CO6571908A2 - Agentes inductores de apoptosis para el tratamiento de cancer y enfermedaded inmunes y autoinmunes - Google Patents

Agentes inductores de apoptosis para el tratamiento de cancer y enfermedaded inmunes y autoinmunes

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Publication number
CO6571908A2
CO6571908A2 CO12096369A CO12096369A CO6571908A2 CO 6571908 A2 CO6571908 A2 CO 6571908A2 CO 12096369 A CO12096369 A CO 12096369A CO 12096369 A CO12096369 A CO 12096369A CO 6571908 A2 CO6571908 A2 CO 6571908A2
Authority
CO
Colombia
Prior art keywords
treatment
immune
cancer
autoimmune diseases
inducing agents
Prior art date
Application number
CO12096369A
Other languages
English (en)
Inventor
Milan Bruncko
Yunjia Dai
Todd M Hansen
Michael D Wendt
Xilu Wang
Le Wang
Gary T Wang
Zhi-Fu Tao
Gerard M Sullivan
Andrew J Souers
Xiaohong Song
Andrew M Petros
Cheol-Min Park
Chang H Park
William J Mcclellan
Robert Mantel
Aaron R Kunzer
Laura Hexamer
Lisa A Hasvold
Steven W Elmore
George Andrew Doherty
Hong Ding
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42463423&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6571908(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of CO6571908A2 publication Critical patent/CO6571908A2/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
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Abstract

Compuestos que inhiben la actividad deproteínas anti-apoptóticas Bc1-2, composiciones quecontienen a dichos compuestos y métodos de tratamientode enfermedades durante cuyo transcurso hay expresiónde la proteína anti-apoptótica Bc1-2.
CO12096369A 2009-12-04 2012-06-07 Agentes inductores de apoptosis para el tratamiento de cancer y enfermedaded inmunes y autoinmunes CO6571908A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/631,367 US20100160322A1 (en) 2008-12-04 2009-12-04 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Publications (1)

Publication Number Publication Date
CO6571908A2 true CO6571908A2 (es) 2012-11-30

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CO12096369A CO6571908A2 (es) 2009-12-04 2012-06-07 Agentes inductores de apoptosis para el tratamiento de cancer y enfermedaded inmunes y autoinmunes

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US (5) US20100160322A1 (es)
EP (1) EP2507211B1 (es)
JP (1) JP5589090B2 (es)
CN (2) CN103097352A (es)
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BR (1) BR112012012918A8 (es)
CA (1) CA2781521A1 (es)
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