RU2012123739A - Фармацевтическая композиция, содержащая агонист гпп-1 и метионин - Google Patents
Фармацевтическая композиция, содержащая агонист гпп-1 и метионин Download PDFInfo
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- RU2012123739A RU2012123739A RU2012123739/15A RU2012123739A RU2012123739A RU 2012123739 A RU2012123739 A RU 2012123739A RU 2012123739/15 A RU2012123739/15 A RU 2012123739/15A RU 2012123739 A RU2012123739 A RU 2012123739A RU 2012123739 A RU2012123739 A RU 2012123739A
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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Abstract
1. Жидкая композиция, содержащая агонист ГПП-1 или/и его фармакологически приемлемую соль и, необязательно, по меньшей мере один фармакологически приемлемый эксципиент, отличающаяся тем, что композиция содержит метионин.2. Жидкая композиция по п.1, отличающаяся тем, что она содержит фармакологически приемлемый консервант, в частности, м-крезол.3. Жидкая композиция по п.1 или 2, отличающаяся тем, что она содержит глицерин.4. Жидкая композиция по п.1, отличающаяся тем, что она имеет pH в диапазоне от 3,5 до 5.5. Жидкая композиция по п.1, отличающаяся тем, что она содержит метионин в количестве от 0,5 мг/мл до 20 мг/мл, предпочтительно от 1 мг/мл до 5 мг/мл.6. Жидкая композиция по п.1, отличающаяся тем, что она проявляет химическую целостность после хранения в течение 6 месяцев при температуре +25°C.7. Жидкая композиция по п.1, отличающаяся тем, что она проявляет физическую целостность после хранения в течение 6 месяцев при температуре +25°C.8. Жидкая композиция по п.1, отличающаяся тем, что агонист ГПП-1 выбран из группы, состоящей из ГПП-1 и его аналогов и производных, эксендина-3 и его аналогов и производных, эксендина-4 и его аналогов и производных, причем агонист ГПП-1 предпочтительно выбран из группы, состоящей из desProэксендин-4(1-39)-Lys-NHи эксендина-4.9. Жидкая композиция по п.1, отличающаяся тем, что она содержит следующие компоненты:(a) desProэксендин-4(1-39)-Lys-NH,(b) ацетат натрия,(c) м-крезол,(d) L-метионин,(e) 85%-ый глицерин,(f) соляную кислоту примерно 0,1 н, если требуется установить pH примерно 4,5,(g) раствор NaOH примерно 0,1 н, если требуется установить pH примерно 4,5, и(h) воду.10. Композиция по п.1, отличающаяся тем, что она является композицией, годной для инъекций.11. Компози
Claims (26)
1. Жидкая композиция, содержащая агонист ГПП-1 или/и его фармакологически приемлемую соль и, необязательно, по меньшей мере один фармакологически приемлемый эксципиент, отличающаяся тем, что композиция содержит метионин.
2. Жидкая композиция по п.1, отличающаяся тем, что она содержит фармакологически приемлемый консервант, в частности, м-крезол.
3. Жидкая композиция по п.1 или 2, отличающаяся тем, что она содержит глицерин.
4. Жидкая композиция по п.1, отличающаяся тем, что она имеет pH в диапазоне от 3,5 до 5.
5. Жидкая композиция по п.1, отличающаяся тем, что она содержит метионин в количестве от 0,5 мг/мл до 20 мг/мл, предпочтительно от 1 мг/мл до 5 мг/мл.
6. Жидкая композиция по п.1, отличающаяся тем, что она проявляет химическую целостность после хранения в течение 6 месяцев при температуре +25°C.
7. Жидкая композиция по п.1, отличающаяся тем, что она проявляет физическую целостность после хранения в течение 6 месяцев при температуре +25°C.
8. Жидкая композиция по п.1, отличающаяся тем, что агонист ГПП-1 выбран из группы, состоящей из ГПП-1 и его аналогов и производных, эксендина-3 и его аналогов и производных, эксендина-4 и его аналогов и производных, причем агонист ГПП-1 предпочтительно выбран из группы, состоящей из desPro36эксендин-4(1-39)-Lys6-NH2 и эксендина-4.
9. Жидкая композиция по п.1, отличающаяся тем, что она содержит следующие компоненты:
(a) desPro36эксендин-4(1-39)-Lys6-NH2,
(b) ацетат натрия,
(c) м-крезол,
(d) L-метионин,
(e) 85%-ый глицерин,
(f) соляную кислоту примерно 0,1 н, если требуется установить pH примерно 4,5,
(g) раствор NaOH примерно 0,1 н, если требуется установить pH примерно 4,5, и
(h) воду.
10. Композиция по п.1, отличающаяся тем, что она является композицией, годной для инъекций.
11. Композиция по п.1 для лечения сахарного диабета.
12. Применение композиции по любому из пп.1-11 для получения лекарственного средства для лечения сахарного диабета, более конкретно, диабета второго типа.
13. Способ получения композиции по любому из пп.1-11, включающий соединение в одной лекарственной форме агониста ГПП-1 или/и его фармакологически приемлемой соли с метионином и, необязательно, по меньшей мере одним фармакологически приемлемым эксципиентом.
14. Способ лечения пациента композицией по любому из пп.1-11, включающий введение композиции пациенту.
15. Применение композиции по одному из предыдущих пп.1-11, отличающееся тем, что оно производится вместе с введением метморфина, сульфонилмочевины, глитазона и/или инсулина/производного инсулина длительного действия, и/или их комбинации, и/или фармакологически приемлемой соли.
16. Применение по п.15, отличающееся тем, что речь идет о дополнительном лечении пациентов, у которых достаточный контроль уровня сахара в крови не может быть достигнут метморфином, сульфонилмочевиной, глитазоном и/или инсулином/производным инсулина длительного действия.
17. Применение композиции по п.15 или 16, отличающееся тем, что получающие лечение пациенты имеют показатель HbA1c в диапазоне от 7% до 10%.
18. Применение композиции по пп.15 или 16 для лечения диабета II типа и/или ожирения.
19. Применение композиции по п.17 для лечения диабета II типа и/или ожирения.
20. Применение композиции по пп.1-11 для введения пациентам с диабетом II типа как дополнение к диете, чтобы улучшить контроль уровня сахара в крови.
21. Применение композиции по пп.1-11 для введения пациенту один раз в день.
22. Применение по п.12 для введения пациенту один раз в день.
23. Способ по п.13, где композицию вводят пациенту один раз в день.
24. Способ по п.14, где композицию вводят пациенту один раз в день.
25. Применение по п.15 для введения пациенту один раз в день.
