ME02215B - Agensi koji induciraju apoptozu za liječenje raka te imunih i autoimunih bolesti - Google Patents

Agensi koji induciraju apoptozu za liječenje raka te imunih i autoimunih bolesti

Info

Publication number
ME02215B
ME02215B MEP-2015-156A MEP15615A ME02215B ME 02215 B ME02215 B ME 02215B ME P15615 A MEP15615 A ME P15615A ME 02215 B ME02215 B ME 02215B
Authority
ME
Montenegro
Prior art keywords
pyridin
methyl
piperazin
pyrrolo
yloxy
Prior art date
Application number
MEP-2015-156A
Other languages
English (en)
Inventor
Milan Bruncko
George Doherty
Laura Hexamer
Aaron R Kunzer
Xiaohong Song
Gerard Sullivan
Zhi-Fu Tao
Le Wang
Xilu Wang
Michael Wendt
Robert A Mantei
Andrew J Souers
Gary T Wang
Todd M Hansen
Hong Ding
Steven Elmore
Lisa Hasvold
Original Assignee
Abbvie Bahamas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43836533&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02215(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Bahamas Ltd filed Critical Abbvie Bahamas Ltd
Publication of ME02215B publication Critical patent/ME02215B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Claims (4)

1. Spoj ili njegova farmaceutski prihvatljiva sol, naznačen time, da je spoj odabran iz skupine koju čine:metil trans-4-{[( 4-{[ 4-( 4-{[2 -( 4-klorofenil )-4,4-d i metilcikloheks-1-en-1-il] meti l}piperazin-1-il}-2 -(l Hpirolo[2,3-b]piridin-5-iloksi}benzoil]sulfamoil}-2-nitrofenil) amino]metil}cikloheksankarboksilat;trans-4-([(4-{[4-(4-{[2 -( 4-klorofeni1}-4,4-dimetilcikloheks-1-en-1-il] metil}piperazin-1-il)-2-(lH-pirolo[2,3-b] piridin-5-iloksi)benzoil] sulfamoi1-2-nitrofenil)amino] metil} cikloheksankarboksilna kiselina;N-(4-{[4-(4-{[2-(4-klorofenil )-4,4-dimetilcikloheks-1-en-1-il] metil}piperazin-l-il )-2 -(l H-pi rolo[2,3-b) piridin-5-iloksi)benzoil]sulfamoil}-2-nitrofenil)-4-cianopiperidin-1-karboksamid;4-(4-{[2-(4-klorfenil)-4,4-dimetilcikloheks-1-en-1-il) metil}piperazin-1-il)-N-{[4-({[ cis-4-(metoksimetil)cikloheksil]metil}amino)-3-nitrofenil]sulfonil}-2-(1H-pirolo[2,3-b]piridin-5-iloksi)benzamid;4-(4-{[2 -( 4-klorofeni1)-4,4-d imetilcikloheks-1-en-1-il] metil}piperazin-1-il)-N-{[ 4-( {[trans-4-(metoksimetil)cikloheksil]metil}amino)-3-nitrofenil]sulfonil}-2-(1H-pirolo[2,3-b]piridin-5-iloksi)benzamid;4-(4-{[2-(4-klorofeni1)-4,4-dimetilcikloheks-1-en-1-il] metil }piperazin-l-i1)-2-( l H-pirolo [2,3-b) piridin-5-iloksi )N-{[l-(tetrahidro-2H-piran-4-ilmetil)-1H-benzotriazol-5-il] sulfonil} benzamid;N-({5-kloro-6-[ (2-okso-1-oksa-3-azaspiro[4.5] dec-8-il)metoksi] piridin-3-il}sulfonil )-4-( 4-{[2-(4-klorofenil )-4 ,4-dimetilcikloheks-1-en-1-il] metil}piperazin-1-i1)-2-( l H-pirolo[2,3-b] piridin-5-iloksi) benzamid;N-(4-{[4-(4-{[2 -( 4-klorofenil )-4,4-dimetilcikloheks-1-en-1-il]metil)piperazin-l-il)-2 -(l H-pirolo[2,3-b) piridin-5-iloksi)benzoil]sulfamoil}-2-nitrofenil)-4-metoksipiperidin-1-karboksamid;N-({5-kloro-6-[ ( 2-metil-4,5, 6,7-tetrahidro-1,3-benzotiazol-5-il)metoksi] piridin-3-il } sulfonil )-4-( 4-{[2-( 