SG11201509781YA - Insulin glargine/lixisenatide fixed ratio formulation - Google Patents
Insulin glargine/lixisenatide fixed ratio formulationInfo
- Publication number
- SG11201509781YA SG11201509781YA SG11201509781YA SG11201509781YA SG11201509781YA SG 11201509781Y A SG11201509781Y A SG 11201509781YA SG 11201509781Y A SG11201509781Y A SG 11201509781YA SG 11201509781Y A SG11201509781Y A SG 11201509781YA SG 11201509781Y A SG11201509781Y A SG 11201509781YA
- Authority
- SG
- Singapore
- Prior art keywords
- fixed ratio
- insulin glargine
- ratio formulation
- lixisenatide fixed
- lixisenatide
- Prior art date
Links
- 108010057186 Insulin Glargine Proteins 0.000 title 1
- COCFEDIXXNGUNL-RFKWWTKHSA-N Insulin glargine Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(=O)NCC(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 COCFEDIXXNGUNL-RFKWWTKHSA-N 0.000 title 1
- XVVOERDUTLJJHN-UHFFFAOYSA-N Lixisenatide Chemical compound C=1NC2=CC=CC=C2C=1CC(C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NCC(=O)NCC(=O)N1C(CCC1)C(=O)NC(CO)C(=O)NC(CO)C(=O)NCC(=O)NC(C)C(=O)N1C(CCC1)C(=O)N1C(CCC1)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)CC)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC=1C=CC=CC=1)NC(=O)C(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)CNC(=O)C(N)CC=1NC=NC=1)C(C)O)C(C)O)C(C)C)CC1=CC=CC=C1 XVVOERDUTLJJHN-UHFFFAOYSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 229960002869 insulin glargine Drugs 0.000 title 1
- 229960001093 lixisenatide Drugs 0.000 title 1
- 108010004367 lixisenatide Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13172341 | 2013-06-17 | ||
| EP13192556 | 2013-11-12 | ||
| PCT/EP2014/062418 WO2014202483A1 (en) | 2013-06-17 | 2014-06-13 | Insulin glargine/lixisenatide fixed ratio formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201509781YA true SG11201509781YA (en) | 2015-12-30 |
Family
ID=50933180
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201509781YA SG11201509781YA (en) | 2013-06-17 | 2014-06-13 | Insulin glargine/lixisenatide fixed ratio formulation |
| SG10201710347PA SG10201710347PA (en) | 2013-06-17 | 2014-06-13 | Insulin glargine/lixisenatide fixed ratio formulation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201710347PA SG10201710347PA (en) | 2013-06-17 | 2014-06-13 | Insulin glargine/lixisenatide fixed ratio formulation |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US20140371141A1 (en) |
| EP (1) | EP3010530B1 (en) |
| JP (1) | JP6438944B2 (en) |
| KR (1) | KR102231074B1 (en) |
| CN (1) | CN105473155B (en) |
| AU (1) | AU2014283423B2 (en) |
| CA (1) | CA2915413A1 (en) |
| CL (1) | CL2015003634A1 (en) |
| CY (1) | CY1121881T1 (en) |
| DK (1) | DK3010530T3 (en) |
| ES (1) | ES2723887T3 (en) |
| HK (1) | HK1217429A1 (en) |
| HR (1) | HRP20190557T1 (en) |
| HU (1) | HUE042796T2 (en) |
| IL (1) | IL242831B (en) |
| LT (1) | LT3010530T (en) |
| MX (1) | MX370923B (en) |
| PH (1) | PH12015502755A1 (en) |
| PL (1) | PL3010530T4 (en) |
| PT (1) | PT3010530T (en) |
| RU (1) | RU2684398C2 (en) |
| SG (2) | SG11201509781YA (en) |
| SI (1) | SI3010530T1 (en) |
| WO (1) | WO2014202483A1 (en) |
| ZA (1) | ZA201508719B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2650621T3 (en) | 2008-10-17 | 2018-01-19 | Sanofi-Aventis Deutschland Gmbh | Combination of an insulin and a GLP-1 agonist |
| PE20121362A1 (en) | 2009-11-13 | 2012-10-17 | Sanofi Aventis Deutschland | PHARMACEUTICAL COMPOSITION INCLUDING DESPRO36EXENDIN-4 (1-39) -LYS6-NH2, INSULIN GLY (A21) -ARG (B31) -ARG (B32) AND METHIONINE |
| TWI468171B (en) | 2009-11-13 | 2015-01-11 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist and methionine |
| RU2546520C2 (en) | 2010-08-30 | 2015-04-10 | Санофи-Авентис Дойчланд Гмбх | Application of ave0010 for production of medication for treatment of type 2 diabetes mellitus |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| RS64300B1 (en) * | 2014-12-12 | 2023-07-31 | Sanofi Aventis Deutschland | Insulin glargine/lixisenatide fixed ratio formulation |