26. Применение по п.16 для введения пациенту один раз в день.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009052832 | 2009-11-13 | ||
| DE102009052832.6 | 2009-11-13 | ||
| DE102010011919A DE102010011919A1 (de) | 2010-03-18 | 2010-03-18 | Pharmazeutische Zusammensetzung umfassend einen GLP-1-Agonisten und Methionin |
| DE102010011919.9 | 2010-03-18 | ||
| PCT/EP2010/067249 WO2011058082A1 (de) | 2009-11-13 | 2010-11-11 | Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten und methionin |
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| Publication Number | Publication Date |
|---|---|
| RU2012123739A true RU2012123739A (ru) | 2013-12-20 |
| RU2573995C2 RU2573995C2 (ru) | 2016-01-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2012123739/15A RU2573995C2 (ru) | 2009-11-13 | 2010-11-11 | Фармацевтическая композиция, содержащая агонист гпп-1 и метионин |
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| US (6) | US9707176B2 (ru) |
| EP (2) | EP2498801B1 (ru) |
| JP (1) | JP5973918B2 (ru) |
| KR (3) | KR101915454B1 (ru) |
| CN (1) | CN102711804B (ru) |
| AR (1) | AR078973A1 (ru) |
| AU (1) | AU2010317994B2 (ru) |
| BR (1) | BR112012011403B8 (ru) |
| CA (1) | CA2780043C (ru) |
| CL (1) | CL2012001233A1 (ru) |
| CO (1) | CO6541566A2 (ru) |
| CR (1) | CR20120242A (ru) |
| CY (1) | CY1120270T1 (ru) |
| DK (1) | DK2498801T3 (ru) |
| DO (1) | DOP2012000132A (ru) |
| EC (1) | ECSP12011889A (ru) |
| ES (2) | ES2667069T3 (ru) |
| HR (1) | HRP20180653T1 (ru) |
| HU (1) | HUE037735T2 (ru) |
| IL (1) | IL219722B (ru) |
| LT (1) | LT2498801T (ru) |
| MA (1) | MA33735B1 (ru) |
| MX (1) | MX2012005184A (ru) |
| MY (1) | MY159565A (ru) |
| NI (1) | NI201200086A (ru) |
| NZ (1) | NZ599847A (ru) |
| PE (1) | PE20121316A1 (ru) |
| PH (1) | PH12012500888A1 (ru) |
| PL (2) | PL3345593T3 (ru) |
| PT (2) | PT2498801T (ru) |
| RU (1) | RU2573995C2 (ru) |
| SG (1) | SG10201500871TA (ru) |
| SI (1) | SI2498801T1 (ru) |
| TN (1) | TN2012000215A1 (ru) |
| TW (1) | TWI468171B (ru) |
| UY (1) | UY33025A (ru) |
| WO (1) | WO2011058082A1 (ru) |
| ZA (1) | ZA201203035B (ru) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ586590A (en) | 2008-01-09 | 2012-06-29 | Sanofi Aventis Deutschland | Insulin analogues or derivatives having an extremely delayed time-action profile |
| LT2349324T (lt) | 2008-10-17 | 2017-12-27 | Sanofi-Aventis Deutschland Gmbh | Insulino ir glp-1 agonisto derinys |
| KR101853606B1 (ko) * | 2009-07-06 | 2018-05-03 | 사노피-아벤티스 도이칠란트 게엠베하 | 메티오닌을 함유하는 수성 인슐린 제제 |
| JP5832439B2 (ja) * | 2009-11-13 | 2015-12-16 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Ｇｌｐ−１アゴニスト、インスリン及びメチオニンを含む薬学的組成物 |
| CN102711804B (zh) | 2009-11-13 | 2015-09-16 | 赛诺菲-安万特德国有限公司 | 包含glp-1激动剂和甲硫氨酸的药物组合物 |
| AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
| CN103179978A (zh) | 2010-08-30 | 2013-06-26 | 赛诺菲-安万特德国有限公司 | Ave0010用于制造供治疗2型糖尿病用的药物的用途 |
| CN107375909A (zh) * | 2011-02-02 | 2017-11-24 | 赛诺菲-安万特德国有限公司 | 在2型糖尿病患者中预防低血糖症 |
| WO2012115208A1 (ja) * | 2011-02-24 | 2012-08-30 | 久光製薬株式会社 | マイクロニードルデバイス用ｇｌｐ－１アナログ組成物 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| WO2013030160A1 (en) | 2011-08-29 | 2013-03-07 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| AR092862A1 (es) * | 2012-07-25 | 2015-05-06 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| SG10201705097PA (en) | 2012-12-21 | 2017-07-28 | Sanofi Sa | Functionalized exendin-4 derivatives |
| CN103893744B (zh) * | 2012-12-24 | 2017-12-19 | 杭州九源基因工程有限公司 | 一种治疗糖尿病的药物制剂及其制备方法 |
| TWI641381B (zh) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物 |
| SG11201506888VA (en) | 2013-04-03 | 2015-09-29 | Sanofi Sa | Treatment of diabetes mellitus by long-acting formulations of insulins |
| TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／升糖素受體促效劑 |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| US9895424B2 (en) | 2014-01-09 | 2018-02-20 | Sanofi | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| EP3091995B1 (en) | 2014-01-09 | 2024-03-20 | Sanofi | Stabilized pharmaceutical formulations of insulin aspart |
| JP6735674B2 (ja) | 2014-01-09 | 2020-08-05 | サノフイＳａｎｏｆｉ | インスリンアスパルトの安定化された医薬製剤 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| MA41138B1 (fr) | 2014-12-12 | 2023-07-31 | Sanofi Aventis Deutschland | Formulation à rapport fixe d'insuline glargine/lixisenatide |
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| EP3922269A1 (en) * | 2016-03-16 | 2021-12-15 | Prolynx LLC | Extended release conjugates of exenatide analogs |
| TW201821434A (zh) | 2016-10-10 | 2018-06-16 | 法商賽諾菲公司 | 製備包含親脂性修飾的離胺酸側鏈的肽的方法 |
| US20190374613A1 (en) * | 2016-11-22 | 2019-12-12 | Biocon Research Limited | Pharmaceutical compositions of glp-1 analogues |
| AR110299A1 (es) | 2016-12-02 | 2019-03-13 | Sanofi Sa | Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico |
| ES3027617T3 (en) | 2017-12-21 | 2025-06-16 | Sanofi Sa | Liquid pharmaceutical composition |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| US11471512B2 (en) * | 2019-03-01 | 2022-10-18 | Merck Sharp & Dohme Llc | Pharmaceutical compositions of a peptide |
| EP3946460A4 (en) | 2019-04-05 | 2023-03-29 | Prolynx LLC | IMPROVED CONJUGATIONAL LINKERS |
| WO2020208541A1 (en) * | 2019-04-08 | 2020-10-15 | Enzene Biosciences Limited | Composition comprising glp-1 analogue |
| CA3152838A1 (en) * | 2019-08-30 | 2021-03-04 | Kashiv Biosciences, Llc | Novel formulation of highly concentrated pharmacologically active antibody |
| WO2021220251A1 (en) | 2020-05-01 | 2021-11-04 | Kashiv Biosciences, Llc | An improved process of purification of protein |
Family Cites Families (413)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB835638A (en) | 1956-12-01 | 1960-05-25 | Novo Terapeutisk Labor As | Insulin crystal suspensions having a protracted effect |
| GB840870A (en) | 1957-08-03 | 1960-07-13 | Novo Terapeutisk Labor As | Improvements in or relating to insulin preparations |
| US3758683A (en) | 1971-04-30 | 1973-09-11 | R Jackson | Insulin product |
| US3868358A (en) | 1971-04-30 | 1975-02-25 | Lilly Co Eli | Protamine-insulin product |
| US3984696A (en) | 1974-12-11 | 1976-10-05 | Medi-Ray, Inc. | Radiation guard for X-ray table |
| GB1554157A (en) | 1975-06-13 | 1979-10-17 | Takeda Chemical Industries Ltd | Stable insulin preparation for intra nasal administration |
| US4153689A (en) | 1975-06-13 | 1979-05-08 | Takeda Chemical Industries, Ltd. | Stable insulin preparation for nasal administration |
| GB1527605A (en) | 1975-08-20 | 1978-10-04 | Takeda Chemical Industries Ltd | Insulin preparation for intranasal administration |
| US4165370A (en) | 1976-05-21 | 1979-08-21 | Coval M L | Injectable gamma globulin |
| JPS6033474B2 (ja) | 1978-05-11 | 1985-08-02 | 藤沢薬品工業株式会社 | 新規なヒアルロニダ−ゼｂｍｐ−８２３１およびその製造法 |
| US4783441A (en) | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
| DE3064888D1 (en) | 1979-04-30 | 1983-10-27 | Hoechst Ag | Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization |
| JPS55153712A (en) | 1979-05-18 | 1980-11-29 | Kao Corp | Insulin pharmaceutical preparation and its production |
| DE3033127A1 (de) | 1980-09-03 | 1982-04-08 | Hoechst Ag, 6000 Frankfurt | Neue analoga des insulins |
| US4367737A (en) | 1981-04-06 | 1983-01-11 | George Kozam | Multiple barrel syringe |
| EP0083619A1 (en) | 1981-07-17 | 1983-07-20 | Nordisk Insulinlaboratorium | A stable aqueous, therapeutic insulin preparation and a process for preparing it |
| NL193099C (nl) | 1981-10-30 | 1998-11-03 | Novo Industri As | Gestabiliseerde insuline-oplossing. |
| DE3316363A1 (de) | 1983-05-05 | 1984-11-08 | Deutsche Babcock Anlagen Ag, 4200 Oberhausen | Walzenrost fuer muellverbrennungsanlagen |
| DE3326473A1 (de) | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
| DE3326472A1 (de) | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
| DE3327709A1 (de) | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
| DE3333640A1 (de) | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung |
| DE3345434A1 (de) | 1983-12-15 | 1985-06-27 | Siemens AG, 1000 Berlin und 8000 München | Roentgenuntersuchungstisch |
| CA1244347A (en) | 1984-05-29 | 1988-11-08 | Eddie H. Massey | Stabilized insulin formulations |
| US4839341A (en) | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
| EP0166971B1 (de) | 1984-06-09 | 1990-02-28 | Hoechst Aktiengesellschaft | Insulinzubereitungen, Verfahren zu deren Herstellung und deren Verwendung |
| DE3440988A1 (de) | 1984-11-09 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung |
| DK113585D0 (da) | 1985-03-12 | 1985-03-12 | Novo Industri As | Nye peptider |
| DK347086D0 (da) | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
| US5008241A (en) | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| CA1274774A (en) | 1985-04-15 | 1990-10-02 | Kenneth S. Su | Method for administering insulin |
| US4689042A (en) | 1985-05-20 | 1987-08-25 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
| DE3526995A1 (de) | 1985-07-27 | 1987-02-05 | Hoechst Ag | Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung |
| US4837316A (en) | 1985-08-29 | 1989-06-06 | Fujirebio Kabushiki Kaisha | Alkylamide derivatives with H2 -receptor antagonistic and cytoprotective action |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US4960702A (en) | 1985-09-06 | 1990-10-02 | Codon | Methods for recovery of tissue plasminogen activator |
| DE3636903A1 (de) | 1985-12-21 | 1987-07-02 | Hoechst Ag | Fusionsproteine mit eukaryotischem ballastanteil |
| US5496924A (en) | 1985-11-27 | 1996-03-05 | Hoechst Aktiengesellschaft | Fusion protein comprising an interleukin-2 fragment ballast portion |
| DE3541856A1 (de) | 1985-11-27 | 1987-06-04 | Hoechst Ag | Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens |
| CA1275922C (en) | 1985-11-28 | 1990-11-06 | Harunobu Amagase | Treatment of cancer |
| DE3544295A1 (de) | 1985-12-14 | 1987-06-19 | Bayer Ag | Thermoplastische formmassen mit hoher kriechstromfestigkeit |
| US5614492A (en) | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
| PH23446A (en) | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
| PT86819B (pt) | 1987-02-25 | 1992-05-29 | Novo Industri As | Processo para a preparacao de novos derivados da insulina e de composicoes farmaceuticas que os contem |
| US5034415A (en) | 1987-08-07 | 1991-07-23 | Century Laboratories, Inc. | Treatment of diabetes mellitus |
| DE3726655A1 (de) | 1987-08-11 | 1989-02-23 | Hoechst Ag | Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten |
| DK257988D0 (da) | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
| US6875589B1 (en) | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
| DE3827533A1 (de) | 1988-08-13 | 1990-02-15 | Hoechst Ag | Pharmazeutische zubereitung zur behandlung des diabetes mellitus |
| US4923162A (en) | 1988-09-19 | 1990-05-08 | Fleming Matthew C | Radiation shield swivel mount |
| DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| US5225323A (en) | 1988-11-21 | 1993-07-06 | Baylor College Of Medicine | Human high-affinity neurotransmitter uptake system |
| KR910700262A (ko) | 1988-12-23 | 1991-03-14 | 안네 제케르 | 사람 인슐린 유사체 |
| US4994439A (en) | 1989-01-19 | 1991-02-19 | California Biotechnology Inc. | Transmembrane formulations for drug administration |
| NZ232375A (en) | 1989-02-09 | 1992-04-28 | Lilly Co Eli | Insulin analogues modified at b29 |
| US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| DK134189D0 (da) | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
| ES2084698T5 (es) | 1989-05-04 | 2005-03-01 | Southern Research Institute | Procedimiento de encapsulacion. |
| US5006718A (en) | 1989-07-21 | 1991-04-09 | Lenhart Mark J | X-ray shield for X-ray examination table |
| US5358857A (en) | 1989-08-29 | 1994-10-25 | The General Hospital Corp. | Method of preparing fusion proteins |
| IL95495A (en) | 1989-08-29 | 1996-10-16 | Hoechst Ag | Fusion proteins their preparation and use |
| US5227293A (en) | 1989-08-29 | 1993-07-13 | The General Hospital Corporation | Fusion proteins, their preparation and use |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| CN1020944C (zh) | 1990-01-30 | 1993-05-26 | 阿图尔-费希尔股份公司费希尔厂 | 紧固件 |
| US5397771A (en) | 1990-05-10 | 1995-03-14 | Bechgaard International Research And Development A/S | Pharmaceutical preparation |
| JP3219096B2 (ja) | 1990-05-10 | 2001-10-15 | ニコメド ファーマ エイエス | ｎ―グリコフロール類及びｎ―エチレングリコール類を含有する医薬製剤 |
| DK155690D0 (da) | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
| DK10191D0 (da) | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
| US5272135A (en) * | 1991-03-01 | 1993-12-21 | Chiron Ophthalmics, Inc. | Method for the stabilization of methionine-containing polypeptides |
| CA2038597A1 (en) | 1991-03-19 | 1992-09-20 | Jose P. Garzaran | A method and a pharmaceutical preparation for treating pain |
| US6468959B1 (en) | 1991-12-05 | 2002-10-22 | Alfatec-Pharm Gmbh | Peroral dosage form for peptide containing medicaments, in particular insulin |
| US5614219A (en) | 1991-12-05 | 1997-03-25 | Alfatec-Pharma Gmbh | Oral administration form for peptide pharmaceutical substances, in particular insulin |
| CH682806A5 (de) | 1992-02-21 | 1993-11-30 | Medimpex Ets | Injektionsgerät. |
| CH682805A5 (de) | 1992-02-24 | 1993-11-30 | Medimpex Ets | Anzeigeeinrichtung für ein Injektionsgerät. |
| DK36392D0 (da) | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Anvendelse af kemisk forbindelse |
| US5846747A (en) | 1992-03-25 | 1998-12-08 | Novo Nordisk A/S | Method for detecting glucagon-like peptide-1 antagonists and agonists |
| DK39892D0 (da) | 1992-03-25 | 1992-03-25 | Bernard Thorens | Peptid |
| US5253785A (en) | 1992-04-02 | 1993-10-19 | Habley Medical Technology Corp. | Variable proportion dispenser |
| EP0600372B1 (de) | 1992-12-02 | 1997-02-05 | Hoechst Aktiengesellschaft | Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken |
| FI953001A0 (fi) | 1992-12-18 | 1995-06-16 | Lilly Co Eli | Insuliinianalogeja |
| US5358708A (en) | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
| US5478323A (en) | 1993-04-02 | 1995-12-26 | Eli Lilly And Company | Manifold for injection apparatus |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| WO1995000550A1 (en) | 1993-06-21 | 1995-01-05 | Novo Nordisk A/S | Aspb28 insulin crystals |
| US5506203C1 (en) | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
| WO1996007399A1 (en) | 1994-09-09 | 1996-03-14 | Takeda Chemical Industries, Ltd. | Sustained release preparation containing metal salt of a peptide |
| US5534488A (en) | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
| EP0729353B2 (en) | 1993-11-19 | 2012-09-12 | Alkermes, Inc. | Preparation of biodegradable microparticles containing a biologically active agent |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| IT1265271B1 (it) | 1993-12-14 | 1996-10-31 | Alcatel Italia | Sistema di predistorsione in banda base per la linearizzazione adattativa di amplificatori di potenza |
| US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| DE4405179A1 (de) | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
| DE4405388A1 (de) | 1994-02-19 | 1995-08-24 | Hoechst Ag | Verfahren zur Herstellung von Polyalkyl-1-oxa-diazaspirodecan-Verbindungen |