4-klorofeni1)-4,4-dimetilcikloheks-1-en-l-il) metil}piperazi n-l-i1)-2 –( 1H-pi rolo[2,3-b] piridin-5-iloksi)benzamid;4-(4-{[2-(4-klorofenil)-4,4-dimetilcikloheks-1-en-1-il]metil}piperazin-l-il}-2-(1H-pirolo[2,3-b]piridin-5-iloksi)N-{[1-( tetrahidro-2 H-piran-4- ilmetil )-1H-pirolo[ 2,3-b] piridin-5-il]sulfonil}benzamid;4-( 4-{[2-( 4-klorofenil)-4 ,4-dimetilcikloheks-1-en-1-il) metil)piperazin-l-il )-N-{[3-kloro-1-(tetrahidro-2H-piran-4-ilmetil)-1H-pirolo[2,3-b] piridin-5-il]sulfoni1}-2 -(1H-pirolo[2,3-b]piridin-5-iloksi) benzamid;4-(4-{[2-( 4-klorofenil)-4-( metoksimetil )-4-metilcikloheks-1-en-1-il] metil}piperazin-1-il )-N-({3-nitro-4-[(tetrahidro-2H-piran-4-ilmetil)amino]fenil}sulfonil)-2-(1H-pirolo[2,3-b] piridin-5-iloksi)benzamid;N-[(4-{[4,4-bis(hidroksimetil)cikloheksil]metoksi}-3-nitrofenil)sulfonil]-4-(4-{[2-{4-klorofenil)-4,4-dimetilcikloheks-1-en-1-il) metil}piperazin-l-il)-2-( l H-pirolo[2,3-b] piridin-5-iloksi )benzamid;N-(2-kloro-4-{[4-(4-{[2-(4-klorofenil)-4 ,4-dimetilcikloheks-1-en-1-il] m etil}piperazin-l-il)-2 -(l H-pirolo[2,3-b] pi ridin-5-iloksi)benzoil]sulfamoil}fenil )-4-metoksipiperidin-l-karboksamid;N-(2-kloro-4-{[ 4-( 4-{[2-( 4-klorofenil)-4,4-dimetilcikloheks-1-en-1-il] metil)piperazin-1-il)-2-(lH-pirolo[ 2,3-b]piridin-5-iloksi)benzoil]sulfamoil}fenil)-4-cianopiperidin-1-karboksamid;N-{2-kloro-4-{[4-(4-{[2-( 4-klorofenil)-4 ,4-dimetilci kloheks-1-en-l-il] metil)piperazi n-1-il)-2-(H-pirolo[2,3-b ]piridin-5-iloksi )benzoil]sulfamoil}fenil)-4-hid roksi-4-metilpiperidin-1-karboksamid;N-(2-kloro-4-{[4-(4-{[2-(4-klorofenil)-4,4-dimetilcikloheks-l-en-l-il]metil}piperazin-l-il)-2-(1H-pirolo[2,3-b ] piridin-5-iloksi )benzoil] sulfamoil}fenil)-4-(metoksimetil)piperidin-l-karboksamid;N-[ (5-kloro-6-{[ (5r,8r)-2-okso-l-oksa-3-azaspiro[ 4.5] dec-8-il] metoksi}piridin-3-il ) sulfonil]-4-(4-{[2-(4-klorofeni1)-4,4-dimetilci kloheks-1-en-1-il] metil)piperazin-1-i1)-2 –( 1H-pi rolo[2,3-b] piridin-5-iloksi )benzamid;N-[(5-kloro-6-{[(5s,8s)-2-okso-1-oksa-3-azaspiro[4.5]dec-8-il]metoksi}piridin-3-il)sulfonil]-4-(4-{[2-(4-klorofeni1)-4,4-dimeti lcikloheks-1-en-l-il] metil}piperazin-1-i1)-2 -(lH-pi rolo [2,3-b] piridin-5-iloksi )benzamid;N-(2 -kloro-4-{[ 4-(4-{[2-( 4-klorofeni1}-4,4-dimetilcikloheks-1-en-1-il] metil}piperazin-l-il)-2-( lH-pirolo [2,3-b]piridin-5-iloksi)benzoil]sulfamoil}fenil)-4-(morpholin-4-il)piperidin-1-karboksamid;N-[(5-kloro-6-{[trans-4-hidroksi-4-(metoksimetil)cikloheksil]metoksi}piridin-3-il)sulfonil]-4-(4-{[2-(4-klorofeni1)-4,4-dimetilei kloheks-1-en-1-il] metil}piperazin-1-i1)-2-( l H-pirolo [2,3-b] piridin-5-iloksi) benzamid;N-[(5-kloro-6-{[cis-4-hidroksi-4-(hidroksimetil)cikloheksil]metoksi}piridin-3-il)sulfonil]-4-(4-{[2-(4-klorofenil)-4 ,4-dimetilcikloheks-l-en-l-il] metil}piperazin-1-il)-2-{lH-pirolo [2,3-b] piridin-5-iloksi) benzamid;N-[(5-kloro-6-{[trans-4-hidroksi-4-(hidroksimetil)cikloheksil]metoksi}piridin-3-il)sulfonil]-4-(4-{[2-(4-klorofenil)-4,4-dimetilcikloheks-l-en-l-il]metil)piperazin-l-il)-2-{1H-pirolo[2,3-b]piridin-5-iloksi)benzamid;N-[ (5-kloro-6-{[ 4-fluoro-1-( oksetan-3-il )piperidin-4-il] metoksi)piridin-3-il )sulfoni1]-4-(4-{[2 -(4-klorofenil)-5-metoksi-5-metilcikloheks-1-en-1-il] metil}piperazin-l-i1)-2-( l H-pirolo[2,3-b] piridin-5-i loksi) benzamid;4-( 4-{[ 2 -(4-klorofenil)cikloheks-1-en-1-il] metil )piperazin-1-il )-N-({3-nitro-4- [(tetrahidro-2H-piran-4-il-metil)amino]fenil}sulfonil)-2-( 1H-pirolo [2,3-b] piridin-5-iloksi) benzamid;4-(4-klorofenil )-1-meti1-3-[(4-{4-[({3-nitro-4-[ (tetrahidro-2 H-piran-4-ilmetil)amino]fenil} sulfonil)karbamoil]-3-(l H-pirolo[2,3-b]piridin-5-iloksi )fenil}piperazin-l-il )metil]cikloheks-3-en-l-karboksilna kiselinaiN-[(5-kloro-6-{[1-(oksetan-3-il)piperidin-4-il]metoksi}piridin-3-il)sulfonil]-4-(4-{[2-(4-klorofenil)-4,4-dimetilcikloheks-1-en-1-il] metil}piperazin-1-il)-2 -(l H-pirolo[2,3-b] piridin-5-iloksi )benzamid.Patent sadrži još 3 patentna zahtjeva.
2. <!--[endif]-->Farmaceutski pripravak,naznačen time, da sadržava inertni nosač i terapijski učinkovitu količinu spoja ili farmaceutski prihvatljive soli u skladu s patentnim zahtjevom I.
3. Pripravak za uporabu u postupku liječenja raka mokraćnog mjehura, raka mozga, raka dojke, raka koštane srži, raka grlića maternice, kronične limfocitne leukemije, raka debelog crijeva, raka jednjaka, hepatocelularnog raka, leukemije, folikula rnog limfoma, limfne malignosti T-stanica ili B-stanica, melanoma, mijelogene leukemije, mijeloma, oralnog karcinoma, karcinoma jajnika, raka ne-malih stanica pluća, raka prostate, raka malih stanica pluća ili raka slezene kod bolesnika, naznačen time, da sadržava terapijski učinkovitu količinu spoja ili farmaceutski prihvatljive soli u skladu s patentnim zahtjevom l.
4. Pripravak za uporabu u postupku liječenja raka mokraćnog mjehura, raka mozga, raka dojke, raka koštane srži, raka grlića maternice, kronične limfocitne leukemije, raka debelog crijeva, raka jednjaka, hepatocelularnog raka, leukemije, folikularnog limfoma, limfne malignosti T-stanica ili B-stanica, melanoma, mijelogene leukemije, mijeloma, oralnog karcinoma, karcinoma jajnika, raka ne-malih stanica pluća, raka prostate, raka malih stanica pluća ili raka slezene kod bolesnika, naznačen time, da sadržava terapijski učinkovitu količinu spoja ili farmaceutski prihvatljive soli u skladu s patentnim zahtjevom I i terapijski učinkovite količine jednog dodatnog terapijskog sredstva ili više dodatnih terapijskih sredstava.
MEP-2015-156A 2010-05-26 2010-11-22 Agensi koji induciraju apoptozu za liječenje raka te imunih i autoimunih bolesti ME02215B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/787,682 US8546399B2 (en) 2009-05-26 2010-05-26 Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
PCT/US2010/057587 WO2011149492A1 (en) 2010-05-26 2010-11-22 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
EP10784398.9A EP2576546B1 (en) 2010-05-26 2010-11-22 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Publications (1)