| TWI748945B (en) * | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | Treatment type 2 diabetes mellitus patients |
| TW201705975A (en) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | Treatment of type 2 diabetes mellitus patients |
| EA039114B1 (en) * | 2015-11-10 | 2021-12-06 | Санофи-Авентис Дойчланд Гмбх | Use of insulin glargine/lixisenatide fixed ratio composition in the treatment of diabetes mellitus type 2 |
| WO2018055539A1 (en) * | 2016-09-22 | 2018-03-29 | Wockhardt Limited | Pharmaceutical composition containing buffered insulin glargine and glp-1 analogue |
| US20210093698A1 (en) | 2019-09-13 | 2021-04-01 | Sanofi | Treatment of type 2 diabetes mellitus |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2650621T3 (en) * | 2008-10-17 | 2018-01-19 | Sanofi-Aventis Deutschland Gmbh | Combination of an insulin and a GLP-1 agonist |
| DE102008053048A1 (en) * | 2008-10-24 | 2010-04-29 | Sanofi-Aventis Deutschland Gmbh | Medicament, useful e.g. for treating diabetes, controlling fasting, postprandial or postabsorptive blood glucose concentration in diabetic patients and improving glucose tolerance, comprises insulin and glucagon-like peptide-1 agonist |
| JP5980466B2 (en) * | 2009-11-13 | 2016-08-31 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Method for treating type 2 diabetes including addition therapy to insulin glargine and metformin |
| DK2329848T4 (en) * | 2009-11-13 | 2019-09-09 | Sanofi Aventis Deutschland | Lixisenatide as adjunctive therapy to insulin glargine and metformin for the treatment of type 2 diabetes |
| US20110118178A1 (en) * | 2009-11-13 | 2011-05-19 | Sanofi-Aventis Deutschland Gmbh | Method of treatment of diabetes type 2 comprising add-on therapy to insulin glargine and metformin |
| AU2011202239C1 (en) * | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
| EP2389945A1 (en) * | 2010-05-28 | 2011-11-30 | Sanofi-Aventis Deutschland GmbH | Pharmaceutical composition comprising AVE0010 and insulin glargine |
-
2014
- 2014-06-13 JP JP2016518515A patent/JP6438944B2/en active Active
- 2014-06-13 CN CN201480045284.4A patent/CN105473155B/en active Active
- 2014-06-13 DK DK14729687.5T patent/DK3010530T3/en active
- 2014-06-13 MX MX2015017540A patent/MX370923B/en active IP Right Grant
- 2014-06-13 AU AU2014283423A patent/AU2014283423B2/en active Active
- 2014-06-13 CA CA2915413A patent/CA2915413A1/en active Pending
- 2014-06-13 PT PT14729687T patent/PT3010530T/en unknown
- 2014-06-13 LT LTEP14729687.5T patent/LT3010530T/en unknown
- 2014-06-13 US US14/303,895 patent/US20140371141A1/en not_active Abandoned
- 2014-06-13 PL PL14729687T patent/PL3010530T4/en unknown
- 2014-06-13 HU HUE14729687A patent/HUE042796T2/en unknown
- 2014-06-13 EP EP14729687.5A patent/EP3010530B1/en active Active
- 2014-06-13 KR KR1020167000728A patent/KR102231074B1/en active IP Right Grant
- 2014-06-13 SG SG11201509781YA patent/SG11201509781YA/en unknown
- 2014-06-13 SI SI201431144T patent/SI3010530T1/en unknown
- 2014-06-13 ES ES14729687T patent/ES2723887T3/en active Active
- 2014-06-13 RU RU2016101064A patent/RU2684398C2/en active
- 2014-06-13 WO PCT/EP2014/062418 patent/WO2014202483A1/en active Application Filing
- 2014-06-13 SG SG10201710347PA patent/SG10201710347PA/en unknown
-
2015
- 2015-11-26 ZA ZA2015/08719A patent/ZA201508719B/en unknown
- 2015-11-29 IL IL242831A patent/IL242831B/en active IP Right Grant
- 2015-12-10 PH PH12015502755A patent/PH12015502755A1/en unknown
- 2015-12-15 CL CL2015003634A patent/CL2015003634A1/en unknown
-
2016
- 2016-05-11 HK HK16105372.9A patent/HK1217429A1/en unknown
-
2017
- 2017-07-24 US US15/657,683 patent/US20180133290A1/en not_active Abandoned
-
2019
- 2019-03-22 HR HRP20190557TT patent/HRP20190557T1/en unknown
- 2019-03-26 CY CY20191100348T patent/CY1121881T1/en unknown
- 2019-04-03 US US16/374,536 patent/US11026999B2/en active Active
-
2021
- 2021-05-03 US US17/306,184 patent/US20220031811A1/en active Pending
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