| KR100419037B1 (ko) | 1994-03-07 | 2004-06-12 | 넥타르 테라퓨틱스 | 폐를통한인슐린의전달방법및그조성물 |
| US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5559094A (en) | 1994-08-02 | 1996-09-24 | Eli Lilly And Company | AspB1 insulin analogs |
| US5879584A (en) | 1994-09-10 | 1999-03-09 | The Procter & Gamble Company | Process for manufacturing aqueous compositions comprising peracids |
| US5547929A (en) | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
| US5766582A (en) | 1994-10-11 | 1998-06-16 | Schering Corporation | Stable, aqueous alfa interferon solution formulations |
| US5707641A (en) | 1994-10-13 | 1998-01-13 | Pharmaderm Research & Development Ltd. | Formulations comprising therapeutically-active proteins or polypeptides |
| AR002976A1 (es) | 1995-03-31 | 1998-05-27 | Lilly Co Eli | Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas |
| US5990077A (en) | 1995-04-14 | 1999-11-23 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
| CA2223272A1 (en) | 1995-05-05 | 1996-11-07 | Ronald Eugene Chance | Single chain insulin with high bioactivity |
| US5824638A (en) | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
| US6143718A (en) | 1995-06-07 | 2000-11-07 | Amylin Pharmaceuticals, Inc. | Treatment of Type II diabetes mellutis with amylin agonists |
| WO1996041606A2 (en) | 1995-06-08 | 1996-12-27 | Therexsys Limited | Improved pharmaceutical compositions for gene therapy |
| CA2224381A1 (en) | 1995-06-27 | 1997-01-16 | Takeda Chemical Industries, Ltd. | Method of producing sustained-release preparation |
| JPH11292787A (ja) | 1995-08-15 | 1999-10-26 | Asahi Chem Ind Co Ltd | 生理活性ペプチドを含有する経粘膜投与製剤 |
| DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| DE19637230A1 (de) | 1996-09-13 | 1998-03-19 | Boehringer Mannheim Gmbh | Exendin-Analoga, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| DK0915910T3 (da) | 1996-06-05 | 2006-05-22 | Roche Diagnostics Gmbh | Exendin-analoger, fremgangsmåder til fremstilling deraf samt lægemidlter der indeholder disse |
| US5948751A (en) | 1996-06-20 | 1999-09-07 | Novo Nordisk A/S | X14-mannitol |
| JP4472027B2 (ja) | 1996-06-20 | 2010-06-02 | ノボ ノルディスク アクティーゼルスカブ | 炭水化物含有インスリン製剤 |
| UA49890C2 (ru) | 1996-06-20 | 2002-10-15 | Ново Нордіск А/С | Водная инсулиновая композиция, парентеральная фармацевтическая композиция и способ повышения химической стабильности инсулиновой композиции |
| US6110703A (en) | 1996-07-05 | 2000-08-29 | Novo Nordisk A/S | Method for the production of polypeptides |
| WO1998005351A1 (en) | 1996-08-08 | 1998-02-12 | Amylin Pharmaceuticals, Inc. | Methods for regulating gastrointestinal motility |
| AU752411B2 (en) | 1996-08-13 | 2002-09-19 | Genentech Inc. | Formulation |
| US5783556A (en) | 1996-08-13 | 1998-07-21 | Genentech, Inc. | Formulated insulin-containing composition |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6277819B1 (en) | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
| ES2283025T3 (es) | 1996-08-30 | 2007-10-16 | Novo Nordisk A/S | Derivados de glp-1.1. |
| US6006753A (en) | 1996-08-30 | 1999-12-28 | Eli Lilly And Company | Use of GLP-1 or analogs to abolish catabolic changes after surgery |
| UA65549C2 (ru) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Применение аналогов и производных glp-1 для периферического введения для борьбы с ожирением |
| DE69831673C5 (de) | 1997-01-07 | 2015-01-22 | Amylin Pharmaceuticals, Llc | Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme |
| US6410511B2 (en) | 1997-01-08 | 2002-06-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| US7312196B2 (en) | 1997-01-08 | 2007-12-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| JP2001512307A (ja) | 1997-02-05 | 2001-08-21 | １１４９３３６ オンタリオ インコーポレーテッド | プロエキセンジンをコードするポリヌクレオチドならびにその作製方法および使用 |
| US5846937A (en) | 1997-03-03 | 1998-12-08 | 1149336 Ontario Inc. | Method of using exendin and GLP-1 to affect the central nervous system |
| DE69834028T2 (de) | 1997-03-20 | 2006-12-07 | Novo Nordisk A/S | Zinkfreie insulinkristalle für die verwendung in medikamenten, die über die lunge verabreicht werden. |
| US6310038B1 (en) | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
| US6043214A (en) | 1997-03-20 | 2000-03-28 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
| JP3919235B2 (ja) | 1997-06-13 | 2007-05-23 | ジェネンテク，インコーポレイテッド | 抗体製剤 |
| CO4750643A1 (es) | 1997-06-13 | 1999-03-31 | Lilly Co Eli | Formulacion estable de la insulina que contiene l-arginina y protamina |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| CA2299425A1 (en) | 1997-08-08 | 1999-02-18 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
| DE19735711C2 (de) | 1997-08-18 | 2001-04-26 | Aventis Pharma Gmbh | Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken |
| US6444641B1 (en) | 1997-10-24 | 2002-09-03 | Eli Lilly Company | Fatty acid-acylated insulin analogs |
| BR9813111A (pt) | 1997-10-24 | 2000-08-15 | Lilly Co Eli | Composições de insulina insolúveis |
| ZA989744B (en) | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
| JP2001522815A (ja) | 1997-11-12 | 2001-11-20 | アルザ コーポレイション | ポリペプチド類の自己会合を減少させる方法 |
| CA2309356C (en) | 1997-11-14 | 2010-09-21 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
| EP1066314B1 (en) | 1997-11-14 | 2007-12-26 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
| EP1049486A4 (en) | 1997-12-05 | 2006-01-04 | Lilly Co Eli | GLP-1 FORMULATIONS |
| US5981964A (en) | 1997-12-22 | 1999-11-09 | Bruce J. McAuley | Adjustable X-ray shield and on-line dosimetry system using same |
| EP1044016B1 (en) | 1998-01-09 | 2005-03-16 | Novo Nordisk A/S | Stabilised insulin compositions |
| CA2320371C (en) | 1998-02-13 | 2012-01-17 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and glp-1 |
| KR20010041238A (ko) | 1998-02-23 | 2001-05-15 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 인슐린의 펩티드 동족체를 사용하는 당뇨병의 치료 방법 |
| WO1999043708A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| CA2321026A1 (en) | 1998-03-09 | 1999-09-16 | Zealand Pharmaceuticals A/S | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| DE69918070T2 (de) | 1998-03-13 | 2005-08-25 | Novo Nordisk A/S | Stabilisierte, wässrige Glukagonlösungen, enthaltend Detergenzien |
| WO1999062558A1 (en) | 1998-06-05 | 1999-12-09 | Technion Research And Development Foundation Ltd. | Insulin supplemented infant formula |
| WO2000020592A1 (en) | 1998-10-07 | 2000-04-13 | Medical College Of Georgia Research Institute, Inc. | Glucose-dependent insulinotropic peptide for use as an osteotropic hormone |
| US6284725B1 (en) | 1998-10-08 | 2001-09-04 | Bionebraska, Inc. | Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue |
| ES2177323T3 (es) | 1998-10-16 | 2002-12-01 | Novo Nordisk As | Preparaciones de insulina concentradas estables para la administracionpor via pulmonar. |
| BR9914568A (pt) | 1998-10-16 | 2001-07-03 | Novo Nordisk As | Formulação aquosa de insulina, preparação de insulina e método de tratamento de diabetes do tipo i ou do tipo ii |
| US6211144B1 (en) | 1998-10-16 | 2001-04-03 | Novo Nordisk A/S | Stable concentrated insulin preparations for pulmonary delivery |
| US6489292B1 (en) | 1998-11-18 | 2002-12-03 | Novo Nordisk A/S | Stable aqueous insulin preparations without phenol and cresol |
| EP1131089B1 (en) | 1998-11-18 | 2004-02-18 | Novo Nordisk A/S | Stable aqueous insulin preparations without phenol and cresol |
| BRPI0007820B8 (pt) | 1999-01-14 | 2021-05-25 | Amylin Pharmaceuticals Llc | formulações farmacêuticas agonistas de exendina e seus usos |