Publication Number Publication Date
ME02215B true ME02215B (me) 2016-02-20

Family

ID=43836533

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2015-156A ME02215B (me) 2010-05-26 2010-11-22 Agensi koji induciraju apoptozu za liječenje raka te imunih i autoimunih bolesti

Country Status (37)

Country Link
US (10) US8546399B2 (me)
EP (1) EP2576546B1 (me)
JP (1) JP5667695B2 (me)
KR (1) KR101725114B1 (me)
CN (1) CN103153993B (me)
AR (1) AR079124A1 (me)
AU (1) AU2010354083B2 (me)
BR (1) BR112012029923A2 (me)
CA (1) CA2799280A1 (me)
CL (1) CL2012003286A1 (me)
CO (1) CO6640274A2 (me)
CR (1) CR20120631A (me)
CY (1) CY1116728T1 (me)
DK (1) DK2576546T3 (me)
DO (1) DOP2012000297A (me)
EC (1) ECSP12012349A (me)
ES (1) ES2546135T3 (me)
GT (1) GT201200314A (me)
HR (1) HRP20150925T1 (me)
IL (1) IL223070A (me)
ME (1) ME02215B (me)
MX (1) MX350726B (me)
MY (1) MY160994A (me)
NZ (1) NZ603463A (me)
PE (1) PE20131044A1 (me)
PH (1) PH12012502324A1 (me)
PL (1) PL2576546T3 (me)
PT (1) PT2576546E (me)
RS (1) RS54289B1 (me)
RU (1) RU2554346C2 (me)
SG (1) SG185638A1 (me)
SI (1) SI2576546T1 (me)
SM (1) SMT201600015B (me)
TW (1) TWI501966B (me)
UA (1) UA107706C2 (me)
WO (1) WO2011149492A1 (me)
ZA (1) ZA201208832B (me)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7973161B2 (en) 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
WO2009085216A2 (en) 2007-12-20 2009-07-09 Squicor Compositions and methods for detecting or elimninating senescent cells to diagnose or treat disease
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
MX2011007681A (es) * 2009-01-19 2011-08-08 Abbott Lab Agentes inducidores de apoptosis para el tratamiento del cancer y enfermedades inmunes y autoinmunes.
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
RU2535347C3 (ru) * 2009-05-26 2019-05-14 ЭббВи Айэленд Анлимитед Компани Индуцирующие апоптоз средства для лечения злокачественной опухоли и иммунных и аутоиммунных заболеваний
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
TWI471321B (zh) * 2009-06-08 2015-02-01 亞培公司 Ｂｃｌ－２族群抑制劑之口服醫藥劑型
US8927009B2 (en) * 2009-12-22 2015-01-06 Abbvie Inc. ABT-263 capsule
TWI520960B (zh) 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑
TWI535712B (zh) 2010-08-06 2016-06-01 阿斯特捷利康公司 化合物
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
EP2632436B1 (en) * 2010-10-29 2018-08-29 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
PT2642999T (pt) * 2010-11-23 2017-01-05 Abbvie Ireland Unlimited Co Métodos de tratamento que utilizam inibidores seletivos de bcl-2
WO2012071336A1 (en) 2010-11-23 2012-05-31 Abbott Laboratories Salts and crystalline forms of an apoptosis-inducing agent
WO2012177927A1 (en) 2011-06-21 2012-12-27 Mayo Foundation For Medical Education And Research Transgenic animals capable of being induced to delete senescent cells
CN103958508B (zh) 2011-10-14 2019-02-12 艾伯维公司 用于治疗癌症以及免疫与自身免疫性疾病的细胞凋亡诱导剂
US20140335074A1 (en) 2011-12-13 2014-11-13 Buck Institute For Research On Aging Methods for improving medical therapies
WO2013130093A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
US20150064137A1 (en) 2012-04-17 2015-03-05 Kythera Biopharmaceuticals, Inc. Use of engineered viruses to specifically kill senescent cells
US9901080B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells
US9901081B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse for determining the role of senescent cells in cancer
HK1212240A1 (en) 2012-09-07 2016-06-10 吉宁特有限公司 Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor
PE20151809A1 (es) 2013-03-13 2015-12-25 Abbvie Inc Procesos para la preparacion de un agente inductor de la apoptosis
US9006438B2 (en) 2013-03-13 2015-04-14 Abbvie Inc. Processes for the preparation of an apoptosis-inducing agent
US20140275082A1 (en) * 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
NZ715776A (en) 2013-07-30 2017-04-28 Gilead Connecticut Inc Polymorph of syk inhibitors
TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
US20190269675A1 (en) 2014-01-28 2019-09-05 Buck Institute for Research and Aging Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents
US9993472B2 (en) 2014-01-28 2018-06-12 Unity Biotechnology, Inc. Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2
US10328058B2 (en) 2014-01-28 2019-06-25 Mayo Foundation For Medical Education And Research Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
US20170216286A1 (en) 2014-01-28 2017-08-03 Mayo Foundation For Medical Education And Research Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid
US9238652B2 (en) 2014-03-04 2016-01-19 Abbvie Inc. Processes for the preparation of an apoptosis-inducing agent
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
MX2017000610A (es) 2014-07-14 2017-04-27 Gilead Sciences Inc Metodos combinados para tratar canceres.
