6,7-dimethoxychinazol-2- yl)-n-methyl-n'-(tetrahydrofuroyl-2)- propylendiamin hydrochlorids(=alfuzosin hydrochlorid dihydrat) und ein verfahren zur herstellung
DE59409248D1 (de) Verwendung von Phenalkylaminen zur Herstellung von cholesterinsenkenden Arzneimitteln
ATE277015T1 (de) Verfahren zur herstellung von 1,4-dihydropyridine sowie in diesem verfahren verwendete verbindungen
ATE172964T1 (de) Verfahren zur herstellung von (-)-n-methyl-n-(4- (4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4- dichlorophenyl)butyl>-benzamid und ihr pharmazeutisch annehmbares salz
DE69632919D1 (de) Verfahren zur herstellung von 2-chlor-5-chloromethyl-thiazol
WO2000018722A3 (es) Nuevos derivados de la 6-(4-fenilbutoxi)hexilamina y procedimiento para la obtencion de salmeterol
DE69737376D1 (de) Verfahren zur Synthese einer Oxonolverbindung
AU655869B2 (en) An amphoteric tricyclic compound
HUT71512A (en) N-(3-chlorophenyl)-piperazine derivatives for producing alkyl-trazodon derivatives and process for producing them
ATE207482T1 (de) Verfahren zur herstellung von n2-arylsulfonyl-l- argininamiden
ATE159246T1 (de) Verfahren zur herstellung von (s)-vinyl- und (s)- allenyl-gaba
ATE173259T1 (de) Verfahren zur herstellung von indolizinderivaten
MX9205408A (es) Metodo para tratar hipertension.
ATE188694T1 (de) Verfahren zur herstellung von benzopyranderivaten
DK460789D0 (da) 2-aminoacetamidderivater
ATE164573T1 (de) Verfahren zur herstellung von 1-unsubstituierten 3-aminopyrrolen
IES950207A2 (en) Process for the resolution of racemic 3-(2-pyridyl)-3-phenyl-N,N-dimethylpropylamines

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification