RU2015132860A - Композиции инсулинов длительного действия - Google Patents
Композиции инсулинов длительного действия Download PDFInfo
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- RU2015132860A RU2015132860A RU2015132860A RU2015132860A RU2015132860A RU 2015132860 A RU2015132860 A RU 2015132860A RU 2015132860 A RU2015132860 A RU 2015132860A RU 2015132860 A RU2015132860 A RU 2015132860A RU 2015132860 A RU2015132860 A RU 2015132860A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Claims (18)
1. Фармацевтическая композиция на водной основе, содержащая 270-330 Ед/мл инсулина гларгина (эквимолярно 270-330 МЕ человеческого инсулина] при условии, что концентрация в указанной композиции не равна 300 ЕД/мл инсулина гларгина.
2. Фармацевтическая композиция на водной основе по п. 1, содержащая аналог эксендина-4.
3. Фармацевтическая композиция на водной основе по п. 2, где аналог эксендина-4 выбран из группы, состоящей из ликсисенатида, экзенатида и лираглутидом.
4. Фармацевтическая композиция на водной основе по п. 3, содержащая от 0,1 мкг до 10 мкг ликсисенатида на Ед инсулина гларгина.
5. Фармацевтическая композиция на водной основе по п. 4, содержащая от 0,2 мкг до 1 мкг ликсисенатида на Ед инсулина гларгина.
6. Фармацевтическая композиция на водной основе по п. 5, содержащая от 0,25 мкг до 0,7 мкг ликсисенатида на Ед инсулина гларгина.
7. Фармацевтическая композиция на водной основе по п. 1, содержащая один или несколько наполнителей, выбранных из группы, включающей цинк, м-крезол, глицерин, полисорбат 20 и натрий.
8. Фармацевтическая композиция на водной основе по п. 7, содержащая 90 мкг/мл цинка, 2,7 мг/мл м-крезола и 20 мг/мл глицерина 85%.
9. Фармацевтическая композиция на водной основе по п. 7, содержащая 90 мкг/мл цинка, 2,7 мг/мл м-крезола, 20 мкг/мл
полисорбата 20 и 20 мг/мл глицерина 85%.
10. Фармацевтическая композиция на водной основе по п. 1, где рН составляет от 3,4 до 4,6.
11. Фармацевтическая композиция на водной основе по п. 10, где рН составляет 4.
12. Фармацевтическая композиция на водной основе по п. 10, где рН составляет 4,5.
13. Фармацевтическая композиция на водной основе по п. 1 для лечения сахарного диабета типа I и типа II у пациента.
14. Фармацевтическая композиция на водной основе по п. 1 для увеличение продолжительности воздействия инсулина длительного действия при лечении сахарного диабета типа I и типа II у пациента.
15. Фармацевтическая композиция на водной основе по п. 1 для снижения частоты гипогликемии при лечении сахарного диабета типа I и типа II у пациента.
16. Фармацевтическая композиция на водной основе по п. 1 для обеспечения базального инсулина безпикового длительного действия при лечении типа I и типа II сахарного диабета у пациента.
17. Применение фармацевтической композиции на водной основе по любому из пп. 1-16 для получения лекарственного средства для лечения сахарного диабета типа I и сахарного диабета типа II.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10305532 | 2010-05-19 | ||
| EP10305532.3 | 2010-05-19 | ||
| EP10305780.8 | 2010-07-13 | ||
| EP10305780 | 2010-07-13 | ||
| EP11305140 | 2011-02-10 | ||
| EP11305140.3 | 2011-02-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011119988/15A Division RU2564104C2 (ru) | 2010-05-19 | 2011-05-18 | Композиции инсулинов длительного действия |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017146048A Division RU2017146048A (ru) | 2010-05-19 | 2017-12-27 | Композиции инсулинов длительного действия |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015132860A true RU2015132860A (ru) | 2017-02-09 |
| RU2642662C2 RU2642662C2 (ru) | 2018-01-25 |
Family
ID=44148980
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011119988/15A RU2564104C2 (ru) | 2010-05-19 | 2011-05-18 | Композиции инсулинов длительного действия |
| RU2015132860A RU2642662C2 (ru) | 2010-05-19 | 2015-08-06 | Композиции инсулинов длительного действия |
| RU2017146048A RU2017146048A (ru) | 2010-05-19 | 2017-12-27 | Композиции инсулинов длительного действия |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011119988/15A RU2564104C2 (ru) | 2010-05-19 | 2011-05-18 | Композиции инсулинов длительного действия |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017146048A RU2017146048A (ru) | 2010-05-19 | 2017-12-27 | Композиции инсулинов длительного действия |
Country Status (43)
Families Citing this family (85)
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