| DE19908041A1 (de) | 1999-02-24 | 2000-08-31 | Hoecker Hartwig | Kovalent verbrückte Insulindimere |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| JP2000247903A (ja) | 1999-03-01 | 2000-09-12 | Chugai Pharmaceut Co Ltd | 長期安定化製剤 |
| JP2007204498A (ja) | 1999-03-01 | 2007-08-16 | Chugai Pharmaceut Co Ltd | 長期安定化製剤 |
| US6227819B1 (en) | 1999-03-29 | 2001-05-08 | Walbro Corporation | Fuel pumping assembly |
| US6271241B1 (en) | 1999-04-02 | 2001-08-07 | Neurogen Corporation | Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors |
| CN1372570A (zh) | 1999-04-30 | 2002-10-02 | 安米林药品公司 | 修饰的exendin和exendin激动剂 |
| CN1191273C (zh) | 1999-05-17 | 2005-03-02 | 康久化学公司 | 长效促胰岛肽 |
| US6485706B1 (en) | 1999-06-04 | 2002-11-26 | Delrx Pharmaceutical Corp. | Formulations comprising dehydrated particles of pharma-ceutical agents and process for preparing the same |
| US6344180B1 (en) | 1999-06-15 | 2002-02-05 | Bionebraska, Inc. | GLP-1 as a diagnostic test to determine β-cell function and the presence of the condition of IGT and type II diabetes |
| JP2003503356A (ja) | 1999-06-25 | 2003-01-28 | メドトロニック ミニメド インコーポレイテッド | 多剤糖尿病治療 |
| US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| DE19930631A1 (de) | 1999-07-02 | 2001-01-11 | Clemens Micheler | Spritzvorrichtung zur Injektion mindestens zweier flüssiger Therapeutika, insbesondere Insuline |
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| US6528486B1 (en) * | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| CA2383233C (en) | 1999-09-21 | 2010-06-08 | Rtp Pharma Inc. | Surface modified particulate compositions of biologically active substances |
| DE19947456A1 (de) | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga |
| IL149008A0 (en) | 1999-10-04 | 2002-11-10 | Chiron Corp | Stabilized liquid polypeptide-containing pharmaceutical compositions |
| WO2001024826A2 (en) | 1999-10-06 | 2001-04-12 | The Brigham And Women's Hospital, Inc. | Inrease of enos activity through activation of the pi3-kinase/akt pathway by estrogens |
| US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| IL149139A0 (en) | 1999-11-03 | 2002-11-10 | Bristol Myers Squibb Co | Pharmaceutical compositions containing metformin and glyburide |
| EP1523993A1 (en) | 1999-12-16 | 2005-04-20 | Eli Lilly & Company | Polypeptide compositions with improved stability |
| US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
| CN1409640A (zh) | 1999-12-16 | 2003-04-09 | 伊莱利利公司 | 稳定性改善的多肽组合物 |
| US20010012829A1 (en) * | 2000-01-11 | 2001-08-09 | Keith Anderson | Transepithelial delivery GLP-1 derivatives |
| AU2353701A (en) * | 2000-01-11 | 2001-07-24 | Novo Nordisk A/S | Transepithelial delivery of glp-1 derivatives |
| US6734162B2 (en) | 2000-01-24 | 2004-05-11 | Minimed Inc. | Mixed buffer system for stabilizing polypeptide formulations |
| US6395767B2 (en) * | 2000-03-10 | 2002-05-28 | Bristol-Myers Squibb Company | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method |
| JP3540240B2 (ja) | 2000-03-10 | 2004-07-07 | 株式会社栗本鐵工所 | 混合・混練羽根の検査用治具 |
| AU2001264789A1 (en) | 2000-06-08 | 2001-12-17 | Eli Lilly And Company | Protein powder for pulmonary delivery |
| US6689353B1 (en) * | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
| AU2001280436A1 (en) | 2000-07-12 | 2002-01-21 | Eli Lilly And Company | Process to increase protein stability |
| MY129760A (en) | 2000-08-14 | 2007-04-30 | Prysmian Kabel Und Systeme Gmbh | Water monitoring system and water monitoring method for high voltage cables |
| DK1326630T3 (da) | 2000-09-18 | 2008-09-15 | Sanos Bioscience As | Anvendelse af GLP-2-peptider |
| KR100508695B1 (ko) | 2001-02-13 | 2005-08-17 | 한국과학기술연구원 | 인슐린의 경구투여용 제형과 그의 제조방법 |
| US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
| DE10108100A1 (de) | 2001-02-20 | 2002-08-29 | Aventis Pharma Gmbh | Verwendung supersekretierbarer Peptide in Verfahren zu deren Herstellung und paralleler Verbesserung der Exportate eines oder mehrerer anderer Polypeptide von Interesse |
| DE10108212A1 (de) | 2001-02-20 | 2002-08-22 | Aventis Pharma Gmbh | Fusionsprotein zur Sekretion von Wertprotein in bakterielle Überstände |
| DE10108211A1 (de) | 2001-02-20 | 2002-08-22 | Aventis Pharma Gmbh | Verwendung von Fusionsproteinen, deren N-terminaler Anteil aus einem Hirudinderivat besteht, zur Herstellung rekombinanter Proteine über Sekretion durch Hefen |
| AU2002248464A1 (en) * | 2001-02-21 | 2002-09-12 | Medtronic Minimed, Inc. | Stabilized insulin formulations |
| WO2002067868A2 (en) | 2001-02-26 | 2002-09-06 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of metabolic disorders, including obesity and diabetes |
| DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| DE60233722D1 (de) | 2001-04-02 | 2009-10-29 | Novo Nordisk As | Insulinvorstufen und verfahren zu deren herstellung |
| CN1160122C (zh) | 2001-04-20 | 2004-08-04 | 清华大学 | 一种制备口服胰岛素油相制剂的方法 |
| US20030026872A1 (en) | 2001-05-11 | 2003-02-06 | The Procter & Gamble Co. | Compositions having enhanced aqueous solubility and methods of their preparation |
| US6737401B2 (en) | 2001-06-28 | 2004-05-18 | Metronic Minimed, Inc. | Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom |
| US7156877B2 (en) | 2001-06-29 | 2007-01-02 | The Regents Of The University Of California | Biodegradable/bioactive nucleus pulposus implant and method for treating degenerated intervertebral discs |
| FR2827604B1 (fr) | 2001-07-17 | 2003-09-19 | Sanofi Synthelabo | Nouveaux derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2- one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
| JP2005501058A (ja) | 2001-07-31 | 2005-01-13 | ザ ガバメント オブ ザ ユナイテッドステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ ザ ナショナル インステ | Ｇｌｐ−１、ｅｘｅｎｄｉｎ−４、そのペプチド・アナログ及びその使用 |
| EP1432430A4 (en) | 2001-08-28 | 2006-05-10 | Lilly Co Eli | PREMIXTURES OF GLP-1 AND BASALINSULIN |
| US6911324B2 (en) | 2001-10-18 | 2005-06-28 | The Regents Of The University Of California | Induction of beta cell differentiation in human cells |
| AU2002335046A1 (en) | 2001-10-19 | 2003-05-06 | Inhale Therapeutic Systems, Inc. | The use of proton sequestering agents in drug formulations |
| JP2005508360A (ja) | 2001-10-19 | 2005-03-31 | イーライ・リリー・アンド・カンパニー | Ｇｌｐ−１およびインスリンの二相混合物 |
| WO2003035028A1 (en) | 2001-10-19 | 2003-05-01 | Nektar Therapeutics | Modulating charge density to produce improvements in the characteristics of spray-dried proteins |
| CA2464616C (en) | 2001-11-19 | 2012-07-24 | Are Bogsnes | Process for preparing insulin compounds |
| WO2003053363A2 (en) | 2001-12-19 | 2003-07-03 | Millennium Pharmaceuticals, Inc. | Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor |
| BR0215029A (pt) | 2001-12-20 | 2005-12-20 | Lilly Co Eli | Molécula de insulina, uso da mesma, composição, uso desta, microcristal, processo para prepará-lo, uso deste, e, métodos para preparar uma molécula de insulina, para tratar hiperglicemia, e para tratar diabetes mellitus |
| CN1607958A (zh) | 2001-12-21 | 2005-04-20 | 诺和诺德医疗保健公司 | 因子ⅶ多肽的液体组合物 |
| US8058233B2 (en) | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
| AU2003203146A1 (en) | 2002-02-07 | 2003-09-02 | Novo Nordisk A/S | Use of glp-1 compound for treatment of critically ill patients |
| US20100069293A1 (en) | 2002-02-27 | 2010-03-18 | Pharmain Corporation | Polymeric carrier compositions for delivery of active agents, methods of making and using the same |
| TWI351278B (en) | 2002-03-01 | 2011-11-01 | Nisshin Pharma Inc | Agent for preventing and treating of liver disease |
| ATE496064T1 (de) | 2002-05-07 | 2011-02-15 | Novo Nordisk As | Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten |
| WO2003094951A1 (en) | 2002-05-07 | 2003-11-20 | Novo Nordisk A/S | Soluble formulations comprising insulin aspart and insulin detemir |
