MX2017000610A - Metodos combinados para tratar canceres. - Google Patents

Metodos combinados para tratar canceres.

Info

Publication number
MX2017000610A
MX2017000610A MX2017000610A MX2017000610A MX2017000610A MX 2017000610 A MX2017000610 A MX 2017000610A MX 2017000610 A MX2017000610 A MX 2017000610A MX 2017000610 A MX2017000610 A MX 2017000610A MX 2017000610 A MX2017000610 A MX 2017000610A
Authority
MX
Mexico
Prior art keywords
cancer
subject
combinations
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
MX2017000610A
Other languages
English (en)
Inventor
Di Paolo Julie
Clarke Astrid
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2017000610A publication Critical patent/MX2017000610A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente invención se describen métodos para tratar un cáncer en un sujeto (por ejemplo, un ser humano) que necesita del mismo, que comprende administrar al sujeto una cantidad terapéuticamente eficaz de un compuesto de la fórmula I: (ver Fórmula) o una sal farmacéuticamente aceptable del mismo, en combinación con un alcaloide de vinca o una sal farmacéuticamente aceptable del mismo. El sujeto puede tener cáncer de muy alto riesgo o de bajo riesgo y puede no responder a ninguno de los agentes administrados como terapia única. El sujeto que tiene el cáncer también puede ser refractario al menos a un tratamiento de quimioterapia, o está en recaída después del tratamiento con quimioterapia o ambos. El cáncer puede ser un tumor maligno hematológico, tal como leucemia o linfoma, o un cáncer de tumor sólido, tal como cáncer de páncreas, de pulmón y de colon.
MX2017000610A 2014-07-14 2015-07-10 Metodos combinados para tratar canceres. MX2017000610A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462024424P 2014-07-14 2014-07-14
PCT/US2015/040029 WO2016010862A1 (en) 2014-07-14 2015-07-10 Combinations for treating cancers

Publications (1)

Publication Number Publication Date
MX2017000610A true MX2017000610A (es) 2017-04-27

Family

ID=53762348

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017000610A MX2017000610A (es) 2014-07-14 2015-07-10 Metodos combinados para tratar canceres.

Country Status (16)

Country Link
US (2) US9707236B2 (es)
EP (1) EP3169366A1 (es)
JP (1) JP6310144B2 (es)
KR (1) KR20170029580A (es)
CN (1) CN106687139A (es)
AR (1) AR103110A1 (es)
AU (1) AU2015290000B2 (es)
BR (1) BR112016028641A2 (es)
CA (1) CA2955180A1 (es)
EA (1) EA201790086A1 (es)
MA (1) MA40075A (es)
MX (1) MX2017000610A (es)
NZ (1) NZ726365A (es)
SG (1) SG11201610551TA (es)
TW (1) TW201613589A (es)
WO (1) WO2016010862A1 (es)

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Also Published As

Publication number Publication date
BR112016028641A2 (pt) 2017-08-22
US20180008608A1 (en) 2018-01-11
SG11201610551TA (en) 2017-01-27
NZ726365A (en) 2018-06-29
WO2016010862A1 (en) 2016-01-21
US9707236B2 (en) 2017-07-18
AR103110A1 (es) 2017-04-19
US10080756B2 (en) 2018-09-25
AU2015290000A1 (en) 2016-12-01
JP6310144B2 (ja) 2018-04-18
KR20170029580A (ko) 2017-03-15
JP2017521442A (ja) 2017-08-03
AU2015290000B2 (en) 2018-05-17
CA2955180A1 (en) 2016-01-21
MA40075A (fr) 2016-01-21
EA201790086A1 (ru) 2017-07-31
CN106687139A (zh) 2017-05-17
EP3169366A1 (en) 2017-05-24
TW201613589A (en) 2016-04-16
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