PE20131044A1 - Agentes inductores de apoptosis para el tratamiento del cancer y de enfermedades inmunes y autoinmunes - Google Patents

Agentes inductores de apoptosis para el tratamiento del cancer y de enfermedades inmunes y autoinmunes

Info

Publication number
PE20131044A1
PE20131044A1 PE2012002218A PE2012002218A PE20131044A1 PE 20131044 A1 PE20131044 A1 PE 20131044A1 PE 2012002218 A PE2012002218 A PE 2012002218A PE 2012002218 A PE2012002218 A PE 2012002218A PE 20131044 A1 PE20131044 A1 PE 20131044A1
Authority
PE
Peru
Prior art keywords
cancer
treatment
immune
autoimmune diseases
inducing agents
Prior art date
Application number
PE2012002218A
Other languages
English (en)
Inventor
Milan Bruncko
Hong Ding
George Doherty
Steven Elmore
Lisa Hasvold
Laura Hexamer
Aaron R Kunzer
Xiahong Song
Andrew J Souers
Gerhard M Sullivan
Zhi-Fu Tao
Gary T Wang
Xilu Wang
Michael Wendt
Robert Mantel
Todd M Hansen
Original Assignee
Abbvie Bahamas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43836533&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20131044(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Bahamas Ltd filed Critical Abbvie Bahamas Ltd
Publication of PE20131044A1 publication Critical patent/PE20131044A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

REFERIDA A UN COMPUESTO DE FORMULA (I), DONDE A1 ES N O C(A2); A2 ES H, F, Cl, NO2, CF3, ENTRE OTROS; B1 ES H, F, Cl, Br, OH, NO2, ENTRE OTROS; D1 ES H, CN, NO2, N3, ENTRE OTROS; E1 ES H, CN, NO2, N3, OH, ENTRE OTROS; Y1 ES H, CN, NO2, C(O)OH, F, Cl, ENTRE OTROS; G1 ES H O C(O)O; Z1 ES R26 O R27; Z2 ES R28, R29 O R30; Z1A Y Z2A SON CH2, CH2CH2 O Z12A; Z12A ES ALQUILENO C2-C6; L1 ES C(N)NH, SO2NH, ENTRE OTROS; R26 ES FENILENO, ENTRE OTROS; R27 ES HETEROARILENO, ENTRE OTROS; R28 ES FENILENO, ENTRE OTROS; R29 ES HETEROARILENO, ENTRE OTROS; R30 ES CICLOALQUILENO, CICLOALQUENILENO, ENTRE OTROS. SON COMPUESTOS FAVORITOS: 4-{4-[(4'-CLORO-1,1'-BIFENIL-2-IL)METIL]PIPERAZIN-1-IL}-N-({3-NITRO-4-[(TETRAHIDRO-2H-PIRAN-4-ILMETIL)AMINO]FENIL}SULFONIL)-2-(1H-PIRROLO[2,3-b]PIRIDIN-5-ILOXI)BENZAMIDA, 4-{4-[(4'-CLORO-1,1'-BIFENIL-2-IL)METIL]PIPERAZIN-1-IL}-N-({4-[(3-MORFOLIN-4-ILPROPIL)AMINO]-3-NITROFENIL}SULFONIL)-2-(1H-PIRROLO[2,3-b]PIRIDIN-5-ILOXI)BENZAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA ACTIVIDAD DE LAS PROTEINAS ANTI-APOPTOTICAS Bcl-2 Y SON UTILES EN EL TRATAMIENTO DEL CANCER Y ENFERMEDADES INMUNES
PE2012002218A 2010-05-26 2010-11-22 Agentes inductores de apoptosis para el tratamiento del cancer y de enfermedades inmunes y autoinmunes PE20131044A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/787,682 US8546399B2 (en) 2009-05-26 2010-05-26 Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases

Publications (1)

Publication Number Publication Date
PE20131044A1 true PE20131044A1 (es) 2013-10-20

Family

ID=43836533

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012002218A PE20131044A1 (es) 2010-05-26 2010-11-22 Agentes inductores de apoptosis para el tratamiento del cancer y de enfermedades inmunes y autoinmunes

Country Status (37)

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US (10) US8546399B2 (es)
EP (1) EP2576546B1 (es)
JP (1) JP5667695B2 (es)
KR (1) KR101725114B1 (es)
CN (1) CN103153993B (es)
AR (1) AR079124A1 (es)
AU (1) AU2010354083B2 (es)
BR (1) BR112012029923A2 (es)
CA (1) CA2799280A1 (es)
CL (1) CL2012003286A1 (es)
CO (1) CO6640274A2 (es)
CR (1) CR20120631A (es)
CY (1) CY1116728T1 (es)
DK (1) DK2576546T3 (es)
DO (1) DOP2012000297A (es)
EC (1) ECSP12012349A (es)
ES (1) ES2546135T3 (es)
GT (1) GT201200314A (es)
HK (1) HK1183866A1 (es)
HR (1) HRP20150925T1 (es)
IL (1) IL223070A (es)
ME (1) ME02215B (es)
MX (1) MX350726B (es)
MY (1) MY160994A (es)
NZ (1) NZ603463A (es)
PE (1) PE20131044A1 (es)
PL (1) PL2576546T3 (es)
PT (1) PT2576546E (es)
RS (1) RS54289B1 (es)
RU (1) RU2554346C2 (es)
SG (1) SG185638A1 (es)
SI (1) SI2576546T1 (es)
SM (1) SMT201600015B (es)
TW (1) TWI501966B (es)
UA (1) UA107706C2 (es)
WO (1) WO2011149492A1 (es)
ZA (1) ZA201208832B (es)

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