RS62713B1 (sr) * 2014-08-11 2022-01-31 Acerta Pharma Bv Terapeutske kombinacije btk inhibitora i bcl-2 inhibitora
TW201639573A (zh) 2015-02-03 2016-11-16 吉李德科學股份有限公司 有關治療癌症之合併治療
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
WO2017007846A1 (en) 2015-07-07 2017-01-12 Genentech, Inc. Combination therapy with an anti-her2 antibody-drug conjugate and a bcl-2 inhibitor
JP6724136B2 (ja) 2015-11-03 2020-07-15 ジェネンテック， インコーポレイテッド がん治療のためのＢｃｌ−２阻害剤及びＭＥＫ阻害剤の組み合わせ
WO2017132474A1 (en) 2016-01-30 2017-08-03 Newave Pharmaceutical Inc. Bcl-2 inhibitors
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
WO2017156398A1 (en) 2016-03-10 2017-09-14 Assia Chemical Industries Ltd. Solid state forms of venetoclax and processes for preparation of venetoclax
US11027021B2 (en) 2016-03-15 2021-06-08 Seagen Inc. Combinations of PBD-based antibody drug conjugates with Bcl-2 inhibitors
JP6651180B2 (ja) * 2016-08-05 2020-02-19 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガンＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｃｈｉｇａｎ Ｂｃｌ−２阻害剤としてのｎ−（フェニルスルホニル）ベンズアミドおよび関連化合物
EP3535264A2 (en) 2016-08-12 2019-09-11 Mylan Laboratories, Limited Process for the preparation of venetoclax
CN109641897B (zh) * 2016-09-01 2021-12-07 北京赛林泰医药技术有限公司 Bcl-2选择性抑制剂及其制备和用途
WO2018069941A2 (en) 2016-10-14 2018-04-19 Mylan Laboratories Limited Polymorphic forms of venetoclax
IL320372A (en) 2016-10-28 2025-06-01 Morphosys Ag Combination of anti-CD19 antibody with BCL-2 inhibitor and uses thereof
US20180133212A1 (en) 2016-11-03 2018-05-17 Gilead Sciences, Inc. Combination of a bcl-2 inhibitor and a bromodomain inhibitor for treating cancer
CN110177788B (zh) * 2017-01-07 2023-03-24 重庆复创医药研究有限公司 作为bcl-2选择性凋亡诱导剂的化合物
JOP20190191A1 (ar) 2017-02-22 2019-08-08 Astrazeneca Ab وحدات شجرية علاجية
WO2018167652A1 (en) * 2017-03-13 2018-09-20 Laurus Labs Limited Process for preparation of amorphous form of venetoclax
WO2018192462A1 (en) * 2017-04-18 2018-10-25 Shanghai Fochon Pharmaceutical Co., Ltd. Apoptosis-inducing agents
WO2018200841A1 (en) 2017-04-28 2018-11-01 Actinium Pharmaceuticals, Inc. Method for treating cancer using a bcl-2 inhibitor in conjunction with an alpha-emitting radioimmunotherapeutic
WO2018202910A1 (en) 2017-05-05 2018-11-08 Fondazione Istituto Italiano Di Tecnologia Combination of antibiotic and bcl-2 inhibitor and uses thereof
LT3630177T (lt) 2017-05-31 2023-10-25 Morphosys Ag Gydymo paradigma, skirta kompleksiniam gydymui anti-cd19 antikūnu ir venetoklaksu
EP3412666A1 (en) 2017-06-07 2018-12-12 Albany Molecular Research, Inc. Process and intermediates for the preparation of bcl-2 inhibitors including venetoclax through reductive amination
US20190062428A1 (en) 2017-06-19 2019-02-28 Surface Oncology, Inc. Combination of anti-cd47 antibodies and cell death-inducing agents, and uses thereof
EP3626241B1 (en) * 2017-06-26 2025-04-23 Shenzhen TargetRx, Inc. Deuterated n-benzenesulfonylbenzamide compound for inhibiting bcl-2 protein and composition and use thereof
US20210371459A1 (en) * 2017-07-25 2021-12-02 Hepagene Therapeutics (HK) Limited Dimeric peptide inhibitors of apoptosis proteins
CN116621860A (zh) 2017-08-23 2023-08-22 广州麓鹏制药有限公司 Bcl-2抑制剂
US11384082B2 (en) 2017-08-25 2022-07-12 Kronos Bio, Inc. Hydrates of polymorphs of 6-(1H-indazol-6-YL)-N-(4-morpholinophenyl)-2,3-dihydroimidazo[1,2-A]pyrazin-8-amine bisemsylate as Syk inhibitors
WO2019135253A1 (en) 2018-01-02 2019-07-11 Mylan Laboratories Limited Polymorphic forms of venetoclax
WO2019139902A1 (en) 2018-01-10 2019-07-18 Zeno Royalties & Milestones, LLC Benzamide compounds
JP2021521138A (ja) 2018-04-29 2021-08-26 ベイジーン リミテッド Ｂｃｌ−２阻害剤
JP7359783B2 (ja) 2018-06-05 2023-10-11 クリネティックス ファーマシューティカルズ，インク． メラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用
WO2020003272A1 (en) 2018-06-29 2020-01-02 Fresenius Kabi Oncology Ltd. An improved process for the preparation of venetoclax
MX2020009759A (es) 2018-07-31 2020-10-08 Ascentage Pharma Suzhou Co Ltd Efecto antitumoral sinergico de un inhibidor de bcl-2 combinado con rituximab y/o bendamustina o un inhibidor de bcl-2 combinado con chop.
AU2019314624B2 (en) 2018-07-31 2022-03-03 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of Bcl-2 inhibitor and MDM2 inhibitor and use thereof in the prevention and/or treatment of diseases
CN110772521A (zh) 2018-07-31 2020-02-11 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
CA3095699A1 (en) 2018-07-31 2020-02-06 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
US11903950B2 (en) 2018-08-22 2024-02-20 Newave Pharmaceutical Inc. BCL-2 inhibitors
JP2022508055A (ja) 2018-11-01 2022-01-19 サイロス ファーマシューティカルズ， インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤
TWI848030B (zh) 2018-12-18 2024-07-11 比利時商阿根思公司 Ｃｄ７０組合治療
CN113950479A (zh) 2019-02-22 2022-01-18 克洛诺斯生物股份有限公司 作为syk抑制剂的缩合吡嗪的固体形式
