RU2600440C3 - Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты - Google Patents

Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты

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RU2600440C3
RU2600440C3 RU2013131913A RU2013131913A RU2600440C3 RU 2600440 C3 RU2600440 C3 RU 2600440C3 RU 2013131913 A RU2013131913 A RU 2013131913A RU 2013131913 A RU2013131913 A RU 2013131913A RU 2600440 C3 RU2600440 C3 RU 2600440C3
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hydroxybenzoyl
amino
agonist
acid salt
caprylic acid
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RU2013131913A
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RU2013131913A (ru
RU2600440C2 (ru
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Ново Нордиск А/С
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pregnancy & Childbirth (AREA)
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  • Child & Adolescent Psychology (AREA)
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Claims (6)

1. Твердая композиция для перорального введения, содержащая агонист GLP-1 и соль N-(8-(2-гидроксибензоил)амино)каприловой кислоты, где количество указанной соли N-(8-(2-гидроксибензоил)амино)каприловой кислоты составляет 1,0 ммоль, указанная композиция находится в форме таблетки и указанный агонист GLP-1 представляет собой семаглутид, и указанная соль N-(8-(2-гидроксибензоил)амино)каприловой кислоты представляет собой N-(8-(2-гидроксибензоил)амино)каприлат натрия (SNAC).
2. Композиция по п. 1, где количество агониста GLP-1 составляет 3, 7 или 14 мг.
3. Композиция по п. 2, где указанная композиция содержит 73% (масс./масс.) или 75% (масс./масс.) SNAC.
4. Композиция по любому из пп. 1-3, где количество SNAC составляет 300 мг.
5. Применение композиции по любому из пп. 1-4 в качестве лекарственного средства, обладающего активностью глюкагоноподобного пептида 1.
6. Применение композиции по любому из пп. 1-4 для лечения диабета типа II.
RU2013131913A 2010-12-16 2011-12-16 Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты RU2600440C3 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10195285 2010-12-16
EP10195285.1 2010-12-16
US201061425087P 2010-12-20 2010-12-20
US61/425,087 2010-12-20
PCT/EP2011/073060 WO2012080471A1 (en) 2010-12-16 2011-12-16 Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid

Publications (3)

Publication Number Publication Date
RU2013131913A RU2013131913A (ru) 2015-01-27
RU2600440C2 RU2600440C2 (ru) 2016-10-20
RU2600440C3 true RU2600440C3 (ru) 2021-12-10

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RU2013131913A RU2600440C3 (ru) 2010-12-16 2011-12-16 Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты

Country Status (20)

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US (6) US9278123B2 (ru)
EP (3) EP3326620B1 (ru)
JP (2) JP5902194B2 (ru)
KR (1) KR101925620B1 (ru)
CN (2) CN105963685B (ru)
AU (1) AU2011343190B2 (ru)
BR (1) BR112013014942B1 (ru)
CA (1) CA2821886A1 (ru)
DK (2) DK2651398T3 (ru)
ES (1) ES2661676T3 (ru)
HR (1) HRP20180425T1 (ru)
HU (1) HUE036066T2 (ru)
LT (1) LT2651398T (ru)
MX (1) MX345501B (ru)
PL (2) PL3326620T3 (ru)
PT (1) PT2651398T (ru)
RS (2) RS56998B1 (ru)
RU (1) RU2600440C3 (ru)
SI (2) SI2651398T1 (ru)
WO (1) WO2012080471A1 (ru)

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