| WO2003097812A2 (en) | 2002-05-17 | 2003-11-27 | Hematech, Llc | Transgenic ungulates capable of human antibody production |
| US7115563B2 (en) | 2002-05-29 | 2006-10-03 | Insignion Holding Limited | Composition and its therapeutic use |
| US20040022792A1 (en) | 2002-06-17 | 2004-02-05 | Ralph Klinke | Method of stabilizing proteins at low pH |
| DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| MXPA04012497A (es) | 2002-07-04 | 2005-07-14 | Zealand Pharma As | Glp-1 y metodos para tratar la diabetes. |
| DE10235168A1 (de) | 2002-08-01 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Verfahren zur Reinigung von Preproinsulin |
| MXPA05003346A (es) | 2002-09-27 | 2005-11-23 | Martek Biosciences Corp | Control glicemico mejorado para prediabetes y/o diabetes tipo ii utilizando acido docosahexaenoico. |
| WO2004035623A2 (en) | 2002-10-02 | 2004-04-29 | Zealand Pharma A/S | Stabilized exendin-4 compounds |
| DK1583541T3 (da) | 2002-11-20 | 2011-04-11 | Neuronova Ab | Forbindelser og fremgangsmåder til at øge neurogenese |
| US6969702B2 (en) | 2002-11-20 | 2005-11-29 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| US20050209142A1 (en) | 2002-11-20 | 2005-09-22 | Goran Bertilsson | Compounds and methods for increasing neurogenesis |
| CN1413582A (zh) | 2002-11-29 | 2003-04-30 | 贵州圣济堂制药有限公司 | 盐酸二甲双胍肠溶片及其制备方法 |
| EP1569682A2 (en) | 2002-12-03 | 2005-09-07 | Novo Nordisk A/S | Combination treatment using exendin-4 and thiazolidinediones |
| GB0309154D0 (en) | 2003-01-14 | 2003-05-28 | Aventis Pharma Inc | Use of insulin glargine to reduce or prevent cardiovascular events in patients being treated for dysglycemia |
| GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| EA200501422A1 (ru) | 2003-03-04 | 2006-04-28 | Дзе Текнолоджи Девелопмент Компани Лтд. | Длительнодействующая инъецируемая композиция инсулина и способы её изготовления и применения |
| JP2007523842A (ja) | 2003-03-11 | 2007-08-23 | ノボ ノルディスク アクティーゼルスカブ | 酸安定化されたインスリンを含有する薬学的製剤 |
| US20040186046A1 (en) | 2003-03-17 | 2004-09-23 | Pfizer Inc | Treatment of type 1 diabetes with PDE5 inhibitors |
| AU2004234345A1 (en) | 2003-04-29 | 2004-11-11 | Eli Lilly And Company | Insulin analogs having protracted time action |
| KR101293507B1 (ko) | 2003-06-03 | 2013-08-06 | 노보 노르디스크 에이/에스 | 안정화된 약학적 펩티드 조성물 |
| DE10325567B4 (de) | 2003-06-05 | 2008-03-13 | Mavig Gmbh | Strahlenschutzanordnung mit separierbarer Umhüllung |
| CA2542372A1 (en) | 2003-08-29 | 2005-03-10 | Centocor, Inc. | Method of promoting graft survival with anti-tissue factor antibodies |
| JP5518282B2 (ja) | 2003-09-01 | 2014-06-11 | ノヴォ ノルディスク アー／エス | 安定なペプチドの製剤 |
| WO2005023291A2 (en) | 2003-09-11 | 2005-03-17 | Novo Nordisk A/S | Use of glp1-agonists in the treatment of patients with type i diabetes |
| WO2005028516A2 (en) * | 2003-09-19 | 2005-03-31 | Novo Nordisk A/S | Albumin-binding derivatives of therapeutic peptides |
| WO2005046716A1 (en) | 2003-11-13 | 2005-05-26 | Novo Nordisk A/S | Soluble pharmaceutical compositions for parenteral administration comprising a glp-1 peptide and a insulin peptide of short time action for treatment of diabetes and bulimia |
| US20060287221A1 (en) | 2003-11-13 | 2006-12-21 | Novo Nordisk A/S | Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia |
| WO2005048950A2 (en) | 2003-11-17 | 2005-06-02 | Biomune, Inc. | Tumor and infectious disease therapeutic compositions |
| JP2007515235A (ja) | 2003-12-22 | 2007-06-14 | ノボ・ノルデイスク・エー／エス | 医薬液を保存するための、透明で、可撓性且つ不浸透性のプラスチック製容器 |
| US20060210614A1 (en) | 2003-12-26 | 2006-09-21 | Nastech Pharmaceutical Company Inc. | Method of treatment of a metabolic disease using intranasal administration of exendin peptide |
| US7192919B2 (en) | 2004-01-07 | 2007-03-20 | Stelios Tzannis | Sustained release compositions for delivery of pharmaceutical proteins |
| US20070027063A1 (en) | 2004-01-12 | 2007-02-01 | Mannkind Corporation | Method of preserving the function of insulin-producing cells |
| US20080248999A1 (en) | 2007-04-04 | 2008-10-09 | Biodel Inc. | Amylin formulations |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| WO2005097175A2 (en) | 2004-03-31 | 2005-10-20 | Centocor, Inc. | Human glp-1 mimetibodies, compositions, methods and uses |
| CA2566873C (en) | 2004-05-20 | 2013-02-12 | Diamedica Inc. | Use of drug combinations for treating insulin resistance |
| US7858082B2 (en) | 2004-06-01 | 2010-12-28 | Ares Trading S.A. | Method of stabilizing proteins |
| BRPI0512535A (pt) | 2004-06-24 | 2008-03-25 | Incyte Corp | compostos de piperidinas n-substituìdas, suas composições e métodos de modulações |
| US20090042781A1 (en) | 2004-06-28 | 2009-02-12 | Novo Nordisk A/S | Methods for Treating Diabetes |
| WO2006091231A2 (en) | 2004-07-21 | 2006-08-31 | Ambrx, Inc. | Biosynthetic polypeptides utilizing non-naturally encoded amino acids |
| EP1778839B1 (en) | 2004-08-13 | 2008-07-09 | Roche Diagniostics GMBH | C-terminal modification of polypeptides |
| DE102004043153B4 (de) | 2004-09-03 | 2013-11-21 | Philipps-Universität Marburg | Erfindung betreffend GLP-1 und Exendin |
| US20060073213A1 (en) | 2004-09-15 | 2006-04-06 | Hotamisligil Gokhan S | Reducing ER stress in the treatment of obesity and diabetes |
| EP1791554A2 (en) | 2004-09-17 | 2007-06-06 | Novo Nordisk A/S | Pharmaceutical compositions containing insulin and insulinotropic peptide |
| JP2006137678A (ja) | 2004-11-10 | 2006-06-01 | Shionogi & Co Ltd | インターロイキン−２組成物 |
| EP1814581B1 (en) | 2004-11-12 | 2016-03-16 | Novo Nordisk A/S | Stable formulations of peptides comprising an acylated glp-1 analogue and a basal insuline |
| ES2735533T3 (es) | 2004-11-12 | 2019-12-19 | Novo Nordisk As | Formulaciones estables de GLP-1 |
| DE102004058306A1 (de) | 2004-12-01 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Carboxy-terminal amidierten Peptiden |
| SE0402976L (sv) | 2004-12-03 | 2006-06-04 | Mederio Ag | Medicinsk produkt |
| SG158158A1 (en) | 2004-12-22 | 2010-01-29 | Centocor Inc | Glp-1 agonists, compositions, methods and uses |
| US7879361B2 (en) | 2005-01-04 | 2011-02-01 | Gp Medical, Inc. | Nanoparticles for drug delivery |
| EP1849024A4 (en) | 2005-02-01 | 2015-08-26 | Canberra Ind Inc | METHOD FOR DETECTING A MAXIMUM ENTROPY SIGNAL |
| US20090142338A1 (en) | 2005-03-04 | 2009-06-04 | Curedm, Inc. | Methods and Compositions for Treating Type 1 and Type 2 Diabetes Mellitus and Related Conditions |
| WO2006110551A2 (en) | 2005-04-08 | 2006-10-19 | Amylin Pharmaceuticals, Inc. | Pharmaceutical formulations comprising incretin peptide and aprotic polar solvent |
| JP2008536881A (ja) * | 2005-04-21 | 2008-09-11 | ガストロテック・ファルマ・アクティーゼルスカブ | Ｇｌｐ−１分子と制吐剤との医薬製剤 |
| CN101180081B (zh) * | 2005-05-25 | 2015-08-26 | 诺沃-诺迪斯克有限公司 | 稳定的多肽制剂 |
| CA2609810C (en) | 2005-06-06 | 2012-05-22 | Camurus Ab | Glp-1 analogue formulations |
| US7902254B1 (en) | 2005-06-27 | 2011-03-08 | Newtree Co., Ltd. | Method for treating conditions mediated by PPAR using macelignan |
| US20080227847A1 (en) | 2005-07-07 | 2008-09-18 | Aditech Pharma Ab | Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use |
| PL2347762T3 (pl) | 2005-08-19 | 2019-09-30 | Amylin Pharmaceuticals, Llc | Eksendyna do leczenia cukrzycy i zmniejszania masy ciała |
| US20090181887A1 (en) | 2005-09-08 | 2009-07-16 | Gastrotech Pharma A/S | Use of a glp-1 molecule for treatment of biliary dyskinesia and/or biliary pain/discomfort |
| KR101304958B1 (ko) | 2005-09-14 | 2013-09-17 | 에프. 호프만-라 로슈 아게 | 트립신 변이체에 의한 인슐린 전구체의 절단 |
| JP5072848B2 (ja) | 2005-09-20 | 2012-11-14 | ノバルティス アーゲー | 低血糖イベントを低減するためのｄｐｐ−ｉｖ阻害剤の使用 |
