SG10201403840VA - Aqueous insulin preparations containing methionine - Google Patents

Aqueous insulin preparations containing methionine

Info

Publication number
SG10201403840VA
SG10201403840VA SG10201403840VA SG10201403840VA SG10201403840VA SG 10201403840V A SG10201403840V A SG 10201403840VA SG 10201403840V A SG10201403840V A SG 10201403840VA SG 10201403840V A SG10201403840V A SG 10201403840VA SG 10201403840V A SG10201403840V A SG 10201403840VA
Authority
SG
Singapore
Prior art keywords
preparations containing
insulin preparations
containing methionine
aqueous insulin
aqueous
Prior art date
Application number
SG10201403840VA
Inventor
Isabell Schoettle
Annika Hagendorf
Christiane Fuerst
Gerrit Hauck
Verena Siefke-Henzler
Walter Kamm
Julia Schnieders
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of SG10201403840VA publication Critical patent/SG10201403840VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
SG10201403840VA 2009-07-06 2010-07-02 Aqueous insulin preparations containing methionine SG10201403840VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009031748 2009-07-06
DE102010013134 2010-03-27

Publications (1)

Publication Number Publication Date
SG10201403840VA true SG10201403840VA (en) 2014-10-30

Family

ID=43429596

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012001335A SG177567A1 (en) 2009-07-06 2010-07-02 Aqueous insulin preparations containing methionine
SG10201403840VA SG10201403840VA (en) 2009-07-06 2010-07-02 Aqueous insulin preparations containing methionine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012001335A SG177567A1 (en) 2009-07-06 2010-07-02 Aqueous insulin preparations containing methionine

Country Status (32)

Country Link
US (1) US20120252724A1 (en)
EP (2) EP3202394A1 (en)
JP (1) JP5735960B2 (en)
KR (2) KR101852328B1 (en)
CN (4) CN103690958A (en)
AR (1) AR077454A1 (en)
AU (1) AU2010270325B2 (en)
BR (1) BR112012000177B1 (en)
CA (2) CA2980198C (en)
CL (1) CL2012000026A1 (en)
CO (1) CO6480996A2 (en)
CY (1) CY1119582T1 (en)
DK (1) DK2451437T3 (en)
ES (1) ES2614161T3 (en)
HR (1) HRP20170155T1 (en)
HU (1) HUE030499T2 (en)
IL (2) IL217327A (en)
LT (1) LT2451437T (en)
MA (1) MA33442B1 (en)
MX (1) MX2012000304A (en)
MY (1) MY159865A (en)
NZ (1) NZ597757A (en)
PH (1) PH12016500606A1 (en)
PL (1) PL2451437T3 (en)
PT (1) PT2451437T (en)
RU (1) RU2540485C2 (en)
SG (2) SG177567A1 (en)
SI (1) SI2451437T1 (en)
TW (1) TWI520745B (en)
UY (1) UY32764A (en)
WO (1) WO2011003822A2 (en)
ZA (1) ZA201200195B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2229407T3 (en) 2008-01-09 2017-06-30 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
PT3228320T (en) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combination of an insulin and a glp-1 agonist
US20120232002A1 (en) * 2009-07-06 2012-09-13 Sanofi-Aventis Deutschland Gmbh Slow-acting insulin preparations
JP5973918B2 (en) 2009-11-13 2016-08-23 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Pharmaceutical composition comprising a GLP-1 agonist and methionine
TR201809460T4 (en) * 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Pharmaceutical composition comprising a GLP-1-agonist, an insulin and methionine.
JP6199186B2 (en) 2010-08-30 2017-09-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
WO2012174478A2 (en) * 2011-06-17 2012-12-20 Halozyme, Inc. Stable formulations of a hyaluronan-degrading enzyme
AR087693A1 (en) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland PHARMACEUTICAL COMBINATION FOR USE IN GLUCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
AR094821A1 (en) * 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd LIQUID FORMULATION OF AN INSULINOTROPIC PEPTIDE CONJUGATE OF PROLONGED ACTION
US10441665B2 (en) 2012-07-25 2019-10-15 Hanmi Pharm. Co., Ltd. Liquid formulation of long acting insulinotropic peptide conjugate
MX2015005662A (en) * 2012-11-05 2015-08-20 Univ Case Western Reserve Long-acting single-chain insulin analogues.
RU2015129087A (en) 2012-12-19 2017-02-02 Вокхардт Лимитед STABLE WATER COMPOSITION CONTAINING HUMAN INSULIN OR ITS ANALOGU OR DERIVATIVE
TWI780236B (en) 2013-02-04 2022-10-11 法商賽諾菲公司 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
TW201605489A (en) * 2013-10-25 2016-02-16 賽諾菲公司 Stable formulation of INSULIN GLULISINE
MX2016008979A (en) 2014-01-09 2016-10-04 Sanofi Sa Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives.
BR112016015851A2 (en) 2014-01-09 2017-08-08 Sanofi Sa STABILIZED PHARMACEUTICAL FORMULATIONS OF INSULIN ASPART
CN105899191B (en) 2014-01-09 2020-06-16 赛诺菲 Stabilized glycerol-free pharmaceutical formulations of insulin analogues and/or insulin derivatives
CA2970200A1 (en) 2014-12-12 2016-06-16 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (en) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 Treatment type 2 diabetes mellitus patients
TW201705975A (en) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 Treatment of type 2 diabetes mellitus patients
EP4334338A1 (en) * 2021-05-03 2024-03-13 The Trustees of Indiana University Molecular design of glucose sensors in glucose-responsive insulin analogues