EP3705109A1 (en) 2019-03-05 2020-09-09 Greenaltech, S.L. Carotenoids in the treatment of senescence-related diseases
SG11202111343TA (en) 2019-05-03 2021-11-29 Morphosys Ag Anti-cd19 therapy in patients having a limited number of nk cells
WO2020232214A1 (en) 2019-05-14 2020-11-19 Abbvie Inc. Treating acute myeloid leukemia (aml) with mivebresib, a bromodomain inhibitor
KR20220034782A (ko) 2019-06-12 2022-03-18 주노 쎄러퓨티크스 인코퍼레이티드 세포 매개 세포 독성 요법 및 친생존 ｂｃｌ2 패밀리 단백질 억제제의 병용 요법
US20220259204A1 (en) * 2019-07-12 2022-08-18 Natco Pharma Limited A process for the preparation of venetoclax and its polymorphs thereof
CA3154120A1 (en) 2019-09-18 2021-03-25 Aprea Therapeutics Ab Combination treatment with a p53 reactivator and an inhibitor of an antiapoptotic bcl-2 family protein
PH12022550879A1 (en) 2019-10-14 2024-03-04 Astrazeneca Ab Combination therapy for treating a hematological malignancy
CN112661751B (zh) * 2019-10-16 2024-06-14 南京天印健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
CN114786680A (zh) 2019-10-21 2022-07-22 诺华股份有限公司 Tim-3抑制剂及其用途
KR20220103947A (ko) 2019-10-21 2022-07-25 노파르티스 아게 베네토클락스 및 tim-3 억제제를 사용한 조합 요법
EP4054583A4 (en) 2019-11-07 2023-10-25 Crinetics Pharmaceuticals, Inc. MELANOCORTIN SUBTYPE 2 RECEPTOR (MC2R) ANTAGONISTS AND THEIR USES
ES2983860T3 (es) 2019-12-06 2024-10-25 Neurocrine Biosciences Inc Antagonistas del receptor muscarínico 4 y métodos de uso
WO2021180040A1 (zh) * 2020-03-12 2021-09-16 南京明德新药研发有限公司 苯并五元环类化合物
WO2021207581A1 (en) 2020-04-10 2021-10-14 Abbvie Inc. Crystalline forms of an apoptosis-inducing agent
AU2021256580A1 (en) 2020-04-15 2022-09-29 Beone Medicines I Gmbh Bcl-2 inhibitor
WO2021231486A1 (en) * 2020-05-13 2021-11-18 Unity Biotechnology, Inc. Cancer treatment by senescence induction followed by a senolytic
WO2022002178A1 (en) * 2020-07-01 2022-01-06 Ascentage Pharma (Suzhou) Co., Ltd. Methods for synthesizing n-(phenylsulfonyl)benzamide compounds and intermediates thereof
CN113727719A (zh) * 2020-07-17 2021-11-30 德尔塔菲制药股份有限公司 血癌的新型治疗方法及新型治疗剂
CN114057728A (zh) * 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
WO2022043538A1 (en) 2020-08-29 2022-03-03 argenx BV Method of treatment of patients having reduced sensitivity to a bcl-2 inhibitor
IL302700A (en) 2020-11-13 2023-07-01 Novartis Ag Combination therapies with chimeric antigen receptor (car)-expressing cells
WO2022133030A1 (en) 2020-12-16 2022-06-23 Juno Therapeutics, Inc. Combination therapy of a cell therapy and a bcl2 inhibitor
CN114835704B (zh) * 2021-02-01 2023-10-27 苏州亚盛药业有限公司 作为bcl-2抑制剂的磺酰基苯甲酰胺衍生物
TW202302108A (zh) 2021-03-19 2023-01-16 美商克林提克斯醫藥股份有限公司 用於治療疾病之黑素皮質素亞型-2受體(mc2r)拮抗劑
CA3211639A1 (en) * 2021-03-19 2022-09-22 Volodymyr KYSIL Compounds having ((3-nitrophenyl)sulfonyl)acetamide as bcl-2 inhibitors
EP4319800A1 (en) 2021-04-07 2024-02-14 Dana-Farber Cancer Institute, Inc. Compositions and methods for the treatment of cancer
WO2022218311A1 (en) * 2021-04-13 2022-10-20 Appicine Therapeutics (Hk) Limited Modulators of bcl-2 or bcl-2/bcl-xl and uses thereof
IT202100025976A1 (it) 2021-10-06 2023-04-06 Univ Degli Studi Di Perugia Combinazione di principi attivi per il trattamento della leucemia acuta mieloide (LAM) con mutazione della nucleofosmina (NPM1)
US20250186451A1 (en) 2022-03-04 2025-06-12 Otsuka Pharmaceutical Co., Ltd. Methods of treating cancer with iap antagonist compounds and combination therapies
CN119213027A (zh) 2022-03-29 2024-12-27 奈特里斯药物公司 新型Mcl-1抑制剂以及Mcl-1与BH3模拟物例如Bcl-2抑制剂的组合
KR20250008772A (ko) 2022-05-06 2025-01-15 트리라인 바이오사이언시스, 인크. 테트라하이드로이소퀴놀린 헤테로이작용성 bcl-xl 분해제
EP4519260A1 (en) 2022-05-06 2025-03-12 Treeline Biosciences, Inc. Tetrahydroisoquinoline heterobifunctional bcl-xdegraders
CA3252016A1 (en) 2022-05-06 2023-11-09 Treeline Biosciences, Inc. HETEROBORCTIONAL TETROHYDROISOQUINOLINE-BASED BCL-XL DEGRADING AGENTS
US20250302954A1 (en) 2022-05-11 2025-10-02 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
CN120202006A (zh) 2022-11-15 2025-06-24 阿斯利康(瑞典)有限公司 卡帕塞替尼和维奈托克的治疗组合
CN116496239A (zh) * 2022-12-14 2023-07-28 南京哈柏医药科技有限公司 一种维奈托克关键中间体及原料药的合成方法
WO2025064952A1 (en) * 2023-09-22 2025-03-27 Eil Therapeutics, Inc. Bcl-2 inhibitors
TW202535872A (zh) 2023-11-07 2025-09-16 美商樹線生物科學公司 四氫異喹啉異雙功能ｂｃｌ－ｘｌ降解劑
WO2025101575A1 (en) 2023-11-07 2025-05-15 Treeline Biosciences, Inc. Tetrahydroisoquinoline heterobifunctional bcl-x l degraders
TW202527930A (zh) 2023-11-07 2025-07-16 美商樹線生物科學公司 四氫異喹啉異雙功能ｂｃｌ－ｘｌ降解劑
US20250195653A1 (en) 2023-11-28 2025-06-19 Sanofi Multifunctional natural killer (nk) cell engager combination therapy for treating hematological neoplastic disorders
TW202533828A (zh) 2024-02-22 2025-09-01 瑞典商阿斯特捷利康公司 Ａｋｔ抑制劑、ｂｃｌ－２抑制劑、及抗ｃｄ２０抗體之治療組合
WO2025181039A1 (en) 2024-03-01 2025-09-04 Molecular Partners Ag Therapeutic combinations comprising a multi-specific t cell engager

