AR118047A2 - Anticuerpo aislado o fragmento del mismo, composición farmacéutica y molécula biespecífica - Google Patents

Anticuerpo aislado o fragmento del mismo, composición farmacéutica y molécula biespecífica

Info

Publication number
AR118047A2
AR118047A2 ARP200100356A ARP200100356A AR118047A2 AR 118047 A2 AR118047 A2 AR 118047A2 AR P200100356 A ARP200100356 A AR P200100356A AR P200100356 A ARP200100356 A AR P200100356A AR 118047 A2 AR118047 A2 AR 118047A2
Authority
AR
Argentina
Prior art keywords
fragment
isolated antibody
pharmaceutical composition
bispecific molecule
antibody
Prior art date
Application number
ARP200100356A
Other languages
English (en)
Inventor
Frederick W Jacobsen
Chaoyang Li
Hua Zhu Ke
Hsieng Sen Lu
William Gleason Richards
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AR118047A2 publication Critical patent/AR118047A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Anticuerpo aislado o fragmento del mismo que bloquea de forma cruzada la unión del anticuerpo que comprende las secuencias representadas en SEQ ID Nº 94 y 96 a Dickkopf-1 humano (DKK1) y/o está bloqueado de forma cruzada para que el anticuerpo que comprende las secuencias representadas en SEQ ID Nº 94 y 96 no se una a DKK1 humano, donde el anticuerpo aislado o fragmento del mismo se une específicamente a un epitope discontinuo en los aminoácidos 221 - 236 y/o 246 - 262 de SEQ ID Nº 2 e inhibe la actividad DKK1 humana; composición farmacéutica; y molécula biespecífica.
ARP200100356A 2010-10-27 2020-02-10 Anticuerpo aislado o fragmento del mismo, composición farmacéutica y molécula biespecífica AR118047A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40712810P 2010-10-27 2010-10-27

Publications (1)

Publication Number Publication Date
AR118047A2 true AR118047A2 (es) 2021-09-15

Family

ID=44910313

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP110103984A AR083740A1 (es) 2010-10-27 2011-10-27 Anticuerpos dkk1 (dickkopf-1) y metodos de uso
ARP200100356A AR118047A2 (es) 2010-10-27 2020-02-10 Anticuerpo aislado o fragmento del mismo, composición farmacéutica y molécula biespecífica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP110103984A AR083740A1 (es) 2010-10-27 2011-10-27 Anticuerpos dkk1 (dickkopf-1) y metodos de uso

Country Status (10)

Country Link
US (3) US9879072B2 (es)
EP (3) EP3838922A1 (es)
JP (2) JP6066912B2 (es)
AR (2) AR083740A1 (es)
AU (3) AU2011319843C1 (es)
CA (2) CA3085710A1 (es)
ES (1) ES2863626T3 (es)
MX (2) MX354481B (es)
TW (2) TWI636994B (es)
WO (1) WO2012058393A2 (es)

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Also Published As

Publication number Publication date
CA2815181C (en) 2020-09-15
EP2632951B1 (en) 2017-08-02
EP3838922A1 (en) 2021-06-23
US20210040189A1 (en) 2021-02-11
MX354481B (es) 2018-03-07
TW201305198A (zh) 2013-02-01
TWI636993B (zh) 2018-10-01
AU2011319843C1 (en) 2017-02-02
AU2016203722A1 (en) 2016-06-23
US20180111985A1 (en) 2018-04-26
ES2863626T3 (es) 2021-10-11
EP3219725A2 (en) 2017-09-20
MX2013004726A (es) 2013-08-29
CA2815181A1 (en) 2012-05-03
JP6353500B2 (ja) 2018-07-04
US20130209475A1 (en) 2013-08-15
AU2011319843A1 (en) 2013-05-09
JP2013545734A (ja) 2013-12-26
JP2017043619A (ja) 2017-03-02
US9879072B2 (en) 2018-01-30
AR083740A1 (es) 2013-03-20
WO2012058393A3 (en) 2012-10-04
WO2012058393A2 (en) 2012-05-03
EP2632951A2 (en) 2013-09-04
US10800839B2 (en) 2020-10-13
AU2018201333B2 (en) 2020-01-16
AU2011319843B2 (en) 2016-03-10
TW201710291A (zh) 2017-03-16
TWI636994B (zh) 2018-10-01
JP6066912B2 (ja) 2017-01-25
AU2018201333A1 (en) 2018-03-15
CA3085710A1 (en) 2012-05-03
EP3219725B1 (en) 2020-12-16
EP3219725A3 (en) 2017-11-22
MX2021001494A (es) 2021-04-28

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