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6033474B2 (en) * 1978-05-11 1985-08-02 藤沢薬品工業株式会社 Novel hyaluronidase BMP-8231 and its production method
DE3316363A1 (en) 1983-05-05 1984-11-08 Deutsche Babcock Anlagen Ag, 4200 Oberhausen ROLLER GRID FOR WASTE COMBUSTION PLANTS
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK257988D0 (en) 1988-05-11 1988-05-11 Novo Industri As NEW PEPTIDES
DE3837825A1 (en) 1988-11-08 1990-05-10 Hoechst Ag NEW INSULIN DERIVATIVES, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM
KR910700262A (en) 1988-12-23 1991-03-14 안네 제케르 Human insulin analogues
PT93057B (en) 1989-02-09 1995-12-29 Lilly Co Eli PROCESS FOR THE PREPARATION OF INSULIN ANALOGS
DK155690D0 (en) 1990-06-28 1990-06-28 Novo Nordisk As NEW PEPTIDES
US5272135A (en) * 1991-03-01 1993-12-21 Chiron Ophthalmics, Inc. Method for the stabilization of methionine-containing polypeptides
EP1044016B1 (en) * 1998-01-09 2005-03-16 Novo Nordisk A/S Stabilised insulin compositions
EP1083930B1 (en) * 1998-06-05 2008-11-12 Nutrinia Limited Insulin supplemented infant formula
JP2007204498A (en) * 1999-03-01 2007-08-16 Chugai Pharmaceut Co Ltd Long-term stabilized formulations
EP1076066A1 (en) * 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides for lowering blood glucose levels
HU0800692D0 (en) * 1999-10-04 2009-01-28 Novartis Vaccines & Diagnostic Stabilized liquid polypeptide-containing pharmaceutical compositions
US6852694B2 (en) * 2001-02-21 2005-02-08 Medtronic Minimed, Inc. Stabilized insulin formulations
DE10114178A1 (en) * 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinc-free and low-zinc insulin preparations with improved stability
GEP20063908B (en) * 2001-10-18 2006-08-25 Bristol Myers Squibb Co Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
HUP0402315A3 (en) * 2001-12-21 2009-03-30 Novo Nordisk Healthcare Ag Liquid composition of factor vii polypeptides
DE10227232A1 (en) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Sour insulin preparations with improved stability
TW200522976A (en) * 2003-09-19 2005-07-16 Novo Nordisk As Novel plasma protein affinity tags
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US20080090753A1 (en) * 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US20090142338A1 (en) * 2005-03-04 2009-06-04 Curedm, Inc. Methods and Compositions for Treating Type 1 and Type 2 Diabetes Mellitus and Related Conditions
US20070191271A1 (en) * 2006-02-10 2007-08-16 Dow Pharmaceutical Sciences Method for stabilizing polypeptides lacking methionine
WO2007098479A2 (en) * 2006-02-21 2007-08-30 University Of Medicine And Dentistry Of New Jersey Localized insulin delivery for bone healing
TW200806317A (en) * 2006-03-20 2008-02-01 Wyeth Corp Methods for reducing protein aggregation
DE102006031962A1 (en) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidated insulin glargine
DK2157967T3 (en) * 2007-04-23 2013-04-08 Intarcia Therapeutics Inc Suspension formulations of insulinotropic peptides and applications thereof
AU2008320844B2 (en) * 2007-11-01 2013-08-29 Merck Serono S.A. LH liquid formulations
PL2229407T3 (en) * 2008-01-09 2017-06-30 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
TWI394580B (en) * 2008-04-28 2013-05-01 Halozyme Inc Super fast-acting insulin compositions
PT3228320T (en) * 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combination of an insulin and a glp-1 agonist
JP2009091363A (en) * 2008-11-21 2009-04-30 Asahi Kasei Pharma Kk Stabilized aqueous injectable solution of pth
US20120232002A1 (en) * 2009-07-06 2012-09-13 Sanofi-Aventis Deutschland Gmbh Slow-acting insulin preparations
JP5973918B2 (en) * 2009-11-13 2016-08-23 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Pharmaceutical composition comprising a GLP-1 agonist and methionine
TR201809460T4 (en) * 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Pharmaceutical composition comprising a GLP-1-agonist, an insulin and methionine.
AU2011202239C1 (en) * 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins

Also Published As

Publication number Publication date
CN102596175A (en) 2012-07-18
SG177567A1 (en) 2012-02-28
KR20160036106A (en) 2016-04-01
HRP20170155T1 (en) 2017-03-24
MX2012000304A (en) 2012-01-27
CN105535943A (en) 2016-05-04
BR112012000177A2 (en) 2020-08-11
BR112012000177B1 (en) 2021-06-01
LT2451437T (en) 2017-02-27
JP5735960B2 (en) 2015-06-17
CA2980198A1 (en) 2011-01-13
WO2011003822A2 (en) 2011-01-13
IL244941A (en) 2017-12-31
US20120252724A1 (en) 2012-10-04
EP2451437B1 (en) 2016-11-02
UY32764A (en) 2011-01-31
JP2012532178A (en) 2012-12-13
EP2451437A2 (en) 2012-05-16
IL244941A0 (en) 2016-05-31
CL2012000026A1 (en) 2012-10-05
EP3202394A1 (en) 2017-08-09
CY1119582T1 (en) 2018-03-07
AU2010270325B2 (en) 2014-06-19
DK2451437T3 (en) 2017-02-13
IL217327A0 (en) 2012-02-29
AR077454A1 (en) 2011-08-31
CA2767251C (en) 2018-08-21
PH12016500606A1 (en) 2016-11-28
CA2980198C (en) 2019-04-30
HUE030499T2 (en) 2017-05-29
NZ597757A (en) 2014-06-27
PL2451437T3 (en) 2017-05-31
PT2451437T (en) 2017-01-17
IL217327A (en) 2017-09-28
ZA201200195B (en) 2012-09-26
AU2010270325A1 (en) 2012-02-16
TWI520745B (en) 2016-02-11
CO6480996A2 (en) 2012-07-16
MA33442B1 (en) 2012-07-03
SI2451437T1 (en) 2017-03-31
TW201113031A (en) 2011-04-16
CN103690958A (en) 2014-04-02
KR101852328B1 (en) 2018-04-26
RU2012103901A (en) 2013-08-20
RU2540485C2 (en) 2015-02-10
CN107080836A (en) 2017-08-22
ES2614161T3 (en) 2017-05-29
CA2767251A1 (en) 2011-01-13
KR20120089442A (en) 2012-08-10
KR101853606B1 (en) 2018-05-03
WO2011003822A3 (en) 2011-08-25
MY159865A (en) 2017-02-15

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