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2579596B1 (fr) 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
CA1338238C (en) 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
CA2016710A1 (en) 1989-05-15 1990-11-15 Prasun K. Chakravarty Substituted benzimidazoles as angiotensin ii antagonists
GB9110625D0 (en) 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
AU673569B2 (en) 1992-12-02 1996-11-14 Pfizer Inc. Catechol diethers as selective PDE-IV inhibitors
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
DK1019385T3 (da) 1995-09-15 2004-05-24 Upjohn Co Aminoaryloxazolidinon-N-oxider
CA2305414A1 (en) 1997-10-03 1999-04-15 Merck Frosst Canada & Co. Aryl thiophene derivatives as pde iv inhibitors
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ES2318899T3 (es) 1998-07-06 2009-05-01 Bristol-Myers Squibb Company Bifenil sulfonamidas como antagonistas duales de los receptores de angiotensina y endotelina.
CO5170498A1 (es) 1999-05-28 2002-06-27 Abbott Lab Biaril sulfonamidas son utiles como inhibidores de proliferacion celular
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
AU776933B2 (en) 1999-12-28 2004-09-23 Eisai R&D Management Co., Ltd. Heterocyclic compounds having sulfonamide groups
GB2361003A (en) 2000-04-07 2001-10-10 Astrazeneca Ab Novel compounds
UY26942A1 (es) 2000-09-20 2002-04-26 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US20020055631A1 (en) 2000-09-20 2002-05-09 Augeri David J. N-acylsulfonamide apoptosis promoters
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
JP2002237014A (ja) 2001-02-09 2002-08-23 Tdk Corp サスペンション、ヘッドジンバルアセンブリ及びヘッドジンバルアセンブリの製造方法
SK14642003A3 (sk) 2001-06-06 2004-12-01 Eli Lilly And Company Benzoylsulfónamidy a sulfonylbenzamidíny ako protinádorové činidlá
EP1429759A4 (en) 2001-09-26 2004-12-15 Bristol Myers Squibb Co COMPOUNDS FOR TREATING HEPATITIS C VIRUS
FR2836914B1 (fr) 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
US8614318B2 (en) 2003-11-13 2013-12-24 Abbvie Inc. Apoptosis promoters
US7642260B2 (en) 2003-11-13 2010-01-05 Abbott Laboratories, Inc. Apoptosis promoters
WO2005049593A2 (en) 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US7973161B2 (en) 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
US7767684B2 (en) * 2003-11-13 2010-08-03 Abbott Laboratories Apoptosis promoters
WO2005099353A2 (en) 2004-04-19 2005-10-27 Symed Labs Limited A novel process for the preparation of linezolid and related compounds
ES2382383T3 (es) * 2004-06-17 2012-06-07 Infinity Discovery, Inc. Compuestos y procedimientos para inhibir la interacción de proteínas Bcl con componentes de unión
PL1768967T3 (pl) 2004-07-20 2009-09-30 Symed Labs Ltd Nowe związki pośrednie do wytwarzania linezolidu oraz związki pokrewne
JP2008514702A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
CA2606147C (en) 2005-05-12 2011-07-05 Abbott Laboratories Apoptosis promoters
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
US20080300267A1 (en) * 2005-05-16 2008-12-04 Barun Okram Compounds and Compositions as Protein Kinase Inhibitors
TW200716636A (en) * 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
PL1893612T3 (pl) * 2005-06-22 2012-01-31 Plexxikon Inc Pochodne pirolo-[2,3-b]pirydyny jako inhibitory kinazy białkowej
US7514068B2 (en) * 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
US20090105388A1 (en) * 2006-06-07 2009-04-23 Sumitomo Chemical Company, Limited Epoxy Resin Composition and Cured Epoxy Resin
JP5277168B2 (ja) 2006-09-05 2013-08-28 アボット・ラボラトリーズ 血小板過剰を治療するｂｃｌインヒビター
US8796267B2 (en) * 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
WO2008064116A2 (en) * 2006-11-16 2008-05-29 Abbott Laboratories Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection
MX2009008465A (es) * 2007-02-15 2009-08-20 Hoffmann La Roche Nuevas 2-aminooxazolinas como ligandos de taar1.
US8536157B2 (en) 2007-04-13 2013-09-17 The University Of Melbourne Non-steroidal compounds
CA2686545C (en) * 2007-04-19 2010-11-02 Concert Pharmaceuticals Inc. Deuterated morpholinyl compounds
US7531685B2 (en) * 2007-06-01 2009-05-12 Protia, Llc Deuterium-enriched oxybutynin
WO2009035598A1 (en) * 2007-09-10 2009-03-19 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
US20090118238A1 (en) * 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090082471A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched fingolimod
US20090088416A1 (en) * 2007-09-26 2009-04-02 Protia, Llc Deuterium-enriched lapaquistat
US20090137457A1 (en) * 2007-10-02 2009-05-28 Concert Pharmaceuticals, Inc. Pyrimidinedione derivatives
US20090098118A1 (en) 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
US20090105338A1 (en) 2007-10-18 2009-04-23 Protia, Llc Deuterium-enriched gabexate mesylate
US8410124B2 (en) * 2007-10-18 2013-04-02 Concert Pharmaceuticals Inc. Deuterated etravirine
WO2009055006A1 (en) * 2007-10-26 2009-04-30 Concert Pharmaceuticals, Inc. Deuterated darunavir
UA108193C2 (uk) * 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
EP3666758A1 (en) * 2008-12-05 2020-06-17 AbbVie Inc. Process for the preparation of a sulfonamide derivative
WO2010077740A2 (en) 2008-12-09 2010-07-08 Cytokine Pharmasciences, Inc. Novel antiviral compounds, compositions, and methods of use
WO2010072734A2 (en) 2008-12-23 2010-07-01 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Targeting prodrugs and compositions for the treatment of gastrointestinal diseases
MX2011007681A (es) 2009-01-19 2011-08-08 Abbott Lab Agentes inducidores de apoptosis para el tratamiento del cancer y enfermedades inmunes y autoinmunes.
CN104945311A (zh) 2009-01-19 2015-09-30 Abbvie公司 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
RU2535347C3 (ru) * 2009-05-26 2019-05-14 ЭббВи Айэленд Анлимитед Компани Индуцирующие апоптоз средства для лечения злокачественной опухоли и иммунных и аутоиммунных заболеваний
NZ628298A (en) 2010-03-25 2015-11-27 Abbvie Inc Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI520960B (zh) * 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
EP2632436B1 (en) 2010-10-29 2018-08-29 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
PT2642999T (pt) 2010-11-23 2017-01-05 Abbvie Ireland Unlimited Co Métodos de tratamento que utilizam inibidores seletivos de bcl-2
WO2012071336A1 (en) 2010-11-23 2012-05-31 Abbott Laboratories Salts and crystalline forms of an apoptosis-inducing agent