| US20070078510A1 (en) | 2005-09-26 | 2007-04-05 | Ryan Timothy R | Prosthetic cardiac and venous valves |
| KR101105871B1 (ko) | 2005-09-27 | 2012-01-16 | 주식회사 엘지생명과학 | 인 난포자극호르몬의 안정한 용액 제형 |
| DE102005046113A1 (de) | 2005-09-27 | 2007-03-29 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen |
| US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| US20090264732A1 (en) | 2005-10-11 | 2009-10-22 | Huntington Medical Research Institutes | Imaging agents and methods of use thereof |
| MY144556A (en) | 2005-10-24 | 2011-09-30 | Nestec Sa | Dietary fiber formulation and method of administration |
| EA200800979A1 (ru) | 2005-11-30 | 2008-10-30 | Дженерекс Фармасьютикалз Инк. | Перорально абсорбируемая фармацевтическая композиция и способ введения |
| US20100029558A1 (en) | 2005-12-06 | 2010-02-04 | Bristow Cynthia L | Alpha1 proteinase inhibitor peptides methods and use |
| JP5096363B2 (ja) | 2005-12-16 | 2012-12-12 | ネクター セラピューティックス | Ｇｌｐ−１のポリマ複合体 |
| JP2009523129A (ja) | 2006-01-05 | 2009-06-18 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | 神経系を標的する薬理学的物質の性質を改善することに関連する方法および組成物 |
| WO2007081824A2 (en) | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Fibrillation resistant proteins |
| US20090324701A1 (en) | 2006-01-20 | 2009-12-31 | Diamedica, Inc. | Compositions containing (s)-bethanechol and their use in the treatment of insulin resistance, type 2 diabetes, glucose intolerance and related disorders |
| US20070191271A1 (en) * | 2006-02-10 | 2007-08-16 | Dow Pharmaceutical Sciences | Method for stabilizing polypeptides lacking methionine |
| WO2007095288A2 (en) | 2006-02-13 | 2007-08-23 | Nektar Therapeutics | Methionine-containing protein or peptide compositions and methods of making and using |
| US7763582B2 (en) | 2006-02-21 | 2010-07-27 | University Of Medicine And Dentistry Of New Jersey | Localized insulin delivery for bone healing |
| ES2397659T3 (es) | 2006-03-15 | 2013-03-08 | Novo Nordisk A/S | Mezclas de amilina e insulina |
| TW200806317A (en) | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
| WO2007113205A1 (en) * | 2006-04-03 | 2007-10-11 | Novo Nordisk A/S | Glp-1 peptide agonists |
| CN101454019A (zh) | 2006-04-12 | 2009-06-10 | 百达尔公司 | 速效和长效胰岛素联合制剂 |
| RU2419452C2 (ru) * | 2006-04-13 | 2011-05-27 | Ипсен Фарма С.А.С. | ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ hGLP-1, ЭКСЕНДИНА-4 И ИХ АНАЛОГОВ |
| CA2800389A1 (en) * | 2006-04-20 | 2007-11-01 | Amgen Inc. | Glp-1 compounds |
| JP2009539778A (ja) | 2006-06-08 | 2009-11-19 | ダイアベコア メディカル インコーポレイテッド | インスリンオリゴマー誘導体 |
| DE102006031962A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
| EP2076242B8 (en) | 2006-07-27 | 2013-02-20 | Nektar Therapeutics | Aerosolizable formulation comprising insulin for pulmonary delivery |
| EP2057188B1 (en) | 2006-08-17 | 2013-07-31 | Amylin Pharmaceuticals, LLC | Dpp-iv resistant gip hybrid polypeptides with selectable properties |
| US20090318353A1 (en) | 2006-08-25 | 2009-12-24 | Novo Nordisk A/S | Acylated Exendin-4 Compounds |
| US20100179131A1 (en) | 2006-09-07 | 2010-07-15 | Nycomed Gmbh | Combination treatment for diabetes mellitus |
| PL2074141T3 (pl) | 2006-09-22 | 2017-02-28 | Novo Nordisk A/S | Analogi insuliny oporne na proteazę |
| CN104000779A (zh) | 2007-04-23 | 2014-08-27 | 精达制药公司 | 促胰岛素释放肽的混悬制剂及其应用 |
| WO2008145323A1 (en) | 2007-05-31 | 2008-12-04 | F. Hoffmann-La Roche Ag | Pharmaceutical formulation for interferons |
| JP2010528792A (ja) | 2007-06-14 | 2010-08-26 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 二重チャンバーカルプル |
| EP2167169B2 (de) | 2007-06-14 | 2016-03-09 | Sanofi-Aventis Deutschland GmbH | Zweikammerkarpule mit aufsatz |
| US9173991B2 (en) | 2007-07-02 | 2015-11-03 | Roche Diabetes Care, Inc. | Device for drug delivery |
| EP2182917B1 (en) | 2007-07-06 | 2011-07-13 | BASF Corporation | A gastroretentive composition on the basis of a water-soluble reaction product from a vinyl group- containing precursor |
| CA2697265A1 (en) | 2007-08-09 | 2009-02-19 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
| WO2009021955A1 (en) | 2007-08-13 | 2009-02-19 | Novo Nordisk A/S | Rapid acting insulin analogues |
| CN101366692A (zh) * | 2007-08-15 | 2009-02-18 | 江苏豪森药业股份有限公司 | 一种稳定的艾塞那肽制剂 |
| GB0717399D0 (en) | 2007-09-07 | 2007-10-17 | Uutech Ltd | Use of GLP-1 analogues for the treatment of disorders associated with dysfunctional synaptic transmission |
| GB0717388D0 (en) | 2007-09-07 | 2007-10-17 | Uutech Ltd | Use of GIP for the treatment of disorders associated with dysfunctional synaptic transmission |
| CA2699257A1 (en) | 2007-09-11 | 2009-04-16 | Mondobiotech Laboratories Ag | Cgrp as a therapeutic agent |
| US20090104210A1 (en) | 2007-10-17 | 2009-04-23 | Tota Michael R | Peptide compounds for treating obesity and insulin resistance |
| MY153976A (en) | 2007-11-01 | 2015-04-30 | Merck Serono Sa | Lh liquid formulations |
| CN101932601B (zh) | 2007-11-08 | 2016-08-03 | 诺沃-诺迪斯克有限公司 | 胰岛素衍生物 |
| DK2597103T3 (en) | 2007-11-16 | 2017-02-13 | Novo Nordisk As | Stable pharmaceutical compositions comprising liraglutide and degludec |
| CN101444618B (zh) | 2007-11-26 | 2012-06-13 | 杭州九源基因工程有限公司 | 含有艾塞那肽的药物制剂 |
| CN102026666B (zh) | 2007-12-11 | 2013-10-16 | 常山凯捷健生物药物研发（河北）有限公司 | 促胰岛素肽缀合物制剂 |
| AU2009204309B2 (en) | 2008-01-04 | 2012-11-22 | Biodel, Inc. | Insulin formulations for insulin release as a function of tissue glucose levels |
| DE102008003566A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| AU2009203810B2 (en) | 2008-01-09 | 2013-07-25 | Sanofi-Aventis Deutschland Gmbh | Novel insulin derivatives having an extremely delayed time-action profile |
| DE102008003568A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| NZ586590A (en) | 2008-01-09 | 2012-06-29 | Sanofi Aventis Deutschland | Insulin analogues or derivatives having an extremely delayed time-action profile |
| DE202009009905U1 (de) | 2008-02-08 | 2009-10-29 | Biogenerix Ag | Flüssig-Formulierung von FSH |
| CA2726861C (en) * | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| WO2009104199A1 (en) | 2008-02-19 | 2009-08-27 | Biocon Limited | A method of obtaining purified heterologous insulins expressed in yeast |
| TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
| WO2009143014A1 (en) | 2008-05-23 | 2009-11-26 | Amylin Pharmaceuticals, Inc. | Glp-1 receptor agonist bioassays |
| TWI451876B (zh) | 2008-06-13 | 2014-09-11 | Lilly Co Eli | 聚乙二醇化之離脯胰島素化合物 |
| CA2726894A1 (en) | 2008-06-27 | 2009-12-30 | Duke University | Therapeutic agents comprising elastin-like peptides |
| US8574214B2 (en) | 2008-08-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Cartridge and needle system therefor |
| US20100069292A1 (en) | 2008-09-02 | 2010-03-18 | Biodel, Inc. | Insulin with a basal release profile |
| WO2010030670A2 (en) | 2008-09-10 | 2010-03-18 | Genentech, Inc. | Compositions and methods for the prevention of oxidative degradation of proteins |
| CN101670096B (zh) | 2008-09-11 | 2013-01-16 | 杭州九源基因工程有限公司 | 含有艾塞那肽的药物制剂 |
| EP2349200A1 (en) * | 2008-10-15 | 2011-08-03 | Intarcia Therapeutics, Inc | Highly concentrated drug particles, formulations, suspensions and uses thereof |
| DE102008051834A1 (de) * | 2008-10-17 | 2010-04-22 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem Insulin und einem GLP-1-Agonisten |
| LT2349324T (lt) | 2008-10-17 | 2017-12-27 | Sanofi-Aventis Deutschland Gmbh | Insulino ir glp-1 agonisto derinys |
| DE102008053048A1 (de) | 2008-10-24 | 2010-04-29 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem Insulin und einem GLP-1-Agonisten |