Also Published As

Publication number Publication date
US20140113910A1 (en) 2014-04-24
SG185638A1 (en) 2012-12-28
JP2013527202A (ja) 2013-06-27
GT201200314A (es) 2014-03-14
TWI501966B (zh) 2015-10-01
CL2012003286A1 (es) 2014-02-21
TW201141860A (en) 2011-12-01
PT2576546E (pt) 2015-10-28
ECSP12012349A (es) 2013-09-30
RU2012156844A (ru) 2014-07-10
ES2546135T3 (es) 2015-09-18
PL2576546T3 (pl) 2015-12-31
CO6640274A2 (es) 2013-03-22
DK2576546T3 (en) 2015-11-02
IL223070A0 (en) 2013-02-03
US20100305122A1 (en) 2010-12-02
AU2010354083B2 (en) 2015-02-12
US20210221789A1 (en) 2021-07-22
AR079124A1 (es) 2011-12-28
RU2554346C2 (ru) 2015-06-27
DOP2012000297A (es) 2013-01-15
ZA201208832B (en) 2013-07-31
MX2012013708A (es) 2013-02-26
EP2576546B1 (en) 2015-07-22
IL223070A (en) 2016-02-29
RS54289B1 (sr) 2016-02-29
US9174982B2 (en) 2015-11-03
UA107706C2 (uk) 2015-02-10
MX350726B (es) 2017-09-14
US20150329541A1 (en) 2015-11-19
US20200231566A1 (en) 2020-07-23
HRP20150925T1 (hr) 2015-10-09
AU2010354083A1 (en) 2012-11-29
PE20131044A1 (es) 2013-10-20
NZ603463A (en) 2014-11-28
US20130267534A1 (en) 2013-10-10
CN103153993B (zh) 2016-06-01
SMT201600015B (it) 2016-02-25
JP5667695B2 (ja) 2015-02-12
US20120190688A1 (en) 2012-07-26
HK1183866A1 (en) 2014-01-10
CN103153993A (zh) 2013-06-12
US20140094471A1 (en) 2014-04-03
US20170158666A1 (en) 2017-06-08
KR20130116002A (ko) 2013-10-22
WO2011149492A1 (en) 2011-12-01
KR101725114B1 (ko) 2017-04-10
CA2799280A1 (en) 2011-12-01
EP2576546A1 (en) 2013-04-10
CY1116728T1 (el) 2017-03-15
BR112012029923A2 (pt) 2017-02-21
PH12012502324A1 (en) 2017-07-26
US20190119247A1 (en) 2019-04-25
US8546399B2 (en) 2013-10-01
SI2576546T1 (sl) 2015-10-30
US9045475B2 (en) 2015-06-02
MY160994A (en) 2017-03-31
CR20120631A (es) 2013-03-19

Similar Documents

Publication Publication Date Title
ME02215B (me) Agensi koji induciraju apoptozu za liječenje raka te imunih i autoimunih bolesti
JP2013527202A5 (me)
NZ603284A (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
RU2018127315A (ru) Индуцирующие апоптоз средства для лечения злокачественной опухоли и иммунологических и аутоиммунных заболеваний
NZ610746A (en) Methods of treatment using selective bcl-2 inhibitors
RU2012127760A (ru) Bcl-2-селективные апоптоз-индуцирующие средства для лечения рака и иммунных заболеваний
JP2013523889A5 (me)
NZ593594A (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
JP2020040989A5 (me)
NZ595708A (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
NZ629432A (en) Heterocyclyl compounds as mek inhibitors
RU2014115476A (ru) Производные пиразоло[4, 3-с]птридина в качестве ингибиторов киназ
NZ612544A (en) Heterocyclic compounds suitable for the treatment of dyslipidemia
MX343014B (es) Sales y formas cristalinas de un agente inductor de apoptosis.
RU2015108898A (ru) 3-ЦИКЛОГЕКСЕНИЛ И ЦИКЛОГЕКСИЛ ЗАМЕЩЕННЫЕ ИНДОЛЬНЫЕ И ИНДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RORгаммаТ И ИХ ПРИМЕНЕНИЯ
JP2004527560A5 (me)
RU2007134396A (ru) Химические соединения
JP2014531449A5 (me)
HRP20230069T1 (hr) Selektivni inhibitori jak1
HRP20170352T1 (hr) Spojevi bis(fluroalkil)-1,4-benzodiazepinona kao notch inhibitori
RU2015124381A (ru) Производные 2,3-дигидро-изоиндол-1-она и способы их применения в качестве ингибиторов тирозинкиназы брутона
FI4055021T3 (fi) Heterosyklisiä rip1:tä estäviä yhdisteitä
HRP20120202T1 (hr) AMIDOFENOKSIINDAZOLI, KORISNI KAO INHIBITORI c-MET
JP2015500842A5 (me)
RU2018104702A (ru) Новые соединения пирролопиримидина в качестве ингибиторов протеинкиназ