| ES2607003T3 (es) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria |
| JP2009091363A (ja) | 2008-11-21 | 2009-04-30 | Asahi Kasei Pharma Kk | Ｐｔｈの安定化水溶液注射剤 |
| EP2393412B1 (en) | 2009-02-04 | 2017-08-30 | Sanofi-Aventis Deutschland GmbH | Medical device and method for providing information for glycemic control |
| EA029759B1 (ru) | 2009-02-13 | 2018-05-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Антидиабетические лекарственные средства, содержащие ингибитор dpp-4 (линаглиптин) необязательно в комбинации с другими антидиабетическими средствами |
| WO2010138671A1 (en) | 2009-05-28 | 2010-12-02 | Amylin Pharmaceuticals, Inc. | Glp-1 receptor agonist compounds for sleep enhancement |
| KR101853606B1 (ko) | 2009-07-06 | 2018-05-03 | 사노피-아벤티스 도이칠란트 게엠베하 | 메티오닌을 함유하는 수성 인슐린 제제 |
| WO2011003820A1 (de) | 2009-07-06 | 2011-01-13 | Sanofi-Aventis Deutschland Gmbh | Hitze- und schüttelstabile insulinzubereitungen |
| EP2451471A1 (de) | 2009-07-06 | 2012-05-16 | Sanofi-Aventis Deutschland GmbH | Langsamwirkende insulinzubereitungen |
| US8709400B2 (en) | 2009-07-27 | 2014-04-29 | Washington University | Inducement of organogenetic tolerance for pancreatic xenotransplant |
| UA108475C2 (ru) | 2009-07-31 | 2015-05-12 | Санофі-Авентіс Дойчланд Гмбх | Композиция инсулина длительного действия |
| WO2011017554A2 (en) | 2009-08-07 | 2011-02-10 | Mannkind Corporation | Val (8) glp-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome |
| AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| CA2685638C (en) | 2009-11-13 | 2017-02-28 | Sanofi-Aventis Deutschland Gmbh | Method of treatment of diabetes type 2 comprising add-on therapy to insulin glargine and metformin |
| CN102711804B (zh) | 2009-11-13 | 2015-09-16 | 赛诺菲-安万特德国有限公司 | 包含glp-1激动剂和甲硫氨酸的药物组合物 |
| PT2329848E (pt) | 2009-11-13 | 2013-01-23 | Sanofi Aventis Deutschland | Lixisenatida como terapia de extensão à insulina glargina e à metformina para tratar a diabetes do tipo |
| US20110118178A1 (en) | 2009-11-13 | 2011-05-19 | Sanofi-Aventis Deutschland Gmbh | Method of treatment of diabetes type 2 comprising add-on therapy to insulin glargine and metformin |
| JP5832439B2 (ja) | 2009-11-13 | 2015-12-16 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Ｇｌｐ−１アゴニスト、インスリン及びメチオニンを含む薬学的組成物 |
| US20110118180A1 (en) | 2009-11-13 | 2011-05-19 | Sanofi-Aventis Deutschland Gmbh | Method of treatment of diabetes type 2 comprising add-on therapy to metformin |
| EP2324853B1 (en) | 2009-11-13 | 2015-08-26 | Sanofi-Aventis Deutschland GmbH | Lixisenatide as add-on to metformin in the treatment of diabetes type 2 |
| WO2011075623A1 (en) | 2009-12-18 | 2011-06-23 | Latitude Pharmaceuticals, Inc. | One - phase gel compos ition compri s ing phos pholi pids |
| EP2460527A1 (en) | 2010-01-21 | 2012-06-06 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
| JP2013520175A (ja) | 2010-02-22 | 2013-06-06 | ケース ウェスタン リザーブ ユニバーシティ | 可溶形および結晶形の長時間作用型インスリン類似体製剤 |
| AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| UY33326A (es) | 2010-04-14 | 2011-12-01 | Sanofi Aventis | Conjugados de insulina-sirna |
| US8637458B2 (en) | 2010-05-12 | 2014-01-28 | Biodel Inc. | Insulin with a stable basal release profile |
| AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
| WO2011144674A2 (en) | 2010-05-20 | 2011-11-24 | Sanofi-Aventis Deutschland Gmbh | PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND SBE4-ß-CYD |
| EP2389945A1 (en) | 2010-05-28 | 2011-11-30 | Sanofi-Aventis Deutschland GmbH | Pharmaceutical composition comprising AVE0010 and insulin glargine |
| WO2011160066A1 (en) | 2010-06-17 | 2011-12-22 | Regents Of The University Of Minnesota | Production of insulin producing cells |
| US8532933B2 (en) | 2010-06-18 | 2013-09-10 | Roche Diagnostics Operations, Inc. | Insulin optimization systems and testing methods with adjusted exit criterion accounting for system noise associated with biomarkers |
| WO2012012352A2 (en) | 2010-07-19 | 2012-01-26 | Amidebio, Llc | Modified peptides and proteins |
| CN103179978A (zh) | 2010-08-30 | 2013-06-26 | 赛诺菲-安万特德国有限公司 | Ave0010用于制造供治疗2型糖尿病用的药物的用途 |
| SI2632478T1 (sl) | 2010-10-27 | 2019-11-29 | Novo Nordisk As | Zdravljenje sladkorne bolezni z uporabo inzulinskih injekcij, ki se dajejo v različnih injicirnih intervalih |
| WO2012065996A1 (en) | 2010-11-15 | 2012-05-24 | Sanofi-Aventis Deutschland Gmbh | PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND MALTOSYL-ß-CYCLODEXTRIN |
| WO2012066086A1 (en) | 2010-11-17 | 2012-05-24 | Sanofi-Aventis Deutschland Gmbh | PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND SULFOBUTYL ETHER 7-ß-CYCLODEXTRIN |
| EP2651432A1 (en) | 2010-12-14 | 2013-10-23 | Novo Nordisk A/S | Fast-acting insulin in combination with long-acting insulin |
| CN107375909A (zh) | 2011-02-02 | 2017-11-24 | 赛诺菲-安万特德国有限公司 | 在2型糖尿病患者中预防低血糖症 |
| PL2683406T3 (pl) | 2011-03-11 | 2019-11-29 | Beth Israel Deaconess Medical Ct Inc | Przeciwciała anty-cd40 i ich zastosowania |
| US20120277147A1 (en) | 2011-03-29 | 2012-11-01 | Sanofi-Aventis Deutschland Gmbh | Prevention of hypoglycaemia in diabetes mellitus type 2 patients |
| US20130040878A1 (en) | 2011-05-13 | 2013-02-14 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in the treatment of diabetes type 2 patients |
| US8735349B2 (en) | 2011-05-13 | 2014-05-27 | Sanofi-Aventis Deutschland Gmbh | Method for improving glucose tolerance in a diabetes type 2 patient of younger than 50 years and having postprandial plasma glucose concentration of at least 14 mmol/L |
| ES2556466T3 (es) | 2011-05-13 | 2016-01-18 | Sanofi-Aventis Deutschland Gmbh | Lixisenatida y metformina para el tratamiento de la diabetes tipo 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| WO2012177929A2 (en) | 2011-06-24 | 2012-12-27 | Amylin Pharmaceuticals, Inc. | Methods for treating diabetes with extended release formulations of glp-1 receptor agonists |
| WO2013030160A1 (en) | 2011-08-29 | 2013-03-07 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| US20130096059A1 (en) | 2011-10-04 | 2013-04-18 | Jens Stechl | Glp-1 agonist for use in the treatment of stenosis or/and obstruction in the biliary tract |
| HUE028568T2 (en) | 2011-10-04 | 2016-12-28 | Sanofi Aventis Deutschland | For use in the treatment of constriction and / or obstruction of the lysine senate and pancreatic duct system |
| CA2851690C (en) | 2011-10-28 | 2022-07-26 | Sanofi-Aventis Deutschland Gmbh | Treatment protocol of diabetes type 2 |
| US8901484B2 (en) | 2012-04-27 | 2014-12-02 | Sanofi-Aventis Deutschland Gmbh | Quantification of impurities for release testing of peptide products |
| US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
| AR092862A1 (es) | 2012-07-25 | 2015-05-06 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion |
| TWI641381B (zh) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物 |
| GB201303771D0 (en) | 2013-03-04 | 2013-04-17 | Midatech Ltd | Nanoparticles peptide compositions |
| LT3010530T (lt) | 2013-06-17 | 2019-04-10 | Sanofi-Aventis Deutschland Gmbh | Kompozicija su fiksuotu insulino glargino / liksisenatido santikiu |
| AR098168A1 (es) | 2013-10-25 | 2016-05-04 | Sanofi Sa | Formulación estable de insulina glulisina |
| MA41138B1 (fr) | 2014-12-12 | 2023-07-31 | Sanofi Aventis Deutschland | Formulation à rapport fixe d'insuline glargine/lixisenatide |
| AR103415A1 (es) | 2015-01-16 | 2017-05-10 | Sanofi Aventis Deutschland | Tratamiento de pacientes pediátricos con diabetes mellitus de tipo 2 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
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